45 results match your criteria mard clarke


Device profile of the Eversense continuous glucose monitoring system for glycaemic control in type-1 diabetes: overview of its safety and efficacy.

Expert Rev Med Devices 2021 Sep 16. Epub 2021 Sep 16.

Senseonics, Inc., Germantown, Maryland, US.

Introduction: Continuous glucose monitoring (CGM) systems offer real-time data to facilitate diabetes management. The novel Eversense CGM has been approved in Europe and the US. The unique characteristics are the fully implantable sensor and the sensor life up to 180 days. Read More

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September 2021

Accuracy of CGM Systems During Continuous and Interval Exercise in Adults with Type 1 Diabetes.

J Diabetes Sci Technol 2021 Jun 11:19322968211023522. Epub 2021 Jun 11.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University and Hospital of Verona, Verona, Italy.

Background: continuous glucose monitoring systems (CGMs) play an important role in the management of T1D, but their accuracy may reduce during rapid glucose excursions. The aim of study was to assess the accuracy of recent rt-CGMs available in Italy, in subjects with T1D during 2 sessions of physical activity: moderate continuous (CON) and interval exercise (IE).

Method: we recruited 22 patients with T1D, on CSII associated or integrated with a CGM, to which a second different sensor was applied. Read More

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Accuracy of Dexcom G6 Continuous Glucose Monitoring in Non-Critically Ill Hospitalized Patients With Diabetes.

Diabetes Care 2021 Jun 7. Epub 2021 Jun 7.

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA

Objective: Advances in continuous glucose monitoring (CGM) have transformed ambulatory diabetes management. Until recently, inpatient use of CGM has remained investigational, with limited data on its accuracy in the hospital setting.

Research Design And Methods: To analyze the accuracy of Dexcom G6, we compared retrospective matched-pair CGM and capillary point-of-care (POC) glucose data from three inpatient CGM studies (two interventional and one observational) in general medicine and surgery patients with diabetes treated with insulin. Read More

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Continuous Glucose Monitoring in the Intensive Care Unit Following Total Pancreatectomy with Islet Autotransplantation in Children: Establishing Accuracy of the Dexcom G6 Model.

J Clin Med 2021 Apr 27;10(9). Epub 2021 Apr 27.

Division of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Hyperglycemia is detrimental to postoperative islet cell survival in patients undergoing total pancreatectomy with islet autotransplantation (TPIAT). This makes continuous glucose monitoring (CGM) a useful management tool. We evaluated the accuracy of the Dexcom G6 CGM in pediatric intensive care unit patients following TPIAT. Read More

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Performance of the Intermittently Scanned Continuous Glucose Monitoring (isCGM) System during a High Oral Glucose Challenge in Adults with Type 1 Diabetes-A Prospective Secondary Outcome Analysis.

Biosensors (Basel) 2021 Jan 15;11(1). Epub 2021 Jan 15.

Cardiovascular Diabetology Research Group, Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.

To assess intermittently scanned continuous glucose monitoring (isCGM) performance for different rates of change in plasma glucose (RCPG) during glycemic challenges in type 1 diabetes (T1D). Nineteen people with T1D (7 females; age 35 ± 11 years; HbA 7.3 ± 0. Read More

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January 2021

Replay Simulations with Personalized Metabolic Model for Treatment Design and Evaluation in Type 1 Diabetes.

J Diabetes Sci Technol 2020 Nov 20:1932296820973193. Epub 2020 Nov 20.

Center for Diabetes Technology, University of Virginia, Charlottesville, VA, USA.

Background: The capacity to replay data collected in real life by people with type 1 diabetes mellitus (T1DM) would lead to individualized (vs population) assessment of treatment strategies to control blood glucose and possibly true personalization. Patek et al introduced such a technique, relying on regularized deconvolution of a population glucose homeostasis model to estimate a residual additive signal and reproduce the experimental data; therefore, allowing the subject-specific replay of scenarios by altering the model inputs (eg, insulin). This early method was shown to have a limited domain of validity. Read More

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November 2020

Continuous Glucose Monitoring in Critically Ill Patients With COVID-19: Results of an Emergent Pilot Study.

