397,052 results match your criteria mapping


Thalamic Deep Brain Stimulation for Spasmodic Dysphonia: A Phase I Prospective Randomized Double-Blind Crossover Trial.

Neurosurgery 2021 Apr 16. Epub 2021 Apr 16.

Division of Otolaryngology, University of British Columbia, Vancouver, Canada.

Background: Adductor spasmodic dysphonia (SD) is a dystonia of the vocal folds causing difficulty with speech. The current standard of care is repeated botulinum toxin injections to weaken the adductor muscles. We sought to ameliorate the underlying neurological cause of SD with a novel therapy-deep brain stimulation (DBS). Read More

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Radon risk mapping: A new geostatistical method based on Lorenz Curve and Gini index.

J Environ Radioact 2021 Apr 13;233:106612. Epub 2021 Apr 13.

Advanced Biomedical Science Department, University of Naples, Federico II, Naples, Italy.

In confined spaces such as living environments and workplaces, the concentration levels of radon (Rn) can be very high as compared to the external environment. Since Rn has been classified as the second leading cause of lung cancer after cigarette smoking, to apply efficient locally based risk reduction actions, dense maps of indoor radon concentration are needed. These maps would provide information about the areas prone to high radon concentrations and therefore more dangerous to human health. Read More

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Effects from loaded walking with polyurethane and styrene-butadiene rubber midsole military boots on kinematics and external forces: A statistical parametric mapping analysis.

Appl Ergon 2021 Apr 13;94:103429. Epub 2021 Apr 13.

La Trobe Rural Health School, La Trobe University, Flora Hill Campus, Bendigo, Victoria, 3550, Australia.

This study compared ground reaction forces (GRF) and lower limb two-dimensional (2D) kinematic waveforms, with and without load carriage, in military personnel walking in two different types of boots. Data were measured in 24-soldiers walking on a 10-m walkway under four randomized crossover trials: wearing two military boots (styrene-butadiene rubber midsole - SBR - 63 Shore A; and polyurethane midsole - PU - 48 Shore A); with and without a 15-kg backpack. GRF traditional parameters were evaluated by two-way ANOVAs. Read More

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Mapping Interactions between Glycans and Glycan-Binding Proteins by Live Cell Proximity Tagging.

Curr Protoc 2021 Apr;1(4):e104

Department of Molecular Medicine, Scripps Research Institute, Jupiter, Florida.

Interactions between glycans and glycan-binding proteins (GBPs) consist of weak, noncovalent, and transient binding events, making them difficult to study in live cells void of a static, isolated system. Furthermore, the glycans are often presented as protein glycoconjugates, but there are limited efforts to identify these proteins. Proximity labeling permits covalent tagging of the glycoprotein interactors to query GBP in live cells. Read More

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Heterogeneous Face Interpretable Disentangled Representation for Joint Face Recognition and Synthesis.

IEEE Trans Neural Netw Learn Syst 2021 Apr 16;PP. Epub 2021 Apr 16.

Heterogeneous faces are acquired with different sensors, which are closer to real-world scenarios and play an important role in the biometric security field. However, heterogeneous face analysis is still a challenging problem due to the large discrepancy between different modalities. Recent works either focus on designing a novel loss function or network architecture to directly extract modality-invariant features or synthesizing the same modality faces initially to decrease the modality gap. Read More

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Digital Health Interventions in Prevention, Relapse, and Therapy of Mild and Moderate Depression: Scoping Review.

JMIR Ment Health 2021 Apr 16;8(4):e26268. Epub 2021 Apr 16.

School of Public Health, Bielefeld University, Bielefeld, Germany.

Background: Depression is a major cause for disability worldwide, and digital health interventions are expected to be an augmentative and effective treatment. According to the fast-growing field of information and communication technologies and its dissemination, there is a need for mapping the technological landscape and its benefits for users.

Objective: The purpose of this scoping review was to give an overview of the digital health interventions used for depression. Read More

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Modeling and mapping the habitat suitability and the potential distribution of Arboviruses vectors in Morocco.

Parasite 2021 14;28:37. Epub 2021 Apr 14.

Laboratory of Microbiology and Virology, Department of Medical Biology, Faculty of Medicine and Pharmacy, Cadi Ayyad University, PO Box 7010, 40000 Marrakech, Morocco.

