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Clinical Characteristics and Outcomes of Oral Mucositis Associated With Immune Checkpoint Inhibitors in Patients With Cancer.

J Natl Compr Canc Netw 2021 Aug 4. Epub 2021 Aug 4.

3Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Immune checkpoint inhibitor (ICI) therapy predisposes patients to immune-related adverse events (irAEs). Data are limited regarding the incidence, management, and outcomes of one such irAE: mucositis. In this study, we evaluated the clinical characteristics, disease course, treatment, and outcomes of ICI-mediated mucositis. Read More

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Application of manual aspiration thrombectomy in the treatment of deep vein thrombosis in cancer patients: Descriptive retrospective cohort study.

PLoS One 2021 4;16(8):e0255539. Epub 2021 Aug 4.

Division of Medical Oncology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seocho-Gu, Seoul, Republic of Korea.

Objectives: To determine the outcomes and feasibility of endovascular treatment, mainly based on manual aspiration thrombectomy (MAT) with adjunctive percutaneous balloon angioplasty with or without stent deployment, for treatment of symptomatic ilio-femoral deep vein thrombosis (IFDVT) in cancer patients.

Materials And Methods: In this retrospective cohort study, 135 consecutive patients (56 men; mean age, 63 years; 149 limbs) with acute (n = 113; 83.7%) and subacute to chronic (n = 22; 16. Read More

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Training Characteristics, Academic Accomplishments, and Motivation of Current Chairs in Physical Medicine and Rehabilitation.

Am J Phys Med Rehabil 2021 Aug 3. Epub 2021 Aug 3.

Department of Physical Medicine and Rehabilitation McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas. Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas. Boonshoft School of Medicine at Wright State University, Dayton, Ohio Department of Rehabilitation and Human Performance, The Mount Sinai Hospital/Icahn School of Medicine at Mount Sinai, New York, New York. Department of Rehabilitation Medicine, Long School of Medicine at the University of Texas Health Science Center at San Antonio, San Antonio, Texas. H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas.

Objectives: To report the training characteristics, academic accomplishments, and motivation of current United States (US) academic Physical Medicine and Rehabilitation (PM&R) Chairs.

Design: The authors developed a 23-question survey was developed and disseminated via email to 86 current chairs who were members of the Chairs Council from the Association of Academic Physiatrists (AAP) in May 2020. Follow-up emails were sent 2 and 4 weeks after the initial distribution, and the survey closed after 6 weeks in June 2020. Read More

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Tertiary Chiral Nanostructures from C-H∙∙∙F Directed Assembly of Chiroptical Superatoms.

Angew Chem Int Ed Engl 2021 Aug 4. Epub 2021 Aug 4.

Xiamen University, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, CHINA.

Chiral hierarchical structures are universal in nature, whereas quite challenging to mimic in man-made synthesis. We report herein the synthesis and structure of tertiary chiral nanostructures with 100% optical purity. A novel synthetic strategy, using chiral reducing agent, R and S -BINAPCuBH 4 (BINAP is 2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl), is developed to access to atomically precise, intrinsically chiral [Au 7 Ag 6 Cu 2 ( R - or S -BINAP) 3 (SCH 2 Ph) 6 ]SbF 6 nanoclusters in one-pot synthesis. Read More

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Symptomatic kidney stones in an anuric patient on dialysis: A case report.

Urologia 2021 Aug 4:3915603211035927. Epub 2021 Aug 4.

Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

Introduction: Renal colic is a colicky-type of flank pain that can commonly be presented in patients undergoing dialysis especially if they are anuric considering the fact that there are multiple controversies and little published experience on this topic, we found it very important to report this case. We also aimed to increase awareness and emphasize the importance of renal colic in anuric patients on dialysis.

Case Description: We herein report a case of a 42-year old man with a chief complaint of bilateral colic flank pain, He had developed end stage renal disease due to ADPKD and was on hemodialysis since the past 5 years. Read More

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Patients' Experience of Attending a Binge Eating Group Program - Qualitative Evaluation of a Pilot Study.

