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Exp Gerontol 2021 Apr 6:111344. Epub 2021 Apr 6.

Emeritus Professor of Hematology, Medical School, Aristotle University of Thessaloniki, Faculty of Health Sciences, Greece.

The daily consumption of Extra Virgin Olive Oil (EVOO) in Mediterranean nutrition is tightly associated with lower frequency of many diseases' appearance, including Alzheimer's disease (AD). Fibrinolytic system is already assumed to be involved in AD pathophysiology through various factors, especially plasminogen activator inhibitor-1 (PAI-1), a2-antiplasmin (α2ΑP) and tissue plasminogen activator (tPA). We, here, present a biochemical study, as a continuation of a clinical trial of a cohort of 84 participants, focusing on the pleiotropic effect of the annual EVOO consumption on the fibrinolytic factors of Mild Cognitive Impairment (MCI) patients. Read More

J Mol Neurosci 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurology, Changzhou Third People's Hospital, Changzhou, 213000, Jiangsu, China.

Circular RNAs (circRNAs) have key roles in a variety of neurological diseases, including epilepsy. This objective of this study was to perform the functional exploration and mechanism investigation of circRNA Ubiquilin1 (circUBQLN1) in epilepsy. Epilepsy cell model was established by the treatment of Mg-free in human neurons-hippocampal (HN-h) cells. Read More

Front Physiol 2021 23;12:649462. Epub 2021 Mar 23.

Medical Physiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: Few data are available about the role of herbal extract loaded nanoparticles as an alternative safe medicine for the management of a gastric ulcer.

Aim: This work is targeted at exploring the physiological effects of pomegranate loaded nanoparticles (PLN) against an indomethacin IND-induced gastric ulcer and comparing the results with traditional pomegranate peel extract (PPE).

Methods: Twenty-four rats were equally distributed into four groups: control, IND-treated, PLN-treated, and PPE-treated groups. Read More

Int J Chron Obstruct Pulmon Dis 2021 1;16:887-899. Epub 2021 Apr 1.

Department of Physical Examination Center, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People's Republic of China.

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of death because of its high incidence and mortality, which is chiefly resulted from cigarette smoke exposure. A large number of studies show that circular RNA (circRNA) participates in regulating COPD process. This study aims to reveal the role of circRNA ankyrin repeat domain 11 (circANKRD11) in cigarette smoke extract (CSE)-induced cell apoptosis, inflammation, and oxidative stress. Read More

BMC Nephrol 2021 Apr 9;22(1):126. Epub 2021 Apr 9.

Centre for Public Health, Queen's University Belfast, Belfast, UK.

Background: Haemodialysis (HD) patients tend to have higher levels of oxidative stress (OS), associated with increased morbidity and premature mortality, compared to the general population. Levels of malondialdehyde (MDA), a biomarker of OS, are reduced by the antioxidant properties of vitamin E (VE) but outcomes from randomised control trials of VE supplementation on MDA in HD patients have been inconsistent.

Methods: We undertook a systematic review and meta-analysis of adult HD patients from VE supplementation studies with measures of MDA. Read More

Food Sci Technol Int 2021 Apr 8:10820132211005297. Epub 2021 Apr 8.

Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Antioxidant activity of Klunzinger's mullet () muscle hydrolysates obtained using fermentation and enzymatic hydrolysis was determined. Hydrolysates obtained after 6 days of fermentation with showed the highest free radical scavenging activity, metal chelating ability and ferric reducing antioxidant power (FRAP) (P ≤ 0.05). Read More

J Ethnopharmacol 2021 Apr 5:114102. Epub 2021 Apr 5.

Department of Pharmacology, Shenyang Pharmaceutical University, 110016, Shenyang, PR China. Electronic address:

Ethnopharmacological Relevance: Aconiti Lateralis Radix Praeparata (Chinese name: Fuzi), the root of Aconitum carmichaelii Debx., is a representative medicine for restoring yang and rescuing patient from collapse. However, less studies had been reported on the reproductive toxicity and genotoxicity of Fuzi. Read More

Brain Res 2021 Apr 5:147468. Epub 2021 Apr 5.

The Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. Electronic address:

Status epilepticus (SE) is a neurological emergency. The pathological hallmark of neuronal damage after epileptic seizures could be the chain reaction of oxygen free radicals. Hydroxylated fullerenes (HFs) are novel and effective free radical scavengers, which play an important role in various neurological diseases. Read More

PLoS One 2021 8;16(4):e0247558. Epub 2021 Apr 8.

Department of Food and Tourism Engineering and Management, Transilvania University of Brasov, Brasov, Romania.

Water shortage is among the major abiotic stresses that restrict growth and productivity of citrus. The existing literature indicates that tetraploid rootstocks had better water-deficit tolerance than corresponding diploids. However, the associated tolerance mechanisms such as antioxidant defence and nutrient uptake are less explored. Read More

Diabetes Obes Metab 2021 Apr 8. Epub 2021 Apr 8.

Department of Diabetes & Endocrinology, Morriston Hospital, Swansea Bay University Health Board, Swansea.

Aims: Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) have cardiorenal protective properties in patients with type 2 diabetes (T2DM) that are not fully understood. Inflammation and oxidative stress play a role in the pathogenesis of T2DM and its associated cardiorenal complications. Anti-inflammatory and antioxidant properties may contribute towards explaining the beneficial effects of GLP-1RAs. Read More

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Mar;52(2):229-234

Department of Respiratory and Critical Care Medicine, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, China.

Objective: To investigate the effects of morin-regulated NLRP3/Caspase-1 pathway on experimental autoimmune thyroiditis in rats.

Methods: The rats were randomly assigned to 6 groups: control group, experimental autoimmune thyroiditis group (EAT), low-, medium- and high-dose morin groups (post-modeling gavage of 50, 100 and 200 mg/kg morin hydrate per day for 6 weeks) and tripterygium wilfordii polyglycosides group (LGT group, post-modeling gavage of 6.25 mg/kg tripterygium wilfordii polyglycosidesper day for 6 weeks). Read More

Sci Rep 2021 Apr 7;11(1):7643. Epub 2021 Apr 7.

Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing, 210011, Jiangsu, China.

This study aimed to explore the effect of calcitonin gene-related peptide (CGRP) on bladder smooth muscle cells (BSMCs) under high glucose (HG) treatment in vitro. BSMCs from Sprague-Dawley rat bladders were cultured and passaged in vitro. The third-generation cells were cultured and divided into control group, HG group, HG + CGRP group, HG + CGRP + asiatic acid (AA, p-p38 activator) group, CGRP group, AA group, HG + CGRP + CGRP-8-37 (CGRP receptor antagonist) group and HG + LY2228820 (p38 MAPK inhibitor) group. Read More

Nutr Metab (Lond) 2021 Apr 7;18(1):36. Epub 2021 Apr 7.

Integrative Biomedical Research Unit (IBRU), Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, 65000, Thailand.

Background: Hypercholesterolemia is a major risk factor for cardiovascular disease. It has been reported that pineapple contains healthy nutrients and phytochemicals associated with antioxidant and anti-inflammatory capacities. No investigation exists concerning the effect of pineapple consumption modulating hypercholesterolemia-induced cardiac damage in high-cholesterol diet (HCD)-fed rats. Read More

Ecotoxicol Environ Saf 2021 Apr 4;216:112169. Epub 2021 Apr 4.

Nuclear Agriculture Research School, Nuclear Science and Technology Research Institute, Karaj, Iran.

Plants and their accompanying microorganisms growing in contaminated sites with long-lived gamma-emitting radionuclides may be affected by radiation stress. The present study aimed to investigate the effects of gamma radiation on symbiotic relationship between Epichloë endophyte and Festuca arundinacea plant along with the radio-sensitivity of a pair of clones of tall fescue with (E+) and without (E-) symbiotic Epichloë endophyte exposed to different doses of gamma radiation including 25, 50, 75, 100, 150, 200, 300, and 400 Gray (Gy) from a Cobalt-60 source. Both irradiated and non-irradiated seeds of each status were grown under controlled conditions. Read More

Metab Brain Dis 2021 Apr 7. Epub 2021 Apr 7.

Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Alzheimer's disease is the most common neurodegenerative disease associated with deposition of amyloid-beta and the increased oxidative stress. High free radical scavenging ability of selenium nanoparticles (SeNPs) has been acknowledged, so in the present study, the effects of treatment with SeNPs on Streptozotocin (STZ)-induced neurotoxicity were evaluated in the male rats. Learning and memory impairment was induced by intraventricular injection of STZ. Read More

Intensive Care Med Exp 2021 Apr 7;9(1):19. Epub 2021 Apr 7.

