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Comparison of the effect of citalopram, bupropion, sertraline, and tricyclic antidepressants on QTc: A cross-sectional study.

J Affect Disord 2021 Sep 3;296:476-484. Epub 2021 Sep 3.

Pharmacy Department (119A), Battle Creek Veterans Affairs Medical Center, 5500 Armstrong Road, Battle Creek, MI, USA.

Background: Some data suggests that citalopram has more risk of corrected QT interval (QTc) prolongation than other selective serotonin reuptake inhibitors. Consequently the U.S. Read More

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September 2021

Virtual preoperative assessment in surgical patients: A systematic review and meta-analysis.

J Clin Anesth 2021 Oct 11;75:110540. Epub 2021 Oct 11.

Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada. Electronic address:

Study Objective: Preoperative assessment is a standard evaluation, traditionally done in-person in a preanesthesia clinic, for patients who will be undergoing a procedure involving anesthesia. Given the increased adoption of virtual care during the coronavirus disease 2019 (COVID-19) pandemic, the purpose of this systematic review and meta-analysis is to review the effectiveness of virtual preoperative assessment for the evaluation of surgical patients.

Design: Systematic review and meta-analysis. Read More

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October 2021

Investigating ABCD1 mutations in a Taiwanese cohort with hereditary spastic paraplegia phenotype.

Parkinsonism Relat Disord 2021 Oct 9;92:7-12. Epub 2021 Oct 9.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:

Background: Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disorder caused by mutations in the ABCD1 gene. The clinical manifestations of ALD vary widely with some patients presenting with adrenomyeloneuropathy (AMN) that resembles the phenotype of hereditary spastic paraplegia (HSP). The aim of this study is to investigate the frequency, spectrum, and clinical features of ABCD1 mutations in Taiwanese patients with HSP phenotype. Read More

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October 2021

Intracranial tuberculomas: A case report of clinical, radiological, and pathological characteristics.

Int J Surg Case Rep 2021 Oct 8;88:106477. Epub 2021 Oct 8.

Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Alfaisal University, Riyadh, Saudi Arabia.

Background: Intracranial tuberculomas are uncommon yet devastating forms of extrapulmonary tuberculosis with a high mortality rate and morbidity risk. A high level of suspicion is required for a prompt diagnosis and treatment.

Case Description: A 67-year-old male, medically free, presented at the Emergency Department with a 1-day history of nausea and vomiting, and a 15-day history of imbalance and dizziness. Read More

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October 2021

Development of a 2-step algorithm to identify emergency department patients for HIV pre-exposure prophylaxis.

Am J Emerg Med 2021 Oct 6;51:6-12. Epub 2021 Oct 6.

Department of Emergency Medicine, Highland Hospital, Alameda Health System, Oakland, CA, United States of America.

Background: Expanded access to HIV PrEP is a central pillar of the "Ending the HIV Epidemic" initiative. Identification of PrEP eligible individuals in EDs remains understudied. Our goal was to estimate the accuracy of the Denver HIV Risk Score (DHRS), a quantitative HIV risk tool, for determining PrEP eligibility, and to incorporate it into a novel screening algorithm to optimize sensitivity and specificity. Read More

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October 2021

Preeclampsia-like syndrome in a pregnant patient with Coronavirus Disease 2019 (COVID-19).

J Obstet Gynaecol Can 2021 Oct 11. Epub 2021 Oct 11.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, ON, Canada.

Background: Hypertension, proteinuria, and hepatic dysfunction have been described as manifestations of coronavirus disease 2019 (COVID-19) and are generally accepted as poor prognostic factors. However, these same findings can also occur in pregnant women with preeclampsia, thus creating a diagnostic challenge.

Case: We report a case of COVID-19 infection in an otherwise healthy pregnant patient with secondary hypertension, proteinuria, and significant hepatic dysfunction. Read More

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October 2021

Clinical Predictors of Mortality in Patients with Moderate to Severe Mitral Regurgitation.

Am J Med 2021 Oct 11. Epub 2021 Oct 11.

Division of Cardiovascular Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon. Electronic address:

Background: Mitral regurgitation is the most common form of valvular heart disease worldwide, however, there is an incomplete understanding of predictors of mortality in this population. This study sought to identify risk factors of mortality in a real-world population with mitral regurgitation.

Methods: All patients with moderate or severe mitral regurgitation were identified at a single center from 1/1/16 to 8/31/17. Read More

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October 2021

Analysis of cartilage injury patterns and risk factors for knee joint damage in patients with primary lateral patella dislocations.

PLoS One 2021 14;16(10):e0258240. Epub 2021 Oct 14.

Center for Musculoskeletal Surgery, Charité -Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Lateral patellar dislocation (LPD) frequently causes damage to the knee. Injury patterns and risk factors contributing to such injuries have not yet been examined in detail.

