498,673 results match your criteria males received


Dexamethasone is associated with early deaths in light chain amyloidosis patients with severe cardiac involvement.

PLoS One 2021 15;16(9):e0257189. Epub 2021 Sep 15.

The French Cardiac Amyloidosis Reference Center, GRC Amyloid Research Institute, Réseau amylose Mondor, and DHU A-TVB, Créteil, France.

Background: Cardiac light chain amyloidosis (AL-CA) patients often die within three months of starting chemotherapy. Chemotherapy for non-immunoglobulin M gammopathy with AL-CA frequently includes bortezomib (Bor), cyclophosphamide (Cy), and dexamethasone (D). We previously reported that NT-ProBNP levels can double within 24h of dexamethasone administration, suggesting a deleterious impact on cardiac function. Read More

View Article and Full-Text PDF
September 2021

The Online Life Story Book: A randomized controlled trial on the effects of a digital reminiscence intervention for people with (very) mild dementia and their informal caregivers.

PLoS One 2021 15;16(9):e0256251. Epub 2021 Sep 15.

Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.

This paper describes a randomized controlled trial on the Online Life Story Book (OLSB), a digital reminiscence intervention for people with (very) mild dementia living at home. The aim of the study was to investigate the effectiveness of the OLSB on (i) neuropsychiatric symptoms (NPS) in persons with dementia and (ii) the distress and quality of life (QOL) of primary informal caregivers. A randomized controlled trial with individual randomization to one of two conditions was conducted: 1) intervention "Online Life Story Book"; 2) wait list control condition. Read More

View Article and Full-Text PDF
September 2021

Paraprobiotic Lacticaseibacillus rhamnosus Protects Intestinal Damage in an Experimental Murine Model of Mucositis.

Probiotics Antimicrob Proteins 2021 Sep 15. Epub 2021 Sep 15.

Programa de Pós-Graduação Em Nutrição E Saúde, Departamento de Nutrição, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Intestinal mucositis (IM) is a common side effect resulting from cancer treatment. However, the management so far has not been very effective. In the last years, the role of the gut microbiota in the development and severity of mucositis has been studied. Read More

View Article and Full-Text PDF
September 2021

Evaluation of Community-Level Vulnerability and Racial Disparities in Living Donor Kidney Transplant.

JAMA Surg 2021 Sep 15. Epub 2021 Sep 15.

Comprehensive Transplant Institute, University of Alabama at Birmingham.

Importance: Living donor kidney transplant (LDKT) is the ideal treatment for end-stage kidney disease, but racial disparities in LDKT have increased over the last 2 decades. Recipient clinical and social factors do not account for LDKT racial inequities, although comprehensive measures of community-level vulnerability have not been assessed.

Objective: To determine if racial disparities persist in LDKT independent of community-level vulnerability. Read More

View Article and Full-Text PDF
September 2021

CARDIOTOXIC EFFECTS OF THE ANTINEOPLASTIC DOXORUBICIN IN A MODEL OF METABOLIC SYNDROME: OXIDATIVE STRESS AND TRANSPORTERS EXPRESSION IN THE HEART.

J Cardiovasc Pharmacol 2021 Sep 8. Epub 2021 Sep 8.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Ciencias Biológicas, Cátedra de Fisiología, Instituto de Química y Metabolismo del Fármaco, CONICET, Ciudad Autónoma de Buenos Aires, Argentina Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Ciencias Biológicas, Cátedra de Anatomía e Histología, Ciudad Autónoma de Buenos Aires, Argentina. Universidad de Buenos Aires, Instituto Alberto C. Taquini de Investigaciones en Medicina Traslacional (IATIMET), CONICET, Ciudad Autónoma de Buenos Aires, Argentina. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Instituto de Investigaciones Farmacológicas, CONICET, Ciudad Autónoma de Buenos Aires, Argentina.

Abstract: The aim of the present work was to examine whether metabolic syndrome-like conditions in rats with fructose (F) overload modify the cardiotoxic effects induced by doxorubicin (DOX) and whether the treatment altered the expression of P-gp, BCRP and OCTN transporters in the heart. Male Sprague-Dawley rats received either tap water (C, control group; n=16) or water with F 10% w/v (n=16) during eight weeks. Three days before sacrifice, the animals received a single dose of DOX (6 mg/kg, ip, md) (C-DOX and F-DOX groups) or vehicle (VEH; ISS 1ml/kg BW; ip) (C-VEH and F-VEH groups) (n=8 per group). Read More

View Article and Full-Text PDF
September 2021

Treatment with angiotensin receptor neprilysin inhibitor for Taiwan heart failure patients: Rationale and baseline characteristics of the TAROT-HF study.