Mosquitoes transmit several agents of diseases and the presence of different species represents a threat to animal and public health. Aedes and Culex mosquitoes are of particular concern giving their potential vector competence for Arbovirus transmission. In Morocco, the lack of detailed information related to their spatial distribution raises major concerns and hampers effective vector surveillance and control. Read More

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T1 mapping for the diagnosis of early chronic pancreatitis: correlation with Cambridge classification system.

Br J Radiol 2021 Apr 16:20200685. Epub 2021 Apr 16.

Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.

Objective: This study aims to determine if T1 relaxation time of the pancreas can detect parenchymal changes in early chronic pancreatitis (CP).

Methods: This study retrospectively analyzed 42 patients grouped as no CP (Cambridge 0; = 21), equivocal (Cambridge 1; = 12) or mild CP (Cambridge 2; = 9) based on magnetic resonance cholangiopancreatography findings using the Cambridge classification as the reference standard. Unenhanced T1 maps were acquired using a three-dimensional dual flip-angle gradient-echo technique on the same 1. Read More

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Correlating Bedrock Folds to Higher Rates of Arsenic Detection in Groundwater, Southeast Wisconsin, USA.

Ground Water 2021 Apr 16. Epub 2021 Apr 16.

Wisconsin Geological and Natural History Survey, Division of Extension, University of Wisconsin-Madison, 3817 Mineral Point Road, Madison, WI, 53705, USA.

Arsenic in private drinking water wells is a significant problem across much of eastern Wisconsin, USA. The release mechanism and stratigraphic distribution of sulfide and iron (hydr)oxide sources of arsenic in bedrock aquifers are well understood for northeastern Wisconsin. However, recent geologic mapping has identified numerous small bedrock folds to the south, and the impact of these geologic structures on local groundwater flow and well contamination has been little studied. Read More

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Salud y Orgullo Mexicano: Development of a Culturally Specific Transnational Linkage and Retention in Care Intervention for Mexican Men Who Have Sex with Men Living with HIV in Chicago.

J Immigr Minor Health 2021 Apr 16. Epub 2021 Apr 16.

Center for AIDS Prevention Studies, University of California San Francisco Prevention Research Center, San Francisco, USA.

This manuscript documents the development of an innovative individual-level peer navigation intervention "Salud y Orgullo Mexicano" (SOM) designed to increase linkage and retention to HIV care for Mexican men who have sex with men (MSM) in Chicago, Illinois. The intervention was developed via a modified intervention mapping process. Elements of two existing interventions were combined and refined with input from the Mexican MSM community, including informant interviews, an expert advisory board, and a design team. Read More

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Extra-basal ganglia iron content and non-motor symptoms in drug-naïve, early Parkinson's disease.

Neurol Sci 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Although iron dyshomeostasis is associated with Parkinson's disease (PD) pathogenesis, the relationship between iron deposition and non-motor involvement in PD is not fully understood. In this study, we investigated basal ganglia and extra-basal ganglia system iron contents and their correlation with non-motor symptoms in drug-naïve, early-stage PD patients.

Methods: We enrolled 14 drug-naïve, early-stage PD patients and 12 age/sex-matched normal controls. Read More

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Quantitative analysis of endotoxin-induced inflammation in human lung cells by Chipcytometry.

Cytometry A 2021 Apr 15. Epub 2021 Apr 15.

Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.

Chipcytometry is a tool that uses iterative staining cycles with multiple antibodies for a detailed characterization of cells. Cell recognition is based on morphological features. Cells fixed on microfluidic chips can be stored and shipped enabling a centralized analysis, which is important for assessments in multi-center clinical trials. Read More

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pH-amplified CRET nanoparticles for in vivo imaging of tumor metastatic lymph nodes.

Angew Chem Int Ed Engl 2021 Apr 15. Epub 2021 Apr 15.

Peking University, School of Pharmaceutical Sciences, #38 Xueyuan Rd., Haidian District, 100191, Beijing, CHINA.

