77,330 results match your criteria malignant benign


Histopathological evidence of intrahepatic cholangiocarcinoma occurring in ductal plate malformation: A clinicopathologic study of 5 cases.

Ann Diagn Pathol 2021 Sep 22;55:151828. Epub 2021 Sep 22.

Department of Pathology, Yueyang Integrated Traditional Chinese and Western Medicine Hospital, Shanghai University of traditional Chinese Medicine, Shanghai, China. Electronic address:

Ductal plate malformations (DPM) arise from abnormal remodeling of the embryologic ductal plate of the liver. Malignant transformation of DPMs to intrahepatic cholangiocarcinoma (iCCA) has been reported in very rare instances but is viewed with some skepticism. We report the clinicopathological findings in five cases of iCCA, occurring in liver with DPM-like features. Read More

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September 2021

Cutaneous solitary fibrous tumor: report of three cases with review of histological mimics.

J Cutan Pathol 2021 Sep 27. Epub 2021 Sep 27.

Department of Dermatology, College of Medicine, University of Florida, Gainesville, FL.

Solitary fibrous tumor (SFT) is a relatively uncommon spindle cell mesenchymal neoplasm that is most often based in the pleura but may rarely arise in extrapleural locations, including the skin. Herein, we describe three cases of cutaneous SFTs. SFT is characterized by epithelioid and spindle cells arranged in random patterns with focal prominent stromal collagen and pericytomatous vessels. Read More

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September 2021

Outcomes of organ-sparing surgery for adult testicular tumors: A systematic review of the literature.

BJUI Compass 2021 Sep 23;2(5):306-321. Epub 2021 Feb 23.

Department of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.

Objective: To perform a systematic review on the effects of testicular sparing surgery (TSS) on the oncological, functional, and hormonal outcomes of adults with testicular tumors.

Methods: A literature search was performed after PROSPERO registration (CRD42020200842) and reported in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methods. We conducted a systematic search of Medline (Ovid), Embase, Cochrane CENTRAL, CINAHL, Scopus, Web of Science, ClinicalTrials. Read More

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September 2021

Case Report and Literature Review: Pulmonary Sclerosing Pneumocytoma With Multiple Metastases Harboring E17K Somatic Mutation and C176Y Germline Mutation.

Front Med (Lausanne) 2021 8;8:655574. Epub 2021 Sep 8.

Department of Pathology, Daping Hospital, Army Medical University, Chongqing, China.

Pulmonary Sclerosing Pneumocytoma (PSP) is considered as a benign tumor, although a few cases have been reported to have multiple lesions, recurrence, and even regional lymph nodes (LNs) metastasis. Here, we report a case of PSP with atypical histologic features and malignant biological behavior, and explore its molecular genetic changes. The 23-year-old male showed a 6. Read More

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September 2021

Radiomics Models for the Preoperative Prediction of Pelvic and Sacral Tumor Types: A Single-Center Retrospective Study of 795 Cases.

Front Oncol 2021 9;11:709659. Epub 2021 Sep 9.

Department of Radiology, Peking University People's Hospital, Beijing, China.

Purpose: To assess the performance of random forest (RF)-based radiomics approaches based on 3D computed tomography (CT) and clinical features to predict the types of pelvic and sacral tumors.

Materials And Methods: A total of 795 patients with pathologically confirmed pelvic and sacral tumors were analyzed, including metastatic tumors (n = 181), chordomas (n = 85), giant cell tumors (n =120), chondrosarcoma (n = 127), osteosarcoma (n = 106), neurogenic tumors (n = 95), and Ewing's sarcoma (n = 81). After semi-automatic segmentation, 1316 hand-crafted radiomics features of each patient were extracted. Read More

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September 2021

The Key Gene Expression Patterns and Prognostic Factors in Malignant Transformation from Enchondroma to Chondrosarcoma.

Front Oncol 2021 10;11:693034. Epub 2021 Sep 10.

Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Enchondroma (EC) is a common benign bone tumor. It has the risk of malignant transformation to Chondrosarcoma (CS). However, the underlying mechanism is unclear. Read More

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September 2021

Is Elevated Choline on Magnetic Resonance Spectroscopy a Reliable Marker of Breast Lesion Malignancy?

Front Oncol 2021 10;11:610354. Epub 2021 Sep 10.

Department of Radiology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Background: Contemporary magnetic resonance imaging (MRI) of the breast represents a powerful diagnostic modality for cancer detection, with excellent sensitivity and high specificity. Magnetic resonance spectroscopy (MRS) is being explored as an additional tool for improving specificity in breast cancer detection, using multiparametric MRI. The aim of this study was to examine the possibility of 1H-MRS to discriminate malignant from benign breast lesions, using elevated choline (Cho) peak as an imaging biomarker. Read More

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September 2021

Submucosal Lipoma Causing Small Bowel Intussusception.

Cureus 2021 Aug 22;13(8):e17367. Epub 2021 Aug 22.

Surgery, Northwell Health, New York, USA.

Intussusception involves telescoping of one segment of the intestine into an adjacent segment. Although this diagnosis is common in the pediatric population, it is much less common in adults. One of the main reasons it may occur in adults is due to a mass. Read More

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Papillary Carcinoma in Struma Ovarii: A Radiological Dilemma.

Cureus 2021 Aug 22;13(8):e17360. Epub 2021 Aug 22.

Radiology, Barking, Havering and Redbridge University Hospitals National Health Service (NHS) Trust, London, GBR.

Struma ovarii is a very rare tumour of the ovary, which is usually benign. It is a solid cystic swelling of the ovary, which is characterised by the presence of histologically detectable thyroid tissue. Confirmatory diagnosis is usually on histopathology after resection of the tumour. Read More

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The Application of the Big Data Medical Imaging System in Improving the Medical and Health Examination.

J Healthc Eng 2021 16;2021:8251702. Epub 2021 Sep 16.

School of Economics and Management, China University of Geosciences (Wuhan), Wuhan 430000, China.

To explore the application effect of the big data medical imaging tertiary diagnostic system in improving the medical and health examination, cases in township health centers were collected by the medical imaging tertiary diagnosis system. Clinical cases examined by the tertiary diagnostic system of big data medical imaging will be set as the observation group. Clinical cases not involved in the tertiary diagnostic system of big data medical imaging were set as the control group. Read More

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September 2021

The role of chemical shift magnetic resonance imaging in differentiating osteoporotic benign and malignant vertebral marrow lesions.

Pol J Radiol 2021 6;86:e468-e473. Epub 2021 Aug 6.

Government Medical College and Hospital, Chandigarh, India.

Purpose: To evaluate the usefulness of chemical shift imaging (CSI) in differentiating benign osteoporotic and malignant vertebral marrow lesions.

Material And Methods: Patients undergoing spinal magnetic resonance imaging (MRI) for back pain, which showed altered marrow signal intensity on conventional MRI sequences, were included in the study. Patients with acute traumatic vertebral fractures, infective spondylodiscitis, paravertebral collections, etc. Read More

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Myofibroblastoma of the Breast: A Morphologic and Immunohistochemical Study of Three Cases.

Iran J Pathol 2021 6;16(4):451-455. Epub 2020 Jul 6.

Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.

Myofibroblastoma (MFB) of the breast is an uncommon entity of benign spindle neoplasms of the breast. This tumour possesses a broad spectrum of histomorphological patterns. Distinguishing of myofibroblastoma variants from malignant mimics of this benign neoplasm is essential for pathologists to avoid further invasive surgical procedures. Read More

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Collision Tumor of the Kidney: Renal Cell Carcinoma Hidden in a Giant Angiomyolipoma in a Patient With Tuberous Sclerosis Complex.

