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Silent Neurological Lesions Detected by Magnetic Resonance Imaging: Relationship to Hyperparathyroidism among End Stage Renal Disease Young Patients on Hemodialysis.

Int J Clin Pract 2021 Jun 24:e14569. Epub 2021 Jun 24.

Department of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Background: End-stage renal disease (ESRD) patients on hemodialysis (HD) suffer from several peripheral and central neurological complications. They are at high risk for developing silent neurological lesions (SNL) that may detected accidentally by magnetic resonance imaging (MRI). Many factors are implicated in the development of neurological deficits in ESRD patients on HD. Read More

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Ticagrelor effectively inhibits platelet aggregation in comatose survivors of cardiac arrest undergoing primary percutaneous coronary intervention treated with mild therapeutic hypothermia.

Cardiol J 2021 Jun 24. Epub 2021 Jun 24.

Jagiellonian University Medical College Institute of Cardiology, Department of Interventional Cardiology, Krakow, Poland.

Background: Mild therapeutic hypothermia (MTH) is believed to reduce the effectiveness of antiplatelet drugs. Effective dual-antiplatelet therapy after percutaneous coronary intervention (PCI) is mandatory to avoid acute stent thrombosis (ST). The effectiveness of ticagrelor in MTH-treated out-of-hospital cardiac arrest (OHCA) survivors is still a matter of debate. Read More

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Letter to the Editor from Colle .

J Immunother Cancer 2021 Jun;9(6)

Sorbonne Université and Hospital Saint Antoine, Department of Medical rodiology, AP-HP, Paris, France.

In their article, Fucà highlight that early tumor shrinkage and depth of response predict the prognosis of patients with metastatic colorectal cancer (mCRC) microsatellite instability (MSI-H)/deficient mismatch repair (dMMR) treated by immune checkpoint inhibitors (ICI). We are surprised that no cases of pseudoprogression (PSPD) were reported in their study. PSPDs were described under ICI in patients treated for MSI/dMMR mCRC. Read More

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Percutaneous Endoscopic Gastrostomy in Children: An Update to the ESPGHAN Position Paper.

J Pediatr Gastroenterol Nutr 2021 Jun 22. Epub 2021 Jun 22.

Faculty of Medicine, University Children's Hospital, University of Ljubljana, Ljubljana, Slovenia KidZ Health Castle UZ Brussel, Brussels, Belgium Department of Human Pathology in Adulthood and Childhood "G. Barresi"- University of Messina, Italy Al Jalila Children's Specialty Hospital, Dubai, UAE Digestive Endoscopy and Surgery Unit, Bambino Gesù Children's Hospital IRCCS, Rome. Italy University Lille, CHU Lille, Infinite U1286, Lille, F-59000, France Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb Croatia, University J.J. Strossmayer, School of Medicine, Osijek, Croatia Sheffield Children's Hospital NHS Foundation Trust, Sheffield, South Yorkshire, UK Université Libre de Bruxelles, Hôpital Universitaire des Enfants Reine Fabiola, Belgium University Children's Hospital Basel, Division of Pediatric Gastroenterology & Nutrition, University of Basel, Switzerland Maternal and Child Health Department, Sapienza, University of Rome, Italy Centro Hospitalar S. João, Porto, Portugal.

Background: The ESPGHAN position paper from 2015 on percutaneous endoscopic gastrostomy (PEG) required updating in the light of recent clinical knowledge and data published in medical journals since 2014.

Methods: A systematic review of medical literature from 2014 to 2020 was carried out. Consensus on the content of the manuscript, including recommendations, was achieved by the authors through electronic and virtual means. Read More

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Comparing the Effect of Different Antibiotics in Frozen-Thawed Ram Sperm: Is It Possible to Avoid Their Addition?

Front Vet Sci 2021 7;8:656937. Epub 2021 May 7.

Investigación en Técnicas de Reproducción Asistida - Universidad de León, Instituto de Desarrollo Ganadero y Sanidad Animal, University of León, León, Spain.

