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Clinical analysis and a novel risk predictive nomogram for 155 adult patients with hemophagocytic lymphohistiocytosis.

Ann Hematol 2021 May 12. Epub 2021 May 12.

Department and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Recently, more and more attention has been paid on adult hemophagocytic lymphohistiocytosis (HLH), a disease with complicated symptoms and high mortality. In order to analyze the clinical characteristics and prediction risk factors of mortality, we designed a retrospective study with 1-year follow-up and included 155 patients admitted to Tongji Hospital diagnosed as HLH. One hundred seven patients formed the training cohort for nomogram development, and 48 patients formed the validation cohort to confirm the model's performance. Read More

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Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey.

Health Qual Life Outcomes 2021 May 7;19(1):140. Epub 2021 May 7.

Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, No.168, Litang Road, Changping District, Beijing, 102218, China.

Background: Health Related Quality of Life (HRQL) is a multi-dimensional construct that can comprehensively evaluate the patient's health status, including physical, emotional, mental and social well-being. In this study, we aimed to evaluate the impact of non-alcoholic fatty liver disease (NAFLD) on HRQL in a Chinese population.

Methods: In this national multicenter cross-sectional survey, patients with NAFLD were enrolled. Read More

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Long-Term Oncological Outcomes of Reduced Three-Port Laparoscopic Gastrectomy for Early-Stage Gastric Carcinoma: a Retrospective Large-Scale Multi-Institutional Study.

J Gastric Cancer 2021 Mar 26;21(1):93-102. Epub 2021 Mar 26.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: With advances in surgical techniques, reduced-port laparoscopic surgery is increasingly being performed for the treatment of gastric carcinoma. Many studies have reported satisfactory short-term outcomes after reduced 3-port laparoscopic gastrectomy (LG). The aim of this study was to investigate the long-term oncological outcomes of 3-port LG in patients with gastric carcinoma. Read More

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Psychological symptoms among healthcare workers handling COVID-19 patients.

Med J Malaysia 2021 03;76(2):138-144

Universiti Malaysia Sarawak, Faculty of Medicine and Health Sciences, Kota Samarahan, Sarawak, Malaysia.

Introduction: Healthcare workers serve as the frontliners against the coronavirus 2019 disease (COVID-19) and this puts them most at risk of infection as they attend to numerous patients with unknown status. This study aimed to examine stress, anxiety, and depression among healthcare workers caring for COVID-19 patients in Sarawak General Hospital (SGH), Malaysia.

Materials And Methods: This cross-sectional observational study conducted in SGH during the pandemic with an online self-administered questionnaire composed of two parts, the socio-demographic characteristics, and the Depression Anxiety Stress Scale (DASS). Read More

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Prophylactic transcatheter angiographic embolization reduces Forrest IIa ulcer rebleeding: A retrospective study.

Medicine (Baltimore) 2021 Mar;100(11):e23855

Department of Gastroenterology.

Abstract: The application of transcatheter angiographic embolization (TAE) is controversial in the treatment of ulcer bleeding. This study aims to determine rebleeding risk factors and evaluate the efficacy of prophylactic TAE (p-TAE) following endoscopic hemostasis in rebleeding prevention of Forrest lla ulcers.The medical records of Forrest lla ulcer patients who underwent endoscopic hemostasis (E group) and endoscopic hemostasis plus p-TAE (E + p-TAE group) in West China Hospital from May 2009 to May 2018 were retrospectively reviewed. Read More

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Care and treatments related to intensive care unit-acquired muscle weakness: A cohort study.

Aust Crit Care 2021 Mar 1. Epub 2021 Mar 1.

Bellvitge University Hospital, Hospitalet de Llobregat, Spain.

Background: Intensive care unit-acquired muscle weakness (ICUAW) has an incidence of 40-46%. Early mobilisation is known to be a protective factor.

Objective: The aim of the study was to identify the incidence of ICUAW in Spain and to evaluate variables likely to contribute to the development of ICUAW. Read More

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[Association between child care environment and childhood early development].

Zhonghua Er Ke Za Zhi 2021 Mar;59(3):175-180

Department of Developmental and Behavioral Pediatrics, MOE-Shanghai Key Laboratory of Environment and Child Health, Shanghai Children's Medical Center Afflilated Shanghai Jiao Tong University School of Medicine, National Children's Medical Center, Shanghai 200127, China.

To investigate the factors related to child care environment and the association between child care environment and children's early development. Using stratified cluster random sampling, a total of 22 509 children newly enrolled to kindergarten from 187 kindergartens of 16 districts in Shanghai in 2017 were enrolled. A survey was conducted by parent-reported questionnaire. Read More

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Edema-Mass Ratio Based On Magnetic Resonance Imaging As A Preoperative Diagnostic Factor For Posterior Fossa Metastasis.