J Chin Med Assoc 2021 Sep;84(9):833-841

Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.

Background: This study used a real-world database to investigate the prescription patterns of sacubitril/valsartan (Sac/Val) among Taiwanese patients with heart failure with reduced ejection fraction (HFrEF).

Methods: The Treatment with Angiotensin Receptor neprilysin inhibitor fOr Taiwan Heart Failure patients (TAROT-HF) study is a principal investigator-initiated, multicenter, observational, retrospective study on Taiwanese HFrEF patients. A total of 1772 patients with HFrEF (mean age 62. Read More

View Article and Full-Text PDF
September 2021

Evaluating a Middle-School Digital Citizenship Curriculum (Screenshots): Quasi-Experimental Study.

JMIR Ment Health 2021 Sep 15;8(9):e26197. Epub 2021 Sep 15.

Media Power Youth, Manchester, NH, United States.

Background: Screenshots is an in-school curriculum that seeks to develop positive digital social skills in middle school students with the long-term goal of improving their health and well-being. The program imparts knowledge and teaches skills upon which young adolescents can build a set of beliefs and behaviors that foster respectful interactions, prosocial conflict resolutions, and safe and secure use of communication technology. Intervening in this way can improve young people's mental health by limiting their exposure to cyberbullying and other forms of negative online interactions. Read More

View Article and Full-Text PDF
September 2021

Diabetes Technology Use in Remote Pediatric Patients with Type 1 Diabetes Using Clinic-to-Clinic Telemedicine.

Diabetes Technol Ther 2021 Sep 15. Epub 2021 Sep 15.

University of Colorado - Anschutz Medical Campus, 129263, Barbara Davis Center for Diabetes, 1775 Aurora Court, Aurora, Colorado, United States, 80045-2559;

Background: Clinic-to-clinic telemedicine can increase visit frequency in pediatric patients with type 1 diabetes (T1D) living far from a diabetes specialty clinic, but the impact on adoption of diabetes technology is unclear.

Methods: Pediatric patients with T1D in Colorado and surrounding states who received diabetes care using clinic-to-clinic telemedicine were enrolled. Medical records and surveys were reviewed to ascertain technology use, and data were compared to patients from the main clinic population. Read More

View Article and Full-Text PDF
September 2021

A phase I study to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of ocular GLH8NDE in healthy male adults.

Clin Transl Sci 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea.

GLH8NDE, a derivative of eupatilin, is currently under development to treat dry eye disease. We conducted a randomized, double-masked, placebo-controlled, single- and multiple-day study to evaluate safety, tolerability, pharmacodynamics, and pharmacokinetics of ocular GLH8NDE in healthy male adults. Subjects randomly received topical ocular dosing of GLH8NDE or its matching placebo for a day, then for 7 consecutive days with a 62-h washout at one of the following daily doses: 9, 18, 36 (Koreans), and 36 mg (Whites). Read More

View Article and Full-Text PDF
September 2021

Original Designed Uniportal-Bichannel Spinal Endoscopic System (UBiSES) for Foraminoplasty in Percutaneous Endoscopic Transforaminal Discectomy.

Orthop Surg 2021 Sep 15. Epub 2021 Sep 15.

Orthopaedics Department, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Objective: The study introduced uniportal-bichannel spinal endoscopic system (UBiSES) and explored the feasibility of applying UBiSES to conduct lumbar foraminoplasty in percutaneous endoscopic transforaminal discectomy (PETD).

Methods: This is a cohort study. 36 patients confirmed as L5/S1 lumbar disc herniation (LDH) in our hospital from March, 2019 to November, 2019 were enrolled. Read More

View Article and Full-Text PDF
September 2021

Quercetin improves myocardial redox status in rats with type 2 diabetes.

Endocr Regul 2021 Sep 13;55(3):142-152. Epub 2021 Sep 13.

V. Danilevsky Institute for Endocrine Pathology Problems, National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine.