SAGE Open Nurs 2021 Jan-Dec;7:23779608211026504. Epub 2021 Jun 30.

Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.

We developed a group program for patients with binge eating disorders (BED), comprising cognitive therapy, affect consciousness, and therapeutic writing. We wished to investigate how therapeutic writing and affect consciousness were experienced by the patients when integrated in a cognitive behavioral therapy (CBT) program. To our knowledge, such an intervention has not been tried in patients with BED. Read More

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High Risk Coronavirus Disease 2019: The Primary Results of the CoronaHeart Multi-Center Cohort Study.

Int J Cardiol Heart Vasc 2021 Jul 30:100853. Epub 2021 Jul 30.

Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Background: Patients with Coronavirus Disease 2019 (COVID-19) may present high risk features, including cardiovascular manifestations, during hospitalization. However, less is known about the factors that may further increase the risk of death in these patients.

Methods: We included patients with COVID-19 and high risk features according to clinical and/or laboratory criteria at 21 sites in Brazil from June 10 to October 23 of 2020. Read More

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Takotsubo Cardiomyopathy as a Manifestation of Dysautonomia in Guillain-Barré Syndrome: A Case Series and Review of the Literature.

Cureus 2021 Jun 30;13(6):e16069. Epub 2021 Jun 30.

Neurology, University of Miami, Miami, USA.

Guillain-Barré syndrome (GBS) is an inflammatory polyneuropathy that classically presents with low back pain, sensory paresthesias, and rapidly progressive weakness. Patients with GBS can develop dysautonomia, and Takotsubo cardiomyopathy (TCM) is a rare potential manifestation of this dysautonomia. This association has been reported only 12 times in the literature so far, which we review here. Read More

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Ventricular empyema associated with severe pyogenic meningitis in COVID-19 adult patient: Case report.

Surg Neurol Int 2021 12;12:346. Epub 2021 Jul 12.

Department of Neurosurgery, Fundação Faculdade Regional de Medicina de São José do Rio Preto (FUNFARME), São José do Rio Preto, São Paulo, Brazil.

Background: Coronavirus Disease 2019 (COVID-19) pandemic raised global attention especially due to the severe acute respiratory symptoms associated to it. However, almost one third of patients also develop neurological symptoms. The aim of the present study is to describe the case of a previously health adult that evolved cerebral ventricular empyema in the IV ventricle during COVID-19 infection treatment. Read More

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Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in mutation carriers.

Ann Rheum Dis 2021 Aug 3. Epub 2021 Aug 3.

Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland

Objectives: To estimate lifetime risk of developing rheumatoid arthritis-associated interstitial lung disease (RA-ILD) with respect to the strongest known risk factor for pulmonary fibrosis, a promoter variant.

Methods: FinnGen is a collection of epidemiological cohorts and hospital biobank samples, integrating genetic data with up to 50 years of follow-up within nationwide registries in Finland. Patients with RA and ILD were identified from the Finnish national hospital discharge, medication reimbursement and cause-of-death registries. Read More

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Complex case of COVID-19 and infective endocarditis.

BMJ Case Rep 2021 Aug 3;14(8). Epub 2021 Aug 3.

Cardiology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.

A 50-year-old man with no medical history of note presented with new onset of confusion and dyspnoea. He tested positive for coronavirus (COVID-19), and subsequently, was admitted to the intensive care unit due to severe sepsis and acute renal failure requiring haemodialysis. Shortly afterwards, he was intubated due to haemodynamic instability. Read More

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Tylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology.

BMJ Case Rep 2021 Aug 3;14(8). Epub 2021 Aug 3.

Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA

An 87-year-old man with a history of osteoarthritis presented with worsening knee pain. He was prescribed acetaminophen with codeine. A few days later, he developed a rash on his right buttock and proximal thigh, similar to a rash he experienced in the past when he took over-the-counter (OTC) acetamenophen and an unknown lozenge to treat a presumed viral illness. Read More

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Using Competing Risk of Mortality to Inform the Transition from Prostate Cancer Active Surveillance to Watchful Waiting.

