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Randomized Phase II Trial of Capecitabine and Lapatinib with or without IMC-A12 (Cituxumumab) in Patients with HER2-Positive Advanced Breast Cancer Previously Treated with Trastuzumab and Chemotherapy: NCCTG N0733 (Alliance).

Breast Cancer Res Treat 2021 Apr 14. Epub 2021 Apr 14.

Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.

Purpose: To compare efficacy and safety of capecitabine and lapatinib with or without IMC-A12 (cituxumumab) in patients with HER2-positive metastatic breast cancer (MBC) previously treated with trastuzumab.

Patients And Methods: Following an initial safety run-in cohort, patients were randomized 1:2 to Arm A (capecitabine and lapatinib) or to Arm B (capecitabine, lapatinib, and cituxumumab). Given the frequency of non-hematologic grade ≥ 3 adverse events in those receiving the three-drug combination in the safety cohort, lapatinib and capecitabine doses were reduced in Arm B only. Read More

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The risk scoring system for assessing the technical difficulty of endoscopic submucosal dissection in cases of remnant gastric cancer after distal gastrectomy.

Surg Endosc 2021 Apr 14. Epub 2021 Apr 14.

Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, 7-5-1 Chu-o-ku, Kusunoki-Cho, Kobe, Hyogo, 650-0017, Japan.

Background: Endoscopic submucosal dissection (ESD) for remnant gastric cancer (RGC) after distal gastrectomy (DG) is considered technically challenging due to the narrow working space, and severe fibrosis and staples from the previous surgery. Technical difficulties of ESD for RGC after DG have not been thoroughly investigated. This study aimed to develop and validate a risk-scoring system for assessing the technical difficulty of ESD for RGC after DG in a large multicenter cohort. Read More

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Prediction of the early recurrence in spinal giant cell tumor of bone using radiomics of preoperative CT: Long-term outcome of 62 consecutive patients.

J Bone Oncol 2021 Apr 16;27:100354. Epub 2021 Mar 16.

Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China.

Objectives: To determine if radiomics analysis based on preoperative computed tomography (CT) can predict early postoperative recurrence of giant cell tumor of bone (GCTB) in the spine.

Methods: In a retrospective review, 62 patients with pathologically confirmed spinal GCTB from March 2008 to February 2018, with a minimum follow-up of 24 months, were identified. The mean follow-up was 73. Read More

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Analysis of risk factors of bladder neck contracture following transurethral surgery of prostate.

BMC Urol 2021 Apr 11;21(1):59. Epub 2021 Apr 11.

Department of Urology, MacKay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Zhongshan Dist., Taipei, 104, Taiwan.

Backgrounds: The aim of the present study was to investigate the perioperative parameters associated with bladder neck contracture (BNC) after transurethral surgery of the prostate and to compare the incidence of BNC after transurethral resection of the prostate (TURP) or Thulium vaporesection (resection group) versus Thulium vapoenucleation or enucleation of the prostate (enucleation group).

Methods: Between March 2008 and March 2020, 2363 patients received TURP and 1656 patients received transurethral surgery of the prostate with Thulium laser (ThuP) at Mackay Memorial Hospital. A total of 62 patients developed BNC. Read More

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Measuring Progress of Regulatory Convergence and Cooperation Among Asia-Pacific Economic Cooperation (APEC) Member Economies in the Context of the COVID-19 Pandemic.

Ther Innov Regul Sci 2021 Apr 11. Epub 2021 Apr 11.

Duke-NUS Medical School, Centre of Regulatory Excellence, Singapore, Singapore.

Purpose: Regulatory convergence and cooperation among medical product regulatory authorities are essential to delivering safe and efficacious products quickly to patients. The COVID-19 pandemic highlights the urgent need for streamlined regulatory approval processes-which can be achieved in part through regulatory convergence and cooperation-both to accelerate availability of COVID-19 vaccines, treatments and diagnostics and to maintain the availability of the existing medical products unrelated to COVID-19.

Methods: The Asia-Pacific Economic Cooperation (APEC) Life Sciences Innovation Forum (LSIF) established the Regulatory Harmonization Steering Committee (RHSC) in 2008 to advance regulatory convergence among APEC's 21 member economies. Read More

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Diagnostic value of culture results from aqueous tap versus vitreous tap in cases of bacterial endophthalmitis.

