15,187 results match your criteria mantle

A globally fragmented and mobile lithosphere on Venus.

Proc Natl Acad Sci U S A 2021 Jun;118(26)

Lamont-Doherty Earth Observatory, Columbia University, Palisades, NY 10964

Venus has been thought to possess a globally continuous lithosphere, in contrast to the mosaic of mobile tectonic plates that characterizes Earth. However, the Venus surface has been extensively deformed, and convection of the underlying mantle, possibly acting in concert with a low-strength lower crust, has been suggested as a source of some surface horizontal strains. The extent of surface mobility on Venus driven by mantle convection, however, and the style and scale of its tectonic expression have been unclear. Read More

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14-3-3ζ and 14-3-3ε are involved in innate immune responses in Pacific abalone (Haliotis discus hannai).

Dev Comp Immunol 2021 Jun 18:104176. Epub 2021 Jun 18.

Muping Coastal Environmental Research Station, Yantai Institute of Coastal Zone Research, Yantai Shandong 264117, P. R. China; Center for Ocean Mega-science, Chinese Academy of Sciences, Qingdao Shandong 266071, P. R. China; Research and Development Center for Efficient Utilization of Coastal Bioresources, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai Shandong 264003, P. R. China. Electronic address:

The 14-3-3 proteins play important roles in various cellular processes by binding to different ligands, but little is known about these proteins in mollusks. In this study, two 14-3-3 cDNAs were identified from the Pacific abalone Haliotis discus hannai (designated 14-3-3ζ and 14-3-3ε), possessing 59.40% identity with each other. Read More

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Zanubrutinib for the treatment of relapsed or refractory mantle cell lymphoma.

Blood Adv 2021 Jun;5(12):2577-2585

Concord Repatriation Hospital, The University of Sydney, Sydney, NSW, Australia.

Zanubrutinib, a highly selective Bruton tyrosine kinase inhibitor, was evaluated in a phase 1/2 study in patients with various B-cell malignancies. In the subgroup of patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL), zanubrutinib was administered as 160 mg twice daily (n = 14), 320 mg once daily (n = 18), or ≤160 mg total dose (n = 5). Herein, we report results for patients receiving a total daily dose of 320 mg (N = 32). Read More

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Bilateral vision loss as the initial presentation for central nervous system involvement of mantle cell lymphoma: A case series.

Am J Ophthalmol Case Rep 2021 Sep 3;23:101131. Epub 2021 Jun 3.

Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.

Purpose: Mantle cell lymphoma is a rare aggressive subtype of non-Hodgkins B cell lymphoma. It typically presents with asymptomatic monoclonal lymphocytosis, lymphadenopathy or bulky extranodal disease. Mantle cell lymphoma rarely affects the central nervous system. Read More

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September 2021

Distal chromosome 1q aberrations and initial response to ibrutinib in central nervous system relapsed mantle cell lymphoma.

Leuk Res Rep 2021 1;15:100255. Epub 2021 Jun 1.

Haematology-Pathology Research Laboratory, Research Unit for Haematology and Research Unit for Pathology, University of Southern Denmark and Odense University Hospital, Odense, Denmark.

Relapse involving the central nervous system (CNS) is an infrequent event in the progression of mantle cell lymphoma (MCL) with an incidence of approximately four percent. We report four cases of MCL with CNS relapse. In three of the four patients a large chromosomal copy-number alteration (CNA) of 1q was demonstrated together with TP53 mutation/deletion. Read More

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The differences of muscle proteins between neon flying squid (Ommastrephes bartramii) and jumbo squid (Dosidicus gigas) mantles via physicochemical and proteomic analyses.

Food Chem 2021 Jun 16;364:130374. Epub 2021 Jun 16.

Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, College of Food Science and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China. Electronic address:

Neon flying squid (OB) and jumbo squid (DG) mantles were evaluated to reveal the similarities and differences in their physicochemical features and protein abundances. Microstructural results indicated that the OB mantle exhibited numerous myofibril fragments and disordered microstructures after frozen storage compared with DG tissues. Chemical analysis suggested that freezing resulted in a rapid decrease in myofibrillar protein (MP) content, Ca-ATPase activity, and total sulfhydryl content, and promoted the increase in carbonyl content of MPs in both OB and DG. Read More

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Ultrasonographic approach and findings in calves with hydranencephaly.