Methods: We retrospectively analyzed 50 consecutive patients with primary LPD. Read More

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October 2021

Identification of plasma SAA2 as a candidate biomarker for the detection and surveillance of non-small cell lung cancer.

Neoplasma 2021 Oct 14. Epub 2021 Oct 14.

School of Life Science and Biopharmaceutical, Guangdong Pharmaceutical University, Guangzhou, China.

This study aimed to measure the expression of SAA2 in plasma and to assess its diagnostic efficacy as a biomarker for non-small cell lung cancer (NSCLC). The gene expression of SAA2 in NSCLC was analyzed based on a database. Then, SAA2 expression was detected by immunohistochemistry in lung tissue and by enzyme-linked immunosorbent assay in 90 patients with NSCLC and 61 normal controls. Read More

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October 2021

Outcomes of MCGR at > 3 year average follow-up in severe scoliosis: who undergoes elective revision vs UPROR?

Spine Deform 2021 Oct 14. Epub 2021 Oct 14.

Shriners Hospitals for Children, 3101 SW Sam Jackson Park Road, Portland, OR, 97229, USA.

Purpose: The purpose of this study was to evaluate mid-term outcomes of magnetically controlled growing rods (MCGR), evaluate factors associated with unplanned return to the operating room (UPROR) vs achieving full length. Full length was defined as achieving > 85% of the elongating portion of the rod.

Methods: IRB approved retrospective single site study. Read More

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October 2021

Talimogene Laherparepvec (T-VEC) for the Treatment of Advanced Locoregional Melanoma After Failure of Immunotherapy: An International Multi-Institutional Experience.

Ann Surg Oncol 2021 Oct 14. Epub 2021 Oct 14.

Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA.

Background: Talimogene laherparepvec (T-VEC) is an oncolytic virus approved for the treatment of unresectable, recurrent melanoma. The role of T-VEC after progression on systemic immunotherapy (IO) remains undefined. The goal of this study was to characterize the efficacy of T-VEC after failure of IO in patients with unresectable metastatic melanoma. Read More

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October 2021

Clinical features and long-term prognosis of patients with congestive heart failure taking tolvaptan: a comparison of patients with preserved and reduced left ventricular ejection fraction.

Heart Vessels 2021 Oct 14. Epub 2021 Oct 14.

Department of Cardiovascular Medicine, Nippon Medical School, 1-1-5 Bunkyo-ku, Sendagi, Tokyo, 113-0022, Japan.

Few studies have investigated the clinical benefit of the long-term use of tolvaptan (TLV) for heart failure (HF). This study evaluated the long-term prognosis of patients administered TLV for > 1 year among patients who had HF with preserved ejection fraction (HFpEF) and those who had HF with reduced ejection fraction (HFrEF). Overall, 591 consecutive patients were admitted to our hospital and administered TLV for HF between 2011 and 2018. Read More

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October 2021

Safety and Cost Effectiveness of Outpatient Surgery in Acute Burn Care.

J Burn Care Res 2021 Oct 14. Epub 2021 Oct 14.

Division of Plastic and Reconstructive Surgery, Department of Surgery, University of British Columbia, Vancouver, Canada.

Introduction: Outpatient burn surgery is increasingly utilized in acute burn care. Reports of its safety and efficacy are limited. This study aims to evaluate the safety and cost reduction associated with outpatient burn surgery and to describe our centre's experience. Read More

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October 2021

Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in recent 12 years: a single-center experience.

Endocr Connect 2021 Oct 1. Epub 2021 Oct 1.

X Zhang, Department of Endocrinology, Shandong University Qilu Hospital, Jinan, China.

The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. Read More

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October 2021

Successful management of tumor necrosis factor-alpha inhibitor-induced Sweet syndrome in a patient with ulcerative colitis: A case report.

Int J Clin Pharmacol Ther 2021 Oct 14. Epub 2021 Oct 14.

Tumor necrosis factor (TNF) α inhibitors are widely used to treat inflammatory bowel disease (IBD); however, some patients have unexpected inflammatory episodes during anti-TNF therapy. The objective of our research was to highlight a paradoxical case of anti-TNF-agent-induced Sweet syndrome compared with Sweet syndrome treated by anti-TNF agents. We describe a 62-year-old male with a history of ulcerative colitis presenting with multiple polymorphic indurated skin macules and plaques after 2 months of adalimumab therapy. Read More

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October 2021

Severe cisplatin-induced renal toxicity in a patient with xeroderma pigmentosum.

J Oncol Pharm Pract 2021 Oct 14:10781552211038246. Epub 2021 Oct 14.

Cancer Care Services, Toowoomba Hospital, Australia.

