404,061 results match your criteria malignant


Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography.

Lasers Surg Med 2021 Jun 15. Epub 2021 Jun 15.

Department of Biomedical Engineering, The University of Texas Austin, Austin, Texas, 78712, USA.

Background And Objectives: Despite rapid advances and discoveries in medical imaging, monitoring therapeutic efficacy for malignant gliomas and monitoring tumor vasculature remains problematic. The purpose of this study is to utilize optical coherence angiography for vasculature characterization inside and surrounding brain tumors in a murine xenograft brain tumor model. Features included in our analysis include fractional blood volume, vessel tortuosity, diameter, orientation, and directionality. Read More

View Article and Full-Text PDF

Toward a Liver Cell Atlas: Understanding Liver Biology in Health and Disease at Single-Cell Resolution.

Semin Liver Dis 2021 Jun 15. Epub 2021 Jun 15.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

Single-cell technologies are revolutionizing our understanding of cellular heterogeneity and functional diversity in health and disease. Here, we review the current knowledge and advances in liver biology using single-cell approaches. We focus on the landscape of the composition and the function of cells in a healthy liver in the context of its spatial organization. Read More

View Article and Full-Text PDF

Performance of the EarlyCDT® Lung test in detection of lung cancer and pulmonary metastases in a high-risk cohort.

Lung Cancer 2021 Jun 10;158:85-90. Epub 2021 Jun 10.

Institute of Regional Health Research, University of Southern Denmark, J.B. Winsløws Vej 19, 3, 5000 Odense C, Denmark; Department of Internal Medicine, Vejle Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100 Vejle, Denmark. Electronic address:

Objectives: Early detection of lung cancer is pivotal for an optimal prognosis. CT screening is currently implemented in USA. To decrease the amount of CT scans, the application of a blood-based biomarker as part of screening criteria is desirable. Read More

View Article and Full-Text PDF

Saliva based non invasive screening of Oral Submucous Fibrosis using ATR-FTIR spectroscopy.

J Pharm Biomed Anal 2021 Jun 8;203:114202. Epub 2021 Jun 8.

Department of Life Science, School of Sciences, Gujarat University, India. Electronic address:

Oral Submucous Fibrosis (OSMF) is a type of precancerous condition of Oral cancer and considered to have the greatest malignant potential. Biopsy is an ultimate option for the conformation of the malignancy. But the invasiveness of the procedure makes it interdict. Read More

View Article and Full-Text PDF

A multicenter study to develop a non-invasive radiomic model to identify urinary infection stone in vivo using machine-learning.

Kidney Int 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmacy, the First People's Hospital of Kashi Prefecture; Affiliated Kashi Hospital of Sun Yat-Sen University, Kashi, People's Republic of China. Electronic address:

Urolithiasis is a common urological disease, and treatment strategy options vary between different stone types. However, accurate detection of stone composition can only be performed in vitro. The management of infection stones is particularly challenging with yet no effective approach to pre-operatively identify infection stones from non-infection stones. Read More

View Article and Full-Text PDF

Inhibiting microRNA-424 in bone marrow mesenchymal stem cells-derived exosomes suppresses tumor growth in colorectal cancer by upregulating TGFBR3.

Arch Biochem Biophys 2021 Jun 12:108965. Epub 2021 Jun 12.

Oncology Department, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 North Baoshan Road, Yunyan District, Guiyang, 550001, Guizhou, China. Electronic address:

Objective: MicroRNAs (miRNAs) have been demonstrated to be differently expressed in colorectal cancer (CRC) and were identified as biomarkers and therapeutic targets for CRC. We aimed to identify the effect of microRNA-424 (miR-424) on process of CRC.

Methods: Exosomes were obtained from bone marrow mesenchymal stem cells (BMSCs). Read More

View Article and Full-Text PDF

Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2.

Carcinogenesis 2021 Jun 15. Epub 2021 Jun 15.

