Int J Mol Sci 2021 Apr 27;22(9). Epub 2021 Apr 27.
Department of Cancer Biology, University of Toledo Health Science Campus, 3000 Arlington Ave., Toledo, OH 43614, USA.
S-nitrosylation is a selective and reversible post-translational modification of protein thiols by nitric oxide (NO), which is a bioactive signaling molecule, to exert a variety of effects. These effects include the modulation of protein conformation, activity, stability, and protein-protein interactions. S-nitrosylation plays a central role in propagating NO signals within a cell, tissue, and tissue microenvironment, as the nitrosyl moiety can rapidly be transferred from one protein to another upon contact. Read More