Introduction: Xeroderma pigmentosum is a rare genetic disorder of DNA repair, defined by extreme sensitivity to sunlight, leading to sunburn, skin pigmentation and increased incidence of skin cancers. Cisplatin acts by interfering with DNA repair mechanisms to cause DNA damage and apoptosis. It has indications in many malignancies including bladder, head and neck and lung cancers. Read More

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October 2021

Tracheobronchography for pediatric airway disease is still a valuable technique?

Minerva Pediatr (Torino) 2021 Oct 14. Epub 2021 Oct 14.

UOC Radiologia, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Background: Congenital and acquired airway anomalies represent a relatively common albeit diagnostic and therapeutic challenge. Obtaining maximum definition of the abnormality is imperative prior to attempting surgical procedure because some tracheal lesions have a significant risk of mortality. Are Tracheobronchography (TBG) and Tracheobronchofluoroscopy (TBF) valuable or obsolete tecniques?

Methods: We retrospectively reviewed all the diagnostic and interventional TBG-TBF requested by the multidisciplinary conference, during the last 10 years in a tertiary care hospital exclusively dedicated to pediatric patients. Read More

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October 2021

Olfaction in COPD.

Rhinology 2021 Oct 14. Epub 2021 Oct 14.

Dept of Otolaryngology, Head and Neck Surgery, St. Olavs University Hospital, Trondheim, Norway.

Background: Olfaction is poorly characterized in COPD. To test the hypothesis that olfaction is reduced in COPD, we assessed olfaction with the "Sniffin' Sticks" test and a questionnaire addressing olfaction in COPD and a corresponding control group in respect to age and sex. We also explored whether there is an association between COPD, chronic rhinosinusitis without nasal polyps (CRSsNP), and other predefined covariates with olfactory function. Read More

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October 2021

Preexisting immune-mediated inflammatory disease is associated with improved survival and increased toxicity in melanoma patients who receive immune checkpoint inhibitors.

Cancer Med 2021 Oct 14. Epub 2021 Oct 14.

Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA.

Background: Immune-related adverse events (irAEs) are common, clinically significant autoinflammatory toxicities observed with immune checkpoint inhibitors (ICI). Preexisting immune-mediated inflammatory disease (pre-IMID) is considered a relative contraindication to ICI due to the risk of inciting flares. Improved understanding of the risks and benefits of treating pre-IMID patients with ICI is needed. Read More

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October 2021

Chylothorax caused by left atrial myxoma: A rare case report.

J Card Surg 2021 Oct 13. Epub 2021 Oct 13.

Department of Cardiothoracic Surgery, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan Central Hospital, Xiaogan, Hubei, PR China.

Background: Myxoma is the most common tumor of the heart that can cause embolism, obstruction, and cardiac failure, but rarely causes chylothorax. We herein report a case of chylothorax caused by left atrial myxoma, which responded to diuretic therapy and was subsequently cured by resecting cardiac myxoma.

Case Presentation: This is a case of a 63-year-old male with symptoms of cardiac insufficiency who was diagnosed with a left atrial myxoma. Read More

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October 2021

Assessment of Mortality Rate in 10 Years and the Associated Risk Factors in Schizophrenia.

Turk Psikiyatri Derg 2021 ;32(3):151-159

Objective: The aim of the study was to explore the mortality rate and the associated risks factors in patients with schizophrenia during a10- year follow up period.

Method: We searched the records of patients with schizophrenia receiving treatment as outpatients and/or inpatients in the psychiatric clinic of a university hospital between 2004 and 2008 and determine the survival of these patients by the end of 2018. The results were compared with the all cause mortality rate in the general population during the same period. Read More

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January 2021

Prognostic factors for refractory pheochromocytoma and paraganglioma after I-metaiodobenzylguanidine therapy.

Ann Nucl Med 2021 Oct 13. Epub 2021 Oct 13.

Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Objective: Given the rarity of refractory pheochromocytoma and paraganglioma (PPGL), outcomes and prognostic factors after I-metaiodobenzylguanidine (I-mIBG) treatment still remain unclear. Therefore, this study evaluated whether baseline characteristics at initial I-mIBG therapy and imaging response to repeated I-mIBG therapy could be prognostic factors for refractory PPGL.

Methods: All patients [n = 59 (male/female = 35/24), median age; 49. Read More

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October 2021

Prophylactic tamsulosin and urinary retention rates following elective colorectal surgery: a retrospective cohort study.

Int J Colorectal Dis 2021 Oct 13. Epub 2021 Oct 13.

Department of Surgery, Division of General Surgery, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

Purpose: Postoperative urinary retention (POUR) is a known morbidity after colorectal surgery. This study investigated the effect of prophylactic tamsulosin on urinary retention rates after colorectal surgery.

Methods: A retrospective cohort study of male patients 50 years or older undergoing elective colonic and rectal resections from May 2014 to November 2019 was performed. Read More

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October 2021

Decreased nitric oxide content mediated by asymmetrical dimethylarginine and protein L-arginine methyltransferase 3 in macrophages induces trophoblast apoptosis: a potential cause of recurrent miscarriage.

