1,695 results match your criteria manner atypical


Pluripotent Stem Cell Derived Neurons as In Vitro Models for Studying Autosomal Recessive Parkinson's Disease (ARPD): PLA2G6 and Other Gene Loci.

Adv Exp Med Biol 2021 May 15. Epub 2021 May 15.

National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru, India.

Parkinson's disease (PD) is a neurodegenerative motor disorder which is largely sporadic; however, some familial forms have been identified. Genetic PD can be inherited by autosomal, dominant or recessive mutations. While the dominant mutations mirror the prototype of PD with adult-onset and L-dopa-responsive cases, autosomal recessive PD (ARPD) exhibit atypical phenotypes with additional clinical manifestations. Read More

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Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales.

Genes (Basel) 2021 Apr 17;12(4). Epub 2021 Apr 17.

Departamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.

Mucorales are the causal agents for the lethal disease known as mucormycosis. Mortality rates of mucormycosis can reach up to 90%, due to the mucoralean antifungal drug resistance and the lack of effective therapies. A concerning urgency among the medical and scientific community claims to find targets for the development of new treatments. Read More

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GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, 61231, Germany;

G protein-coupled receptor 182 (GPR182) has been shown to be expressed in endothelial cells; however, its ligand and physiological role has remained elusive. We found GPR182 to be expressed in microvascular and lymphatic endothelial cells of most organs and to bind with nanomolar affinity the chemokines CXCL10, CXCL12, and CXCL13. In contrast to conventional chemokine receptors, binding of chemokines to GPR182 did not induce typical downstream signaling processes, including G- and G-mediated signaling or β-arrestin recruitment. Read More

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Anti-inflammatory effects of FS48, the first potassium channel inhibitor from the salivary glands of the flea Xenopsylla cheopis.

J Biol Chem 2021 Apr 14:100670. Epub 2021 Apr 14.

Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address:

The voltage-gated potassium (Kv) 1.3 channel plays a crucial role in the immune responsiveness of T-lymphocytes and macrophages, presenting a potential target for treatment of immune- and inflammation related-diseases. FS48, a protein from the rodent flea Xenopsylla cheopis, shares the three disulfide bond feature of scorpion toxins. Read More

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Computational identification of variables in neonatal vocalizations predictive for postpubertal social behaviors in a mouse model of 16p11.2 deletion.

Mol Psychiatry 2021 Apr 15. Epub 2021 Apr 15.

Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Autism spectrum disorder (ASD) is often signaled by atypical cries during infancy. Copy number variants (CNVs) provide genetically identifiable cases of ASD, but how early atypical cries predict a later onset of ASD among CNV carriers is not understood in humans. Genetic mouse models of CNVs have provided a reliable tool to experimentally isolate the impact of CNVs and identify early predictors for later abnormalities in behaviors relevant to ASD. Read More

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Novel MEAF6-SUZ12 fusion in ossifying fibromyxoid tumor with unusual features.

Genes Chromosomes Cancer 2021 Apr 11. Epub 2021 Apr 11.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm of uncertain differentiation that has the capacity for local recurrence and metastasis. Many OFMTs, including typical, atypical, and malignant tumors, have demonstrated recurrent gene fusions. The fusion partners reported to date share a common core function in that they play either a direct or indirect role in processes influencing histone modification. Read More

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Inhibition of the Growth of Breast Cancer-Associated Brain Tumors by the Osteocyte-Derived Conditioned Medium.

Cancers (Basel) 2021 Mar 3;13(5). Epub 2021 Mar 3.

Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA.

The brain is a common site of metastasis from advanced breast cancer but few effective treatments are available. We examined a therapeutic option with a conditioned medium (CM), focusing on the role of Lrp5 and β-catenin in Wnt signaling, and IL1ra in osteocytes. Osteocytes presented the innate anti-tumor effect and the overexpression of the above genes strengthened their action. Read More

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Atypical Pleomorphic Lipomatous Tumor: Expanding Our Current Understanding in a Clinicopathologic Analysis of 64 Cases.