It is crucial to perform a deep study about the most extensively used antibiotics in sperm extenders. Most of the protocols and concentrations used in ram are direct extrapolations from other species. It is important to establish species-specific antibiotic treatments to optimize their use and if it is possible to reduce the quantity. Read More

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Pollution threat to water and soil quality by dumpsites and non-sanitary landfills in Brazil: A review.

Waste Manag 2021 Jun 17;131:163-176. Epub 2021 Jun 17.

São Carlos School of Engineering, University of São Paulo (EESC-USP), São Carlos, Brazil.

This work presents an overview of environmental studies performed in areas affected by dumpsites and non-sanitary landfills in Brazil, focusing on physicochemical analysis of surface water, groundwater, and soils, as well as geophysical surveys. The objective was to identify the main contaminants found in these areas and to assess their environmental impact, guiding possible intervention measures, indicating the priority areas, and showing whether post-closure activities are mandatory. The results should support governmental actions, especially considering the recent approval of Brazil's new sanitation framework. Read More

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Extent of awareness and attitudes on plagiarism among post-graduate resident doctors and junior medical faculty in India: a cross-sectional, multicentric study.

BMJ Open 2021 06 16;11(6):e046904. Epub 2021 Jun 16.

Microbiology, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India.

Objectives: Though dissertation is mandatory for postgraduates (PG), it is unknown if adequate knowledge on plagiarism exists at that level. Thus, we intended to study the knowledge and attitude towards plagiarism among junior doctors in India.

Design: Cross-sectional study SETTING: PG medical residents and Junior faculty from various teaching institutions across south India. Read More

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[Necrotizing Fasciitis].

Handchir Mikrochir Plast Chir 2021 Jun 16;53(3):312-319. Epub 2021 Jun 16.

Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil; Universitätsklinik für Plastische Chirurgie und Handchirurgie, Schwerbrandverletztenzentrum, Sarkomzentrum.

Necrotizing fasciitis (NF) is a soft tissue infection spreading along the fasciae to the surrounding subcutaneous fat, overlying skin and finally musculature, that may rapidly lead to septic shock and death. In order to avoid a massive systemic spread of the infective process, an immediate and extensive radical debridement of necrotic tissues is mandatory complemented by a broad spectrum intravenous antibiotic therapy. Nevertheless, mortality is persistently high at 20-40 %. Read More

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Contribution of three-dimensional images in the planning of cementoblastoma resection.

BJR Case Rep 2021 May 8;7(3):20200156. Epub 2021 Jan 8.

OMFS-IMPATH Research Group, Department of Imaging & Pathology, Faculty of Medicine, KU Leuven. Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.

Cementoblastomas are rare benign tumours that represent less than 1% of all odontogenic tumours. Complete resection is mandatory to avoid recurrence. This case report describes the contribution of three-dimensional imaging and three-dimensional printing in the pre-operative surgical planning of a large cementoblastoma that not only caused substantial compression on the inferior alveolar and mental nerves, but also caused thinning and partial erosion of the lingual and vestibular cortical bone, thus increasing the risk of pre-operative mandibular fracture. Read More

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The role of axillary reverse mapping in intraoperative nodal palpation during sentinel lymph node biopsy.

Breast J 2021 Jun 13. Epub 2021 Jun 13.

Department of Clinical Pathology, Kanazawa Medical University Hospital, Kahoku, Japan.

Intraoperative nodal palpation in the axilla is a mandatory part of sentinel lymph node biopsy. However, there is no consensus regarding the definition of suspicious palpable node. The sampling rate and involvement rate of suspicious palpable nodes are inconsistent. Read More

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VICTORIA: VIrtual neck Curve and True Ostium Reconstruction of Intracranial Aneurysms.

Cardiovasc Eng Technol 2021 Jun 7. Epub 2021 Jun 7.

Department of Simulation and Graphics, University of Magdeburg, Magdeburg, Germany.

Purpose: For the status evaluation of intracranial aneurysms (IAs), morphological and hemodynamic parameters can provide valuable information. For their extraction, a separation of the aneurysm sac from its parent vessel is required that yields the neck curve and the ostium. However, manual and subjective neck curve and ostium definitions might lead to inaccurate IA assessments. Read More

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Mandatory multidisciplinary management of hepatocellular carcinoma: Need of the hour in a country with high prevalence of hepatitis C virus infection.

