2,792 results match your criteria manuscript describes

Ipsilateral Protection and Bailout for Large-Bore Access.

J Invasive Cardiol 2021 Aug;33(8):E658-E661

Division of Cardiology, Robert Packer Hospital, 1 Guthrie Square, Sayre, PA, 18840 USA. or

This manuscript describes the refinements of ipsilateral wire protection and bailout strategy for large-bore femoral access and especially transcatheter aortic valve replacement. This ipsilateral wire protection requires no additional expenses and can provide effective arteriotomy site protection without the need for contralateral femoral access, especially in cases when contralateral wiring and crossover are not feasible. Ipsilateral wiring can be done both as prophylactic protection and as bailout strategy. Read More

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Chinese public's panic buying at the beginning of COVID-19 outbreak: The contribution of perceived risk, social media use, and connection with close others.

Curr Psychol 2021 Jul 23:1-10. Epub 2021 Jul 23.

Department of Psychology and Research Center of Adolescent Psychology and Behavior, School of Education, Guangzhou University, Guangzhou, 510006 China.

Panic buying is a globally witnessed behavior during the outbreak of COVID-19. This consumer behavior is related to many undesirable consequences, ranging from disrupting economic stability to hindering timely provision of supplies to those in dire need. As such, to understand the causes and underlying mechanisms of panic buying is crucial. Read More

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A doggy tale: Risk of zoonotic infection with Bordetella bronchiseptica for cystic fibrosis (CF) patients from live licenced bacterial veterinary vaccines for cats and dogs.

J Clin Pharm Ther 2021 Jul 30. Epub 2021 Jul 30.

Laboratory for Disinfection and Pathogen Elimination Studies, Northern Ireland Public Health Laboratory, Nightingale (Belfast City) Hospital, Belfast, UK.

What Is Known And Objective: Live-attenuated bacterial veterinary vaccines can constitute an infection risk for individuals with any defect in their phagocytic function, including chronic granulomatous disease, leukocyte adhesion deficiency, myeloperoxidase deficiency, as well as Chediak-Higashi syndrome, from accidental acquisition of licenced attenuated live bacterial vaccine, at vaccination or from their vaccinated pet. Ownership of small companion animals, including cats and dogs, is popular within the cystic fibrosis (CF) community. These animals require vaccines as part of their routine care, which may involve live viral and bacterial vaccines, with potential for infection in the CF owner. Read More

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Current Perspectives in the Discovery of Newer Medications Against the Outbreak of COVID-19.

Front Mol Biosci 2021 12;8:648232. Epub 2021 Jul 12.

Department of Chemistry, College of Science, Deanship of Scientific Research, Taif University, Taif, Saudi Arabia.

A rapid and increasing spread of COVID-19 pandemic disease has been perceived worldwide in 2020. The current COVID-19 disease outbreak is due to the spread of SARS-CoV-2. SARS-CoV-2 is a new strain of coronavirus that has spike protein on the envelope. Read More

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The Multi-Domain Intervention Trial in Older Adults With Diabetes Mellitus for Prevention of Dementia in Japan: Study Protocol for a Multi-Center, Randomized, 18-Month Controlled Trial.

Front Aging Neurosci 2021 12;13:680341. Epub 2021 Jul 12.

Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan.

The Japan-Multi-domain Intervention Trial for Prevention of Dementia in Older Adults with Diabetes (J-MIND-Diabetes) is an 18-month, multi-centered, open-labeled, randomized controlled trial designed to identify whether multi-domain intervention targeting modifiable risk factors for dementia could prevent the progression of cognitive decline among older adults with type 2 diabetes mellitus (T2DM). This manuscript describes the study protocol for the J-MIND-Diabetes trial. Subjects of this trial will comprise a total of 300 T2DM outpatients aged 70-85 years with mild cognitive impairment. Read More

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Learning Together: Sharing Circles in Rural Alaska on Cancer Education Priorities for Youth.