Curr Med Imaging 2021 Mar 2. Epub 2021 Mar 2.

Katip Çelebi University, Medical Faculty, Department of Neurosurgery, Izmir. Turkey.

Background: Peritumoral edema of primary brain tumors is an important cause of morbidity and mortality. The number of studies currently available on the prognostic role of peritumoral brain edema in the posterior fossa is extremely limited.

Objective: Based on the known importance of magnetic resonance imaging in diagnosing supratentorial metastases, this study aimed to investigate the effects of peritumoral edema on survival of patients with posterior fossa metastases and the preoperative diagnostic value of MRI. Read More

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High flow oxygen and risk of mortality in patients with a suspected acute coronary syndrome: pragmatic, cluster randomised, crossover trial.

BMJ 2021 03 2;372:n355. Epub 2021 Mar 2.

Hauroa Tairāwhiti, Gisborne and Heart Foundation of New Zealand, Gisborn, New Zealand.

Objective: To determine the association between high flow supplementary oxygen and 30 day mortality in patients presenting with a suspected acute coronary syndrome (ACS).

Design: Pragmatic, cluster randomised, crossover trial.

Setting: Four geographical regions in New Zealand. Read More

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Non-association between low vitamin d levels and aeroallergen-positivity evaluated using multiple allergen simultaneous test in Korean adults.

Allergy Asthma Clin Immunol 2021 Feb 27;17(1):23. Epub 2021 Feb 27.

Sensory Organ Research Institute, Medical Research Center, Seoul National University, Seoul, Korea.

Background: Studies on the association between vitamin D levels and allergen sensitization have reported conflicting results. We aimed to evaluate the association between low vitamin D levels and sensitization to 59 aeroallergens in Korean adults.

Methods: We retrospectively reviewed serum 25-hydroxyvitamin D (25[OH]D) measurements of participants (n = 57,467) in a healthcare center between May 2003 and June 2020. Read More

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February 2021

The Neutrophil-to-Lymphocyte Ratio at the Time of Admission: A New Prognostic Indicator for Hospital Mortality of Trauma Patients.

Iran J Allergy Asthma Immunol 2021 Jan 30;20(1):33-45. Epub 2021 Jan 30.

Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

The elevated neutrophil-to-lymphocyte ratio (NLR) is associated with poor clinical outcomes, especially in pro-inflammatory states such as surgical injuries and severe hemorrhages. Therefore, it was hypothesized whether NLR value at the time of admission could be a prognostic indicator of hospital mortality in trauma patients. This retrospective cohort study was conducted on 865 trauma patients referred to Rajaee Hospital between April 2016 and July 2019. Read More

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January 2021

Factors associated with non-adherence to social distancing rules during the COVID-19 pandemic: a logistic regression analysis.

BMC Public Health 2021 02 13;21(1):352. Epub 2021 Feb 13.

School of Social Professions, London Metropolitan University, 166-220 Holloway Rd, London, N7 8DB, England.

Background: On March 23, 2020, the government of the United Kingdom told the British people to stay home, an unprecedented request designed to limit the spread of the COVID-19 virus and stop the National Health Service from being overwhelmed.

Methods: This study undertook a cross-sectional design to survey a convenience sample of 681 residents of North London on their social distancing (SD) behaviours, demographics, housing situation, politics, psychology and social support using an online questionnaire. Logistic regression was used to measure the associations between these explanatory factors and non-adherence to all SD rules and intentional non-adherence to SD rules. Read More

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February 2021

A cross-sectional survey of knowledge, attitude and practice (KAP) towards COVID-19 pandemic among the Syrian residents.

Sanaa Al Ahdab

BMC Public Health 2021 02 5;21(1):296. Epub 2021 Feb 5.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Rasheed International University for Science and Technology, Ghabagheb, Daraa', Syrian Arab Republic.

Background: Effective COVID-19 pandemic management requires adequate understanding of factors that influence behavioral changes. This study aims to assess knowledge, attitudes and practices towards COVID-19 among Syrians in a post-conflict context.

Method: A cross sectional web-based survey was conducted on the Syrian residents of 16 years and above. Read More

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February 2021

A gene-environment-induced epigenetic program initiates tumorigenesis.