Emerging data indicate that oxidative stress is closely associated with the pathogenesis of cardiovascular disease in type 2 diabetes mellitus (T2DM). The present study aimed to assess the effect of the most abundant flavonoid in the human diet quercetin (Q) on the myocardial redox status in rats with T2DM. T2DM was induced in male Wistar rats by a high caloric diet (for 14 weeks) and two streptozotocin (25 mg/kg b. Read More

View Article and Full-Text PDF
September 2021

[Comparison of refracture risk between sandwich vertebrae and ordinary adjacent vertebrae].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1161-1166

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Objective: To compare the refracture risk between sandwich vertebrae and ordinary adjacent vertebrae, and to explore the risk factors related to refracture.

Methods: Retrospective analysis was performed on the data of patients who received percutaneous vertebral augmentation (PVA) and formed sandwich vertebrae between April 2015 and October 2019. Of them, 115 patients were enrolled in the study. Read More

View Article and Full-Text PDF
September 2021

A Western diet with alcohol in drinking water model recapitulates features of alcohol-associated liver disease in mice.

Alcohol Clin Exp Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Internal Medicine, University of Kansas, Medical Center, Kansas City, KS, 66160, U.S.A.

Background: Mouse models of alcohol-associated liver disease vary greatly in their ease of implementation and the pathology they produce. This ranges from steatosis and mild inflammation in Lieber-DeCarli liquid diet, and severe inflammation, fibrosis and pyroptosis seen in the Tsukamoto-French intragastric feeding model. Implementation of all these models is limited by the labor-intensive nature of the protocols and the specialized skills necessary for successful intragastric feeding. Read More

View Article and Full-Text PDF
September 2021

Surgical Management of Patients with Snakebite-Related Musculoskeletal Complication-A Single Institution Experience in Cambodia.

World J Surg 2021 Sep 14. Epub 2021 Sep 14.

Children's Surgical Centre, Phnom Penh, Cambodia.

Background: Snakebite-related injury is a serious public health issue. In Cambodia, it is estimated that up to 21,500 cases of envenoming occurs from snakebites annually. Musculoskeletal disability is a major long-term complication associated with the injury. Read More

View Article and Full-Text PDF
September 2021

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART).

EClinicalMedicine 2021 Oct 5;40:101116. Epub 2021 Sep 5.

Department of Internal Medicine I, University Hospital Frankfurt, Germany.

Background: De novo steatosis is the main criteria for non-alcoholic fatty liver disease (NAFLD), which is becoming a clinically relevant comorbidity in HIV-infected patients. This may be due to the HIV virus itself, as well as long-term toxicities deriving from antiretroviral therapy. Therefore, HIV infected patients require prevention and monitoring regarding NAFLD. Read More

View Article and Full-Text PDF
October 2021

The potential impact of vaccine passports on inclination to accept COVID-19 vaccinations in the United Kingdom: Evidence from a large cross-sectional survey and modeling study.

EClinicalMedicine 2021 Sep 9:101109. Epub 2021 Sep 9.

School of Psychology & Neuroscience, University of St Andrews, St Andrews, United Kingdom.

Background: The UK Government is considering the introduction of vaccine passports for domestic use and to facilitate international travel for UK residents. Although vaccine incentivisation has been cited as a motivating factor for vaccine passports, it is unclear whether vaccine passports are likely to increase inclination to accept a COVID-19 vaccine.

Methods: We conducted a large-scale national survey in the UK of 17,611 adults between 9 and 27 April 2021. Read More

View Article and Full-Text PDF
September 2021

Spectrum of Renal Lesions on Autopsy: Experience of a Tertiary Level Institute Based on Retrospective Histopathological Analysis.

Cureus 2021 Aug 10;13(8):e17064. Epub 2021 Aug 10.

Pathology, Dr Baba Saheb Ambedkar (BSA) Medical College and Hospital, New Delhi, IND.

Introduction: Last few decades have seen a remarkable increase in the elderly population. Aging is an established risk factor for chronic kidney diseases associated with increased mortality and morbidity. The frequency and spectrum of renal pathology on autopsy specimen is not well documented and is often overlooked by physicians as well as forensic pathologists. Read More

View Article and Full-Text PDF

Reporting at Least One Adverse Effect Post-COVID-19 Vaccination From Primary Health Care in Muscat.

Cureus 2021 Aug 10;13(8):e17055. Epub 2021 Aug 10.

Medicine, Al Nahdha Hospital, Muscat, OMN.