Hum Reprod 2021 Oct 14. Epub 2021 Oct 14.

Shanghai Key Laboratory of Maternal-Fetal Medicine, Clinical and Translational Research Center, Department of Biobank, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Study Question: Is the protein L-arginine methyltransferase 3 (PRMT3)/asymmetrical dimethylarginine (ADMA)/nitric oxide (NO) pathway involved in the development of recurrent miscarriage (RM), and what is the potential mechanism?

Summary Answer: Elevated levels of PRMT3 and ADMA inhibit NO formation in the decidua, thereby impairing the functions of trophoblast cells at the maternal-foetal interface.

What Is Known Already: Decreased NO bioavailability is associated with RM. ADMA, an endogenous inhibitor of nitric oxide synthase (NOS), is derived from the methylation of protein arginine residues by PRMTs and serves as a predictor of mortality in critical illness. Read More

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October 2021

Sternal elevation by the crane technique during pectus excavatum repair: A quantitative analysis.

JTCVS Tech 2021 Oct 17;9:167-175. Epub 2021 Jul 17.

Division of General Thoracic Surgery, Department of Surgery, Zuyderland Medical Center, Heerlen, The Netherlands.

Introduction: The crane technique is used to facilitate sternal elevation to provide safe mediastinal passage during the Nuss procedure. The aim was to objectively quantitate the elevation of the crane by 3-dimensional chest images acquired during the Nuss procedure.

Methods: A prospective cohort study was conducted. Read More

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October 2021

Found Down Extremity Compartment Syndrome Secondary to Substance Use: An Observational Multicenter Study.

JB JS Open Access 2021 Oct-Dec;6(4). Epub 2021 Oct 6.

Harvard Orthopaedic Trauma Initiative, Harvard Medical School, Boston, Massachusetts.

With the worsening opioid epidemic in America, more patients are developing found down extremity compartment syndrome (FDECS). The purpose of this study was to describe this patient population, including their presenting symptoms, laboratory test results, and clinical outcomes.

Methods: We performed a 2-center retrospective review of adult patients who developed FDECS secondary to substance use from January 2006 to December 2019. Read More

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October 2021

Case Report: Oral Cimetidine Administration Causes Drug-Induced Immune Hemolytic Anemia by Eliciting the Production of Cimetidine-Dependent Antibodies and Drug-Independent Non-specific Antibodies.

Front Med (Lausanne) 2021 24;8:723167. Epub 2021 Sep 24.

Department of Blood Transfusion, Dongguan Tungwah Hospital, Dongguan, China.

Previously, it was reported that multiple patients had hemolytic anemia associated with cimetidine administration, while only one patient who had received intravenous cimetidine was serologically diagnosed with drug-induced immune hemolytic anemia (DIIHA) caused by cimetidine-dependent antibodies. However, the ability of oral cimetidine intake to induce the production of antibodies has not been examined. In this study, we report a 44-year-old male patient in whom oral cimetidine administration resulted in cimetidine-dependent antibodies and drug-independent non-specific antibodies, leading to the development of DIIHA. Read More

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September 2021

Gender Discrepancies in SARS-CoV-2 Pandemic Related Beliefs, Attitudes, and Practices.

Front Public Health 2021 27;9:711460. Epub 2021 Sep 27.

Institute for Research and Innovation, MultiCare Health System, Tacoma, WA, United States.

International studies suggest that males may be less likely to adhere to SARS-CoV-2 transmission mitigation efforts than females. However, there is a paucity of research in this field in the United States. The primary aim of this study was to explore the relationship of binary gender identity (female/male) with beliefs, attitudes, and pandemic-related practices in the early stages of the pandemic. Read More

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October 2021

Testicular ischemia in patient with acute epididymitis: A rare case.

Urol Case Rep 2022 Jan 6;40:101882. Epub 2021 Oct 6.

Department Urology, Hasan Sadikin Academic Medical Center, Universitas Padjajaran, Bandung, Indonesia.

Testicular infarction and ischemia are rare complications of acute epididymitis. The condition is difficult to differentiate with testicular torsion clinically and radiologically. There are only a few cases that have been reported. Read More

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January 2022

Thrombotic microangiopathy triggered by podocytopathy.

Clin Nephrol Case Stud 2021 4;9:110-116. Epub 2021 Oct 4.

Nephrology Department, Hospital de Santa Cruz, Centro Hospitalar Lisboa Ocidental, Lisbon,and.

Thrombotic microangiopathy (TMA) is a rare group of diseases characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ damage. It can be divided into primary and secondary TMA. Herein we report a case of TMA associated to a primary glomerular disease. Read More

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October 2021