Br J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and Biomedical Research Centre, Institute of Ophthalmology, UCL, London, UK

Objective: To investigate the concordance between aqueous and vitreous tap culture results among different types of bacterial endophthalmitis.

Methods And Analysis: This retrospective cohort analysis included all cases diagnosed with endophthalmitis at Moorfields Eye Hospital between January 2008 and March 2020. Aqueous and vitreous samples obtained simultaneously at presentation. Read More

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Respondent Characteristics and Dietary Intake Data Collected Using Web-Based and Traditional Nutrition Surveillance Approaches: Comparison and Usability Study.

JMIR Public Health Surveill 2021 Apr 7;7(4):e22759. Epub 2021 Apr 7.

Institute of Food and Health, University College Dublin, Dublin, Ireland.

Background: There are many constraints to conducting national food consumption surveys for national nutrition surveillance, including cost, time, and participant burden. Validated web-based dietary assessment technologies offer a potential solution to many of these constraints.

Objective: This study aims to investigate the feasibility of using a previously validated, web-based, 24-hour recall dietary assessment tool (Foodbook24) for nutrition surveillance by comparing the demographic characteristics and the quality of dietary intake data collected from a web-based cohort of participants in Ireland to those collected from the most recent Irish National Adult Nutrition Survey (NANS). Read More

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Association between lifestyle habits and the prevalence of abdominal obesity after the Great East Japan Earthquake: The Fukushima Health Management Survey.

J Epidemiol 2021 Apr 3. Epub 2021 Apr 3.

Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University.

Background: The proportion of overweight individuals living in the evacuation zone of Fukushima increased after the Great East Japan Earthquake. However, the change in the prevalence of abdominal obesity has not been reported. Lifestyle habits and changes in these habits after the disaster might have affected the onset of abdominal obesity; however, the association between the two is unclear. Read More

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Peripheral Pulmonary Artery Stenosis is Not a Contraindication to Single Ventricle Pathway.

Ann Thorac Surg 2021 Mar 31. Epub 2021 Mar 31.

Department of Cardiac Research, Prince Sultan Cardiac Center, Riyadh, Saudi Arabia.

Background: The presence of peripheral pulmonary artery stenosis (PPAS) involving lobar and/or segmental pulmonary artery (PA) branches might preclude proceeding to single ventricle pathway. We adopted strict strategy for PA rehabilitation and surgical reconstruction in patients who are unable to progress in single ventricle pathway.

Methods: We conducted a retrospective review of 22 patients with single ventricle physiology who underwent surgical reconstruction for PPAS from April 2008 to March 2020. Read More

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Systemic Sclerosis and Associated Interstitial Lung Disease in Ontario, Canada: An Examination of Prevalence and Survival Over 10 Years.

J Rheumatol 2021 Apr 1. Epub 2021 Apr 1.

Schulich School of Medicine and Dentistry, Western University, St. Joseph Health Care, London, Canada; Boehringer Ingelheim (Canada) Limited, Burlington, Canada; HOPE Research Centre, Sunnybrook Research Institute, Toronto, Canada; Dept of Respiratory Medicine, Pathology and Molecular Medicine, McMaster University, Hamilton, Canada. Funding for this study was provided by Boehringer-Ingelheim (Canada) Limited. Pope JE has undertaken consultancy work for AbbVie, Actelion, Baxter, Bayer, BMS, Boehringer Ingelheim, Lilly, Merck, Novartis, Pfizer, Roche, Sandoz, Sanofi and UCB. Quansah K and Flavin J are employees of Boehringer Ingelheim Canada Limited. Hassan S and Seung SJ received unrestricted funding from Boehringer Ingelheim Canada Limited. Kolb M reports grants and personal fees from Roche, Boehringer Ingelheim and Prometic, personal fees from Gilead and Genoa, and grants from Actelion, Respivert, Alkermes and Pharmaxis. Address correspondence to Dr. Janet E Pope, St Joseph's Health Care, 268 Grosvenor St., Rheumatology D2, London, Ontario, Canada, N6G 2S3. E-mail:

Objective: Systemic sclerosis (SSc) is a rare autoimmune disease. Pulmonary complications of SSc are one of the leading causes of morbidity and mortality. The objective of this study was to determine prevalence and survival estimates of SSc and SSc-ILD in a Canadian province (Ontario) using administrative data over 10 years. Read More

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Acute Kidney Injury Following Hyperthermic Intraperitoneal Chemotherapy With Cisplatin.

