176,840 results match your criteria majority studies


Buprenorphine use and disparities in access among emergency department patients with opioid use disorder: A cross-sectional study.

J Subst Abuse Treat 2021 Apr 20;130:108405. Epub 2021 Apr 20.

Cooper Medical School of Rowan University, 401 Broadway, Camden, NJ 08103, United States of America; Cooper University Hospital, Department of Emergency Medicine, Keleman 152, 1 Cooper Plaza, Camden, NJ 08103, United States of America. Electronic address:

Background: Buprenorphine, a partial mu-opioid agonist and kappa-opioid antagonist, is an approved treatment for opioid use disorder (OUD). Studies demonstrate that buprenorphine decreases cravings for other opioids, effectively ameliorates withdrawal symptoms, and decreases opioid overdose and mortality. However, buprenorphine remains under-utilized. Read More

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A rare case of large left internal maxillary artery pseudoaneurysm secondary to mandibular fracture: A case report and review of the literature.

Int J Surg Case Rep 2021 Jun 9;84:106072. Epub 2021 Jun 9.

Department of Surgery, Division of Trauma and Surgical Critical Care, Kendall Regional Medical Center, Miami, FL, USA; University of South Florida, Tampa, FL, USA.

Introduction And Importance: Pseudoaneurysms secondary to traumatic vessel wall disruption are a rare but potentially fatal complication after traumatic injury. The majority of the cases are found incidentally.

Case Presentation: An 80-year-old woman was brought into our Level 1 Trauma Center after sustaining a ground-level fall with significant facial swelling. Read More

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Liver transplantation and bariatric surgery: a new surgical reality: a systematic review of the best time for bariatric surgery.

Updates Surg 2021 Jun 12. Epub 2021 Jun 12.

Fluminense Federal University, Niterói, RJ, Brazil.

Non-alcoholic fatty liver disease has increased in parallel with the obesity. This situation represents a new reality for patients with an indication for liver transplant (LT) and bariatric surgery (BS). We undertook a systematic review of BS and LT using the terms 'liver transplant', 'obesity' and 'bariatric surgery'. Read More

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Five year results of a prospective, randomised, contralateral eye trial of corneal crosslinking for keratoconus.

Clin Exp Ophthalmol 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, University of Auckland, Auckland, New Zealand.

Background: Few studies have evaluated corneal crosslinking in a prospective, randomised fashion. This study aimed to determine the efficacy and safety of corneal crosslinking to reduce the progression of keratoconus.

Methods: Prospective, unmasked, randomised, contralateral eye controlled trial at a tertiary eye centre. Read More

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The influence of bariatric surgery on hip and knee joint pain: a systematic review.

Surg Obes Relat Dis 2021 Apr 28. Epub 2021 Apr 28.

Department of Orthopaedics, Rijnstate Hospital, Arnhem, The Netherlands. Electronic address:

Obesity increases the risk of osteoarthritis and the chance of needing joint replacement arthroplasty to reduce lower limb joint pain. Although nonsurgical weight loss interventions can reduce hip and knee joint pain, bariatric surgery may be a more feasible treatment option for people with severe obesity. However, it is unclear whether weight loss through bariatric surgery can positively influence hip and knee joint pain. Read More

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Difficult binds: A systematic review of facilitators and barriers to treatment among mothers with substance use disorders.

J Subst Abuse Treat 2021 Jul 27;126:108341. Epub 2021 Feb 27.

Department of Psychiatry, Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center, USA. Electronic address:

Background: The United States and Canada have observed sharp increases in substance use disorder among women of child-bearing or child-rearing age. Substance use disorder can have deleterious effects on children, families, and communities. Many evidence-based treatments exist, but engaging mothers in treatment is difficult. Read More

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The Continuum of Recovery from Alcohol Dependence: From Addiction Remission to Complete Mental Health.

Subst Use Misuse 2021 Jun 11:1-12. Epub 2021 Jun 11.