Eur Urol Focus 2021 Jul 31. Epub 2021 Jul 31.

Cleveland Clinic Glickman Urological and Kidney Institute, Cleveland, OH 12000 McCracken Road, Cleveland, OH 44125, USA. Electronic address:

Background: For men on active surveillance (AS) for prostate cancer (PCa), disease progression and age-related changes in health may influence decisions about pursuing curative treatment.

Objective: To evaluate the predicted PCa and non-PCa mortality at the time of reclassification among men on AS, to identify clinical criteria for considering a transition from AS to watchful waiting (WW).

Design, Setting, And Participants: Patients enrolled in a large AS program who experienced biopsy grade reclassification (Gleason grade increase) were retrospectively examined. Read More

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Adults at risk of pneumococcal disease in France.

Infect Dis Now 2021 Jul 31. Epub 2021 Jul 31.

HEVA, Lyon, France.

Background: Immunocompromised patients and those with certain underlying medical conditions are at risk of pneumococcal disease, but in France their vaccine coverage is largely unknown. We aimed to assess the number of adult patients eligible for pneumococcal vaccination in France.

Methods: We conducted an annual cross-sectional study based on retrospective data from the French National Health Data System. Read More

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How relevant for you is to be a moral person? Polish validation of the Self-Importance of Moral Identity Scale.

PLoS One 2021 3;16(8):e0255386. Epub 2021 Aug 3.

Institute of Psychology, Faculty of Social Sciences, University of Silesia in Katowice, Katowice, Poland.

Objective: The Self-Importance of Moral Identity Scale (SMIS) was developed by Aquino and Reeds with the purpose of measuring how people evaluate their private (Internalization subscale) and public (Symbolization subscale) moral identity. SMIS has become commonly and broadly used in many studies. The aim of this paper is to validate the Polish version of SMIS by analyzing its structure and relation to similar measures (such as The Moral Self-Concept Scale developed by Stake and The Moral Self-Image Scale created by Jordan, Leliveld and Tenbrunsel), declared past prosocial behaviors and readiness to donate money. Read More

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Exploration of Immune-Related Gene Expression in Osteosarcoma and Association With Outcomes.

JAMA Netw Open 2021 Aug 2;4(8):e2119132. Epub 2021 Aug 2.

Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Importance: Host immune dysregulation is associated with initiation and development of osteosarcoma. In addition, immunotherapy for osteosarcomas requires some knowledge of the immune state of patients.

Objective: To perform an immunogenomic landscape analysis based on The Cancer Genome Atlas (TCGA) project, which provides osteosarcoma samples with clinical information. Read More

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New-onset Nephrotic Syndrome after Janssen COVID-19 Vaccination: a Case Report and Literature Review.

J Korean Med Sci 2021 Aug 2;36(30):e218. Epub 2021 Aug 2.

Division of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.

Various coronavirus disease 2019 (COVID-19) vaccines are being developed, which show practical preventive effects. Here, we report a 51-year-old healthy man with nephrotic syndrome secondary to minimal change disease (MCD) after Ad26.COV. Read More

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Development of an artificial intelligence diagnostic system for lower urinary tract dysfunction in men.

Int J Urol 2021 Aug 2. Epub 2021 Aug 2.

Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

Objectives: To establish an artificial intelligence diagnostic system for lower urinary tract function in men with lower urinary tract symptoms using only uroflowmetry data and to evaluate its usefulness.

Methods: Uroflowmetry data of 256 treatment-naive men with detrusor underactivity, bladder outlet obstruction, or detrusor underactivity + bladder outlet obstruction were used for artificial intelligence learning and validation using neural networks. An optimal artificial intelligence diagnostic model was established using 10-fold stratified cross-validation and data augmentation. Read More

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The importance of thinking about Guillain-Barré syndrome during the COVID-19 pandemic: a case with pure dysautonomic presentation.

J Neurovirol 2021 Aug 2. Epub 2021 Aug 2.

IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy.