J Diabetes Sci Technol 2020 11 16;14(6):1065-1073. Epub 2020 Oct 16.

Division of Endocrinology, Diabetes and Metabolism, Houston Methodist, Weill Cornell Medical College, Texas A&M Health Sciences Center, Houston, TX, USA.

Background: Amidst the coronavirus disease 2019 (COVID-19) pandemic, continuous glucose monitoring (CGM) has emerged as an alternative for inpatient point-of-care blood glucose (POC-BG) monitoring. We performed a feasibility pilot study using CGM in critically ill patients with COVID-19 in the intensive care unit (ICU).

Methods: Single-center, retrospective study of glucose monitoring in critically ill patients with COVID-19 on insulin therapy using Medtronic Guardian Connect and Dexcom G6 CGM systems. Read More

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November 2020

Adaptive Boosting Based Personalized Glucose Monitoring System (PGMS) for Non-Invasive Blood Glucose Prediction with Improved Accuracy.

Diagnostics (Basel) 2020 May 7;10(5). Epub 2020 May 7.

IBA Community College Naushahro Feroze, Sukkur IBA University, Sindh 65200, Pakistan.

In this paper, we present an architecture of a personalized glucose monitoring system (PGMS). PGMS consists of both invasive and non-invasive sensors on a single device. Initially, blood glucose is measured invasively and non-invasively, to train the machine learning models. Read More

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The Accuracy and Precision of the Continuously Stored Data from Flash Glucose Monitoring System in Type 2 Diabetes Patients during Standard Meal Tolerance Test.

Int J Endocrinol 2020 4;2020:5947680. Epub 2020 Jan 4.

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, China.

Background: The purpose of this study was to investigate the accuracy of the continuously stored data from the Abbott FreeStyle Libre flash glucose monitoring (FGM) system in Chinese diabetes patients during standard meal tests when glucose concentrations were rapidly changing. . Interstitial glucose levels were monitored for 14 days in 26 insulin-treated patients with type 2 diabetes using the FGM system. Read More

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January 2020

Glucose Sensor Accuracy After Subcutaneous Glucagon Injections Near to Sensor Site.

Diabetes Technol Ther 2020 02 30;22(2):131-135. Epub 2019 Dec 30.

Steno Diabetes Center Copenhagen, Clinical Research, Gentofte, Denmark.

Integrated hormone delivery and glucose sensing is warranted, but system performance could be challenged by glucose sensor susceptibility to pharmacological interferences. The aim of this study was to compare sensor accuracy (Medtronic Enlite 2) after subcutaneous (s.c. Read More

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February 2020

Retrospective Continuous-Time Blood Glucose Estimation in Free Living Conditions with a Non-Invasive Multisensor Device.

Sensors (Basel) 2019 Aug 24;19(17). Epub 2019 Aug 24.

Department of Information Engineering, University of Padova, 35131 Padova, Italy.

Even if still at an early stage of development, non-invasive continuous glucose monitoring (NI-CGM) sensors represent a promising technology for optimizing diabetes therapy. Recent studies showed that the Multisensor provides useful information about glucose dynamics with a mean absolute relative difference (MARD) of 35.4% in a fully prospective setting. Read More

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Lag Time Remains with Newer Real-Time Continuous Glucose Monitoring Technology During Aerobic Exercise in Adults Living with Type 1 Diabetes.

Diabetes Technol Ther 2019 06 6;21(6):313-321. Epub 2019 May 6.

1 Kinesiology and Health Science, Faculty of Health, Muscle Health Research Centre, York University, Toronto, Canada.

Real-time continuous glucose monitoring (CGM) devices help detect glycemic excursions associated with exercise, meals, and insulin dosing in patients with type 1 diabetes (T1D). However, the delay between interstitial and blood glucose may result in CGM underestimating the true change in glycemia during activity. The purpose of this study was to examine CGM discrepancies during exercise and the meal postexercise versus self-monitoring of blood glucose (SMBG). Read More

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Comparison of Continuous Glucose Monitoring Accuracy Between Abdominal and Upper Arm Insertion Sites.