Institute for Life Course & Aging, Factor-Inwentash Faculty of Social Work, Cross-appointed to the Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Background: Few representative studies have examined optimal mental health among those with a history of alcohol dependence (AD).

Objectives: In a representative sample of Canadians with a history of AD, to determine prevalence of, and factors associated with 1) remission from AD, 2) the absence of Substance Dependence and Psychiatric Disorders (SDPD) in the past year, and 3) complete mental health (CMH).

Method: Secondary analysis of a publicly available Statistics Canada database, the 2012 Canadian Community Health Survey-Mental Health (820 adults with AD history; 19,945 without AD). Read More

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Motion of the multi-segmented spine in elite dancers during passé and arabesque.

Gait Posture 2021 Jun 6;88:198-202. Epub 2021 Jun 6.

Harkness Center for Dance Injuries, NYU Langone Health, 614 2ndAv, Suite G, 2nd Floor, New York, NY 10016, USA. Electronic address:

Background: The spinal biomechanics of dance tasks have received little study and no studies have used a multi-segmented spinal model. Knowledge of how the segments of the spine move may be useful to the dance clinician and dance educator.

Research Question: What is the direction and amount of motion of the primary segments of the spine in elite dancers during an arabesque and a passé?

Methods: This observational study examined 59 elite dancers performing an arabesque and a passé using a three-dimensional motion analysis system with the trunk divided into a series of five segments: pelvis, lower lumbar, upper lumbar, lower thoracic and upper thoracic spine. Read More

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Is Melanoma Overdiagnosed? A Review of the Evidence.

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT; University of Florida Dermatology Department, Gainesville, FL. Electronic address:

Background: Melanoma is one of the most commonly diagnosed malignancies in the United States (US) and is responsible for the majority of deaths from skin cancer.

Objective: Since the 1970s, the incidence of melanoma has risen appreciably while melanoma-specific mortality has remained stable. This has raised a debate about potential overdiagnosis of melanoma. Read More

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Effects of air pollution on health: A mapping review of systematic reviews and meta-analyses.

Environ Res 2021 Jun 8:111487. Epub 2021 Jun 8.

Laboratory of Sport and Exercise Psychology (Lape) - College of Health and Sport Science of the Santa Catarina State University (UDESC), Florianópolis, SC, Brazil. Electronic address:

Background: There has been a notable increase in knowledge production on air pollution and human health.

Objective: To analyze the state of the art on the effects of air pollution on human health through a mapping review of existing systematic reviews and meta-analyses (SRs and MAs).

Methods: The systematic mapping review was based on the recommendations for this type of scientific approach in environmental sciences. Read More

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Efficacy of an autologous blood patch for prolonged air leak, a systematic review.

Ann Thorac Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Thoracic Surgery, Rijnstate Hospital, Arnhem, the Netherlands; Multi-Modality Medical Imaging Group, TechMed Centre, University of Twente, Enschede, The Netherlands.

Background: Prolonged air leak (PAL) following pulmonary surgery remains a clinical challenge and sometimes needs surgical reintervention. An autologous blood patch (ABP) may provide a noninvasive method to cease air leak. Its value, however, is debatable. Read More

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Exploring polyps to colon carcinoma voyage: can blocking the crossroad halt the sequence?

Authors:
Abdul Arif Khan

J Cancer Res Clin Oncol 2021 Jun 11. Epub 2021 Jun 11.

Division of Microbiology, Indian Council of Medical Research-National AIDS Research Institute, Pune, Maharashtra, India.

Colorectal cancer is an important public health concern leading to significant cancer associate mortality. A vast majority of colon cancer arises from polyp which later follows adenoma, adenocarcinoma, and carcinoma sequence. This whole process takes several years to complete and recent genomic and proteomic technologies are identifying several targets involved in each step of polyp to carcinoma transformation in a large number of studies. Read More

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A comparison of the buttonhole and rope-ladder AVF cannulation techniques and infection rates within the SCOPE collaborative.

