Obstet Gynecol 2021 Dec 2. Epub 2021 Dec 2.
Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Unicamp, Campinas, Centro Integrado de Saúde Amaury de Medeiros - CISAM-UPE, Recife, Pernambuco, the Department of Obstetrics and Gynecology, School of Medicine of Jundiaí, Jundiaí, and the Department of Obstetrics and Gynecology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil; the Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia; and the Aberdeen Centre for Women's Health Research, University of Aberdeen, Aberdeen, United Kingdom.
Objective: To test the effectiveness of cervical pessary in addition to vaginal progesterone for the prevention of preterm birth in women with midpregnancy short cervixes.
Methods: We performed a multicenter, open-label, randomized controlled trial in 17 perinatal centers. Asymptomatic women with singleton or twin pregnancies and cervical lengths of 30 mm or less, measured at 18 0/7-22 6/7 weeks of gestation, were randomized to cervical pessary plus vaginal progesterone (pessary plus progesterone group) or vaginal progesterone only (progesterone-only group) (200 mg/day). Read More