Anticancer Res 2021 Mar;41(3):1641-1646

Hepatobilliary and Surgical Oncology Unit, Department of Surgery, St George Hospital, Kogarah, NSW, Australia.

Background/aim: Cisplatin increases the risk of acute kidney injury (AKI) during systemic chemotherapy. However, little is known about its risk of inducing AKI when used during intraperitoneal chemotherapy. This study aimed to determine the incidence of AKI in patients undergoing cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) with cisplatin. Read More

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Completeness of reporting for systematic reviews of point-of-care ultrasound: a meta-research study.

BMJ Evid Based Med 2021 Mar 30. Epub 2021 Mar 30.

Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada.

Objectives: Systematic reviews are often considered among the highest quality of evidence. Completely reported systematic reviews, however, are required so readers can assess for generalisability of the research to practice and risk of bias. The objective of this study was to assess the completeness of reporting for systematic reviews assessing the diagnostic accuracy of point-of-care ultrasound (POCUS) using the Preferred Reporting Items for Systematic Reviews and Meta-analyses for Diagnostic Test Accuracy (PRISMA-DTA) checklist that was published in 2018. Read More

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Anti-Epidemic Emergency Regimes under Polish Law in Comparative, Historical and Jurisprudential Perspective.

Leszek Bosek

Eur J Health Law 2021 Mar 29:1-29. Epub 2021 Mar 29.

Center for Medical Law and Biotechnology, University of Warsaw Warsaw Poland.

The SARS-CoV-2 crisis of 2020 triggered a number of unprecedented reactions of European states, in particular in the form of either constitutional emergency measures or statutory anti-epidemic emergency measures. Poland chose to deal with the crisis by delegating powers to the executive by ordinary legislative means and declared a nationwide state of epidemic emergency on 13 March 2020 and a week later a state of epidemic on the basis of the Act of 5 December 2008 on preventing and combating infections and infectious diseases. For a century, Poland has been dealing with epidemics by delegating powers to the executive by ordinary legislative means. Read More

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Randomized controlled trial of frozen versus fresh corneal graft carriers in Boston keratoprosthesis type 1 surgery: 10-year outcomes.

Can J Ophthalmol 2021 Mar 26. Epub 2021 Mar 26.

Department of Ophthalmology, Centre Hospitalier de l'Université de Montréal, Montréal, Qué.

Objective: To compare 10-year clinical outcomes of frozen versus fresh corneal graft carriers for the Boston Keratoprosthesis type 1 (KPro).

Design: Prospective, nonmasked randomized controlled trial.

Participants: Nineteen eyes of 19 patients having undergone Boston KPro type 1 implantation using a fresh or frozen graft carrier. Read More

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[Visual analysis of research progress on emotional labor of medical staff in China].

X Y Ji Z Zeng

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2021 Mar;39(3):202-206

Nanjing University Of Chinese Medicine School of Health Economics and Management, Nanjing 210023, China.

To summarize the research progress of medical emotional labor in China, and provide data reference for medical workers in the field of emotional labor. In March 2020, we searched the research content of emotional labor of medical workers through CNKI system, and analyzed it by using CiteSpace software. We visualized the topic of emotional labor of medical workers by using the knowledge map formed by keyword co-occurrence and keyword clustering, as well as the emergent words and time zone map. Read More

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"Cuba's Medical Team in the European Epicenter of COVID-19: Carlos R. Pérez-Díaz MD MS PhD Director, Joaquín Albarrán Provincial Clinical-Surgical Hospital, Havana Henry Reeve Medical Contingent Leader, Lombardy, Italy".

MEDICC Rev 2021 Jan 30;23(1):18-20. Epub 2021 Jan 30.

On March 23, 2020, Cuba's Henry Reeve Emergency Medical Contingent began treating COVID-19 patients at Maggiore Hospital in Crema, Lombardy. Within days, the 52-member contingent comprised of 36 doctors and 15 nurses (plus 1 logistics specialist), together with Italian colleagues, were receiving patients in an adjacent fi eld hospital established and equipped for this purpose. At the time, Lombardy was the epicenter of COVID-19 transmission in Europe. Read More

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January 2021

Borderline Personality Disorder Diagnosis and Symptoms in Outpatient Youth as Risk Factors for Criminal Offenses and Interpersonal Violence.