J Pak Med Assoc 2021 May;71(5):1455-1457

Department of Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.

Hepatocellular carcinoma is the sixth common cancer diagnosed and fourth leading cause of cancer-related deaths worldwide. Its incidence is on rise due to increasing prevalence of chronic hepatitis C virus infection. Pakistan is ranked second in countries burdened by hepatitis C virus in the world. Read More

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Perioperative respiratory adverse events during ambulatory anesthesia in obese children.

Ir J Med Sci 2021 Jun 5. Epub 2021 Jun 5.

Department of Anesthesia, Klinikum Klagenfurt, Feschigstrasse 11, 9020, Klagenfurt, Austria.

Obesity is one of the most common clinical conditions in the pediatric population with an increasing prevalence ranging from 20 to 30% worldwide. It is well known that during ambulatory anesthesia, obese children are more prone to develop perioperative respiratory adverse events (PRAEs) associated with obesity. To avoid or at least minimize these adverse effects, a thorough preoperative assessment should be undertaken as well as consideration of specific anesthetic approaches such as preoxygenation before induction of anesthesia and optimizing drug dosing. Read More

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Extraneural Sclerosing Perineurioma of the Tongue.

Ear Nose Throat J 2021 Jun 1:1455613211020539. Epub 2021 Jun 1.

Department of Pathology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Perineurioma (PN) is an uncommon benign peripheral nerve sheath tumor. For the rarity of this tumor in the oral cavity, otolaryngologists and oral surgeons might not be familiar with this entity. Perineuriomas are typically benign and complete excision is deemed adequate management. Read More

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Surgical Management and Reconstruction of Diaphragm, Pericardium and Chest Wall in Mesothelioma Surgery: A Review.

J Clin Med 2021 May 26;10(11). Epub 2021 May 26.

Division of Thoracic Surgery, IRCCS Azienda Ospedaliera Universitaria di Bologna, 40138 Bologna, Italy.

Mesothelioma is an aggressive disease arising from parietal pleura. Surgery is a valuable option in the frame of a multimodality treatment. Several surgical approaches have been standardized with the aim of a macroscopic complete resection; these often require homolateral diaphragm and pericardial resection and reconstruction. Read More

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Practical Advices for Treating Chronic Pain in the Time of COVID-19: A Narrative Review Focusing on Interventional Techniques.

J Clin Med 2021 May 25;10(11). Epub 2021 May 25.

Pain Relief and Supportive Care, Private Hospital La Maddalena, 90100 Palermo, Italy.

Background: Since the management of chronic pain has become even more challenging secondary to the occurrence of SARS-CoV-2 outbreaks, we developed an exhaustive narrative review of the scientific literature, providing practical advices regarding the management of chronic pain in patients with suspected, presumed, or confirmed SARS-CoV-2 infection. We focused particularly on interventional procedures, where physicians are in closer contact with patients.

Methods: Narrative Review of the most relevant articles published between June and December of 2020 that focused on the treatment of chronic pain in COVID-19 patients. Read More

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Clinical Activities, Contaminations of Surgeons and Cooperation with Health Authorities in 14 Orthopedic Departments in North Italy during the Most Acute Phase of Covid-19 Pandemic.

Int J Environ Res Public Health 2021 May 17;18(10). Epub 2021 May 17.

Department of Biotechnology and Life Sciences (DBSV), Università degli Studi dell'Insubria, 21100 Varese, Italy.

: From 10 March up until 3 May 2020 in Northern Italy, the SARS-CoV-2 spread was not contained; disaster triage was adopted. The aim of the present study is to assess the impact of the COVID-19-pandemic on the Orthopedic and Trauma departments, focusing on: hospital reorganization (flexibility, workload, prevalence of COVID-19/SARS-CoV-2, standards of care); effects on staff; subjective orthopedic perception of the pandemic. : Data regarding 1390 patients and 323 surgeons were retrieved from a retrospective multicentric database, involving 14 major hospitals. Read More

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Reference genes for quantitative real-time PCR normalization of Cenostigma pyramidale roots under salt stress and mycorrhizal association.