Am J Surg Pathol 2021 Mar 29. Epub 2021 Mar 29.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Atypical pleomorphic lipomatous tumor (APLT) is a recently recognized adipocytic neoplasm that lies on a spectrum with atypical spindle cell lipomatous tumor (ASCLT). APLT/ASCLT are included together in the fifth edition World Health Organization Classification of Soft Tissue and Bone Tumours; however limited data on APLT have emerged since its first description in 2017. This study aims to further define the clinicopathologic features of APLT in a large series of 64 cases. Read More

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Effects of age on loudness-dependent auditory ERPs in young autistic and typically-developing children.

Neuropsychologia 2021 Jun 26;156:107837. Epub 2021 Mar 26.

Department of Psychology, UC Davis, United States; Center for Mind and Brain, UC Davis, United States; MIND Institute, UC Davis, United States.

Limited research has investigated the development of auditory ERPs in young children, and particularly how stimulus intensity may affect these auditory ERPs. Previous research has also yielded inconsistent findings regarding differences in the development of auditory ERPs in autism and typical development. Furthermore, stimulus intensity may be of particular interest in autism insofar as autistic people may have atypical experiences of sound intensity (e. Read More

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Accuracy of Chest CT for Differentiating COVID-19 from COVID-19 Mimics.

Rofo 2021 Mar 26. Epub 2021 Mar 26.

Department of Diagnostic and Interventional Radiology, Universitätsklinikum Aachen, Germany.

Purpose:  To determine the performance of radiologists with different levels of expertise regarding the differentiation of COVID-19 from other atypical pneumonias. Chest CT to identify patients suffering from COVID-19 has been reported to be limited by its low specificity for distinguishing COVID-19 from other atypical pneumonias ("COVID-19 mimics"). Meanwhile, the understanding of the morphologic patterns of COVID-19 has improved and they appear to be fairly specific. Read More

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Microtubule-Targeted Self-Assembly Triggers Prometaphase-Metaphase Oscillations Suppressing Tumor Growth.

Nano Lett 2021 Apr 23;21(7):3052-3059. Epub 2021 Mar 23.

Bioinspired Soft Matter Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa 904-0495, Japan.

Microtubules are highly strategic targets of cancer therapies. Small molecule antimitotic agents are so far the best chemotherapeutic medication in cancer treatment. However, the high rate of neuropathy and drug resistance limit their clinical usage. Read More

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Datasets of seed mucilage traits for Arabidopsis thaliana natural accessions with atypical outer mucilage.

Sci Data 2021 03 9;8(1):79. Epub 2021 Mar 9.

INRAE, UR1466 OPAALE, 17 avenue de Cucillé, CS 64427, 35044, Rennes Cedex, France.

The seeds of Arabidopsis thaliana become encapsulated by a layer of mucilage when imbibed. This polysaccharide-rich hydrogel is constituted of two layers, an outer layer that can be easily extracted with water and an inner layer that must be examined in situ in order to study its properties and structure in a non-destructive manner or disintegrated through hydrolysis or physical means in order to analyze its constituents. Mucilage production is an adaptive trait and we have exploited 19 natural accessions previously found to have atypical and varied outer mucilage characteristics. Read More

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Individuals with dyslexia use a different visual sampling strategy to read text.

Sci Rep 2021 Mar 19;11(1):6449. Epub 2021 Mar 19.

Department of Psychology, Concordia University, Montréal, Canada.

Individuals with dyslexia present with reading-related deficits including inaccurate and/or less fluent word recognition and poor decoding abilities. Slow reading speed and worse text comprehension can occur as secondary consequences of these deficits. Reports of visual symptoms such as atypical eye movements during reading gave rise to a search for these deficits' underlying mechanisms. Read More

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Atypical neural topographies underpin dysfunctional pattern separation in temporal lobe epilepsy.

Brain 2021 Mar 17. Epub 2021 Mar 17.

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.

Episodic memory is the ability to accurately remember events from our past. The process of pattern separation is hypothesized to underpin this ability and is defined as the ability to orthogonalize memory traces, to maximize the features that make them unique. Contemporary cognitive neuroscience suggests that pattern separation entails complex interactions between the hippocampus and the neocortex, where specific hippocampal subregions shape neural reinstatement in the neocortex. Read More

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Retrograde entry portal for cephalomedullary nailing in difficult subtrochanteric fractures.

Injury 2021 Mar 5. Epub 2021 Mar 5.

MIOT hospital, Chennai.