Introduction Vaccinations against COVID-19 were licensed with limited testing assurances to the public triggering a widespread hesitancy around expected adverse reactions. Limited data was reported from Arabian Gulf countries on vaccine adverse effects. Objectives This study looked at the rate of reporting at least one side effect post-COVID-19 vaccination and its associated factors (sociodemographic characteristics, clinical condition, and type of vaccines). Read More

View Article and Full-Text PDF

Hypocalcemia in a Patient With Metastatic Prostate Cancer From Denosumab Treatment.

Cureus 2021 Aug 10;13(8):e17046. Epub 2021 Aug 10.

Hematology / Oncology, Bassett Medical Center, Cooperstown, USA.

Denosumab is a humanized monoclonal antibody that binds RANKL to inhibit osteoclast activity. It is indicated for the prevention of skeletal-related events (SRE) in patients with solid tumors who have bone metastasis and in patients with multiple myeloma. Hypocalcemia is one of the known side effects of denosumab, which can be prevented with calcium supplementation. Read More

View Article and Full-Text PDF

Efficacy of Thiamine and Medical Management in Treating Hyperuricemia in AUD Patients with ALD: Role of Hyperuricemia in Liver Injury, Gut-Barrier Dysfunction, and Inflammation.

Clin Exp Pharmacol 2021 28;11(Suppl 7). Epub 2021 Jul 28.

Department of Medicine, University of Louisville, Louisville, Kentucky.

Background: Hyperuricemia has been reported in liver injury; however its role in the early stage of Alcohol-associated Liver Disease (ALD) has not been examined yet. This study investigated the role of Serum Uric Acid (SUA) in alcohol-related liver disease, gut barrier dysfunction, and inflammation activity. This study also evaluated the efficacy of abstinence, treatment with thiamine and medical management to alleviate hyperuricemia. Read More

View Article and Full-Text PDF

Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation.

Theranostics 2021 19;11(18):8964-8976. Epub 2021 Aug 19.

Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.

Modulation of the innate immune system is emerging as a promising therapeutic strategy against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect are ill-understood. Thus, we investigated the potential of 18 kDa translocator protein positron-emission-tomography (TSPO-PET) for assessment of microglial activation in mouse brain before and during chronic immunomodulation. Read More

View Article and Full-Text PDF

Antidiabetic potential of the isolated fractions from the plants of Rosaceae family in streptozotocin-induced diabetic rats.

Res Pharm Sci 2021 Oct 19;16(5):505-515. Epub 2021 Aug 19.

Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.

Background And Purpose: Diabetes is a group of multifactorial disorders characterized by chronic-elevated blood glucose levels (hyperglycemia). Natural remedies are used as alternative medications to treat diabetes. Here, we tested the protective effect of the plant extracts of the Rosaceae family on improving insulin secretion and repairing the pancreatic beta cells in diabetic rats. Read More

View Article and Full-Text PDF
October 2021

[Case Report of Four Patients Received Ramucirumab Monotherapy as Second-Line Chemotherapy for Advanced Gastric Cancer].

Gan To Kagaku Ryoho 2021 Sep;48(9):1169-1171

Dept. of Gastroenterology, Muroran City General Hospital.

Ramucirumab monotherapy is one of the conditionally recommended regimens in second-line chemotherapy for advanced gastric cancer. However, there are few clinical data on ramucirumab monotherapy in Japanese patients. Herein, we present 4 case reports of advanced gastric cancer patients who received ramucirumab monotherapy. Read More

View Article and Full-Text PDF
September 2021

Reasons for canakinumab initiation among patients with periodic fever syndromes: a retrospective medical chart review from the United States.

Pediatr Rheumatol Online J 2021 Sep 14;19(1):143. Epub 2021 Sep 14.

Division of Pediatric Rheumatology, Children's Hospital Medical Center, MLC 4010, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

Background: Although canakinumab has demonstrated efficacy in multiple trials in patients with periodic fever syndromes (PFS), the evidence on initiation of canakinumab among PFS patients in real world setting is not well understood. We aimed to characterize the reasons for canakinumab initiation among patients with PFS, specifically, cryopyrin-associated periodic syndrome (CAPS), hyperimmunoglobulin D syndrome/mevalonate kinase deficiency (HIDS/MKD), TNF receptor-associated periodic syndrome (TRAPS) and familial Mediterranean fever (FMF).

Methods: Physicians retrospectively reviewed the medical charts of PFS patients prescribed canakinumab between 2016 and 2018. Read More

View Article and Full-Text PDF
September 2021

A potential mechanism of the onset of immune-related pneumonitis triggered by anti-PD-1 treatment in a patient with advanced adenocarcinoma lung cancer: case report.