Diabetes Technol Ther 2019 05 17;21(5):295-302. Epub 2019 Apr 17.

1 Department of Endocrinology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

The aim was to compare the accuracy of the Dexcom G4 Platinum continuous glucose monitor (CGM) sensor inserted on the upper arm and the abdomen in adults. Fourteen adults with type 1 diabetes wore two CGMs, one placed on the upper arm and one placed on the abdomen. Three in-clinic visits of 5 h with YSI (2300 STAT, Yellow Springs Instrument) measurements as comparator were performed. Read More

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The usefulness of the FlashStyle Libre system in glycemic control in children with type 1 diabetes during summer camp.

Pediatr Endocrinol Diabetes Metab 2018 ;24(1):11-19

Department of Children's Diabetology, School of Medicine in Katowice, Medical University of Silesia in Katowice.

The Aim Of The Study: was to evaluate the usefulness of Flash FreeStyle Libre in glycemic control in children during summer camp on the basis of the participants' completed questionnaire and on the basis of the assessment o the suitability of the system performed by medical staff based on a comparative analysis: glycemia by sensor and glucometer.

Material And Methods: A study using the new Flash FreeStyle Libre glycemic control system was conducted at a seaside summer camp for children with diabetes at the seaside. The study included 75 children (32 boys and 43 girls), in mean 13. Read More

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December 2018

A Prospective Multicenter Evaluation of the Accuracy of a Novel Implanted Continuous Glucose Sensor: PRECISE II.

Diabetes Technol Ther 2018 03 30;20(3):197-206. Epub 2018 Jan 30.

9 AMCR Institute, Inc. , Escondido, California.

Background: Persistent use of real-time continuous glucose monitoring (CGM) improves diabetes control in individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D).

Methods: PRECISE II was a nonrandomized, blinded, prospective, single-arm, multicenter study that evaluated the accuracy and safety of the implantable Eversense CGM system among adult participants with T1D and T2D (NCT02647905). The primary endpoint was the mean absolute relative difference (MARD) between paired Eversense and Yellow Springs Instrument (YSI) reference measurements through 90 days postinsertion for reference glucose values from 40 to 400 mg/dL. Read More

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The performance of flash glucose monitoring in critically ill patients with diabetes.

Crit Care Resusc 2017 Jun;19(2):167-174

Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia.

Objective: Frequent glucose monitoring may improve glycaemic control in critically ill patients with diabetes. We aimed to assess the accuracy of a novel subcutaneous flash glucose monitor (FreeStyle Libre [Abbott Diabetes Care]) in these patients.

Methods: We applied the FreeStyle Libre sensor to the upper arm of eight patients with diabetes in the intensive care unit and obtained hourly flash glucose measurements. Read More

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Continuous glucose monitoring following pancreatectomy with islet autotransplantation in children.

Pediatr Transplant 2017 Nov 12;21(7). Epub 2017 Jun 12.

Division of General & Thoracic Surgery, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Aim was to determine whether CGM could accurately monitor blood glucose concentration in the immediate postoperative period following pancreatectomy with IAT in children. CGM was used in nine patients undergoing IAT at our institution between April 2015 and September 2016 (eight total pancreatectomy and one subtotal pancreatectomy). MAD and MARD of CGM values compared to time-matched serum blood glucose were calculated during the first 5 days of ICU admission. Read More

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November 2017

Results of a multicenter prospective pivotal trial of the first inline continuous glucose monitor in critically ill patients.

J Trauma Acute Care Surg 2017 06;82(6):1049-1054

From the Acute and Critical Care Surgery (G.V.B., E.N., K.B.), Washington University in St. Louis, St. Louis, Missouri; Tufts University Medical Center (S.N.), Boston, Massachusetts; Memorial Hermann Hospital (L.M.), Houston, Texas; and Star-Wood Cardiac Group (A.F.), Portland, Oregon.