Department of Oncology, The First Affiliated Hospital of Soochow University, Jiangsu, China, Department of Thoracic Surgery, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China, Institute of Cancer and Basic Medicine (IBMC) Chinese Academy of Sciences, Gongshu District, Hangzhou, China.

This study tried to explore the molecular mechanism underlying progression of lung adenocarcinoma (LUAD), and discuss the extracellular communication between cancer cells and vascular endothelial cells. Roughly, differential analysis was carried out to note that miR-30a-5p was lowly expressed in LUAD while CCNE2 was highly expressed. Cell functional experiments demonstrated that overexpressed miR-30a-5p led to suppressed cell abilities in proliferation, migration and invasion. Read More

View Article and Full-Text PDF

Influence of Muscle Mass Area and Visceral Obesity on 30-day Mortality After Colorectal Surgery with Primary Anastomosis.

Rev Invest Clin 2021 Jun 15. Epub 2021 Jun 15.

Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: Muscle mass and visceral fat may be assessed at the level of the third lumbar vertebra (L3) in computed tomography (CT). Both variables have been related with adverse surgical outcomes.

Objective: The objective of the study was to study the association of skeletal muscle index (SMI) and visceral fat area (VFA) with 30-day mortality in colorectal surgery. Read More

View Article and Full-Text PDF

Can Oncology Practice Claims Data Replace Physician Reporting to State Cancer Registries?

J Registry Manag 2020 ;47(3):113-117

Background: Recently, the Surveillance, Epidemiology, and End Results Program facilitated the linkage of claims data from oncology practices to cancer registry data. Since physician reporting places a burden on oncology practices and presents a challenge for cancer registries, the question arises as to whether claims data can replace physician reporting. Using data reported to the New York State Cancer Registry, we evaluated the information that would be lost if oncology practices were to cease reporting abstracted data to the registry. Read More

View Article and Full-Text PDF

Clinical assessment of prophylactic chemotherapy in treating with hydatidiform mole: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26341

Department of Obstetrics and Gynecology, the First People's Hospital of Nantong, Nantong, Jiangsu, China.

Background: Hydatidiform mole (HM) is more common as molar pregnancy. It is a disease classified under the category of gestational trophoblastic diseases, which could metastasize after originating in the placenta. A majority of females suffering from molar pregnancies are curable by evacuating retained products of conception and the patient's fertility is preserved. Read More

View Article and Full-Text PDF

A comparative study of the efficiency and safety of chemotherapy as a therapeutic method for recurrent or resistant gestational trophoblastic neoplasia: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26263

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.

Background: Gestational trophoblastic neoplasia (GTN) is an infrequent spectrum of placental malignant cases. Generally, single-agent or multiple-agent chemotherapy is used to treat the condition. The condition has a significant impact on women in the childbearing age, which makes post-chemo fertility and obstetrical results a significant contemplation. Read More

View Article and Full-Text PDF

Clinicopathological analysis and genomic profiling of a rare histiocyte-rich rhabdomyoblastic tumor: A case report.

Medicine (Baltimore) 2021 Jun;100(24):e26105

Department of General Surgery, Shenzhen University General Hospital & Carson International Cancer Research Centre, Shenzhen, P.R. China.

Rationale: Skeletal muscle tumors are traditionally classified as rhabdomyomas or rhabdomyosarcomas. However, some soft tissue tumors cannot easily be identified as benign or malignant. We report a case of a histiocyte-rich rhabdomyoblastic tumor, with pathologic characteristics distinct from either rhabdomyoma or rhabdomyosarcoma. Read More

View Article and Full-Text PDF

Awareness of thyroid cancer among medical students: A questionnaire-based study.

Sci Prog 2021 Apr-Jun;104(2):368504211023654

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To investigate whether medical students acquire enough knowledge about thyroid cancer (TC). It was a cross-sectional study in a Chinese medical college based on a questionnaire about the knowledge of TC and thyroid self-examination. Medical students enrolled were grouped into preclinical medical students (PMS) and clinical medical students (CMS) according to their grades. Read More

View Article and Full-Text PDF

Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.

