768 results match your criteria manual infusion


[Design of Gas Detection System Based on STM32 Infusion Set].

Zhongguo Yi Liao Qi Xie Za Zhi 2021 Apr;45(2):159-162

Nanchang University, Nanchang, 330031.

Aiming at the low efficiency and low quality detection level of the manual infusion set, a gas detection system for infusion set based on STM32 single-chip microcomputer was designed. The detection system includes hardware system design and software system design. The hardware system is based on the STM32F103 single-chip microcomputer. Read More

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Intravenous Smart Pumps During Actual Clinical Use: A Descriptive Comparison of Primary and Secondary Infusion Practices.

J Infus Nurs 2021 Feb 26. Epub 2021 Feb 26.

University of Massachusetts Amherst, Institute for Applied Life Sciences and College of Nursing, Amherst, Massachusetts (Dr Giuliano); Center for Nursing Research and Advanced Nursing Practice, Orlando Health, Orlando, Florida (Dr Penoyer and, formerly, Ms Bennett); Parkview Regional Medical Center, Fort Wayne, Indiana (Ms Mahuren). Karen K. Giuliano, PhD, MBA, RN, FAAN, is a fellow in the American Academy of Nursing and a six-sigma green belt. She holds a BSN and PhD in nursing from Boston College, a nurse practitioner degree from the University of Massachusetts, and an MBA in global management from Babson College. She completed her postdoctoral research fellowship on intravenous (IV) infusion device safety at Yale University. Dr Giuliano actively contributes to many professional organizations and works with small, medium, and large companies on medical product development and innovation. In addition, her own interdisciplinary program of research is focused in 2 main areas: nonventilator hospital-acquired pneumonia and IV infusion safety using IV smart pumps. With a clinical background in critical care and 25+ years of global experience in the development of new medical products, Dr Giuliano is passionate about improving health care through innovation. Her expertise includes human-centered design and clinical outcomes research. Daleen Penoyer, PhD, RN, CCRP, FCNS, FCCM, has more than 45 years of nursing experience and has held roles in academia, advanced practice, research, and leadership. She holds a PhD in nursing and is a certified clinical research professional, a fellow clinical nurse specialist, and a fellow in critical care medicine. Dr Penoyer currently serves as the director for the Center for Nursing Research at Orlando Health as an active nurse scientist. She has many publications in peer-reviewed journals to her credit and speaking engagements at the local, regional, and national levels. Her research interests are in critical care, intravenous therapy devices and practices, and prevention of hospital-acquired pneumonia. Rebecca S. Mahuren, BSN, RN, received her BSN from Indiana Wesleyan University, her associate's degree in applied of science in nursing from Purdue University, and associate's degree in applied science in accounting from Indiana Vocational Technical College. She has been a registered nurse at Parkview Health for nearly 30 years. Her clinical nursing experience includes perioperative, labor and delivery, medical-surgical patient populations, and staff educator for the pharmacy and nursing departments. Since 2016, Ms Mahuren has served 12 locations across 8 Parkview campuses as their medication safety integration nurse. She is a member of the multidisciplinary smart pump steering committee and medication safety team in which she provides data analysis and reviews events involving smart pump technology. She works on process improvements and the development of sustainable interventions and communicates the changes and issues impacting such technology. Ms Mahuren participated at the 2018 Institute for Safe Medication Practices Summit to revise the guidelines for smart pump use as an infusion device and interoperability subject matter expert. Melody Bennett, MN, RN, CCRN, has more than 40 years of clinical nursing experience in a variety of settings, including critical care. She received her master's in nursing from the University of Washington, Seattle. Although she has recently retired, at the time of this study, Ms Bennett was a clinical research coordinator at Orlando Regional Medical Center, where she completed the data collection for this article, as well as many other studies.

