Can Vet J 2021 02;62(2):160-166
Tufts University, Cummings School of Veterinary Medicine, Department of Clinical Sciences, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Grady, Kakar); Colorado State University, College of Veterinary Medicine and Biomedical Science, Department of Microbiology, Immunology, and Pathology, 200 West Lake Street, Fort Collins, Colorado 80523 USA (Avery, Moore, Harris, Rout).
A restricted polyclonal or biclonal gammopathy resulting in bleeding tendencies was diagnosed in a young, neutered male English bulldog with concurrent splenomegaly, anemia, and severe elevations in IgM and, to a lesser degree, IgA immunoglobulins. There was a positive clinical response to treatment with prednisone and chlorambucil. This case bears similarity to a recently published syndrome of polyclonal gammopathy that is not neoplastic in origin in this breed. Read More