Ochsner J 2021 ;21(3):287-290

Department of Urology, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

A renal angiomyolipoma is a mixed mesenchymal benign tumor composed of smooth muscle, adipose tissue, and blood vessels. Malignant transformation of angiomyolipomas is anecdotal. To our knowledge, only 6 cases have been reported, and 4 of the patients had tuberous sclerosis complex diagnosed. Read More

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January 2021

Giant eccrine acrospiroma of the scalp.

J Cutan Aesthet Surg 2021 Apr-Jun;14(2):238-240

Department of General Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Eccrine acrospiroma is a benign skin tumor that arises from the ducts of sweat glands, presents as small solid or cystic lesions that rarely can undergo malignant transformation, and leads to a diagnostic dilemma. We report a 32-year-old woman who presented with a large pedunculated tumor of the scalp that was excised and histopathologically proven to be a giant eccrine acrospiroma. This case is being presented because of its infrequent occurrence and the unusual large size of the lesion on the scalp that has been not reported in the literature so far. Read More

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September 2021

A renal angiomyolipoma with a challenging presentation: a case report.

J Med Case Rep 2021 Sep 27;15(1):477. Epub 2021 Sep 27.

University of Tunis ElManar, Tunis, Tunisia.

Introduction: Renal angiomyolipoma is considered a benign mesenchymal tumor composed of fat, smooth muscle, and blood vessels. It represents 1-3% of solid renal tumors. Despite this tumor's benignity, it can be aggressive with a locoregional extension. Read More

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September 2021

Breast Hemangioma: Unique Presentation In a Patient with Klippel-Trenaunay-Syndrome.

Curr Med Imaging 2021 Sep 24. Epub 2021 Sep 24.

Radiology Department; Pakistan Institute of Medical Sciences . Pakistan.

Background: Klippel-Trénaunay-Syndrome (KTS) is characterized by triad of varicose veins, port wine stain and soft tissue or bony hypertrophy and the diagnosis of KTS can be made if any two of these three features are present. Hemangiomas in various location e.g. Read More

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September 2021

Etiologies of remarkably elevated serum levels of carbohydrate antigen 19-9.

J BUON 2021 Jul-Aug;26(4):1653-1658

Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China.

Purpose: To investigate the etiologies of remarkably elevated serum levels of CA 19-9.

Methods: During January 2014 to June 2020 patients with CA 19-9>1000 U/ml were included. The frequencies of distant metastases for malignant patients and serum levels of carbohydrate embryonic antigen (CEA) and carbohydrate antigen 125 (CA 125) were analyzed. Read More

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September 2021

Diagnostic value of combined detection of multiple tumor markers and blood lipid indexes in colorectal cancer and its prediction on adverse reactions of chemotherapy.

J BUON 2021 Jul-Aug;26(4):1226-1230

Department of Hematology and Oncology, Tianjin Fifth Central Hospital, Tianjin 300450, China.

Purpose: The purpose of this study was to explore the clinical diagnostic value of combined detection of multiple tumor markers (CEA, CA242, CA19.9 and CA125) and blood lipid indexes in colorectal cancer, and to analyze their predictive effect on adverse reactions after chemotherapy.

Methods: The clinical data of 35 patients with colorectal adenoma, 64 patients with colorectal cancer I-II and 29 patients with colorectal cancer III-IV were retrospectively analyzed. Read More

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September 2021

Seeing the whole picture: Added value of MRI for extraperitoneal findings in CRS-HIPEC candidates.

Eur J Surg Oncol 2021 Sep 20. Epub 2021 Sep 20.

Dept. of Radiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, the Netherlands.

Purpose: In colorectal cancer (CRC) patients the selection of suitable cytoreductive surgery and hyperthermic peritoneal chemotherapy (CRS-HIPEC) candidates is based on the location and extent of peritoneal metastases (PM) and presence of extraperitoneal metastases. MRI is increasingly being used to accurately assess the extent of PM, however, the significance of extraperitoneal findings in these scans has never been evaluated before.