This descriptive observational study was conducted to increase understanding of medication administration practices during actual clinical use between 2 commonly used, different types of intravenous (IV) smart pumps. Compliance with manufacturer-recommended setup requirements for both primary and secondary infusions and secondary medication administration delay was compared between a head-height differential system and a cassette system. A total of 301 medication administration observations were included in this study: 102 (34%) for the linear peristaltic IV smart pump (medical-surgical: N = 51; critical care: N = 51) and 199 (66%) for the cassette pump (medical-surgical: N = 88; critical care: N = 111). Read More

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February 2021

Clinical presentation and improvised management of neonatal pneumothorax in the setting of a low-resource country: Conakry, Guinea.

BMJ Case Rep 2021 Mar 22;14(3). Epub 2021 Mar 22.

Clinic of Neonatology, Department Woman-Mother-Child, CHUV, Lausanne, VD, Switzerland.

Two neonates were presented at the Neonatology Department of the Institute of Child Nutrition and Health in Conakry, Guinea, with tension pneumothoraces as confirmed by chest X-ray. They were initially managed with needle thoracentesis but required continuous thoracic drainage. Due to scarce resources in the public health sector, no prepacked and dedicated pleural drainage systems were available as is the case in many developing countries. Read More

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Normotensive presentation in primary aldosteronism: A report of two cases.

J Renin Angiotensin Aldosterone Syst 2021 Jan-Dec;22(1):14703203211003780

Department of Endocrinology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Normotensive patients with primary aldosteronism (PA) are relatively rare. Herein, we report two patients with normotensive PA and present a literature review to improve an understanding of the disease. Patient 1, a 56-year-old man, presented with recurrent hypokalemia that lasted for more than 2 years. Read More

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Automated liquid-liquid extraction of organic compounds from aqueous samples using a multifunction autosampler syringe.

J Chromatogr A 2021 Apr 3;1642:462032. Epub 2021 Mar 3.

ARC Training Centre for Portable Analytical Separation Technologies (ASTech), University of Tasmania, Private Bag 75 Hobart, 7001 Australia; Trajan Scientific and Medical, 7 Argent Place Ringwood, 3134 Australia; CASS Food Research Centre, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway Burwood, 3125 Australia. Electronic address:

Liquid-liquid extraction is one of the most widely used and simplest sample preparation techniques. However, consumption of large volumes of organic solvent and manual handling are two major drawbacks of this technique. A multifunction autosampler syringe is introduced which permits automated liquid-liquid extraction in an enclosed operating environment, with low consumption of organic solvents. Read More

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Smart agent system for insulin infusion protocol management: a simulation-based human factors evaluation study.

BMJ Qual Saf 2021 Mar 10. Epub 2021 Mar 10.

Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Objective: To compare the insulin infusion management of critically ill patients by nurses using either a common standard (ie, human completion of insulin infusion protocol steps) or smart agent (SA) system that integrates the electronic health record and infusion pump and automates insulin dose selection.

Design: A within subjects design where participants completed 12 simulation scenarios, in 4 blocks of 3 scenarios each. Each block was performed with either the manual standard or the SA system. Read More

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Prevalence and factors associated with anxiety and depressive symptoms among patients hospitalized with hematological malignancies after chimeric antigen receptor T-cell (CAR-T) therapy: A cross-sectional study.

J Affect Disord 2021 May 18;286:33-39. Epub 2021 Feb 18.

Xuzhou Medical University, Jiangsu, China. Electronic address:

Background: We conducted a survey to investigate the prevalence and factors associated with anxiety and depressive symptoms among patients hospitalized with hematological malignancies after chimeric antigen receptor T-cell (CAR-T) therapy.

Methods: In total, 130 eligible patients completed the Self-Rating Anxiety Scale and Self-Rating Depression Scale at week 4 after CAR-T cell infusion. We collected sociodemographic information during the same period. Read More

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Interindividual Variability in the Pharmacodynamic and Pharmacokinetic Characteristics of Recombinant Human Insulin and Insulin Aspart.