An entry point medial to the tip of the greater trochanter is considered optimal for antegrade femur nailing. The deforming forces in a subtrochanteric fracture often make it difficult to establish a perfect entry point during antegrade cephalomedullary nailing. To overcome this problem, we report a simple technique of making a retrograde entry portal for select difficult subtrochanteric fractures. Read More

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The flavodoxin FldA activates the class Ia ribonucleotide reductase of Campylobacter jejuni.

Mol Microbiol 2021 Mar 15. Epub 2021 Mar 15.

Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, UK.

Campylobacter jejuni is a microaerophilic zoonotic pathogen with an atypical respiratory Complex I that oxidizes a flavodoxin (FldA) instead of NADH. FldA is essential for viability and is reduced via pyruvate and 2-oxoglutarate oxidoreductases (POR/OOR). Here, we show that FldA can also be reduced by FqrB (Cj0559), an NADPH:FldA reductase. Read More

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CDK1 is up-regulated by temozolomide in an NF-κB dependent manner in glioblastoma.

Sci Rep 2021 Mar 11;11(1):5665. Epub 2021 Mar 11.

Department of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL, 60637, USA.

The alkylating agent, temozolomide (TMZ), is the most commonly used chemotherapeutic for the treatment of glioblastoma (GBM). The anti-glioma effect of TMZ involves a complex response that includes G2-M cell cycle arrest and cyclin-dependent kinase 1 (CDK1) activation. While CDK1 phosphorylation is a well-described consequence of TMZ treatment, we find that TMZ also robustly induces CDK1 expression. Read More

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Direct Nanopore Sequencing of mRNA Reveals Landscape of Transcript Isoforms in Apicomplexan Parasites.

mSystems 2021 Mar 9;6(2). Epub 2021 Mar 9.

Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia

Alternative splicing is a widespread phenomenon in metazoans by which single genes are able to produce multiple isoforms of the gene product. However, this has been poorly characterized in apicomplexans, a major phylum of some of the most important global parasites. Efforts have been hampered by atypical transcriptomic features, such as the high AU content of RNA, but also the limitations of short-read sequencing in deciphering complex splicing events. Read More

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Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance.

Elife 2021 Mar 5;10. Epub 2021 Mar 5.

Graduate School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.

Transmembrane protein Golden goal (Gogo) interacts with atypical cadherin Flamingo (Fmi) to direct R8 photoreceptor axons in the visual system. However, the precise mechanisms underlying Gogo regulation during columnar- and layer-specific R8 axon targeting are unknown. Our studies demonstrated that the insulin secreted from surface and cortex glia switches the phosphorylation status of Gogo, thereby regulating its two distinct functions. Read More

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Bile acids and their receptors in metabolic disorders.

Prog Lipid Res 2021 Feb 23;82:101094. Epub 2021 Feb 23.

Dipartimento di Medicina e Chirurgia, Università di Perugia, Perugia, Italy.

Bile acids are a large family of atypical steroids which exert their functions by binding to a family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid activated receptors, FXR and GPBAR1, that are exclusively activated by bile acids, while other receptors CAR, LXRs, PXR, RORγT, S1PR2and VDR are activated by bile acids in addition to other more selective endogenous ligands. In the intestine, activation of FXR and GPBAR1 promotes the release of FGF15/19 and GLP1 which integrate their signaling with direct effects exerted by theother receptors in target tissues. Read More

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February 2021

Arthritis as an initial presentation of malignancy: two case reports.

J Med Case Rep 2021 Feb 23;15(1):94. Epub 2021 Feb 23.

Department of Radiology, Faculty of Medicine and Health Sciences, University Malaysia Sarawak, Kota Samarahan, Malaysia.

Background: Arthritis is rarely reported as a paraneoplastic manifestation of occult malignancy. We report herein two cases of paraneoplastic arthritis due to occult malignancy. CASE 1: The patient was a 65-year-old woman of asian descent who was a former smoker with a history of spine surgery performed for L4/L5 degenerative disc disease. Read More

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February 2021

Genetic ablation of the Rho GTPase Rnd3 triggers developmental defects in internal capsule and the globus pallidus formation.

J Neurochem 2021 Feb 11. Epub 2021 Feb 11.

IRBLLEIDA/Universitat de Lleida, Serra Húnter associate professor, Lleida, Spain.