J Pers Disord 2021 Jan 21:1-24. Epub 2021 Jan 21.

Orygen, Melbourne, Australia.

The aim of the current study was to examine the risk for offending among outpatient youth with borderline pathology. Demographic and diagnostic data from 492 outpatients who attended a public mental health service for 15- to 25-year-olds between January 1998 and March 2008 were linked with information regarding criminal offenses and intervention orders collected from a statewide police database between March 1993 and June 2017. BPD diagnosis and number of BPD criteria were both associated with an elevated risk for violent and nonviolent offenses and family violence intervention orders. Read More

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January 2021

First Report of Powdery Mildew Caused by Podosphaera xanthii on Cuphea hyssopifolia (Lythraceae) in Mainland China.

Plant Dis 2021 Mar 29. Epub 2021 Mar 29.

Minjiang University, 26465, Institute of Oceanography, Fuzhou, Fujian, China;

Cuphea hyssopifolia (Mexican heather) is a popular evergreen perennial shrub used for ornamental and medicinal purposes. Due to its high ornamental value, it is often used as a ground cover in parks and gardens in China. During February and March 2019 & 2020, powdery mildew was observed on C. Read More

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The first report of bacterial streak and rot of onion caused by Pseudomonas viridiflava in Japan.

Plant Dis 2021 Mar 29. Epub 2021 Mar 29.

Akita Prefectural University Faculty of Bioresource Sciences Department of Biological Production, 98407, Akita, Japan;

In March 2020, a bacterial streak and rot symptom was observed on the onion (Allium cepa L.) leaves in Akita Prefecture of Japan. On the beginning, oval and dark-greenish water-soaked lesions with grayish-white necrotic center, 2-3 mm in diameter, appeared on the middle or the tip of upper leaves. Read More

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Are Automated and Visual Greulich and Pyle-Based Methods Applicable to Caucasian European Children With a Moroccan Ethnic Origin When Assessing Bone Age?

Cureus 2021 Feb 21;13(2):e13478. Epub 2021 Feb 21.

Radiology, Queen Fabiola Children's University Hospital, Brussels, BEL.

Introduction To test the accuracy of the visual and automated bone age assessment base on the Greulich and Pyle (GP) method in healthy Caucasian European children with a Moroccan ethnic origin. Material and methods Moroccan Caucasian (MC) children were retrospectively and consecutively enrolled along with age- and sex-matched control group (CG) of European Caucasian (EC) children enrolled from the general population. The two groups included 423 children aged from 2 to 15 years with a normal left-hand radiograph performed to rule out a trauma between March 2008 and December 2017. Read More

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February 2021

Abstracts from the 45th Annual Meeting of Japanese Society for Microcirculation.

Kazuto Masamoto

Microcirculation 2021 Mar 26:e12695. Epub 2021 Mar 26.

Journal Committee, Japanese Society for Microcirculation, Japan.

On August 10, 1971, Dr. Masaharu Tsuchiya established "Gathering of Microcirculation Researchers" in consultation with founders, Dr. Takehiko Azuma, Dr. Read More

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Is it essential to remove the submandibular gland in neck dissection in tongue cancer patients?

J Stomatol Oral Maxillofac Surg 2021 Mar 23. Epub 2021 Mar 23.

Surgical oncology unit, oncology center Mansoura University (OCMU), Mansoura, Egypt.

Introduction: Submandibular sialadenectomy is a part of the classic technique of neck dissection for oral cavity cancers. However, its removal is associated with a reduction in the salivary outflow in many patients, as well as, some uncommon complications such as lingual and hypoglossal nerve injuries. Assessment of the necessity of such maneuvers should be addressed. Read More

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The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography parameters in patients with malignant pleural mesothelioma.

Turk Gogus Kalp Damar Cerrahisi Derg 2021 Jan 13;29(1):92-100. Epub 2021 Jan 13.

Department of Thoracic Surgery, Ankara University School of Medicine, Ankara, Turkey.

Background: In this study, we aimed to investigate the prognostic value of metabolic F-fluorodeoxyglucose positron emission tomography/computed tomography parameters in malignant pleural mesothelioma patients.