J Clin Invest 2021 Jun;131(12)

Cancer cells reprogram lipid metabolism during their malignant progression, but limited information is currently available on the involvement of alterations in fatty acid synthesis in cancer development. We herein demonstrate that acetyl-CoA carboxylase 1 (ACC1), a rate-limiting enzyme for fatty acid synthesis, plays a critical role in regulating the growth and differentiation of leukemia-initiating cells. The Trib1-COP1 complex is an E3 ubiquitin ligase that targets C/EBPA, a transcription factor regulating myeloid differentiation, for degradation, and its overexpression specifically induces acute myeloid leukemia (AML). Read More

View Article and Full-Text PDF

Pathological and Immunohistochemical Microscopy of Natural Cases of Canine and Feline Neoplastic Mammary Lesions.

Microsc Microanal 2021 Jun 15:1-13. Epub 2021 Jun 15.

Pathology Department, Faculty of Veterinary Medicine, Alexandria University, Edfina22758, Egypt.

Mammary cancer is the second most common tumor worldwide. Small animal mammary neoplasms provide an outstanding model to study cancer in humans, as tumors in both share a similar environment, histopathologic features, and biological behavior. This study aims to investigate the percentage and microscopy of breast tumors in affected dogs and cats; its relationship to breed, age, and sex; and the immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PR), Ki-67, and cytokeratin 8. Read More

View Article and Full-Text PDF

A novel nomogram with preferable capability in predicting the overall survival of patients after radical esophageal cancer resection based on accessible clinical indicators: A comparison with AJCC staging.

Cancer Med 2021 Jun 15. Epub 2021 Jun 15.

Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: Esophageal cancer (EC) is a malignant tumor with high mortality. Nomogram is an important tool used in clinical prognostic assessment. We aimed to establish a novel nomogram to predict the overall survival (OS) of EC patients after radical esophagectomy. Read More

View Article and Full-Text PDF

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review.

Head Neck Pathol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pathology, School of Medicine, Hospital Universitário Antônio Pedro, Federal Fluminense University, Av. Marquês do Paraná, 303, 4ºandar, sala 01, Centro, Niterói, RJ, 24033-900, Brazil.

Dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC) form a spectrum of rare benign and malignant odontogenic neoplasms, respectively. The aim of this study was to perform a comparative systematic review of the clinicopathological, genetic, therapeutic, and prognostic features of DGCT and GCOC. The electronic search was performed until December 2020 on seven electronic databases. Read More

View Article and Full-Text PDF

Myoepithelial Carcinoma Ex-Pleomorphic Adenoma: A Rare Pathology Misdiagnosed as Pleomorphic Adenoma; With a Novel TERT Promoter Mutation and High PD-L1 Expression.

Head Neck Pathol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pathology, University of New Mexico School of Medicine, University of New Mexico, MSC08 4640, Albuquerque, NM, 87131, USA.

Myoepithelial carcinoma (MECA) is a rare salivary gland (SG) neoplasm (0.1-0.45% of all SG tumors) that often presents with bland cytomorphology and can be misclassified as cellular pleomorphic adenoma (PA) or myoepithelioma. Read More

View Article and Full-Text PDF

The paradigm of hematological malignant versus non-malignant manifestations, driven by primary immunodeficiencies: a complex interplay.

Fam Cancer 2021 Jun 15. Epub 2021 Jun 15.

Department of Pediatric Hematology-Oncology, "Aghia Sophia" Children's Hospital, Thivon 1 & Papadiamantopoulou, 11527, Athens, Greece.