Pediatr Nephrol 2021 Jun 11. Epub 2021 Jun 11.

Department of Pediatrics, Division of Nephrology, Children's Mercy Kansas City, University of Missouri-Kansas City, Kansas City, MO, USA.

Background: Studies regarding hemodialysis (HD) arteriovenous fistula (AVF) cannulation in adults indicate a higher risk of infection with the buttonhole (BH) technique compared to the rope-ladder (RL) technique. Pediatric data on this issue is sparse.

Methods: We compared infection rates within the Standardizing Care to Improve Outcomes in Pediatric End stage kidney disease (SCOPE) centers performing BH cannulation versus RL cannulation of AVF. Read More

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CT angiography of abdomen and pelvis in critically ill COVID-19 patients: imaging findings and correlation with the CT chest score.

Abdom Radiol (NY) 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology and Radiological Science, Johns Hopkins Hospital, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD, 21287, USA.

Purpose: To assess the spectrum of computed tomography angiogram (CTA) abdominal and pelvic findings in critically ill COVID-19 patients and investigate correlation with CT chest scores.

Methods: An IRB approved retrospective study of CTA of the chest, abdomen and pelvis between dates March 1st to September 15th, 2020 was performed in the hospitalized COVID-19 positive patients. CTA studies of solely the chest were excluded. Read More

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Attitudes, beliefs and practice of Egyptian healthcare workers towards seasonal influenza vaccination.

Influenza Other Respir Viruses 2021 Jun 11. Epub 2021 Jun 11.

World Health Organization Country Office, Cairo, Egypt.

Background: Seasonal influenza vaccination is highly recommended for healthcare workers (HCWs) every year to protect them and reduce the risk of disease transmission at workplaces. Relatively few studies addressed influenza vaccination in the Eastern Mediterranean Region.

Objectives: The main objective of this study was to explore the attitudes, beliefs and practice of Egyptian HCWs towards seasonal influenza vaccine. Read More

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Characterisation of patients with supine nighttime reflux: observations made with prolonged wireless oesophageal pH monitoring.

Aliment Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Department of Gastroenterology & Hepatology, Amsterdam Gastroenterology and Metabolism, University Medical Centers Amsterdam, Amsterdam, the Netherlands.

Background: Although nighttime reflux symptoms are common, the presence of nocturnal reflux is seldom confirmed with a standard 24 hours pH study.

Aim: To study patients with supine nighttime reflux symptoms using prolonged wireless pH monitoring.

Methods: In this retrospective study, patients with typical acid reflux symptoms were studied using 96-h pH monitoring. Read More

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Single-cell transcriptome profiling of thyroid hormone effectors in the human fetal neocortex: expression of SLCO1C1, DIO2, and THRB in specific cell types.

Thyroid 2021 Jun 11. Epub 2021 Jun 11.

Consejo Superior de Investigaciones Científicas, 16379, Instituto de Investigaciones Biomedicas, Madrid, Madrid, Spain.

Background: Thyroid hormones are crucial for brain development, acting through the thyroid hormone nuclear receptors (TR) α1 and β to control gene expression. T3, the receptor-ligand, is transported into the brain from the blood by the monocarboxylate transporter 8 (MCT8). Another source of brain T3 is from the local deiodination of T4 by type 2 deiodinase (DIO2). Read More

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A bibliometric analysis of orthogeriatric care: top 50 articles.

Eur J Trauma Emerg Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Geriatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Background: Population is ageing and orthogeriatric care is an emerging research topic.

Purpose: This bibliometric review aims to provide an overview, to investigate the status and trends in research in the field of orthogeriatric care of the most influential literature.

Methods: From the Core Collection databases in the Thomson Reuters Web of Knowledge, the most influential original articles with reference to orthogeriatric care were identified in December 2020 using a multistep approach. Read More

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Athletes' and Coaches' Attitudes Toward Protective Headgear as Concussion and Head Injury Prevention: A Scoping Review.

Front Sports Act Living 2021 25;3:680773. Epub 2021 May 25.