BMC Pulm Med 2021 Sep 14;21(1):291. Epub 2021 Sep 14.

Department of Respiratory Medicine, Shanghai East Hospital, Affiliated to Tongji University, Shanghai, 200120, China.

Background: In recent years, the application of immunotherapy combined with chemotherapy in the first-line lung cancer has showed significant benefit in improving long-term survival. Immunotherapy also has risks of immune-related pneumonitis (IRP) after long-term treatment. Despite the treatment strategy of the IRP has been very clear. Read More

View Article and Full-Text PDF
September 2021

[High frequency ultrasound combined with ultrasound-guided core needle biopsy for the diagnosis of primary thyroid lymphoma].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Aug;56(8):858-862

Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou 310016, China.

To investigate the sonographic features of primary thyroid lymphoma (PTL) and to evaluate the clinical significance of ultrasound-guided core needle biopsy (US-CNB) in PTL. A total of 24 patients with suspected PTL in Sir Run Run Shaw Hospital from January 2013 to June 2018 were analyzed retrospectively. All cases were confirmed by pathology, of them 23 patients received US-CNB and 1 patient chose operation without US-CNB, including 5 males and 19 females, aged from 39 to 75 years old. Read More

View Article and Full-Text PDF

[Prediction of perioperative hyperkalemia in dialysis patients with secondary hyperparathyroidism].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Aug;56(8):854-857

Department of Otorhinolaryngology Head and Neck Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510030, China.

To explore the influencing factors for serum potassium >4.4 mmol/L in the morning of parathyroidectomy in hemodialysis patients with secondary hyperparathyroidism (SHPT). The clinical data of 72 patients with SHPT who received regular hemodialysis and underwent parathyroidectomy in Guangdong Provincial People's Hospital from January 2012 to December 2018 were analyzed retrospectively. Read More

View Article and Full-Text PDF

[Parathyroid hormone assay with eluent of aspirated tissues in parathyroidectomy].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Aug;56(8):844-847

Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430060, China.

To explore the values of intraoperative fine-needle aspiration (IFNA) and parathyroid hormone (PTH) detection in the eluate of aspirated tissue during parathyroidectomy. Fifty-four patients with secondary hyperparathyroidism (SHPT) including 24 males and 30 females, aged 20-83 years, admitted to Zhongnan Hospital of Wuhan University from January 2019 to October 2019, were included. All patients received subtotal parathyroidectomy with autologous transplantation, during surgery, IFNA and PTH detection in the eluate of aspirated tissue were performed, and also routine postoperative pathological examination was performed. Read More

View Article and Full-Text PDF

[Studies on efficacy of a bioabsorbable steroid-eluting sinus stent in the frontal sinus opening of chronic rhinosinusitis with nasal polyps].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Aug;56(8):824-829

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, Shanghai 200433, China.

To assess the efficacy of a bioabsorbable steroid-eluting sinus stent in improving surgical outcomes when placed in the frontal sinus ostium (FSO) following full endoscopic sinus surgery (ESS) in patients with whole group chronic rhinosinusitis with nasal polyps (CRSwNP). Patients with whole group CRSwNP who had similar lesions on bilateral sinus between September 2019 and March 2020 in Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Changhai Hospital were chosen. Patients with CRSwNP who underwent extended ESS were randomly assigned to receive a steroid-eluting sinus stent in one FSO whereas the contralateral side received surgery alone. Read More

View Article and Full-Text PDF

Accumulation of the Major Components from Polygoni Multiflori Radix in Liver and Kidney after Its Long-Term Oral Administrations in Rats.

Planta Med 2021 Sep 14. Epub 2021 Sep 14.

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong SAR, P. R. China.

Although Polygoni Multiflori Radix (PMR) has been widely used as a tonic and an anti-aging remedy for centuries, the extensively reported hepatotoxicity and potential kidney toxicity hindered its safe use in clinical practice. To better understand its toxicokinetics, the current study was proposed, aiming to evaluate the biodistributions of the major PMR components including 2,3,5,4'-tetrahydroxystilbene-2---D-glucopyranoside (TSG), emodin, emodin-8---D-glucopyranoside (EMG) and physcion as well as their corresponding glucuronides following bolus and multiple oral administrations of PMR to rats. Male Sprague-Dawley rats received a bolus dose or 21 days of oral administrations of PMR concentrated granules at 4. Read More

View Article and Full-Text PDF
September 2021