J Cancer Educ 2021 Jul 27. Epub 2021 Jul 27.

Institute of Social and Economic Research, University of Alaska Anchorage, 3211 Providence Dr., Anchorage, AK, 99508, USA.

Culturally relevant health promotion with youth is an opportunity to reduce health inequities in cancer. This manuscript describes sharing circles conducted with three communities in the Northwest Arctic region of Alaska. The circles were designed to begin understanding community priorities and lay the foundation to develop culturally relevant cancer education. Read More

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Four-year-old anti-N-methyl-D-aspartate receptor encephalitis patient with ovarian teratoma: A case report.

World J Clin Cases 2021 Jul;9(19):5319-5324

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.

Background: A population-based comparative study in United States shows that the prevalence and incidence of autoimmune encephalitis are comparable to those of infectious encephalitis and its detection is increasing over time. Some patients are complicated with ovarian teratoma. The younger the patient is, the less likely a tumor will be present. Read More

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Liver injury in COVID-19: Known and unknown.

World J Clin Cases 2021 Jul;9(19):4980-4989

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China.

Since the first report of the coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, China, the outbreak of the disease is currently continuously evolving. Previous studies have shown varying degrees of liver damage in patients with COVID-19. However, the exact causes of liver injury and the relationship between COVID-19 and liver injury is unclear. Read More

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Granulomatous Sarcoidosis Mimics.

Marc A Judson

Front Med (Lausanne) 2021 8;8:680989. Epub 2021 Jul 8.

Division of Pulmonary and Critical Care Medicine MC-91, Department of Medicine, Albany, NY, United States.

Many granulomatous diseases can mimic sarcoidosis histologically and in terms of their clinical features. These mimics include infectious granulomatous diseases, granulomatous reactions to occupational and environmental exposures, granulomatous drug reactions, vasculitides and idiopathic granulomatous conditions. It is important to distinguish sarcoidosis from these mimics, as a misdiagnosis of these diseases may have serious consequences. Read More

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Application of proteomic to investigate the different degrees of meat tenderness in Nellore breed.

J Proteomics 2021 Jul 22:104331. Epub 2021 Jul 22.

São Paulo State University (UNESP), School of Veterinary Medicine and Animal Science (FMVZ), Botucatu, São Paulo, Brazil.

This study describes the association between meat tenderness and abundance of soluble muscle proteins in Nellore bulls (Bos indicus) using a proteomic approach. We evaluated shear force (SF) of Longissimus thoracis muscle 24 h after slaughter and selected three experimental groups of animals with moderately tender (TE; SF = 3.9 ± 0. Read More

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Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study.

Lancet Neurol 2021 Aug;20(8):605-614

Sant Pau Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Madrid, Spain; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain; Horizon 21 Consortium, Paris, France. Electronic address:

Background: Adults with Down syndrome are at an ultra-high risk of Alzheimer's disease, but diagnosis of Alzheimer's disease in this population is challenging. We aimed to validate the clinical utility of plasma neurofilament light chain (NfL) for the diagnosis of symptomatic Alzheimer's disease in Down syndrome, assess its prognostic value, and establish longitudinal changes in adults with Down syndrome.

Methods: We did a multicentre cohort study, including adults with Down syndrome (≥18 years), recruited from six hospitals and university medical centres in France, Germany, Spain, the UK, and the USA, who had been assessed, followed up, and provided at least two plasma samples. Read More

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Driving Behaviour Analysis Using Machine and Deep Learning Methods for Continuous Streams of Vehicular Data.

Sensors (Basel) 2021 Jul 9;21(14). Epub 2021 Jul 9.

Institute of Communication and Computer Systems, Zografou, 15773 Athens, Greece.