Genet Mol Biol 2021 31;44(2):e20200424. Epub 2021 May 31.

Universidade Federal de Pernambuco, Departamento de Genética, Recife, PE, Brazil.

Cenostigma pyramidale is a native legume of the Brazilian semiarid region which performs symbiotic association with arbuscular mycorrhizal fungi (AMF), being an excellent model for studying genes associated with tolerance against abiotic and biotic stresses. In RT-qPCR approach, the use of reference genes is mandatory to avoid incorrect interpretation of the relative expression. This study evaluated the stability of ten candidate reference genes (CRGs) from C. Read More

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Ultrastructural aberrations, histological disruption and upregulation of the VEGF, CD34 and ASMA immunoexpression in the myocardium of anemic albino rats.

Acta Histochem 2021 May 27;123(5):151731. Epub 2021 May 27.

Department of Anatomy, Faculty of Medicine, Mansoura University, Egypt; Department of Anatomy, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia.

Iron deficiency anemia (IDA) is a global health problem affecting various body systems and tissues including the cardiovascular system. Several literatures described the associated physiological and clinical changes in the cardiovascular system and heart. However, the associated structural changes were poorly investigated. Read More

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Optimizing investigation of suspected allergy to polyethylene glycols.

J Allergy Clin Immunol 2021 May 27. Epub 2021 May 27.

Allergy Clinic, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark. Electronic address:

Background: Polyethylene glycols (PEGs) are polymers of varying molecular weight (MW) used widely as excipients in drugs and products, including the mRNA vaccines against COVID-19. Allergy to PEGs is very rare. Skin testing and graded challenge carries a high risk of inducing systemic reactions. Read More

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Reactance revisited: Consequences of mandatory and scarce vaccination in the case of COVID-19.

Appl Psychol Health Well Being 2021 May 25. Epub 2021 May 25.

Department of Psychology, University of Copenhagen, Copenhagen, Denmark.

Psychological reactance theory assumes that the restriction of valued behaviors elicits anger and negative cognitions, motivating actions to regain the limited freedom. Two studies investigated the effects of two possible restrictions affecting COVID-19 vaccination: the limitation of non-vaccination by mandates and the limitation of vaccination by scarce vaccine supply. In the first study, we compared reactance about mandatory and scarce vaccination scenarios and the moderating effect of vaccination intentions, employing a German quota-representative sample (N = 973). Read More

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Spontaneous acute bleeding within subdural effusion from dural metastasis of gastric cancer: A case report.

Neurocirugia (Astur : Engl Ed) 2021 May 14. Epub 2021 May 14.

Department of Neurosurgery, Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain.

Dural metastases are uncommon findings and at diagnosis normally appear in disseminated stages of malignant tumors. Usually clinically silent, these could become symptomatic due to mass effect or after developing subdural collections. We present the case of a young woman recently operated from gastric cancer who presented consciousness deterioration and hemiparesis caused by subdural collection. Read More

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Atomistic Polarizable Embeddings: Energy, Dynamics, Spectroscopy, and Reactivity.

Acc Chem Res 2021 May 7. Epub 2021 May 7.

Laboratoire de Chimie Théorique, Sorbonne Université, UMR 7616 CNRS, 75005 Paris, France.

ConspectusThe computational modeling of realistic extended systems, relevant in, e.g., Chemistry and Biophysics, is a fundamental problem of paramount importance in contemporary research. Read More

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[Oro- and Nasopharyngeal Swab for Detection of SARS-CoV-2 - Step-by-step Approach].

Pneumologie 2021 May 3;75(5):383-388. Epub 2021 May 3.

Oro- and nasopharyngeal swab specimens by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) to detect SARS-CoV-2 is currently the main diagnostic tool during the ongoing COVID-19 pandemia. Accurate performance of the procedure to avoid false negative results, adequate personal protective equipment and material sparing algorithms are mandatory while obtaining swab specimens. In the current stey-by-step review a feasible approach will be presented. Read More

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The rare Ogilvie's Syndrome in pregnancy. How to manage? A case report and literature review.

