J Anesth 2021 Apr 5. Epub 2021 Apr 5.
Department of Anesthesiology, School and Hospital of Stomatological, China Medical University, Liaoning Provincial Key Laboratory of Ora Disease, No. 117 Nanjing North Street, Heping District, Shenyang, 110002, China.
Purpose: Dexmedetomidine (DEX) has been associated with inflammation, oxidative stress, and apoptosis, but its effects on lipopolysaccharide (LPS)-induced lung injury remain uncertain. The present study explored the effects of DEX on LPS-induced lung injury and studied the possible molecular mechanisms by testing the effects of the phosphoinositide-3 kinase (PI3K) inhibitor LY294002 and BEZ235.
Methods: Seventy C57BL/6 mice were randomly divided into the control, LPS, LPS + DEX, LPS + LY294002, LPS + BEZ235, LPS + DEX + LY294002, and LPS + DEX + BEZ235groups. Read More