In the last few decades, vehicles are equipped with a plethora of sensors which can provide useful measurements and diagnostics for both the vehicle's condition as well as the driver's behaviour. Furthermore, the rapid increase for transportation needs of people and goods together with the evolution of Information and Communication Technologies (ICT) push the transportation domain towards a new more intelligent and efficient era. The reduction of CO emissions and the minimization of the environmental footprint is, undeniably, of utmost importance for the protection of the environment. Read More

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Therapeutic Cancer Vaccination with Immunopeptidomics-Discovered Antigens Confers Protective Antitumor Efficacy.

Cancers (Basel) 2021 Jul 7;13(14). Epub 2021 Jul 7.

Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, 00790 Helsinki, Finland.

Knowledge of clinically targetable tumor antigens is becoming vital for broader design and utility of therapeutic cancer vaccines. This information is obtained reliably by directly interrogating the MHC-I presented peptide ligands, the immunopeptidome, with state-of-the-art mass spectrometry. Our manuscript describes direct identification of novel tumor antigens for an aggressive triple-negative breast cancer model. Read More

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Longitudinal Changes of Fixation Stability and Location within 24 Months in Stargardt Disease: ProgStar Report No. 16: Short title: Longitudinal Changes of Fixation in Stargardt Disease.

Am J Ophthalmol 2021 Jul 20. Epub 2021 Jul 20.

Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.; Department of Ophthalmology, University of Basel, Basel, Switzerland.. Electronic address:

Objective: Stargardt Disease type 1 (STGD1) is the most common macular dystrophy. The assessment of fixation describes an important dimension of visual function but there is limited data on its progression over time. We present longitudinal changes and investigate its usefulness for clinical trials. Read More

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The Potential of Narrative Analysis for HPE Research: Highlighting Five Analytic Lenses.

Med Educ 2021 Jul 21. Epub 2021 Jul 21.

Maastricht University.

Context: Health professions education (HPE) has increasingly turned to qualitative methodology to address a number of the field's difficult research problems. While several different methodologies have been widely accepted and used in HPE research (e.g. Read More

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Effectiveness of ultrasound-guided cannulation of AVF on infiltration rates: A single center quality improvement study.

J Vasc Access 2021 Jul 21:11297298211034280. Epub 2021 Jul 21.

Health Systems Management, Emory Dialysis, Atlanta, GA, USA.

Though ultrasonography is increasingly used throughout the spectrum of hemodialysis access, its role in outpatient dialysis units in the United States has been limited so far. This may, in part, be due to limited ultrasound exposure, knowledge and training of dialysis staff. We implemented a quality improvement initiative in our dialysis units to expand the use of ultrasound by our frontline dialysis staff to prospectively evaluate newly placed AVF and guide cannulation. Read More

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How do I think about blood donor eligibility criteria for medical conditions?

Mindy Goldman

Transfusion 2021 Jul 21. Epub 2021 Jul 21.

Medical Affairs and Innovation, Canadian Blood Services, Ottawa, Ontario, Canada.

Every blood center must determine blood donor eligibility criteria for donors with medical conditions, often based on very limited published data and variable practice. This manuscript briefly outlines possible impacts of donor medical conditions on donor and recipient safety and product quality, and describes the multidisciplinary approach used in Canada to think about donor criteria issues. Many years of experience are distilled into practical considerations in determining criteria, possible sources of information, and factors for successful change implementation, to hopefully assist medical and technical staff engaged in decision-making around donor eligibility. Read More

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Synthetic Studies of the Rubellin Natural Products: Development of a Stereoselective Strategy and Total Synthesis of (+)-Rubellin C.

J Org Chem 2021 Jul 21. Epub 2021 Jul 21.

Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States.

This manuscript describes our studies of the class of natural products known as the rubellins, culminating in the total synthesis of (+)-rubellin C. These anthraquinone-based natural products contain a variety of stereochemical and architectural motifs, including a 6-5-6-fused ring system, 5 stereogenic centers, and a central quaternary center. Herein, we report our development of a strategy to target the stereochemically dense core and anthraquinone nucleus, including approaches such as a bifunctional allylboron and vinyl triflate reagent, an anthraquinone benzylic metalation strategy, and a late-stage anthraquinone introduction strategy. Read More

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Isomerization of a cis-(2-Borylalkenyl)gold Complex via a 'Retro-1,2-Metalate Shift': Cleavage of a C-C/C-Si Bond trans to a C-Au Bond.