Vet Med Sci 2021 Jun 19. Epub 2021 Jun 19.

Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Background: Teratogenic viral infections may proceed to hydranencephaly in cattle. Post-mortem and antemortem diagnosis can be achieved by necropsy or ultrasonography, CT-scan and MRI techniques.

Objectives: The aim of this study was to determine how effective ultrasonography approach is in detecting hydranencephaly in calves. Read More

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Large air pressure changes triggered by P-SV ground motion in a cave in northern Taiwan.

Sci Rep 2021 Jun 18;11(1):12850. Epub 2021 Jun 18.

Institute of Earth Sciences, Academia Sinica, Taipei, Taiwan.

Acoustic-gravity waves are generally considered to be one of the major factors that drive changes of the total electron content in the ionosphere. However, causal mechanisms of couplings between sources in the lithosphere and responses in the atmosphere and the ionosphere are not fully understood, yet. A barometer in the cave of the SBCB station records an unusual phenomenon of larger amplitudes in air pressure changes inside than those at the Xinwu station (outside). Read More

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Loncastuximab Tesirine: First Approval.

Arnold Lee

Drugs 2021 Jun 18. Epub 2021 Jun 18.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Loncastuximab tesirine (loncastuximab tesirine-lpyl; ZYNLONTA™) is an antibody-drug conjugate being developed for the treatment of B cell lymphomas by ADC Therapeutics SA. Loncastuximab tesirine consists of a pyrrolobenzodiazepine DNA-alkylating warhead covalently attached via a cleavable linker to an anti-CD19 antibody that binds to B cells. It is currently approved in the US for the treatment of relapsed/refractory diffuse large B cell lymphoma (DLBCL), and is being developed for the treatment of mantle-cell lymphoma, follicular lymphoma and acute lymphoblastic leukaemia. Read More

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First description of freshwater mite Unionicola sauerensis sp. nov. infesting thick-shelled river mussel Unio crassus.

Dis Aquat Organ 2021 Jun 17;145:63-77. Epub 2021 Jun 17.

Clinical Division of Fish Medicine, University of Veterinary Medicine, 1210 Vienna, Austria.

A sample of 30 thick-shelled river mussels Unio crassus Philipsson (Unionida: Unionidae) was collected from the River Sauer in Luxembourg to acquire data on parasitic infestations of the mussels. Among other parasites, different development stages of freshwater mites were collected from the gills and the mantle of the mussels and were documented with bright-field, stereo, and confocal laser scanning microscopy and microscopic X-ray computed tomography. The retrieved data allowed a morphological description of larvae and female adults of the mites and assigning them to the genus Unionicola Haldeman (Trombidiformes: Unionicolidae) and the subgenus Pentatax Thor. Read More

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Extranodal Head and Neck Mantle Cell Lymphoma: Characteristics, Treatment, and Survival.

Ann Otol Rhinol Laryngol 2021 Jun 17:34894211025171. Epub 2021 Jun 17.

Division of Otolaryngology, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

Objectives: To describe disease characteristics and treatment and to analyze survival and mortality for extranodal mantle cell lymphoma (MCL) of the head and neck.

Methods: Patients with extranodal MCL-excluding primary sites in the salivary glands, eye, and adnexa-were identified from the Surveillance, Epidemiology, and End Results (SEER) 18 Registries (2000-2015). Overall survival (OS) and cumulative incidence of MCL and non-MCL mortality were calculated. Read More

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Role of pH in Skin Cleansing.

Int J Cosmet Sci 2021 Jun 17. Epub 2021 Jun 17.

JL Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, 45267, USA.