Noninvasive imaging strategies have been extensively investigated for in vivo mapping of sentinel lymph nodes (SLNs). However, the current imaging strategies fail to accurately assess tumor metastatic status in SLNs with high sensitivity. Here we report pH-amplified self-illuminating near-infrared nanoparticles, which integrate chemiluminescence resonance energy transfer (CRET) and signal amplification strategy, enabling accurate identification of metastatic SLNs. Read More

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Matrix Phase Fractionation: Investigating the Compromise Between Dynamic Range Of Analyte Extraction and Spatial Resolution In Imaging Mass Spectrometry.

Rapid Commun Mass Spectrom 2021 Apr 16:e9106. Epub 2021 Apr 16.

Sydney Mass Spectrometry, Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.

Rationale: MALDI-MSI has seen rapid development in recent years and as such is a becoming an important technique for the mapping of biomolecules from the surface of tissues. One key area of development is the optimisation of analyte extraction by using modified matrices or mixes of common ones.

Methods: A series of serial sections were prepared for lipid MSI by either dry coating (sublimation) or by wet spray application of several matrices. Read More

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New [2,2]Fluorenophanes with Unexplored Insight: Asymmetric Charge Transfer-Mediated Exciton Delocalization along the π-π Packing Direction.

Chemistry 2021 Apr 15. Epub 2021 Apr 15.

National Taiwan University, Department of Chemistry, TAIWAN.

A series of new [2,2] fluorenophanes  were synthesized and characterized, among which molecules of crystallographically asymmetric  anti-[2.2](1,4)(4,1)fluorenophane ( K2C-2) aggregate to form one-dimensional  supramolecular  chain structures through effective intermolecular  π-π  overlapping . This, in combination with the synergistic intramolecular  π-π  interaction, leads to prominent dual emission  mediated by charge transfer (CT) exciton delocalization. Read More

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Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using Ga-FAPI-04.

J Nucl Cardiol 2021 Apr 15. Epub 2021 Apr 15.

Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675, Munich, Germany.

Our previous study has demonstrated the feasibility of noninvasive imaging of fibroblast activation protein (FAP)-expression after myocardial infarction (MI) in MI-territory in a rat model with Ga-FAPI-04-PET. In the current extended clinical case, we sought to delineate cardiac uptake of Ga-FAPI-04 in a patient after MI with clinical indication for the evidence of fibroblast activation. Carcinoma patients without cardiac disease underwent Ga-FAPI-04-PET/CT as control. Read More

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Mapping PedsQL™ Generic Core Scales to EQ-5D-3L utility scores in transfusion-dependent thalassemia patients.

Eur J Health Econ 2021 Apr 15. Epub 2021 Apr 15.

Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Science, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia.

Purpose: To develop a mapping algorithm for generating EQ-5D-3L utility scores from the PedsQL Generic Core Scales (PedsQL GCS) in patients with transfusion-dependent thalassemia (TDT).

Methods: The algorithm was developed using data from 345 TDT patients. Spearman's rank correlation was used to evaluate the conceptual overlap between the instruments. Read More

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Spatial disease mapping using directed acyclic graph auto-regressive (DAGAR) models.

Bayesian Anal 2019 Dec 3;14(4):1221-1244. Epub 2019 Oct 3.

University of California Los Angeles.

Hierarchical models for regionally aggregated disease incidence data commonly involve region specific latent random effects that are modeled jointly as having a multivariate Gaussian distribution. The covariance or precision matrix incorporates the spatial dependence between the regions. Common choices for the precision matrix include the widely used ICAR model, which is singular, and its nonsingular extension which lacks interpretability. Read More

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December 2019

Comprehensive Identification and Alternative Splicing of Microexons in .

Front Genet 2021 30;12:642602. Epub 2021 Mar 30.

RNA Institute, State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Science, Wuhan University, Wuhan, China.

Interrupted exons in the pre-mRNA transcripts are ligated together through RNA splicing, which plays a critical role in the regulation of gene expression. Exons with a length ≤ 30 nt are defined as microexons that are unique in identification. However, microexons, especially those shorter than 8 nt, have not been well studied in many organisms due to difficulties in mapping short segments from sequencing reads. Read More

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Early Detection of Stripe Rust in Winter Wheat Using Deep Residual Neural Networks.

Front Plant Sci 2021 30;12:469689. Epub 2021 Mar 30.