Nature 2021 02 3;590(7847):642-648. Epub 2021 Feb 3.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Tissue damage increases the risk of cancer through poorly understood mechanisms. In mouse models of pancreatic cancer, pancreatitis associated with tissue injury collaborates with activating mutations in the Kras oncogene to markedly accelerate the formation of early neoplastic lesions and, ultimately, adenocarcinoma. Here, by integrating genomics, single-cell chromatin assays and spatiotemporally controlled functional perturbations in autochthonous mouse models, we show that the combination of Kras mutation and tissue damage promotes a unique chromatin state in the pancreatic epithelium that distinguishes neoplastic transformation from normal regeneration and is selected for throughout malignant evolution. Read More

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February 2021

Role of shear wave elastography measured in the flaccid state in predicting arteriogenic erectile dysfunction.

Andrologia 2021 May 1;53(4):e13996. Epub 2021 Feb 1.

The Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Province, China.

The gold-standard method for diagnosing arteriogenic erectile dysfunction (AED) is the penile Doppler ultrasonography. We proposed a novel method for predicting AED using ultrasonic shear wave elastography (SWE) considering that the former was invasive and variable. A total of 98 male patients were enrolled in our study, referred for ED between December 2018 and October 2020. Read More

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The optimal management of anti-drug antibodies to infliximab and identification of anti-drug antibody values for clinical outcomes in patients with inflammatory bowel disease.

Int J Colorectal Dis 2021 Jun 29;36(6):1231-1241. Epub 2021 Jan 29.

Beaumont Hospital, Dublin, Ireland.

Purpose: Secondary loss of response (LOR) to infliximab (IFX) commonly occurs. One cause is the development of anti-drug antibodies (ADAs). Evidence regarding the optimal management of ADAs is lacking. Read More

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Prevalence and its associated factors of depressive symptoms among Chinese college students during the COVID-19 pandemic.

BMC Psychiatry 2021 01 29;21(1):66. Epub 2021 Jan 29.

Department of Social Medicine, School of Public Health, China Medical University, Shenyang, 110122, China.

Background: The COVID-19 pandemic has caused a mental health crisis around the world. The psychological health of college students also faces great challenges. This study aimed to investigate the prevalence and the related factors of depressive symptoms among Chinese college students. Read More

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January 2021

Association of clade-G SARS-CoV-2 viruses and age with increased mortality rates across 57 countries and India.

Infect Genet Evol 2021 06 27;90:104734. Epub 2021 Jan 27.

National Institute of Biomedical Genomics, Kalyani, West Bengal, India. Electronic address:

Several reports have highlighted the contributions of host factors such as age, gender and co-morbidities such as diabetes, hypertension and coronary heart disease in determining COVID-19 disease severity. However, inspite of initial efforts at understanding the contributions of SARS-CoV-2 variants, most were unable to delineate causality. Hence, in this study we re-visited the contributions of different clades of viruses (G, GR and GH) along with other attributes in explaining the disparity in mortality rates among countries. Read More

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Patterns of traumatic injuries and outcomes to motorcyclists in a developing country: A cross-sectional study.

Traffic Inj Prev 2021 26;22(2):162-166. Epub 2021 Jan 26.

Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

Objective: Motorcyclists are frequently involved in road traffic accidents and may suffer polytraumatic injuries, contributing a substantial burden on healthcare systems particularly in lower-middle-income countries. This study aimed to describe patterns of injury, in-hospital course, and outcomes of road accident trauma in motorcyclists, including polytrauma, at a Trauma Facility in Pakistan.

Methods: A retrospective review was conducted by using relevant trauma codes to extract data from records for all victims presenting with motorcycle trauma between January 2018 and June 2019, to a tertiary care hospital in Pakistan. Read More

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January 2021

Effect of Supplementation of Zinc-Methionine on Egg Production, Semen Quality, Reproductive Hormones, and Hatchability in Broiler Breeders.

Biol Trace Elem Res 2021 Jan 26. Epub 2021 Jan 26.

Division of Avian Physiology and Reproduction, ICAR-Central Avian Research Institute, Izatnagar, 243122, India.

A biological study was conducted to explore the effect of zinc-methionine (Zn-Met) supplementation on productive, reproductive, and immunological response in broiler breeders. Adult healthy 45-week breeder males (192) and females (288) were used in a completely randomized design. Birds were randomly divided into four treatments consisting of six replicates and fed basal diet (control, 40 mg/kg), basal diet supplemented with Zn-Met 20 (T1), 40 (T2), and 60 mg/kg (T3). Read More

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January 2021

[Impact of Aperture Shape Controller on Knowledge-based VMAT Planning of Prostate Cancer].

Nihon Hoshasen Gijutsu Gakkai Zasshi 2021 ;77(1):23-31

Department of Radiological Technology, Kobe City Nishi-Kobe Medical Center.