The importance of maintaining the acid-mantle of human stratum corneum to maintain its healthy barrier and skin's biological functions such as desquamation and lipid biosynthesis is well recognized in the literature. An outcome of this has been an increase in the number of skincare products formulated at or near the skin pH with an implication that a product formulated at skin pH will be good for skin. Such an assumption often does not take into account the specific interactions of ingredients in the product with the stratum corneum under skin pH conditions. Read More

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Scale of plume clustering in large-Prandtl-number convection.

Phys Rev E 2021 May;103(5-1):053103

Institute of Geosciences and Earth Resources (IGG), National Research Council (CNR), Pisa 56124, Italy.

Clustering of plumes in turbulent Rayleigh-Bénard convection has been numerically observed in low-Prandtl-number fluids. In this framework, turbulent plumes undergo a phase-separation process leading to large-scale clusters and circulations, sometimes called plume superstructures and reminiscent of solar granulation and supergranulation. On the other hand, the possible presence of large-scale plume aggregates has not been explored in the case of large values of the Prandtl number, Pr, relevant to geological settings such as convection in planetary interiors. Read More

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Cement use in total knee arthroplasty: 40 versus 80 grams.

Knee 2021 Jun 13;31:110-117. Epub 2021 Jun 13.

Houston Methodist, Department of Orthopedic Surgery, 6445 Main St Suite 2500, Houston, TX 77030, United States. Electronic address:

Background: Studies of cement use in total knee arthroplasty (TKA) have historically addressed mechanical properties and application strategies. Recently, cement technique has been studied as a means to reduce cost. We transitioned from opening two bags (80 grams) of cement to one bag (40 grams) of cement for primary TKA to improve cost efficacy. Read More

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Adjoint traveltime tomography unravels a scenario of horizontal mantle flow beneath the North China craton.

Sci Rep 2021 Jun 15;11(1):12523. Epub 2021 Jun 15.

Division of Mathematical Sciences, School of Physical and Mathematical Sciences and Asian School of the Environment, Nanyang Technological University, Singapore, Singapore.

The North China craton (NCC) was dominated by tectonic extension from late Cretaceous to Cenozoic, yet seismic studies on the relationship between crust extension and lithospheric mantle deformation are scarce. Here we present a three dimensional radially anisotropic model of NCC derived from adjoint traveltime tomography to address this issue. We find a prominent low S-wave velocity anomaly at lithospheric mantle depths beneath the Taihang Mountains, which extends eastward with a gradually decreasing amplitude. Read More

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Mantle-derived helium released through the Japan trench bend-faults.

Sci Rep 2021 Jun 14;11(1):12026. Epub 2021 Jun 14.

Center for Advanced Marine Core Research, Kochi University, Nankoku, Japan.

Plate bending-related normal faults (i.e. bend-faults) develop at the outer trench-slope of the oceanic plate incoming into the subduction zone. Read More

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Cadmium bioaccumulation and distribution in the freshwater bivalve Anodonta woodiana exposed to environmentally relevant Cd levels.

Sci Total Environ 2021 Jun 8;791:148289. Epub 2021 Jun 8.

Key Laboratory of Fishery Eco-Environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China. Electronic address:

Anodonta woodiana is a globally distributed freshwater bivalve, which is a unique bioindicator in the "Freshwater Mussel Watch" project. Numerous countries have used A. woodiana for biomonitoring the aqueous cadmium (Cd) contamination. Read More

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Increased complexity of t(11;14) rearrangements in plasma cell neoplasms compared with mantle cell lymphoma.

Genes Chromosomes Cancer 2021 Jun 14. Epub 2021 Jun 14.

Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Plasma cell neoplasms (PCN) and mantle cell lymphoma (MCL) can both harbor t(11;14)(q13;q32) (CCND1/IGH), usually resulting in cyclin D1 overexpression. In some cases, particularly at low levels of disease, it can be morphologically challenging to distinguish between these entities in the bone marrow (BM) since PCN with t(11;14) are often CD20-positive with lymphoplasmacytic cytology, while MCL can rarely have plasmacytic differentiation. We compared the difference in CCND1/IGH by fluorescence in situ hybridization (FISH) in PCN and MCL to evaluate for possible differentiating characteristics. Read More

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A Review of the Bruton Tyrosine Kinase Inhibitors in B-Cell Malignancies.