Department of Engineering for Crop Production, Leibniz Institute for Agricultural Engineering and Bioeconomy, Potsdam, Germany.

Stripe rust (Pst) is a major disease of wheat crops leading untreated to severe yield losses. The use of fungicides is often essential to control Pst when sudden outbreaks are imminent. Sensors capable of detecting Pst in wheat crops could optimize the use of fungicides and improve disease monitoring in high-throughput field phenotyping. Read More

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Quantitative mapping of the cellular small RNA landscape with AQRNA-seq.

Nat Biotechnol 2021 Apr 15. Epub 2021 Apr 15.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Current next-generation RNA-sequencing (RNA-seq) methods do not provide accurate quantification of small RNAs within a sample, due to sequence-dependent biases in capture, ligation and amplification during library preparation. We present a method, absolute quantification RNA-sequencing (AQRNA-seq), that minimizes biases and provides a direct, linear correlation between sequencing read count and copy number for all small RNAs in a sample. Library preparation and data processing were optimized and validated using a 963-member microRNA reference library, oligonucleotide standards of varying length, and RNA blots. Read More

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Strain fields in twisted bilayer graphene.

Nat Mater 2021 Apr 15. Epub 2021 Apr 15.

Department of Chemistry, University of California, Berkeley, CA, USA.

Van der Waals heteroepitaxy allows deterministic control over lattice mismatch or azimuthal orientation between atomic layers to produce long-wavelength superlattices. The resulting electronic phases depend critically on the superlattice periodicity and localized structural deformations that introduce disorder and strain. In this study we used Bragg interferometry to capture atomic displacement fields in twisted bilayer graphene with twist angles <2°. Read More

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Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer's disease human brain tissue.

Commun Biol 2021 Apr 15;4(1):474. Epub 2021 Apr 15.

Department of Physics and Astronomy, LaserLaB Amsterdam, VU Amsterdam, Amsterdam, The Netherlands.

Alzheimer's disease (AD) neuropathology is characterized by hyperphosphorylated tau containing neurofibrillary tangles and amyloid-beta (Aβ) plaques. Normally these hallmarks are studied by (immuno-) histological techniques requiring chemical pretreatment and indirect labelling. Label-free imaging enables one to visualize normal tissue and pathology in its native form. Read More

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Soil CO emission and soil attributes associated with the microbiota of a sugarcane area in southern Brazil.

Sci Rep 2021 Apr 15;11(1):8325. Epub 2021 Apr 15.

School of Agricultural and Veterinarian Sciences (FCAV), São Paulo State University (Unesp), Via de Acesso Prof. Paulo Donato Castellane s/n, Jaboticabal, São Paulo, 14884-900, Brazil.

The spatial structure of soil CO emission (FCO) and soil attributes are affected by different factors in a highly complex way. In this context, this study aimed to characterize the spatial variability patterns of FCO and soil physical, chemical, and microbiological attributes in a sugarcane field area after reform activities. The study was conducted in an Oxisol with the measurement of FCO, soil temperature (Ts), and soil moisture (Ms) in a regular 90 × 90-m grid with 100 sampling points. Read More

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Differential spatial computations in ventral and lateral face-selective regions are scaffolded by structural connections.

Nat Commun 2021 04 15;12(1):2278. Epub 2021 Apr 15.

Department of Psychology, Stanford University, Stanford, CA, USA.

Face-processing occurs across ventral and lateral visual streams, which are involved in static and dynamic face perception, respectively. However, the nature of spatial computations across streams is unknown. Using functional MRI and population receptive field (pRF) mapping, we measured pRFs in face-selective regions. Read More

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Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets.

Nat Commun 2021 04 15;12(1):2277. Epub 2021 Apr 15.

Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.

Determining the epigenetic program that generates unique cell types in the kidney is critical for understanding cell-type heterogeneity during tissue homeostasis and injury response. Here, we profile open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution. We show critical reliance of gene expression on distal regulatory elements (enhancers). Read More

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Aeration of the Human Prussak's Space: A 3D Synchrotron Imaging Study.

Otol Neurotol 2021 Apr 14. Epub 2021 Apr 14.