Background: We have previously demonstrated that tight glycemic control (80-120 mg/dL) improves outcome in critically injured patients. However, many centers have gotten away from aggressive glucose control due to the workload and risk of hypoglycemia. The objective of this pivotal trial is to evaluate the first in human continuous inline glucose monitor (OptiScanner) in critically ill patients. Read More

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Manual versus Automated moNitoring Accuracy of GlucosE II (MANAGE II).

Crit Care 2016 11 25;20(1):380. Epub 2016 Nov 25.

Department of Intensive Care, Erasme University Hospital, Université libre de Bruxelles, 808 route de Lennik, Brussels, B-1070, Belgium.

Background: Intravascular continuous glucose monitoring (CGM) may facilitate glycemic control in the intensive care unit (ICU). We compared the accuracy of a CGM device (OptiScanner®) with a standard reference method.

Methods: Adult patients who had blood glucose (BG) levels >150 mg/dl and required insertion of an arterial and central venous catheter were included. Read More

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November 2016

Accuracy and Longevity of an Implantable Continuous Glucose Sensor in the PRECISE Study: A 180-Day, Prospective, Multicenter, Pivotal Trial.

Diabetes Care 2017 Jan 4;40(1):63-68. Epub 2016 Nov 4.

Department of Endocrinology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.

Objective: It is known that continuous glucose monitoring (CGM) systems can lower mean glucose compared with episodic self-monitoring of blood glucose. Implantable CGM systems may provide additional benefits.

Research Design And Methods: We studied the Eversense (Senseonics Inc. Read More

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January 2017

From Two to One Per Day Calibration of Dexcom G4 Platinum by a Time-Varying Day-Specific Bayesian Prior.

Diabetes Technol Ther 2016 08;18(8):472-9

Department of Information Engineering, University of Padova , Padova, Italy .

Background: In the DexCom G4 Platinum (DG4P) continuous glucose monitoring (CGM) sensor, the raw current signal generated by glucose-oxidase is transformed to glucose concentration by a calibration function whose parameters are periodically updated by matching self-monitoring of blood glucose references, usually twice a day, to compensate for sensor variability in time. The aim of this work is to reduce DG4P calibration frequency to once a day by a recently proposed Bayesian calibration algorithm, which employs a time-varying calibration function and suitable day-specific priors.

Methods: The database consists of 57 CGM signals that are collected by the DG4P for 7 days. Read More

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Accuracy, reliability, feasibility and nurse acceptance of a subcutaneous continuous glucose management system in critically ill patients: a prospective clinical trial.

Ann Intensive Care 2016 Dec 21;6(1):70. Epub 2016 Jul 21.

Department of Anesthesiology and Operative Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: Continuous glucose monitoring (CGM) has not yet been implemented in the intensive care unit (ICU) setting. The purpose of this study was to evaluate reliability, feasibility, nurse acceptance and accuracy of the Medtronic Sentrino(®) CGM system in critically ill patients.

Methods: Sensors were inserted into the subcutaneous tissue of the patient's thigh, quantifying interstitial glucose concentration for up to 72 h per sensor. Read More

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December 2016

Results of a near continuous glucose monitoring technology in surgical intensive care and trauma.

Contemp Clin Trials 2016 09 6;50:1-4. Epub 2016 Jul 6.

Acute and Critical Care Surgery, Washington University in St. Louis, St. Louis, MO, United States.

Introduction: Near-continuous glucose monitoring is expected to increase time in range (TIR) of 80-120mg/dL and to avoid hypoglycemia without increasing workload. We investigated a near-continuous glucose monitor in surgical critically ill and trauma patients.

Methods: Patients were enrolled at a surgical intensive care unit associated with a level 1 trauma center. Read More

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September 2016

Head-to-head comparison between flash and continuous glucose monitoring systems in outpatients with type 1 diabetes.

J Endocrinol Invest 2016 Dec 10;39(12):1391-1399. Epub 2016 Jun 10.

Division of Metabolic Diseases, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padua, Italy.

Purpose: Continuous glucose monitoring (CGM) is being increasingly used in clinical practice. The flash glucose monitoring (FGM) and CGM are different systems of interstitial glucose recording. We aimed to determine the agreement between the factory-calibrated FGM FreeStyle Libre (FSL) and the gold-standard CGM Dexcom G4 Platinum (DG4P). Read More

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December 2016

Accuracy of Continuous Glucose Monitoring in Patients After Total Pancreatectomy with Islet Autotransplantation.