Clin Ther 2021 Mar 5;43(3):594-601.e1. Epub 2021 Feb 5.

Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Purpose: The present study compared the interindividual variability in the pharmacodynamic (PD) and pharmacokinetic (PK) properties of a short-acting recombinant human insulin to those of insulin aspart through manual euglycemic glucose clamp tests.

Methods: Sixty healthy Chinese male volunteers were randomly assigned to receive human insulin or insulin aspart, administered via SC injection (0.2 U/kg). Read More

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Application of ultrasound-guided external jugular vein puncture in intensive care unit (ICU) patients with severe sepsis: a randomised trial.

Ann Palliat Med 2021 Jan;10(1):530-537

Department of Critical Care Medicine, the First Medical Centre, Chinese PLA General Hospital, Beijing, China.

Background: Sepsis is one of the most common critical illnesses in intensive care unit (ICU) clinical practice. Intravenous infusion technology is an important method for life support. The commonly used deep vein indwelling is expensive, and the incidence of infection due to long-term placement is high. Read More

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January 2021

Comparison of the target-controlled infusion and the manual infusion of propofol anesthesia during electroconvulsive therapy: an open-label randomized controlled trial.

BMC Psychiatry 2021 Feb 4;21(1):71. Epub 2021 Feb 4.

School of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Target-controlled infusion (TCI) of propofol is a well-established method of procedural sedation and has been used in Japan for anesthesia during electroconvulsive therapy (ECT). However, the usefulness of the TCI of propofol for ECT has yet to be determined. This study aimed to compare the TCI and manual infusion (MI) of propofol anesthesia during ECT. Read More

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February 2021

Development and Evaluation of an Intravenous Infusion Sequence Annotation System.

Appl Clin Inform 2021 01 3;12(1):65-72. Epub 2021 Feb 3.

Hefei Binhu Hospital, Hefei, Anhui, China.

Objectives: The sequence of intravenous infusions may impact the efficacy, safety, and cost of intravenous medications. The study describes and assesses a computerized clinical decision support annotation system capable of analyzing the sequence of intravenous infusions.

Methods: All intravenous medications on the hospital formulary were analyzed based on factors that impact intravenous infusion sequence. Read More

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January 2021

Bispectral index monitoring of the clinical effects of propofol closed-loop target-controlled infusion: Systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2021 Jan;100(4):e23930

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, China.

Background: To investigate whether closed-loop systems under bispectral index anesthesia depth monitoring can reduce the intraoperative propofol dosage.

Methods: All randomized controlled trials (RCTs) on reducing propofol dosage under closed-loop systems were collected, and the literature was screened out, the abstracts and full texts were carefully read, and the references were tracked, data extraction and quality evaluation were conducted on the included research, and the RevMan5.3 software was used for meta-analysis. Read More

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January 2021

Comparison of anesthesia effects between closedloop and openloop target controlled infusion of propofol using the bispectral index in abdominal surgery.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Dec;45(12):1419-1424

Department of Anesthesiology, Beijing Hospital; National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

Objectives: Bispectral index (BIS) can reflect the depth of propofol sedation. This study aims to compare the anesthetic satisfaction, anesthetic dose, and hemodynamic changes between closed-loop target controlled infusion (CLTCI) and open-loop target controlled infusion (OLTCI) during abdominal surgery.

Methods: From December 2016 to December 2018, 70 patients undergoing abdominal surgery under general anesthesia were selected in Beijing Hospital, including 51 males and 19 females, at the age from 49 to 65 years old. Read More

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December 2020

Virtual training on the hybrid close loop system in people with type 1 diabetes (T1D) during the COVID-19 pandemic.

Diabetes Metab Syndr 2021 Jan-Feb;15(1):243-247. Epub 2021 Jan 5.

Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá, Colombia. Electronic address:

Background And Aims: In Colombia, the government established mandatory isolation after the first case of COVID-19 was reported. As a diabetes care center specialized in technology, we developed a virtual training program for patients with type 1 diabetes (T1D) who were upgrading to hybrid closed loop (HCL) system. The aim of this study is to describe the efficacy and safety outcomes of the virtual training program. Read More

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Prospective, double-blind, randomized, placebo-controlled phase III study evaluating efficacy and safety of octagam 10% in patients with dermatomyositis ("ProDERM Study").

Medicine (Baltimore) 2021 Jan;100(1):e23677

Department of Neurology, Phoenix Neurological Associates, Ltd., Phoenix, AZ.

Introduction: Dermatomyositis (DM) is an inflammatory myopathy characterized by distinct skin manifestations and muscle weakness. Intravenous immunoglobulin (IVIg) has been used off-label as adjuvant therapy in DM, but is not indicated for DM, due to lack of proven efficacy in a large randomized controlled trial. The objective of the ProDERM (Progress in DERMatomyositis) study was to evaluate the efficacy, safety and long-term tolerability of IVIg (Octagam 10%) in patients with DM in a randomized, placebo-controlled, double-blind, Phase III study. Read More

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January 2021

Postoperative Neurocognitive Disorders After Closed-Loop Versus Manual Target Controlled-Infusion of Propofol and Remifentanil in Patients Undergoing Elective Major Noncardiac Surgery: The Randomized Controlled Postoperative Cognitive Dysfunction-Electroencephalographic-Guided Anesthetic Administration Trial.

Anesth Analg 2020 Nov 10. Epub 2020 Nov 10.

From the Department of Anesthesiology and Intensive Care Medicine, University Hospital of Besancon, Besancon, France.

Background: The aim of the study was to investigate whether closed-loop compared to manual bispectral index (BIS)-guided target-controlled infusion of propofol and remifentanil could decrease the incidence of postoperative neurocognitive disorders after elective major noncardiac surgery.

Methods: Patients aged >50 admitted for elective major noncardiac surgery were included in a single-blind randomized (ratio 2:1) trial. The anesthetic protocol was allocated by randomization into either closed-loop or manual BIS-guided propofol and remifentanil titration. Read More

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November 2020

In vitro iatrogenic hemolysis of canine packed red blood cells during various rapid transfusion techniques.

J Vet Emerg Crit Care (San Antonio) 2021 Jan 3;31(1):25-31. Epub 2020 Nov 3.

Department of Small Animal Emergency and Critical Care, BluePearl Veterinary Partners, Tampa, Florida.

Objective: To evaluate which rapid blood administration technique causes the least iatrogenic hemolysis in canine packed red blood cells (pRBCs) as determined by plasma free hemoglobin (fHb) and percent hemolysis (% hemolysis).

Design: Prospective in vitro randomized study.

Setting: Private referral center. Read More

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January 2021

Phases of fluid management and the roles of human albumin solution in perioperative and critically ill patients.

Curr Med Res Opin 2020 Dec 5;36(12):1961-1973. Epub 2020 Nov 5.

Institute of Public Health, Medical Decision Making and HTA, University of Health Sciences, Medical Informatics and Technology, Hall (Tyrol), Austria.

Objective: Positive fluid balance is common among critically ill patients and leads to worse outcomes, particularly in sepsis, acute respiratory distress syndrome, and acute kidney injury. Restrictive fluid infusion and active removal of accumulated fluid are being studied as approaches to prevent and treat fluid overload. Use of human albumin solutions has been investigated in different phases of restrictive fluid resuscitation, and this narrative literature review was undertaken to evaluate hypoalbuminemia and the roles of human serum albumin with respect to hypovolemia and its management. Read More

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December 2020

Effect of warming and infusion of red blood cell concentrates on markers of haemolysis: An ex vivo simulation study.

Aust Crit Care 2020 Oct 14. Epub 2020 Oct 14.