J Obstet Gynaecol 2021 May 2:1-9. Epub 2021 May 2.

Obstetrics and Gynecology Department, Academic Hospital of Udine, Department of Medicine, University of Udine, Udine, Italy.

Acute colonic pseudo-obstruction, or Ogilvie's syndrome (OS), is a complication in gynaecology and obstetrics. Its occurrence during pregnancy is rare, redefining the therapeutic decision-making and treatment options. In this review we describe the case of a 37-year-old pregnant patient who developed OS at the 30th week of gestation. Read More

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The "COVID-19 Pandemic Gap" and Its Influence on Oncologic Outcomes of Bladder Cancer.

Cancers (Basel) 2021 Apr 7;13(8). Epub 2021 Apr 7.

Department of Urology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.

Coronavirus-19 (COVID-19)-induced effects on deferred diagnosis and treatment of bladder cancer (BC) patients are currently not clarified. The aim of this study was to evaluate outcomes of the COVID-19 pandemic by considering its effects on tumor stage and grade, and to create feasible clinical triage decisions. A retrospective single-center analysis of all patients who underwent diagnostic and surgical procedures due to BC, during January 2019 and December 2020, was performed. Read More

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Pharmacological Management of Gastro-Esophageal Reflux Disease: An Update of the State-of-the-Art.

Drug Des Devel Ther 2021 19;15:1609-1621. Epub 2021 Apr 19.

Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.

Gastro-esophageal reflux disease (GERD) is a highly prevalent, chronic disorder, whose knowledge remains limited and the management of these patients changes continuously. This review provides a summary of the most recent advancements in the pathogenesis of this disease and the new drugs introduced into the market to overcome some of the unmet needs of traditional therapies. Nowadays, the most fruitful diagnostic examinations are 24-hour impedance-pH monitoring, which allows us to separate true NERD from esophageal functional disorders and high-resolution manometry, which helps to exclude the existence of motility disorders sharing the same symptoms of GERD. Read More

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Pandemic and hospital avoidance: Evidence from the 2015 Middle East respiratory syndrome outbreak in South Korea.

Econ Lett 2021 Jun 17;203:109852. Epub 2021 Apr 17.

Yeungnam University, School of Economics and Finance, Gyeongsan 38541, South Korea.

Existing literature shows that people exhibit disease avoidance behaviors in response to contagious disease outbreaks. We examine hospital avoidance behaviors during the 2015 Middle East respiratory syndrome (MERS) outbreak in South Korea. The outbreak provides an excellent setting for the analysis because unlike the coronavirus disease-19 (COVID-19) situation, no mandatory lockdown was imposed during the outbreak, and the economic impact was also not large. Read More

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Prognostic impact of conservative surgery for pancreatic IPMNs.

Surg Oncol 2021 Apr 16;38:101582. Epub 2021 Apr 16.

General Surgery, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy; EndoCAS (Center for Computer Assisted Surgery), University of Pisa, Italy.

Background: The extent of pancreatic resection for intraductal papillary mucinous neoplasms (IPMNs) remains an unresolved issue. The study aims at analyzing the prognostic impact of conservative surgery (CS) i.e. Read More

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Microbiomes in supragingival biofilms and saliva of adolescents with gingivitis and gingival health.

Oral Dis 2021 Apr 19. Epub 2021 Apr 19.

Department of Biotechnology, University of Szeged, Szeged, Hungary.

Background: Important alterations exist in the microbiomes of supragingival biofilm and saliva samples from adolescent patients developing induced or spontaneous gingivitis relative to healthy controls. These and the relationships to dental health are not fully understood yet.

Subjects And Methods: Supragingival biofilm samples (n = 36) were collected from the teeth of 9 adolescents with gingivitis induced by orthodontic appliances, as well as dental plaques (n = 40) from 10 adolescents with spontaneous gingivitis, in addition to similar samples (n = 36) from 9 healthy controls. Read More

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