Angew Chem Int Ed Engl 2021 Jul 20. Epub 2021 Jul 20.

Nagoya University, Department of Applied Chemistry, Graduate School of Engineering, Furo-cho, Chikusa-ku, 464-8603, Nagoya, JAPAN.

This manuscript describes the first example of an alkyne insertion to the Au-B bond of a di( o -tolyl)borylgold complex to afford a cis -2-borylalkenylgold complex, and its isomerization to result in interchanging substituents on the alkenyl carbon atom and the boron atom. The former reaction is the first example of an alkyne insertion to a Au-B bond. In the latter reaction, the regiochemistry of the isomerized alkenylgold products varied depending on the substituents. Read More

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Efficacy of the unified protocol for the treatment of comorbid alcohol use and anxiety disorders: Study protocol and methods.

Contemp Clin Trials 2021 Jul 17:106512. Epub 2021 Jul 17.

The Center for Anxiety and Related Disorders, Boston University, 900 Commonwealth Avenue, 2nd Floor, Boston, MA 02215, United States of America.

Alcohol Use Disorder (AUD) and anxiety disorders (ANX) are each highly prevalent and frequently co-occur, resulting in a complex clinical presentation. The existing literature to date has not yet identified how to best treat comorbid AUD/ANX, partially due to limitations in understanding what factors and mechanisms are implicated in their co-occurrence. This manuscript describes the rationale and methods for an ongoing randomized-controlled trial designed to evaluate the efficacy of a cognitive behavioral intervention, the Unified Protocol for transdiagnostic treatment of emotional disorders (UP), compared to Take Control (TC), a psychosocial and motivational treatment serving as a control condition in this study, for comorbid AUD/ANX. Read More

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Generalizability of heterogeneous treatment effects based on causal forests applied to two randomized clinical trials of intensive glycemic control.

Ann Epidemiol 2021 Jul 16. Epub 2021 Jul 16.

Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.

Purpose: Machine learning is an attractive tool for identifying heterogeneous treatment effects (HTE) of interventions but generalizability of machine learning derived HTE remains unclear. We examined generalizability of HTE detected using causal forests in two similarly designed randomized trials in type 2 diabetes patients.

Methods: We evaluated published HTE of intensive versus standard glycemic control on all-cause mortality from the Action to Control Cardiovascular Risk in Diabetes study (ACCORD) in a second trial, the Veterans Affairs Diabetes Trial (VADT). Read More

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An Ethical Roadmap for Prioritizing Medical Resources Within Muslim Societies During the COVID-19 Pandemic.

J Relig Health 2021 Jul 17. Epub 2021 Jul 17.

University of California San Diego, 9500 Gilman Dr. MC 0628, La Jolla, CA, 92093 0628, USA.

Profound ethical challenges have been generated by the emergence of the COVID-19 pandemic. The unprecedented plights that have arisen have led nations to devise ethical roadmaps for handling their finite resources. Muslim countries are no exception and must continue to endure the effects of the pandemic, as more waves of infections from new strains are being reported. Read More

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A multi-institutional partnership catalyzing the commercialization of medical devices and biotechnology products.

J Clin Transl Sci 2021 8;5(1):e119. Epub 2021 Apr 8.

Massachusetts Medical Device Development Center, Lowell, MA, USA.