Guillain-Barré syndrome (GBS) is a peripheral nervous system disease caused by an immune-mediated inflammatory mechanism, usually triggered by a previous infectious process or vaccine; its typical presentation is a rapid and progressive bilateral limb hyposthenia, associated with sensory deficits and reduction or absence of osteotendinous reflexes. However, also autonomic nervous system can be involved with heart rate fluctuations, blood pressure instability, pupillary dysfunction, and urinary retention. Since the beginning of COVID-19 pandemic, GBS has been reported among neurological complications of SARS-CoV-2 infection, although etiopathological mechanisms still have to be clearly defined. Read More

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Incidence and prediction nomogram for metabolic syndrome in a middle-aged Vietnamese population: a 5-year follow-up study.

Endocrine 2021 Aug 2. Epub 2021 Aug 2.

Department of Nutrition & Non-communication Disease, National Institute of Nutrition, 48B Tang Bat Ho, Hanoi, Vietnam.

Purpose: We aimed to determine the incidence and prediction nomogram for new-onset metabolic syndrome (MetS) in a middle-aged Vietnamese population.

Methods: A population-based prospective study was conducted in 1150 participants aged 40-64 years without MetS at baseline and followed-up for 5 years. Data on lifestyle factors, socioeconomic status, family diabetes history, and anthropometric measures were collected. Read More

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Disseminated Herpes Simplex Virus-2 (HSV-2) as a Cause of Viral Hepatitis in an Immunocompetent Host.

Am J Case Rep 2021 Aug 3;22:e932474. Epub 2021 Aug 3.

Division of Infectious Diseases and Immunology, Department of Medicine, New York University (NYU) Grossman School of Medicine, New York City, NY, USA.

BACKGROUND Herpes simplex virus-2 (HSV-2) affects nearly 1 in 5 adults in the United States. Complications such as viral hepatitis and dissemination are rare in immunocompetent hosts. In this report, we describe a case of viral hepatitis secondary to disseminated HSV-2 in an immunocompetent patient with recurrent fevers and elevated aminotransferases. Read More

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Haemolytic anaemia induced by flutamide: a case report.

Eur J Hosp Pharm 2021 Aug 2. Epub 2021 Aug 2.

Department of Pharmacy, Ningbo City First Hospital, Ningbo, Zhejiang, China

Flutamide-induced haemolytic anaemia is rare but can be fatal. We describe the case of an 88-year-old man with prostatic carcinoma who, in addition to clinically obvious jaundice, developed haemolytic anaemia after undergoing treatment with flutamide for 5 days. When flutamide was replaced with temporary adrenocortical hormone treatment and blood transfusion, the blood indices and liver function of the patient improved gradually. Read More

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Depression Outcomes Among Patients Treated With Fluoxetine for Stroke Recovery: The AFFINITY Randomized Clinical Trial.

JAMA Neurol 2021 Aug 2. Epub 2021 Aug 2.

The George Institute for Global Health, Faculty of Medicine, The University of New South Wales, Camperdown, New South Wales, Australia.

Importance: One in 3 adults experiences clinically significant symptoms of depression during the first year after a stroke, but evidence to support the use of antidepressants in this population remains scant.

Objective: To investigate whether daily treatment with 20 mg of fluoxetine hydrochloride reduces the proportion of people affected by clinically significant symptoms of depression after stroke.

Design, Setting, And Participants: In this secondary analysis of the Assessment of Fluoxetine in Stroke Recovery parallel-group, randomized (1:1 assignment), double-blind, placebo-controlled clinical trial, 1221 participants in Australia, New Zealand, and Vietnam were recruited between January 11, 2013, and June 30, 2019, and were followed up for 6 months. Read More

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The impact of antisperm antibodies on human male reproductive function: an update.

Reproduction 2021 Aug 1. Epub 2021 Aug 1.

S Amaral, University of Coimbra, University of Coimbra Center for Neuroscience and Cell Biology, Coimbra, Portugal.

Immune infertility occurs due to the presence of antisperm antibodies (ASA). This type of infertility has a relatively low prevalence (2.6-6. Read More

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Psychometric Assessment of the Persian Translated Version of the Romantic Perfectionism Scale Among Couples.