Faculty of Social Sciences, Nord University, Bodø, Norway.

The purpose of this article is to map existing research literature on athletes and coaches' attitudes toward protective headgear in sport in relation to concussion and head injury prevention, and to identify and analyse knowledge gaps in the field. A scoping review was conducted in three databases; PubMed, Scopus, SportDiscus, and reference lists were searched to identify relevant grey literature. This process lead to an in-depth analysis of 18 peer-reviewed journal articles. Read More

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A Scoping Review of Non-Communicable Diseases and Maternal and Child Health Needs of Venezuelan Migrants in South America.

J Glob Health Rep 2021 15;5. Epub 2021 May 15.

Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States.

Background: Migration of Venezuelan citizens to other South American countries has increased in recent years. While the prevalence, morbidity, and mortality of infectious diseases in Venezuelan migrants across South America appears to be well described, the non-communicable disease (NCD) and maternal and child health needs in this population is less clear. A scoping review of existing peer-reviewed primary research and grey literature describing the epidemiology of NCDs and maternal and child health needs in Venezuelan migrants in major South American host countries was performed in order to highlight important gaps in knowledge. Read More

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-Generated CAR19-T Cells Plus Lenalidomide Cause Durable Complete Remission of Triple-Hit Refractory/Relapsed DLBCL: A Case Report.

Front Immunol 2021 25;12:599493. Epub 2021 May 25.

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

MYC/BCL2/BCL6 triple-hit lymphoma (THL) is an uncommon subset of high-grade B-cell lymphoma with aggressive clinical behavior and poor prognosis. TP53 mutation is an independently poor progonistic indicator in patients with THL, hence novel therapeutic strategies are needed for these patients. CD19-directed chimeric antigen receptor(CAR19)-T cell therapy has shown promising efficacy for relapsed/refractory diffuse large B cell lymphoma (RR DLBCL), but the majority of CAR19-T cell products to date have been manufactured using viral vectors. Read More

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Overexpressed Na 1.7 Channels Confer Hyperexcitability to Trigeminal Sensory Neurons of Ca 2.1 Mutant Hemiplegic Migraine Mice.

Front Cell Neurosci 2021 25;15:640709. Epub 2021 May 25.

Department of Neuroscience, International School for Advanced Studies (SISSA), Trieste, Italy.

Trigeminal sensory neurons of transgenic knock-in (KI) mice expressing the R192Q missense mutation in the α1A subunit of neuronal voltage-gated Ca 2.1 Ca channels, which leads to familial hemiplegic migraine type 1 (FHM1) in patients, exhibit a hyperexcitability phenotype. Here, we show that the expression of Na 1. Read More

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Nutrition and sulfur.

Adv Food Nutr Res 2021 24;96:123-174. Epub 2021 Mar 24.

Faculty of Medicine, Imperial College London, London, England, United Kingdom. Electronic address:

Sulfur is unusual in that it is a mineral that may be taken into the body in both inorganic and organic combinations. It has been available within the environment throughout the development of lifeforms and as such has become integrated into virtually every aspect of biochemical function. It is essential for the nature and maintenance of structure, assists in communication within the organism, is vital as a catalytic assistant in intermediary metabolism and the mechanism of energy flow as well as being involved in internal defense against potentially damaging reactive species and invading foreign chemicals. Read More

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Patient and hospital factors associated with 30-day readmissions after coronary artery bypass graft (CABG) surgery: a systematic review and meta-analysis.

J Cardiothorac Surg 2021 Jun 10;16(1):172. Epub 2021 Jun 10.

Centre for Big Data Research in Health, University of New South Wales (UNSW) Sydney, Kensington, Australia.

Background: Readmission after coronary artery bypass graft (CABG) surgery is associated with adverse outcomes and significant healthcare costs, and 30-day readmission rate is considered as a key indicator of the quality of care. This study aims to: quantify rates of readmission within 30 days of CABG surgery; explore the causes of readmissions; and investigate how patient- and hospital-level factors influence readmission.