Safety, Technology and Care Research Group, Department of Paediatric Nursing, Universidade Federal de São Paulo (Federal University of Sao Paulo), R. Napoleão de Barros, 754 - Vila Clementino, Sao Paulo, SP, 04024-002, Brazil; Alliance for Vascular Access Teaching and Research Group, School of Nursing and Midwifery, Menzies Health Institute Queensland, Griffith University, 170 Kessels Road Nathan, Qld, 4111, Brisbane, Queensland, Australia. Electronic address:

Background: Transfusion of red blood cell (RBC) concentrates is a common procedure to restore blood volume and tissue oxygen delivery in patients with trauma. Although RBC warmers may prevent hypothermia, some warming or infusion equipment may lead to haemolysis and patient injury.

Objectives: The aim of this study was to test the effect of (i) RBC warming and (ii) administration via manual vs. Read More

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October 2020

Use of a Smart Pump and Dedicated Medication Line to Reduce Peripherally Inserted Central Catheter Damage.

Adv Neonatal Care 2021 Feb;21(1):61-67

Sanford USD Medical Center, Sioux Falls, South Dakota.

Background: Neonatal intensive care unit (NICU) infants frequently require peripherally inserted central catheter (PICC) placement for medication and nutrition. The occurrence of leaking catheters led to practice evaluation of manual intravenous (IV) flush and medication push technique in an upper Midwest NICU. A variation in unit practice was revealed. Read More

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February 2021

Automated closed-loop versus manually controlled norepinephrine infusion in patients undergoing intermediate- to high-risk abdominal surgery: a randomised controlled trial.

Br J Anaesth 2021 01 8;126(1):210-218. Epub 2020 Oct 8.

Department of Anesthesiology and Perioperative Care, University of California Irvine, Irvine, CA, USA.

Background: Hypotension occurs frequently during surgery and may be associated with adverse complications. Vasopressor titration is frequently used to correct hypotension, but requires considerable time and attention, potentially reducing the time available for other clinical duties. To overcome this issue, we have developed a closed-loop vasopressor (CLV) controller to help correct hypotension more efficiently. Read More

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January 2021

Evaluation of Automated Delivery of Propofol Using a Closed-Loop Anesthesia Delivery System in Patients Undergoing Thoracic Surgery: A Randomized Controlled Study.

J Cardiothorac Vasc Anesth 2021 Apr 13;35(4):1089-1095. Epub 2020 Sep 13.

Department of Anaesthesiology, Pain, and Perioperative Medicine, Sir Ganga Ram Hospital, New Delhi, India.

Objective: Automated propofol total intravenous anesthesia (TIVA) administered by a closed-loop anesthesia delivery system (CLADS) exhibits greater efficiency than conventional manual methods, but its use in major thoracic surgery is limited.

Design: Prospective, single-blind, randomized controlled study.

Setting: Single-center tertiary care hospital. Read More

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Safety and Tolerability of Manual Push Administration of Subcutaneous IgPro20 at High Infusion Rates in Patients with Primary Immunodeficiency: Findings from the Manual Push Administration Cohort of the HILO Study.

J Clin Immunol 2021 Jan 6;41(1):66-75. Epub 2020 Oct 6.

CSL Behring LLC, 1020 First Avenue, King of Prussia, PA, 19406, USA.

Purpose: To evaluate the safety and tolerability of IgPro20 manual push (also known as rapid push) infusions at flow rates of 0.5-2.0 mL/min. Read More

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January 2021

A Comparison of Manual and Robot Assisted Retinal Vein Cannulation in Chicken Chorioallantoic Membrane.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:5101-5105

Retinal vein occlusion (RVO) is a vision threatening condition occurring in the central or the branch retinal veins. Risk factors include but are not limited to hypercoagulability, thrombus or other cause of low blood flow. Current clinically proven treatment options limit complications of vein occlusion without treating the causative occlusion. Read More

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Manual push technique, an alternative route of subcutaneous immunoglobulin administration in chronic inflammatory demyelinating polyradiculoneuropathy: A proof-of-concept study.