J Adv Pract Oncol 2021 May 1;12(4):439-447. Epub 2021 May 1.

Atrium Health Cabarrus, Department of Pharmacy, Concord, North Carolina.

The B-cell receptor signaling pathway plays an integral role in the proliferation and survival of malignant B cells. Targeting the B-cell receptor pathway via the inhibition of Bruton tyrosine kinase (BTK) has evolved the treatment of a variety of B-cell malignancies, including chronic lymphocytic leukemia, mantle cell lymphoma, marginal zone lymphoma, and Waldenström macroglobulinemia. Currently, there are three BTK inhibitors approved by the U. Read More

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Zircon record of an Archaean crustal fragment and supercontinent amalgamation in quaternary back-arc volcanic rocks.

Sci Rep 2021 Jun 11;11(1):12367. Epub 2021 Jun 11.

Key Laboratory of Marine Geology and Environment, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China.

Magmatism has profoundly influenced the evolution of the geosphere, hydrosphere, atmosphere, and biosphere in back-arc basins. However, the timing of the magmatism in the Okinawa Trough (OT) is not well constrained by the age spectra of zircons. Here, for the first time, we carry out an integrated study combining in situ analysis of zircon U-Th-Pb and Hf-O isotopes, and trace element compositions of zircons from the volcanic rocks from the southernmost part of the OT. Read More

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Recent advances in composite hydrogels prepared solely from polysaccharides.

Colloids Surf B Biointerfaces 2021 Jun 2;205:111891. Epub 2021 Jun 2.

Biochemical Engineering Research & Process Development Centre (BERPDC), Institute of Microbial Technology (IMTECH), Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh, 160036, India. Electronic address:

The proliferating demand for sustainable, biodegradable, and biologically safe materials has triggered the development of polysaccharide-based hydrogels. The translation of research on single polysaccharide-based hydrogels into their desired clinical or industrial application is minimal. This is attributable to their lack of mechanical strength, inadequate stability, and constrained the possibility of their modulation to obtain the desired property. Read More

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Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells.

Prostaglandins Other Lipid Mediat 2021 Jun 8;156:106575. Epub 2021 Jun 8.

Department of Medicine Solna, Division of Hematology, Karolinska University Hospital and Institutet, Stockholm, Sweden. Electronic address:

Human B-lymphocytes express 5-lipoxygenase (5-LOX) and 5-LOX activating protein (FLAP) and can convert arachidonic acid to leukotriene B. Mantle cell lymphoma (MCL) cells contain similar amounts of 5-LOX as human neutrophils but the function and mechanism of activation of 5-LOX in MCL cells, and in normal B-lymphocytes, are unclear. Here we show that the intrinsic 5-LOX pathway in the MCL cell line JeKo-1 has an essential role in migration and adherence of the cells, which are important pathophysiological characteristics of B-cell lymphoma. Read More

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The pathologic diagnosis of mantle cell lymphoma.

Histol Histopathol 2021 Jun 11:18351. Epub 2021 Jun 11.

Department of Hematopathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Mantle cell lymphoma (MCL) is a mature B-cell non-Hodgkin lymphoma usually characterized by t(11;14) (q13;q32), or CCND1 translocation and Cyclin D1 over expression. A very small subset of MCL may lack the t(11;14) (q13;q32) translocation and Cyclin D1 over expression, but show alternative translocations involving CCND2 and CCND3, and over expression of SOX11. In general, MCL has been considered a very aggressive and incurable lymphoma and patients with MCL usually have a poor prognosis. Read More

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Risk of radiation necrosis after stereotactic radiosurgery for melanoma brain metastasis by anatomical location.

Strahlenther Onkol 2021 Jun 10. Epub 2021 Jun 10.

Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

Purpose: In this retrospective study, we have explored the anatomical factors that lead to the development of radiation necrosis (RN) in the setting of stereotactic radiosurgery (SRS) for melanoma brain metastases (MBM).