The commercialization of medical devices and biotechnology products is characterized by high failure rates and long development lead times particularly among start-up enterprises. To increase the success rate of these high-risk ventures, the University of Massachusetts Lowell (UML) and University of Massachusetts Medical School (UMMS) partnered to create key academic support centers with programs to accelerate entrepreneurship and innovation in this industry. In 2008, UML and UMMS founded the Massachusetts Medical Device Development Center (M2D2), which is a business and technology incubator that provides business planning, product prototyping, laboratory services, access to clinical testing, and ecosystem networking to medical device and biotech start-up firms. Read More

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Individualized coaching in health system-wide provider communication training.

Patient Educ Couns 2021 Jun 30. Epub 2021 Jun 30.

Department of Family Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA. Electronic address:

Objectives: Most practicing health professionals lack communication skills training (CST). Increasingly health care systems have implemented CST programs, mainly through single workshops which are limited in creating meaningful change in communication behaviors in practice. This paper describes a provider CST program which includes coaching to reinforce skills learned in CST workshops. Read More

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Active robotic technologies for total knee arthroplasty.

Arch Orthop Trauma Surg 2021 Jul 14. Epub 2021 Jul 14.

St. Vincent Charity Medical Center, 33001 Solon Rd., Suite 112, Solon, OH, 44139, USA.

Introduction: When active robotic technologies for Total Knee Arthroplasty (TKA) were introduced over 20 years ago, broad usage of robotic technology was not felt to be needed as early data suggested no clear improvement in clinical outcomes compared to conventional techniques of implantation. Only recently has there been renewed enthusiasm for use of robotic technologies for implantation.

Materials And Methods: Active robotic technology specifically refers to the use of a robot for planning and executing the surgical procedure-with surgeon guidance and control. Read More

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Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review.

Pharmacol Rev 2021 Jul;73(3):1050-1083

Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, Maryland (I.F., M.V., D.J.R., J.J.C., J.M.B., Y.S.), and Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden

Relapse to drug use during abstinence is a defining feature of addiction. During the last several decades, this clinical scenario has been studied at the preclinical level using classic relapse/reinstatement models in which drug seeking is assessed after experimenter-imposed home-cage forced abstinence or extinction of the drug-reinforced responding in the self-administration chambers. To date, however, results from studies using rat relapse/reinstatement models have yet to result in Food and Drug Administrationapproved medications for relapse prevention. Read More

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Fabrication of a customized impression metal jig for an implant-supported overdenture with a milled bar.

Dent Res J (Isfahan) 2021 6;18:23. Epub 2021 Apr 6.

Department of Prosthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The use of computer-aided design/computer-aided manufacturing technology simplifies the laboratory and clinical steps for the fabrication of implant prostheses. It also reduces additional costs for the prosthetic components and technical procedures. This article describes a modified impression technique using an impression metal jig to enhance the accuracy of final impression and also to eliminate the need for the try-in of resin pattern of the milled bar. Read More

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Development and analytical validation of a novel bioavailable 25-hydroxyvitamin D assay.

PLoS One 2021 9;16(7):e0254158. Epub 2021 Jul 9.

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

Background: Bioavailable 25-hydroxyvitamin D (25OHD) may be a better indicator of vitamin D sufficiency than total 25OHD. This report describes a novel assay for measuring serum bioavailable 25OHD.

Methods: We developed an assay for 25OHD % bioavailability based on competitive binding of 25OHD tracer between vitamin D-binding protein (DBP)-coated affinity chromatography beads and serum DBP. Read More

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Thrombosis and severe acute respiratory syndrome coronavirus 2 vaccines: vaccine-induced immune thrombotic thrombocytopenia.

Young Shil Park

Clin Exp Pediatr 2021 Jun 30. Epub 2021 Jun 30.

Department of Pediatrics, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, Korea.

The development of vaccines against severe acute respiratory syndrome coronavirus 2, which features high mortality and morbidity rates, has progressed at an unprecedented rate, and vaccines are currently in use worldwide. Thrombotic events after vaccination are accompanied by thrombocytopenia, and this issue was recently termed vaccine-induced immune thrombotic thrombocytopenia. This manuscript describes recently published guidelines and other related issues and demonstrates characteristic cases. Read More

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