Clin Neurol Neurosurg 2020 Nov 16;198:106240. Epub 2020 Sep 16.

Divisione di Riabilitazione Neuromotoria, Istituti Clinici Scientifici Maugeri, Presidio Sanitario Major, Via Santa Giulia, 60, 10124, Torino, Italy. Electronic address:

Objective: Subcutaneous immunoglobulin (SCIg) administered through infusion pump has been reported as effective in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients. In this study we evaluate an alternative technique of SCIg administration, based on the delivery of lower volumes administered daily using manual push technique (MPT) in 10 CIDP patients.

Methods: In this randomized, controlled, two-arm, crossover clinical trial, CIDP patients were randomly assigned 1:1 to receive SCIg either by MPT or pumps for 4 consecutive months with crossover to the other. Read More

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November 2020

Effectiveness of a Calculation-Free Weight-Based Unfractionated Heparin Nomogram With Anti-Xa Level Monitoring Compared With Activated Partial Thromboplastin Time.

Ann Pharmacother 2021 May 23;55(5):575-583. Epub 2020 Sep 23.

VA Center for Health Equity Research and Promotion, Pittsburgh, PA, USA.

Background: Accurate monitoring of intravenous unfractionated heparin (UFH) is essential to mitigate the risk of adverse drug events associated with dosing errors. Although recent data support anti-factor Xa (anti-Xa) monitoring preferentially over activated partial thromboplastin time (aPTT) to improve time to therapeutic anticoagulation, the utility of incorporating anti-Xa monitoring with a calculation-free weight-based UFH nomogram has not been formally evaluated.

Objective: The primary objective of this study was to evaluate the time to therapeutic anticoagulation of a calculation-free weight-based UFH nomogram integrated with anti-Xa monitoring versus a historical control of aPTT monitoring utilizing manual dose calculations. Read More

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Transfusion support in patients with sickle cell disease.

Semin Hematol 2020 04 28;57(2):39-50. Epub 2020 Jul 28.

Division of Transfusion Medicine, Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Hematology and Oncology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

Blood transfusions are an integral component of the management of acute and chronic complications of sickle cell disease. Red cells can be administered as a simple transfusion, part of a modified exchange procedure involving manual removal of autologous red cells and infusion of donor red cells, and part of an automated red cell exchange procedure using apheresis techniques. Individuals with sickle cell disease are at risk of multiple complications of blood transfusions, including transfusional hemosiderosis, auto- and alloimmunization to minor red cell and human leukocyte antigens, delayed hemolytic transfusion reactions, and hyper-hemolysis. Read More

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Integrating and Evaluating the Data Quality and Utility of Smart Pump Information in Detecting Medication Administration Errors: Evaluation Study.

JMIR Med Inform 2020 Sep 2;8(9):e19774. Epub 2020 Sep 2.

Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Background: At present, electronic health records (EHRs) are the central focus of clinical informatics given their role as the primary source of clinical data. Despite their granularity, the EHR data heavily rely on manual input and are prone to human errors. Many other sources of data exist in the clinical setting, including digital medical devices such as smart infusion pumps. Read More

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September 2020

A simple tool to automate the insertion process in cochlear implant surgery.

Int J Comput Assist Radiol Surg 2020 Nov 28;15(11):1931-1939. Epub 2020 Aug 28.

Department of Otolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose: Automated insertion of electrode arrays (EA) in cochlear implant surgery is presumed to be less traumatic than manual insertions, but no tool is widely available in the operating room. We sought (1) to design and create a simple tool able to automate the EA insertion process; and (2) to perform preliminary evaluations of the designed prototype.

Methods: A first prototype of a tool with maximum simplicity was designed and fabricated to take advantage of hydraulic actuation. Read More

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November 2020