Purpose: Knowledge-based planning (KBP) has disadvantages of high monitor unit (MU) and complex multi-leaf collimator (MLC) motion. We investigated the optimal aperture shape controller (ASC) level for the KBP to reduce these factors in volumetric modulated arc therapy (VMAT) for prostate cancer.

Methods: The KBP model was created based on 51 clinical plans (CPs) of patients who underwent the VMAT for prostate cancer. Read More

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January 2021

COVID-19 among the inhabitants of the slums in the city of Buenos Aires: a population-based study.

BMJ Open 2021 01 20;11(1):e044592. Epub 2021 Jan 20.

Minister of Health of the City of Buenos Aires, Buenos Aires, Argentina.

Objective: To summarise the unfolding of the COVID-19 epidemic among slum dwellers and different social strata in the city of Buenos Aires during the first 20 weeks after the first reported case.

Design: Observational study using a time-series analysis. Natural experiment in a big city. Read More

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January 2021

The risk factors for acute respiratory distress syndrome in patients with severe acute pancreatitis: A retrospective analysis.

Medicine (Baltimore) 2021 Jan;100(2):e23982

ICU, Ganzhou People's Hospital, GanZhou, JiangXi Province, China.

Abstract: Acute respiratory distress syndrome (ARDS) is very common in patients with severe acute pancreatitis (SAP), the early interventions are essential to the prognosis of SAP patients. We aimed to evaluate the risk factors for ARDS in SAP patients, to provide insights into the management of SAP.SAP patients treated in our hospital from June 1, 2018 to May 31, 2020 were included. Read More

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January 2021

Violence prevention emergency tool (VPET) screening of youth in the pediatric ED.

Am J Emerg Med 2021 03 5;41:139-144. Epub 2020 Dec 5.

Connecticut Children's, 282 Washington Street, Hartford, CT 06106, United States of America; University of Connecticut Storrs Connecticut, United States of America.

Background Violence is an increasingly common and significant problem for youth worldwide. Youth who rely on treatment at urban EDs are more likely to die as the result of violence than any other disease/condition for which they seek care. The first step in helping youth that are at risk, is identifying them. Read More

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Adjuvant Chemotherapy for Patients with Breast Cancer Based on Clinical and Evolving Oncotype DX Criteria.

Breast Care (Basel) 2020 Dec 10;15(6):642-647. Epub 2020 Mar 10.

Medical Oncology Department, King Saud Medical City, Riyadh, Saudi Arabia.

Introduction: Oncotype DX assay recurrence score (ODX-RS) cut-off values have recently changed after the publication of the TAILOR-X trial results. We aim to explore decisions for adjuvant chemotherapy (ACT) based on physicians' clinical assessment and the evolving ODX-RS.

Methodology: Patients who underwent ODX testing after curative surgical resection of estrogen receptor positive (ER+), Her2 non-overexpressed (Her2-) and lymph node-negative (LN-) breast cancer (BC) were eligible. Read More

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December 2020

Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study.

Kobe J Med Sci 2020 Nov 17;66(3):E102-E112. Epub 2020 Nov 17.

Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation.

Methods: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting for other potential confounders. Read More

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November 2020

[Analysis of TMC1 gene variants and prenatal diagnosis in four Chinese families affected with deafness].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Jan;38(1):37-41

Genetic and Prenatal Diagnosis Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Objective: To explore the genetic basis of four Chinese families affected with deafness.

Methods: All probands were subjected to next generation sequencing (NGS). Suspected variant were verified by Sanger sequencing among the family members. Read More

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January 2021

Effect of Mitochondrial Antioxidant (Mito-TEMPO) on Burn-Induced Cardiac Dysfunction.

J Am Coll Surg 2021 Apr 7;232(4):642-655. Epub 2021 Jan 7.

Department of Surgery, University of Texas Medical Branch, Galveston, TX; Department of Pediatrics, University of Texas Medical Branch, Galveston, TX. Electronic address:

Background: Imbalance of oxidants/antioxidants results in heart failure, contributing to mortality after burn injury. Cardiac mitochondria are a prime source of reactive oxygen species (ROS), and a mitochondrial-specific antioxidant may improve burn-induced cardiomyopathy. We hypothesize that the mitochondrial-specific antioxidant, Triphenylphosphonium chloride (Mito-TEMPO), could protect cardiac function after burn. Read More

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Long-term follow-up outcomes in a real-world study cohort after percutaneous patent foramen ovale closure.

Turk Kardiyol Dern Ars 2021 01;49(1):29-39

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objective: In recent years, percutaneous closure of a patent foramen ovale (PFO) has gained widespread use. This study is an evaluation of the safety and efficacy of the Figulla and Amplatzer devices for PFO closure, including long-term follow-up results.

Methods: A total of 305 patients (43. Read More

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January 2021