Methods: We conducted systematic searches (until June 2020) of PubMed and Embase databases to retrieve observational studies that investigated readmission after CABG. Read More

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Comparative analysis of viral infection outcomes in human seminal fluid from prior viral epidemics and Sars-CoV-2 may offer trends for viral sexual transmissibility and long-term reproductive health implications.

Reprod Health 2021 Jun 10;18(1):123. Epub 2021 Jun 10.

Department of Biomedical Sciences, University of South Carolina School of Medicine Greenville, 607 Grove Rd., Greenville, SC, 29605, USA.

Background: Viral detection in seminal fluid indicates their potential for both sexual transmission and impairment of reproductive health. Review of the mechanistic entry, sexual transmission and viral impacts for patients during major recent viral outbreaks of Zika virus (ZIKV), Ebola virus (EBOV), severe acute respiratory syndrome (SARS)-coronavirus (CoV), and SARS-coronavirus 2 (CoV-2) (the virus which causes COVID-19) provides a framework to discuss this potential.

Aim: Comparative analysis of prior viral presence on seminal fluid against current (preliminary) findings for SARS-CoV-2 to predict biological implications of the novel coronavirus upon current sexual transmissibility, viral presence, and reproductive health. Read More

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A novel method to identify gene interaction patterns.

BMC Genomics 2021 Jun 10;22(Suppl 1):436. Epub 2021 Jun 10.

College of Computer Science and Electronic Engineering, Hunan University, Lushan Nan Road, Changsha, 410082, China.

Background: Gene interaction patterns, including modules and motifs, can be used to identify cancer specific biomarkers and to reveal the mechanism of tumorigenesis. Most of the existing module network inferencing methods focus on gene independent functional patterns, while the studies of overlapping characteristics between modules are lacking. The objective of this study was to reveal the functional overlapping patterns in gene modules, helping elucidate the regulatory relationship between overlapping genes and communities, as well as to explore cancer formation and progression. Read More

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P2RX7 gene variation mediates the effect of childhood adversity and recent stress on the severity of depressive symptoms.

PLoS One 2021 10;16(6):e0252766. Epub 2021 Jun 10.

Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.

The P2X purinoceptor 7 (P2RX7) mediates inflammatory microglial responses and is implicated in neuroimmune mechanisms of depression and neurodegenerative disorders. A number of studies suggest that psychosocial stress may precipitate depression through immune activation. Genetic association studies of P2RX7 variants with depression have been inconclusive. Read More

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Which public health interventions are effective in reducing morbidity, mortality and health inequalities from infectious diseases amongst children in low- and middle-income countries (LMICs): An umbrella review.

PLoS One 2021 10;16(6):e0251905. Epub 2021 Jun 10.

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

Despite significant progress in the last few decades, infectious diseases remain a major threat to child health in low- and middle-income countries (LMICs)-particularly amongst more disadvantaged groups. It is imperative to understand the best available evidence concerning which public health interventions reduce morbidity, mortality and health inequalities in children aged under five years. To address this gap, we carried out an umbrella review (a systematic reviews of reviews) to identify evidence on the effects of public health interventions (promotion, protection, prevention) on morbidity, mortality and/or health inequalities due to infectious diseases amongst children in LMICs. Read More

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Knowledge and societal perceptions regarding autopsy amongst different educational backgrounds in Karachi, Pakistan.

J Pak Med Assoc 2021 Jun;71(6):1613-1617

Department of Forensic Medicine and Toxicology, Ziauddin University, Karachi, Pakistan.

Objective: To find out awareness levels about legislation/authorisation and objectives of autopsy among common people, and to assess correlation between opinions and academic levels.

Methods: The cross-sectional questionnaire-based study was conducted from March 2019 to September 2019 after approval from Ziauddin University, Karachi, and comprised adult subjects from the community having various academic backgrounds. Data was collected on their knowledge, perceptions and concerns regarding autopsy. Read More

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