Methods: A total of 65 patients with malignant pleural mesothelioma (34 males, 31 females; median age: 60 years; range, 39 to 84 years) who underwent whole-body F-fluorodeoxyglucose positron emission tomography/computed tomography for staging before treatment between March 2008 and January 2018 were included. Relationships between clinicopathological factors and F-fluorodeoxyglucose positron emission tomography/computed tomography parameters and overall survival were evaluated using a log-rank test and Cox regression analysis. Read More

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January 2021

Stroke Preventability in Large Vessel Occlusion Treated With Mechanical Thrombectomy.

Front Neurol 2021 8;12:608084. Epub 2021 Mar 8.

Department of Neurology, University of California, Irvine, Irvine, CA, United States.

The preventability of strokes treated by mechanical thrombectomy is unknown. The purpose of this study was to analyze stroke preventability for patients treated with mechanical thrombectomy for large vessel occlusion. We conducted retrospective analyses of 300 patients (mean ± SE age 69 ± 0. Read More

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Superficial neoplasia involving the Ileocecal valve: Clinical outcomes of endoscopic submucosal dissection.

Dig Liver Dis 2021 Mar 21. Epub 2021 Mar 21.

Endoscopy Division, Yokohama City University Medical Center, Yokohama, Japan.

Background: Endoscopic submucosal dissection (ESD) is the treatment of choice for colorectal superficial neoplasia, but certain anatomical locations are challenging even for skilled endoscopists. Ileocecal valve (ICV) is considered a technically challenging site for ESD.

Objective: Aim of this study was to analyze efficacy and safety of Endoscopic Submucosal Dissection in the treatment of colorectal neoplasia involving the ileocecal valve (ICV) DESIGN: Retrospective study. Read More

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Microvascular Invasion Status and Its Survival Impact in Hepatocellular Carcinoma Depend on Tissue Sampling Protocol.

Ann Surg Oncol 2021 Mar 22. Epub 2021 Mar 22.

Division of Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: The aim of this work is to explore the impact of the number of sampling sites (NuSS) and sampling location on microvascular invasion (MVI) detection rate and long-term survival of hepatocellular carcinoma (HCC), and determine the minimum NuSS for sufficient MVI detection.

Patients And Methods: From January 2008 to March 2017, 1144 HCC patients who underwent hepatectomy were retrospectively enrolled. Associations between NuSS and MVI positive rates and overall survival were investigated. Read More

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Returning to the emergency room: An analysis of emergency encounters following urologic outpatient surgery.

Can Urol Assoc J 2021 Mar 18. Epub 2021 Mar 18.

Division of Urology, Department of Surgery, The Ottawa Hospital and University of Ottawa, Ottawa, ON, Canada.

Introduction: Previous reports indicate urologic surgeries are associated with high rates of hospital re-admission. This study aims to identify factors associated with emergency room (ER) encounters following urologic outpatient surgery.

Methods: All outpatient surgeries performed at The Ottawa Hospital between April 1, 2008, and March 31, 2018 by urology, general surgery, gynecology, and thoracic surgery were identified. Read More

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Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged less than five years.

Vaccine 2021 Apr 17;39(15):2041-2047. Epub 2021 Mar 17.

Ege University School of Medicine, Department of Pediatric Infectious Diseases, İzmir, Turkey.

Purpose: In Turkey, pneumococcal conjugate vaccine (PCV) was introduced to the national immunization program as PCV7 in 2008, and was replaced with PCV13 in 2011. The aim of the study was to demonstrate the pneumococcal carriage rate and the serotype distribution in healthy children under 5 years in Turkey who were vaccinated with PCV13.

Methods: We conducted a cross-sectional study including the collection of questionnaire data and nasopharyngeal (NP) specimens among children aged <5 years from five centers from March 2019 to March 2020. Read More

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Proton pump inhibitors use and risk of developing spontaneous bacterial peritonitis in cirrhotic patients: A systematic review and meta-analysis.

Gut Pathog 2021 Mar 19;13(1):17. Epub 2021 Mar 19.

Research Center, Dr. Sulaiman Al Habib Medical Group, Riyadh, Saudi Arabia.

Background: Spontaneous bacterial peritonitis (SBP) is one of the most common infectious diseases in patients with cirrhosis and is associated with serious prognosis. A prevailing dogma posits that SBP is exacerbated by the frequent use of proton pump inhibitors (PPIs).

Aims: To re-assess the association between PPIs use and SBP incidence with larger and better-quality data. Read More

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