Hematological malignancies (HM) developed on underlying primary immunodeficiencies (PID) are rare and of unusual features. Differentiating between malignant and non-malignant lymphoproliferation in cases of pediatric hematology and oncology and revealing their molecular predisposition demonstrate the complex interplay between PID and HM. We retrospectively studied a case series of seven pediatric patients, all with PID with manifestations raising suspicion for HM or hypereosinophilic syndrome (HES) or confirmed HM of lymphoid origin. Read More

View Article and Full-Text PDF

Identification of epigenetic regulators in the estrogen signaling pathway siRNA screening.

Mol Omics 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. and University of Chinese Academy of Sciences, Beijing 100049, China and Institute of Environment and Health, Jianghan University, Wuhan 430056, China.

Breast cancer is the most prevalent malignant disease among women across the globe. Notably, estrogen signaling plays a vital role in the progression of estrogen receptor-positive breast cancer. Therefore, targeting epigenetic regulators is a promising therapy for cancer. Read More

View Article and Full-Text PDF

[Cardiac arrest under special circumstances].

Notf Rett Med 2021 Jun 10:1-77. Epub 2021 Jun 10.

Southmead Hospital, North Bristol NHS Trust, Bristol, Großbritannien.

These guidelines of the European Resuscitation Council (ERC) Cardiac Arrest under Special Circumstances are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. This section provides guidelines on the modifications required for basic and advanced life support for the prevention and treatment of cardiac arrest under special circumstances; in particular, specific causes (hypoxia, trauma, anaphylaxis, sepsis, hypo-/hyperkalaemia and other electrolyte disorders, hypothermia, avalanche, hyperthermia and malignant hyperthermia, pulmonary embolism, coronary thrombosis, cardiac tamponade, tension pneumothorax, toxic agents), specific settings (operating room, cardiac surgery, cardiac catheterization laboratory, dialysis unit, dental clinics, transportation [in-flight, cruise ships], sport, drowning, mass casualty incidents), and specific patient groups (asthma and chronic obstructive pulmonary disease, neurological disease, morbid obesity, pregnancy). Read More

View Article and Full-Text PDF

Radiation-induced YAP activation confers glioma radioresistance via promoting FGF2 transcription and DNA damage repair.

Oncogene 2021 Jun 14. Epub 2021 Jun 14.

Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Although radiotherapy is a well-known effective non-surgical treatment for malignant gliomas, the therapeutic efficacy is severely limited due to the radioresistance of tumor cells. Previously, we demonstrated that Yes-associated protein (YAP) promotes glioma malignant progression. However, whether YAP plays a role in radioresistance and its potential value in cancer treatment are still unclear. Read More

View Article and Full-Text PDF

Higher cMET dependence of sacral compared to clival chordoma cells: contributing to a better understanding of cMET in chordoma.

Sci Rep 2021 Jun 14;11(1):12466. Epub 2021 Jun 14.

Division of Biomedical Research, Medical University Graz, Graz, Austria.

Chordomas are rare slow growing, malignant bone tumors of the axial skeleton with no approved medical treatment. As the majority of chordomas express cMET and its ligand, HGF, and crosstalks between EGFR and MET-signaling exist, we aimed to explore cMET activity in chordoma cell lines and clinical samples. We investigated nine chordoma patients and four chordoma cell lines for cMET expression. Read More

View Article and Full-Text PDF

A Case of Rapid Transformation from Hydatidiform Mole to Invasive Mole: The Importance of β-hCG (Human Chorionic Gonadotropin) Serum Levels in Follow-Up Evaluation.

Am J Case Rep 2021 Jun 15;22:e931156. Epub 2021 Jun 15.

Division of Pharmacology and Therapy, Department of Anatomy, Histology, and Pharmacology, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia.