Department of Surgical Sciences, Otorhinolaryngology and Head and Neck Surgery, Uppsala University Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden Department of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario Canadian Light Source Inc., Saskatoon, Saskatchewan Department of Medical Biophysics and Department of Electrical and Computer Engineering, Western University, London, Ontario, Canada.

Objectives: Prussak's space (PS) is an intricate middle ear region which may play an essential role in the development of middle ear disease. The three-dimensional (3D) anatomy of the human PS and its drainage routes remain relatively unknown. Earlier studies have histologically analyzed PS, by micro-dissection and endoscopy. Read More

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Cognitive Demands Influence Upper Extremity Motor Performance During Recovery From Acute Stroke.

Neurology 2021 Apr 15. Epub 2021 Apr 15.

David J. Lin, (1) Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (2) Division of Neurocritical Care, Department of Neurology, Massachusetts General Hospital, Boston, MA (3) Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA (4) VA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of VA Medical Center, Providence, RI; Kimberly S. Erler, (5) Department of Occupational Therapy, MGH Institute of Health Professions, Boston, MA; Samuel B. Snider, (6) Division of Neurocritical Care, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Anna K. Bonkhoff, (7) J Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Boston, MA; Julie A. DiCarlo, (1) Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Nicole Lam, (1) Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (5) Department of Occupational Therapy, MGH Institute of Health Professions, Boston, MA; Jessica Ranford, (1) Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (8) Department of Occupational Therapy, Massachusetts General Hospital, Boston, MA; Kristin Parlman, (1) Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (9) Department of Physical Therapy, Massachusetts General Hospital, Boston, MA; Audrey Cohen, (1) Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (10) Department of Speech, Language, and Swallowing Disorders, Massachusetts General Hospital, Boston, MA; Jennifer Freeburn, (1) Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (10) Department of Speech, Language, and Swallowing Disorders, Massachusetts General Hospital, Boston, MA; Seth P. Finklestein, (3) Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA; Lee H. Schwamm, (3) Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA; Leigh R. Hochberg, (1) Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, (2) Division of Neurocritical Care, Department of Neurology, Massachusetts General Hospital, Boston, MA, (3) Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA (4) VA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of VA Medical Center, Providence, RI, (11) School of Engineering, Brown University, Providence RI; Steven C. Cramer, (12) Department of Neurology, University of California, Los Angeles, (13) California Rehabilitation Hospital, Los Angeles, CA.

Objective: To test the hypothesis that cognitive demands influence motor performance during recovery from acute stroke, we tested acute stroke patients on two motor tasks with different cognitive demands and related task performance to cognitive impairment and neuroanatomic injury.

Methods: We assessed the contralesional and ipsilesional upper extremities of a cohort of 50 patients with weakness after unilateral acute ischemic stroke at three timepoints with two tasks: the Box & Blocks Test, a task with greater cognitive demand, and Grip Strength, a simple and ballistic motor task. We compared performance on the two tasks, related motor performance to cognitive dysfunction, and used voxel-based lesion symptom mapping to determine neuroanatomical sites associated with motor performance. Read More

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Draft Chromosome Sequences of a Clinical Isolate of the Free-Living Ameba Naegleria fowleri.

Microbiol Resour Announc 2021 Apr 15;10(15). Epub 2021 Apr 15.

Biotechnology Core Facility Branch, DSR/NCEZID, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

We present the chromosome sequences of a isolate from a human primary amebic meningoencephalitis (PAM) case. The genome sequences were assembled from Illumina HiSeq and PacBio sequencing data and verified with the optical mapping data. This led to the identification of 37 contigs representing 37 chromosomes in . Read More

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Awareness on menstrual hygiene management in Bangladesh and the possibilities of media interventions: using a nationwide cross-sectional survey.

BMJ Open 2021 Apr 15;11(4):e042134. Epub 2021 Apr 15.

Transport and Road Safety (TARS) Research Centre, School of Aviation, University of New South Wales, Sydney, New South Wales, Australia.

Objectives: Menstrual hygiene management (MHM) has become a growing public health concern in many low-income and middle-income nations for its association with several health risks. This study observed types of menstrual absorbents used among women in Bangladesh and analysed the associated sociodemographic factors with the hypothesis that mass media can increase awareness regarding MHM. The study includes recommendations for possible intervention strategies designed to address this lack of awareness. Read More

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