Psychol Rep 2021 Aug 1:332941211036026. Epub 2021 Aug 1.

Educational Psychology and Inclusive Education, Faculty of Education, Monash University, Australia.

Romantic perfectionismi can be disruptive to relationships, yet no validated measure for assessing romantic perfectionism in Iranian couples has been developed. Therefore, the purpose of this study was to translate and validate the Romantic Perfectionism Scale (RPS) among Iranian couples. Participants in the study were 200 married men and 320 married women from Tehran, Iran, who completed the translated RPS, the Almost Perfect Scale-Revised, and the Depression Anxiety Stress Scale-21 online. Read More

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Combined Longitudinal Clinical and Autopsy Phenomic Assessment in Lethal Metastatic Prostate Cancer: Recommendations for Advancing Precision Medicine.

Eur Urol Open Sci 2021 Aug 2;30:47-62. Epub 2021 Jul 2.

Faculty of Medicine and Health Technology, Prostate Cancer Research Center, Tampere University and Tays Cancer Center, Tampere, FI-33014, Finland.

Background: Systematic identification of data essential for outcome prediction in metastatic prostate cancer (mPC) would accelerate development of precision oncology.

Objective: To identify novel phenotypes and features associated with mPC outcome, and to identify biomarker and data requirements to be tested in future precision oncology trials.

Design Setting And Participants: We analyzed deep longitudinal clinical, neuroendocrine expression, and autopsy data of 33 men who died from mPC between 1995 and 2004 (PELICAN33), and related findings to mPC biomarkers reported in the literature. Read More

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Addition of Prostate Volume and Prostate-specific Antigen Density to Memorial Sloan Kettering Cancer Center Prostate Cancer Nomograms.

Eur Urol Open Sci 2021 Aug 15;30:13-15. Epub 2021 Jun 15.

Department of Urology, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.

Prostate-specific antigen (PSA) density is an established prognostic marker for prostate cancer. We investigated whether the inclusion of PSA density or prostate volume in the Memorial Sloan Kettering Cancer Center nomograms improves the prediction of biochemical recurrence (BCR) after radical prostatectomy (RP). Among the 11 725 men included, 2140 developed BCR. Read More

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External Validation of Two Nomograms Developed for Ga-PSMA-11 Applied to the Prostate-specific Membrane Antigen Tracer F-DCFPyl: Is Prediction of the Optimal Timing of Salvage Therapy Feasible?

Eur Urol Open Sci 2021 Jun 29;28:47-51. Epub 2021 Apr 29.

Department of Urology, The Netherlands Cancer Institute, Prostate Cancer Network Netherlands, Amsterdam, The Netherlands.

Two nomograms have been developed to predict the outcome of positron emission tomography (PET)/computed tomography (CT) imaging withGa-labeled ligands for prostate-specific membrane antigen (Ga-PSMA) for patients with rising prostate-specific antigen after radical prostatectomy (RP). These nomograms quantify the ability of PSMA PET/CT to detect prostate cancer recurrences, and therefore provide critical information in determining the optimal timing for PSMA PET/CT in guiding salvage therapies. We validated the ability of these nomograms to accurately predict PET/CT outcome using another ligand tracer, F-DCFPyL. Read More

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Clinical Utility of Negative Multiparametric Magnetic Resonance Imaging in the Diagnosis of Prostate Cancer and Clinically Significant Prostate Cancer.

Eur Urol Open Sci 2021 Jun 19;28:9-16. Epub 2021 Apr 19.

Department of Urology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.

Background: Multiparametric magnetic resonance imaging (MRI) is increasingly used to diagnose prostate cancer (PCa). It is not yet established whether all men with negative MRI (Prostate Imaging-Reporting and Data System version 2 score <3) should undergo prostate biopsy or not.

Objective: To develop and validate a prediction model that uses clinical parameters to reduce unnecessary prostate biopsies by predicting PCa and clinically significant PCa (csPCa) for men with negative MRI findings who are at risk of harboring PCa. Read More

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