Methods: CRC patients who had undergone an additional MRI scan after standard work-up with CT for preoperative staging between January 2016-January 2020 were selected. Read More

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September 2021

Cervical lymph node biopsies in the evaluation of children with suspected lymphoproliferative disorders: Experience in a tertiary pediatric setting.

J Pediatr Surg 2021 Sep 10. Epub 2021 Sep 10.

Department of Otolaryngology - Head and Neck Surgery, Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1 × 8, Canada. Electronic address:

Background/Purpose The objectives of this study were: (1) to determine the incidence of lymphoproliferative disorders in a cohort of patients requiring a biopsy at a tertiary pediatric center; and (2) to elucidate the demographic, clinical, laboratory and diagnostic imaging characteristics associated with a malignant diagnosis. Methods A retrospective review of pediatric cervical lymph node biopsies performed between 2012 and 2019 at a tertiary center was undertaken. Demographic data, clinical presentations, laboratory results, diagnostic imaging findings, and pathology results were compiled and analyzed to identify characteristics associated with a malignant diagnosis. Read More

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September 2021

Periostin expression and its supposed roles in benign and malignant thyroid nodules: an immunohistochemical study of 105 cases.

Diagn Pathol 2021 Sep 25;16(1):86. Epub 2021 Sep 25.

Department of Pathology, Shizuoka General Hospital, Shizuoka, Japan.

Background: Thyroid tumors are often difficult to histopathologically diagnose, particularly follicular adenoma (FA) and follicular carcinoma (FC). Papillary carcinoma (PAC) has several histological subtypes. Periostin (PON), which is a non-collagenous extracellular matrix molecule, has been implicated in tumor invasiveness. Read More

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September 2021

Adverse events in thyroid surgery: observational study in three surgical units with high volume/year.

BMC Surg 2021 Sep 25;21(1):352. Epub 2021 Sep 25.

Unit of General Surgery, University Hospital of Cagliari, Cagliari, Italy.

Background: Thyroid surgery, performed for benign or malignant pathologies, is one of the most frequently performed procedures and its frequency has even been increasing in recent years. Postoperative bleeding, recurrent laryngeal nerve (RLN) palsy, associated to dysphonia, dysphagia, dyspnea, and hypoparathyroidism represent the most fearful and common complications. We conducted a multicenter, observational study of retrospectively collected data in three high-volume referral centers, enrolling all patients undergone to thyroid surgery between January 2016 and December 2017 in Parma University Hospital, Cagliari University Hospital and Ferrara University Hospital. Read More

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September 2021

Oncological Properties of Intravenous Leiomyomatosis: Involvement of Mesenchymal Tumor Stem-Like Cells.

Curr Issues Mol Biol 2021 Sep 19;43(2):1188-1202. Epub 2021 Sep 19.

National Hospital Organization Kyoto Medical Center, Department of Obstetrics and Gynecology, Kyoto 612-8555, Japan.

Uterine leiomyoma, also known as fibroids, is the most common benign neoplasm of the female genital tract. Leiomyoma is the most common uterine tumor. The leiomyoma subtypes account for approximately 10% of leiomyomas. Read More

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September 2021

An unusual pediatric case of atypical spitzoid neoplasm.

Pediatr Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Spitzoid melanocytic lesions describe a spectrum of pediatric melanocytic proliferations ranging from benign Spitz nevi to malignant spitzoid melanomas typically arising within the first two decades of life. Atypical spitzoid neoplasm (ASN) is a poorly defined category within this spectrum that poses a unique diagnostic challenge due to histologic findings with insufficient atypical characteristics to make the diagnosis of melanoma. This report presents an exceptionally rare case of an ulcerative atypical spitzoid neoplasm mimicking an infantile hemangioma in a two-month-old girl treated with pulse dyed laser (PDL) and surgical excision. Read More

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September 2021

Ultrasonographic evaluation of ovarian mass for predicting malignancy in pregnant women.