Methods: Between 2014 and 2018, 137 patients underwent SRS for 311 MBM. Lesions were assessed according to anatomical zones: zone 1-peripheral grey-white matter junction and cortical mantle, zone 2-deep white matter, including tumours located at base of sulci, zone 3-tumours adjacent to ependymal lining or in deep locations such as brainstem, basal ganglia and thalamus. Read More

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Rapid endogenic rock recycling in magmatic arcs.

Nat Commun 2021 Jun 10;12(1):3533. Epub 2021 Jun 10.

State Key Laboratory for Mineral Deposits Research, School of Earth Sciences and Engineering, Nanjing University, Nanjing, China.

In subduction zones, materials on Earth's surface can be transported to the deep crust or mantle, but the exact mechanisms and the nature of the recycled materials are not fully understood. Here, we report a set of migmatites from western Yangtze Block, China. These migmatites have similar bulk compositions as forearc sediments. Read More

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Crustal rejuvenation stabilised Earth's first cratons.

Nat Commun 2021 Jun 10;12(1):3535. Epub 2021 Jun 10.

Geological Survey of Western Australia, Department of Mines, Industry Regulation and Safety, East Perth, WA, Australia.

The formation of stable, evolved (silica-rich) crust was essential in constructing Earth's first cratons, the ancient nuclei of continents. Eoarchaean (4000-3600 million years ago, Ma) evolved crust occurs on most continents, yet evidence for older, Hadean evolved crust is mostly limited to rare Hadean zircons recycled into younger rocks. Resolving why the preserved volume of evolved crust increased in the Eoarchaean is key to understanding how the first cratons stabilised. Read More

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Transcriptomic analysis of shell repair and biomineralization in the blue mussel, Mytilus edulis.

BMC Genomics 2021 Jun 10;22(1):437. Epub 2021 Jun 10.

British Antarctic Survey, Natural Environment Research Council, High Cross, Madingley Road, CB3 0ET, Cambridge, UK.

Background: Biomineralization by molluscs involves regulated deposition of calcium carbonate crystals within a protein framework to produce complex biocomposite structures. Effective biomineralization is a key trait for aquaculture, and animal resilience under future climate change. While many enzymes and structural proteins have been identified from the shell and in mantle tissue, understanding biomieralization is impeded by a lack of fundamental knowledge of the genes and pathways involved. Read More

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Mantle cell lymphoma continues to surprise, and inform!

Blood 2021 Jun;137(23):3158-3160

University of Virginia Cancer Center.

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Dislocation interactions in olivine control postseismic creep of the upper mantle.

Nat Commun 2021 Jun 9;12(1):3496. Epub 2021 Jun 9.

Los Alamos National Laboratory, Los Alamos, NM, USA.

Changes in stress applied to mantle rocks, such as those imposed by earthquakes, commonly induce a period of transient creep, which is often modelled based on stress transfer among slip systems due to grain interactions. However, recent experiments have demonstrated that the accumulation of stresses among dislocations is the dominant cause of strain hardening in olivine at temperatures ≤600 °C, raising the question of whether the same process contributes to transient creep at higher temperatures. Here, we demonstrate that olivine samples deformed at 25 °C or 1150-1250 °C both preserve stress heterogeneities of ~1 GPa that are imparted by dislocations and have correlation lengths of ~1 μm. Read More

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Postmelting hydrogen enrichment in the oceanic lithosphere.

Sci Adv 2021 Jun 9;7(24). Epub 2021 Jun 9.

Department of Geology and Geophysics, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.

The large range of HO contents recorded in minerals from exhumed mantle rocks has been challenging to interpret, as it often records a combination of melting, metasomatism, and diffusional processes in spatially isolated samples. Here, we determine the temporal variations of HO contents in pyroxenes from a 24-Ma time series of abyssal peridotites exposed along the Vema fracture zone (Atlantic Ocean). The HO contents of pyroxenes correlate with both crustal ages and pyroxene chemistry and increase toward younger and more refractory peridotites. Read More

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