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

Background: To describe the effect of mechanical ventilation on diaphragm mitochondrial oxygen consumption, ATP production, reactive oxygen species (ROS) generation, and cytochrome c oxidase activity and content, and their relationship to diaphragm strength in an experimental model of sepsis.

Methods: A cecal ligation and puncture (CLP) protocol was performed in 12 rats while 12 controls underwent sham operation. Half of the rats in each group were paralyzed and mechanically ventilated. Read More

J Toxicol Environ Health A 2021 Apr 7:1-11. Epub 2021 Apr 7.

Universidade de Franca, Franca, São Paulo, Brazil.

Pohl, a typical species from the Brazilian cerrado, commonly known as "benjoeiro", is used to treat gastroduodenal diseases. In previous studies carried out by our research group, hydroalcoholic extract of stems (SCHE) exhibited antigenotoxic and antiproliferative effects. For a comparative analysis of the chemopreventive effect of SCHE, the aim of this study was to investigate the influence of SCHE against carcinogen 1,2-dimethylhydrazine (DMH)-induced DNA damage and pre-neoplastic lesions in Wistar rat colon. Read More

Int J Environ Health Res 2021 Apr 7:1-11. Epub 2021 Apr 7.

Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, China.

This study was to investigate the effects of oxidative stress in cigarette smoke (CS)-induced cell apoptosis in mice with emphysema. Thirty-two mice were divided into four groups: the control group, the CS group, the CS + Pifithrin-α group, and the CS + NAC group. Pathological changes and apoptosis in lung tissue of mice were detected. Read More

Drug Deliv 2021 Dec;28(1):719-732

School of Pharmaceutical sciences, Jilin University, Changchun, 130021, P.R. China.

The purpose of this study was to optimize the preparation method of injectable Octreotide microspheres. To explore the correlation between the solvent system and the general properties of microspheres to reduce burst release and enable them to be used for portal hypertension. Octreotide microspheres were prepared by modified double emulsion solution evaporation method after optimizing preparation conditions. Read More

J Anesth 2021 Apr 5. Epub 2021 Apr 5.

Department of Anesthesiology, School and Hospital of Stomatological, China Medical University, Liaoning Provincial Key Laboratory of Ora Disease, No. 117 Nanjing North Street, Heping District, Shenyang, 110002, China.

Purpose: Dexmedetomidine (DEX) has been associated with inflammation, oxidative stress, and apoptosis, but its effects on lipopolysaccharide (LPS)-induced lung injury remain uncertain. The present study explored the effects of DEX on LPS-induced lung injury and studied the possible molecular mechanisms by testing the effects of the phosphoinositide-3 kinase (PI3K) inhibitor LY294002 and BEZ235.

Methods: Seventy C57BL/6 mice were randomly divided into the control, LPS, LPS + DEX, LPS + LY294002, LPS + BEZ235, LPS + DEX + LY294002, and LPS + DEX + BEZ235groups. Read More

Curr Diabetes Rev 2021 Apr 4. Epub 2021 Apr 4.

Department of Physiology & Biochemistry, Govt. Yoga & Naturopathy Medical College & Hospital, Chennai- 600106. India.

Background: Diabetes mellitus has a significant impact on public health. Oxidative stress plays a major role in the pathophysiology of type 2 diabetes mellitus (T2DM), leading to various complications of T2DM. Yoga is being widely used in the management of T2DM. Read More

Int Immunopharmacol 2021 Apr 2;96:107593. Epub 2021 Apr 2.

Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Background: Antioxidant and anti-inflammatory effects are two main pharmacological mechanisms of pirfenidone (PFD) besides the anti-fibrotic effect. This study aims to investigate whether PFD could mediate cigarette smoke extract (CSE) induced inflammation and oxidative stress in vitro and in vivo.

Methods: BALB/C mice and alveolar epithelial (A549) cells treated with CSE were established as disease models in vivo and in vitro. Read More

Nutr Cancer 2021 Apr 5:1-18. Epub 2021 Apr 5.

Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Scope: To evaluate the chemopreventive efficacy of hesperidin (Hsd) in 1,2-dimethylhydrazine (DMH)-induced colorectal cancer (CRC) and demonstrate its role in mothers against decapentaplegic homolog 4(Smad4) and activin A signaling pathways.

Methods And Results: A CRC rat model was established by DMH exposure, and the animals were randomly divided into five groups: Control group, Hsd, DMH, DMH + Hsd, and DMH followed by Hsd. The resected colon was subjected to macroscopic, microscopic, molecular, histopathological, and immunohistochemical examination. Read More

J Transl Autoimmun 2021 2;4:100090. Epub 2021 Mar 2.

Laboratory of Immunology and Immunotherapy, CHRU Morvan, Brest, France.

High amount of polyclonal free light chains (FLC) are reported in systemic autoimmune diseases (SAD) and we took advantage of the PRECISESADS study to better characterize them. Serum FLC levels were explored in 1979 patients with SAD (RA, SLE, SjS, Scl, APS, UCTD, MCTD) and 614 healthy controls. Information regarding clinical parameters, disease activity, medications, autoantibodies (Ab) and the interferon α and/or γ scores were recorded. Read More

Open Life Sci 2020 11;15(1):799-807. Epub 2020 Nov 11.

College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, 721013, China.

In this paper, konjac oligoglucomannan (KOGM) was obtained with a hydrolysis rate of 56.24% by controlling the hydrolysis conditions. KOGM was passed through a 0. Read More

Open Life Sci 2019 Jan 31;14:611-618. Epub 2019 Dec 31.

Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Loa Angeles, CA 90089, USA.

Objective: The aim of this study is to investigate the protective effects of emodin (EMD) on the lung injuries in the rat models of liver fibrosis.

Methods: Liver fibrosis was established in rats and the effect of intervention using EMD treatment was determined. Liver and lung weight coefficients were measured and lung content of TNF-α (tumor necrosis factor α), MDA (malondialdehyde), NO (nitric oxide), and ONOO- (peroxynitrite) were determined. Read More

Am J Cardiovasc Dis 2021 20;11(1):176-183. Epub 2021 Feb 20.

Department of Biochemistry, Fırat University Faculty of Veterinary Science Elazığ, Turkey.

Deep vein thrombosis (DVT), a subset of venous thromboembolism (VTE), is a major preventable cause of morbidity and mortality worldwide. We aim to investigate changes in oxidative injury markers and the levels of antioxidant parameters in DVT patients. 50 DVT patients who were admitted to the cardiovascular surgery clinic with acute (<2 weeks) or chronic (≥4 weeks) DVT and 100 healthy individuals were included. Read More

Front Pharmacol 2021 16;12:603316. Epub 2021 Mar 16.

Departments of Neuroscience and Behavioral Medicine and Psychiatry, Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, WV, United States.

Impairment of memory and cognition is one of the major symptoms in women with postmenopausal disorders due to estrogen deficiency, which accounts for the much higher prevalence of Alzheimer's disease in females. Biochanin A (BCA), a natural phytoestrogen, has been reported to protect neurons against ischemic brain injury. However, the neuroprotective effects of BCA in the postmenopausal-like model of ovariectomized (OVX) rats remain to be investigated. Read More

Int J Nanomedicine 2021 26;16:2461-2475. Epub 2021 Mar 26.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.

Aim: To explore the effects of Radix Sophorae Flavescentis carbonisata-based carbon dots (RSFC-CDs) on an ethanol-induced acute gastric ulcer rat model.

Methods: The structure, optical properties, functional groups and elemental composition of RSFC-CDs synthesized by one-step pyrolysis were characterized. The gastric protective effects of RSFC-CDs were evaluated and confirmed by applying a rat model of ethanol-induced acute gastric ulcers. Read More

Mater Sci Eng C Mater Biol Appl 2021 Apr 15;123:111974. Epub 2021 Feb 15.

Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

The study aims to evaluate the impact of silver nanoparticles, phytosynthesized with polyphenols from Sambucus nigra L. (SN) fruit extract (AgSN), on dysplastic oral keratinocytes (DOK) and human gingival fibroblasts (HGF) in terms of cell viability and apoptosis. The morphology and ultrastructure of treated cells as well as the mechanisms involved in cell death induction were investigated in DOK cultures. Read More