The forebrain includes the cerebral cortex, the thalamus, and the striatum and globus pallidus (GP) in the subpallium. The formation of these structures and their interconnections by specific axonal tracts take place in a precise and orchestrated time and spatial-dependent manner during development. However, the knowledge of the molecular and cellular mechanisms that are involved is rather limited. Read More

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February 2021

Neural Basis of Biased Competition in Development: Sensory Competition in Visual Cortex of School-Aged Children.

Cereb Cortex 2021 May;31(6):3107-3121

Department of Psychology and Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.

The fundamental receptive field (RF) architecture in human visual cortex becomes adult-like by age 5. However, visuo-spatial functions continue to develop until teenage years. This suggests that, despite the early maturation of the RF structure, functional interactions within and across RFs may mature slowly. Read More

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Effect of comorbid developmental dyslexia on oculomotor behavior in children with developmental coordination disorder: A study with the Developmental Eye Movement test.

Hum Mov Sci 2021 Apr 4;76:102764. Epub 2021 Feb 4.

Aix Marseille University, PSYCLE, Aix-en-Provence, France.

Studies have suggested a dysfunction in oculomotor skills in children with developmental coordination disorder (DCD). It has been proposed that the Developmental Eye Movement (DEM) test is useful in testing the dyslexics' (DD) oculomotor behavior during reading, in a simple and indirect manner. The present study aimed at exploring the oculomotor behavior in children with DCD as assessed with the DEM test. Read More

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Atypical anti-glomerular basement membrane disease with anti-GBM antibody negativity and ANCA positivity: a case report.

BMC Nephrol 2021 Feb 5;22(1):53. Epub 2021 Feb 5.

Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, 610041, China.

Background: Anti-glomerular basement membrane (anti-GBM) disease is an organ-specific autoimmune disease that involves the lung and kidneys and leads to rapid glomerulonephritis progression, with or without diffuse alveolar hemorrhage, and even respiratory failure. Classic cases of anti-GBM disease are diagnosed based on the presence of the anti-GBM antibody in serum samples and kidney or lung biopsy tissue samples. However, atypical cases of anti-GBM disease are also seen in clinical practice. Read More

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February 2021

Histoplasmosis tenosynovitis of the forearm and wrist: imaging, surgical and pathologic findings.

Skeletal Radiol 2021 Feb 3. Epub 2021 Feb 3.

Department of Radiology, Musculoskeletal Group, Fleury Medicina e Saúde, Mato Grosso St, 306 - Higienópolis, São Paulo, SP, 01239-040, Brazil.

Histoplasmosis is a disease endemic to several parts of the world, including South America. It progresses in a mostly asymptomatic and self-limiting manner but has the potential to cause disseminated pulmonary infection, especially in immunocompromised patients. Rare reports from the literature describe musculoskeletal manifestations related to the two varieties of the pathogen that cause histoplasmosis, namely, the capsulatum or duboissi variety. Read More

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February 2021

Thalamocortical connectivity is associated with autism symptoms in high-functioning adults with autism and typically developing adults.

Transl Psychiatry 2021 Feb 3;11(1):93. Epub 2021 Feb 3.

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

Alterations in sensorimotor functions are common in individuals with autism spectrum disorder (ASD). Such aberrations suggest the involvement of the thalamus due to its key role in modulating sensorimotor signaling in the cortex. Although previous research has linked atypical thalamocortical connectivity with ASD, investigations of this association in high-functioning adults with autism spectrum disorder (HFASD) are lacking. Read More

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February 2021

The NF-κB regulator Bcl-3 restricts terminal differentiation and promotes memory cell formation of CD8+ T cells during viral infection.

PLoS Pathog 2021 01 28;17(1):e1009249. Epub 2021 Jan 28.

Immune Activation Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

Bcl-3 is an atypical member of the IκB family that acts in the nucleus to modulate transcription of many NF-κB targets in a highly context-dependent manner. Accordingly, complete Bcl-3-/- mice have diverse defects in both innate and adaptive immune responses; however, direct effects of Bcl-3 action in individual immune cell types have not been clearly defined. Here, we document a cell-autonomous role for Bcl-3 in CD8+ T cell differentiation during the response to lymphocytic choriomeningitis virus infection. Read More

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January 2021