BACKGROUND Gestational trophoblastic disease (GTD) is a spectrum of disorders consisting of premalignant (ie, complete [CHM] and partial hydatidiform moles [PHM]) and malignant conditions (ie, invasive moles, choriocarcinoma, placental site trophoblastic tumors, and epithelioid trophoblastic tumor). If GTD persists after initial treatment and has persistent elevated beta human chorionic gonadotropin (ß-hCG), it is referred to as post-molar gestational trophoblastic neoplasia (pGTN). To date, there is no detailed information regarding how fast invasive moles can develop from CHM. Read More

View Article and Full-Text PDF

Monoclonal B lymphocytosis in a kidney transplant recipient.

BMJ Case Rep 2021 Jun 14;14(6). Epub 2021 Jun 14.

Department of Surgical, Medical, Dental and Morphological Sciences, Università degli Studi di Modena e Reggio Emilia, Modena, Emilia-Romagna, Italy.

Monoclonal B lymphocytosis (MBL) is a lymphoproliferative condition characterised by expansion of a B-cell clone in peripheral blood, with an often indolent clinical course. The presence of a B clonal population alone is several hundred times more common in the general population than chronic lymphocytic leukaemia and other non-Hodgkin's lymphoma subtypes, it usually does not represent a malignant condition and it requires follow-up only, without specific treatment. There are few studies describing MBL in solid organ transplant recipients, thus, the concern is raised when enrolling MBL affected subjects in waiting lists. Read More

View Article and Full-Text PDF

Malignant struma ovarii with late recurrence harbouring high microsatellite instability.

BMJ Case Rep 2021 Jun 14;14(6). Epub 2021 Jun 14.

Monter Cancer Center, Medical Oncology and Hematology, Northwell Health, Lake Success, New York, USA

Struma ovarii (SO) is a rare ovarian teratoma containing abundant mature thyroid tissue. Malignant transformation is even less common and distant metastasis is documented in about 5%-10%. The time from diagnosis of primary SO to metastatic disease varies. Read More

View Article and Full-Text PDF

Effect of multimorbidity patterns on the decline in health-related quality of life: a nationwide prospective cohort study in Japan.

BMJ Open 2021 06 14;11(6):e047812. Epub 2021 Jun 14.

Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan

Objectives: Longitudinal studies, which consider multimorbidity patterns, are useful for better clarifying the effect of multimorbidity on health-related quality of life (HRQoL) and for identifying the target population with poorer clinical outcomes among patients with multimorbidity. This study aimed to examine the effects of different multimorbidity patterns on the decline in HRQoL.

Design: Nationwide prospective cohort study. Read More

View Article and Full-Text PDF

Accuracy of Frozen Section Analysis of Urethral and Ureteral Margins During Radical Cystectomy for Bladder Cancer: A Systematic Review and Diagnostic Meta-Analysis.

Eur Urol Focus 2021 Jun 11. Epub 2021 Jun 11.

Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

Context: The question of the ability of frozen section analysis (FSA) to accurately detect malignant pathology intraoperatively has been discussed for many decades.

Objective: We aimed to conduct a systematic review and meta-analysis assessing the diagnostic estimates of FSA of the urethral and ureteral margins in patients treated with radical cystectomy (RC) for bladder cancer (BCa).

Evidence Acquisition: The MEDLINE and EMBASE databases were searched in February 2021 for studies analyzing the association between FSA and the final urethral and ureteral margin status in patients treated with RC for BCa. Read More

View Article and Full-Text PDF

Characterization of Suspicious Microcalcifications on Mammography Using 2D Shear-Wave Elastography.

Ultrasound Med Biol 2021 Jun 11. Epub 2021 Jun 11.

Department of Pathology, Gaziosmanspasa Education and Research Hospital, Gaziosmanpasa, Istanbul, Turkey.

Our aim was to investigate the correlations between the findings of two-dimensional shear-wave elastography (2D-SWE) and the histopathologic results of microcalcifications (MCs) visualized using ultrasonography (USG). Fifty people with suspicious MCs without accompanying mass were evaluated. They underwent USG and 2D-SWE before USG-guided tru-cut biopsy. Read More

View Article and Full-Text PDF