Diabetes Technol Ther 2016 08 22;18(8):455-63. Epub 2016 Apr 22.

1 Department of Pediatrics, University of Minnesota Medical Center , Minneapolis, Minnesota.

Background: Among postsurgical and critically ill patients, malglycemia is associated with increased complications. Continuous glucose monitoring (CGM) in the inpatient population may enhance glycemic control. CGM reliability may be compromised by postsurgical complications such as edema or vascular changes. Read More

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Feasibility of an Orthogonal Redundant Sensor incorporating Optical plus Redundant Electrochemical Glucose Sensing.

J Diabetes Sci Technol 2016 05 3;10(3):679-88. Epub 2016 May 3.

Department of Medicine, St Vincent's Hospital, University of Melbourne, Melbourne, Australia Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne, Melbourne, Australia

Background: Orthogonal redundancy for glucose sensing (multiple sensing elements utilizing distinct methodologies) may enhance performance compared to nonredundant sensors, and to sensors with multiple elements utilizing the same technology (simple redundancy). We compared the performance of a prototype orthogonal redundant sensor (ORS) combining optical fluorescence and redundant electrochemical sensing via a single insertion platform to an electrochemical simple redundant sensor (SRS).

Methods: Twenty-one adults with type 1 diabetes wore an ORS and an SRS concurrently for 7 days. Read More

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Accuracy of continuous glucose monitoring during differing exercise conditions.

Diabetes Res Clin Pract 2016 Feb 19;112:1-5. Epub 2015 Dec 19.

Division of Endocrinology, Diabetes & Clinical Nutrition, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland. Electronic address:

Aim: Depending on intensity, exercise may induce a strong hormonal and metabolic response, including acid-base imbalances and changes in microcirculation, potentially interfering with the accuracy of continuous glucose monitoring (CGM). The present study aimed at comparing the accuracy of the Dexcom G4 Platinum (DG4P) CGM during continuous moderate and intermittent high-intensity exercise (IHE) in adults with type 1 diabetes (T1DM).

Methods: Ten male individuals with well-controlled T1DM (HbA1c 7. Read More

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February 2016

NIR photoacoustic spectroscopy for non-invasive glucose measurement.

Annu Int Conf IEEE Eng Med Biol Soc 2015 Aug;2015:7978-81

The use of near infra red (NIR) photoacoustic spectroscopy (PAS) for continuous non-invasive glucose measurement is outlined in the paper. A photoacoustic (PA) measurement apparatus was constructed and PA measurements were made on glucose solutions at multiple NIR excitation wavelengths. A variety of time and frequency domain features, including amplitude and area based features, were extracted from the PA measurements. Read More

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Redundancy in Glucose Sensing: Enhanced Accuracy and Reliability of an Electrochemical Redundant Sensor for Continuous Glucose Monitoring.

J Diabetes Sci Technol 2016 05 3;10(3):669-78. Epub 2016 May 3.

Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne, Melbourne, Australia Department of Medicine, St Vincent's Hospital, University of Melbourne, Melbourne, Australia

Background: Current electrochemical glucose sensors use a single electrode. Multiple electrodes (redundancy) may enhance sensor performance. We evaluated an electrochemical redundant sensor (ERS) incorporating two working electrodes (WE1 and WE2) onto a single subcutaneous insertion platform with a processing algorithm providing a single real-time continuous glucose measure. Read More

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Modelling, verification, and calibration of a photoacoustics based continuous non-invasive blood glucose monitoring system.

Rev Sci Instrum 2015 Jun;86(6):064901

Department of Electronics and Electrical Communication Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.

This paper examines the use of photoacoustic spectroscopy (PAS) at an excitation wavelength of 905 nm for making continuous non-invasive blood glucose measurements. The theoretical background of the measurement technique is verified through simulation. An apparatus is fabricated for performing photoacoustic measurements in vitro on glucose solutions and in vivo on human subjects. Read More

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