Gynecol Oncol 2021 Sep 21. Epub 2021 Sep 21.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: The purpose of this study is to compare ultrasonographic ovarian mass scoring systems in pregnant women.

Study Design: This multicenter study included women with an ovarian mass during pregnancy who were evaluated using ultrasound and underwent surgery in 11 referral hospitals. The ovarian mass was evaluated and scored using three different scoring systems(International Ovarian Tumor Analysis Assessment of Different NEoplasias in the adnexa[IOTA ADNEX], Sassone, and Lerner). Read More

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September 2021

Tumors and pseudotumors of foot and ankle: Bone lesions.

Foot (Edinb) 2021 Jun 29;49:101845. Epub 2021 Jun 29.

Radiology & Orthopeadic Surgery, UT Southwestern, 5323 Harry Hines Blvd, Dallas, TX, United States. Electronic address:

Bone tumors and tumor-like lesions (pseudotumors) are not uncommonly encountered as asymptomatic findings on imaging, or as symptomatic lesions clinically. Radiographic imaging is the first diagnostic tool for their management strategy, since the symptoms are commonly non-specific, such as pain, swelling, and redness. Image findings must be analyzed with attention to the specific features such as lesion location, margination, zone of transition, mineralization, size and multifocality, soft tissue component and/or loco-regional extent. Read More

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Discrimination between malignant and benign thyroid tumors by diffusion-weighted imaging - A systematic review and meta analysis.

Magn Reson Imaging 2021 Sep 21. Epub 2021 Sep 21.

Department of Radiology and Nuclear Medicine, University of Magdeburg, Magdeburg, Germany.

Purpose: Magnetic resonance imaging is used to stage thyroid tumors. Diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) can be used to reflect tumor microstructure. Our aim was to compare ADC values of malignant and benign thyroid lesions based on a large sample. Read More

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September 2021

Diffusion weighted imaging for evaluation of breast lesions: Comparison between high b-value single-shot and routine readout-segmented sequences at 3 T.

Magn Reson Imaging 2021 Sep 21;84:35-40. Epub 2021 Sep 21.

Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen, the Netherlands; Department of Radiology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066, CX, Amsterdam, the Netherlands.

Purpose: In this study, we compare readout-segmented echo-planar imaging (rs-EPI) Diffusion Weighted Imaging (DWI) to a work-in-progress single-shot EPI with modified Inversion Recovery Background Suppression (ss-EPI-mIRBS) sequence at 3 T using a b-value of 2000 s/mm on image quality, lesion visibility and evaluation time.

Method: From September 2017 to December 2018, 23 women (one case used for training) with known breast cancer were included in this study, after providing signed informed consent. Women were scanned with the conventional rs-EPI sequence and the work-in-progress ss-EPI-mIRBS during the same examination. Read More

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September 2021

Selective Single-Cell Sorting Using a Multisectorial Electroactive Nanowell Platform.

ACS Nano 2021 Sep 24. Epub 2021 Sep 24.

Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada.

Current approaches in targeted patient treatments often require the rapid isolation of specific rare target cells. Stream-based dielectrophoresis (DEP) based cell sorters have the limitation that the maximum number of sortable cell types is equivalent to the number of output channels, which makes upscaling to a higher number of different cell types technically challenging. Here, we present a microfluidic platform for selective single-cell sorting that bypasses this limitation. Read More

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September 2021

Epidemiologic profile and outcome of primary pediatric brain tumors in Iran: retrospective study and literature review.

Childs Nerv Syst 2021 Sep 24. Epub 2021 Sep 24.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.

Purpose: Primary pediatric tumors are the most common solid tumors in children. There are limited reports on the management and outcome of these tumors in the developing countries. In recent years, advances have been done in the diagnosis, treatment, and outcome of these tumors. Read More

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September 2021