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Acute gastrointestinal bleeding: results from the prospective German electronic registry of nearly 11 000 endoscopies (ALGK GI-bleeding registry).

Z Gastroenterol 2021 Apr 9. Epub 2021 Apr 9.

ALGK (Arbeitsgemeinschaft Leitende Gastroenterologische Krankenhausärzte; Working Group of Leading German Gastroenterologists in Hospitals).

Background And Study Aims:  Gastrointestinal bleeding is frequently observed in the German population. However, recent epidemiological data are not available. This study aimed to elucidate gastrointestinal bleeds under real-life conditions in 3 German hospitals. Read More

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Origins of major and minor ash constituents of solid recovered fuel for co-processing in the cement industry.

Waste Manag 2021 Apr 6;126:423-432. Epub 2021 Apr 6.

Chair of Waste Processing Technology and Waste Management, Montanuniversitaet Leoben, Leoben, Austria. Electronic address:

Solid recovered fuel (SRF) ash consists of element oxides, which are valuable materials for cement manufacturers. When SRF is co-processed in the cement industry, its mineral content is incorporated into the clinker. Therefore, from a technical perspective, SRF ash is recycled. Read More

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Reclassification of as gen. nov., comb. nov., of as comb. nov, with an emended description of the genus , recognition that the genus names and are heterotypic synonyms and description of sp. nov., a halotolerant isolate from surface soil sampled at an ancient copper smelter.

Int J Syst Evol Microbiol 2021 Apr;71(4)

Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany.

In the course of screening the surface soils of ancient copper mines and smelters (East Harz, Germany) an aerobic, non-motile and halotolerant actinobacterium forming small rods or cocci was isolated. The strain designated F300 developed creamy to yellow colonies on tryptone soy agar and grew optimally at 28 °C, pH 7-8 and with 0.5-2 % (m/v) NaCl. Read More

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Bioavailability of copper and nickel in naturally metal-enriched soils of Carajás Mining Province, Eastern Amazon, Brazil.

Environ Monit Assess 2021 Apr 9;193(5):256. Epub 2021 Apr 9.

Soil Science Department, Federal University of Lavras, Lavras, Minas Gerais, 3037, 37200-900, Brazil.

Naturally elevated contents of copper (Cu) and nickel (Ni) are found in soils worldwide, and their potential toxicity is better understood when geochemical reactive fractions are identified and monitored. Thus, this study aimed to assess the bioavailability of Cu and Ni and estimate environmental risks in naturally metal-enriched soils of Carajás Mining Province, Eastern Amazon, Brazil. For that, 58 surficial soil samples were analyzed for their extractable contents of Cu and Ni by Mehlich 1. Read More

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A random parameter negative binomial model for signalized intersection accidents in Seoul, Korea.

Int J Inj Contr Saf Promot 2021 Apr 9:1-11. Epub 2021 Apr 9.

Department of Transportation Engineering and Department of Smart Cities, University of Seoul, Seoul, Korea.

A variety of statistical models were generally considered to better understand the relationship between crash occurrences and diverse factors. However, most of statistical models adapted fixed parameters which cannot incorporate time variation or sement-specific effects. To relieve this problem, this study focuses on a traffic accident frequency model using a random parameter negative binomial approach. Read More

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Paclitaxel-Coated Balloons for the Treatment of Symptomatic Central Venous Stenosis in Vascular Access: Results From a European, Multicenter, Single-Arm Retrospective Analysis.

J Endovasc Ther 2021 Apr 9:15266028211007471. Epub 2021 Apr 9.

Interventional Radiology, Patras University Hospital, Patras, Greece.

Introduction: This was a European, multicenter, investigator-initiated and run, single-arm retrospective analysis to assess the safety and the clinical benefit of the use of paclitaxel-coated balloon (PCB) for the treatment of symptomatic central venous stenosis (CVS).

Materials And Methods: Eleven centers from 7 countries across Europe, submitted 86 cases performed during the period between October 2015 and June 2018. Minimum follow-up was 6 months. Read More

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Salivary glands are a target for SARS-CoV-2: A source for saliva contamination.

J Pathol 2021 Apr 8. Epub 2021 Apr 8.

Department of Pathology, School of Medicine, University of Sao Paulo, São Paulo, Brazil.

The ability of the new coronavirus SARS-CoV-2 to spread and contaminate is one of the determinants of the COVID-19 pandemic status. SARS-CoV-2 has been detected in saliva consistently, with similar sensitivity as observed in nasopharyngeal swabs. We conducted ultrasound-guided postmortem biopsies in COVID-19 fatal cases. Read More

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Task MRI-Based Functional Brain Network of Major Depression.

Authors:
Chien-Han Lai

Adv Exp Med Biol 2021 ;1305:19-33

Psychiatry & Neuroscience Clinic, Taoyuan, Taiwan.

This chapter will focus on task magnetic resonance imaging (MRI) to understand the biological mechanisms and pathophysiology of brain in major depressive disorder (MDD), which would have minor alterations in the brain function. Therefore, the functional study, such as task MRI functional connectivity, would play a crucial role to explore the brain function in MDD. Different kinds of tasks would determine the alterations in functional connectivity in task MRI studies of MDD. Read More

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January 2021

What Does CATS Have to Do With Cancer? The Cognitive Activation Theory of Stress (CATS) Forms the SURGE Model of Chronic Post-surgical Pain in Women With Breast Cancer.

Front Psychol 2021 23;12:630422. Epub 2021 Mar 23.

The Mind-Body Lab, Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway.

Chronic post-surgical pain (CPSP) represents a highly prevalent and significant clinical problem. Both major and minor surgeries entail risks of developing CPSP, and cancer-related surgery is no exception. As an example, more than 40% of women undergoing breast cancer surgery struggle with CPSP years after surgery. Read More

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Gender-specific differences in feasibility of pre-lacrimal window approach.

Sci Rep 2021 Apr 8;11(1):7791. Epub 2021 Apr 8.

Department of Otorhinolaryngology, Medical University of Graz, Graz, Austria.

The feasibility and surgical effort of a pre-lacrimal window approach (PLWA) depends on the width of the bony window anterior to the nasolacrimal duct. This study aimed to investigate gender-specific differences in feasibility of PLWA. A consecutive series of paranasal computed tomography scans from 50 females (n = 100) and 50 males (n = 100) were retrospectively analyzed. Read More

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The Impact of Premastectomy Versus Postmastectomy Radiation Therapy on Outcomes in Prepectoral Implant-Based Breast Reconstruction.

Ann Plast Surg 2021 Mar 18. Epub 2021 Mar 18.

From the Long Island Plastic Surgical Group, Garden City, NY Temple University School of Medicine, Philadelphia, PA Keck School of Medicine of University of Southern California, Los Angeles Stanford University School of Medicine, Stanford, CA Yale New Haven Health/Bridgeport Hospital, Bridgeport, CT.

Purpose: Prepectoral implant-based breast reconstruction is being increasingly performed over subpectoral reconstruction because of the reduced invasiveness of the procedure, postoperative pain, and risk of animation deformity. Radiation therapy is a well-known risk factor for complications in implant-based breast reconstruction. The effect of premastectomy versus postmastectomy radiation therapy on outcomes after prepectoral breast reconstruction has not been well-defined. Read More

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Is It Worth the Risk? Contralateral Prophylactic Mastectomy With Immediate Bilateral Breast Reconstruction.

Ann Plast Surg 2021 Mar 18. Epub 2021 Mar 18.

From the Division of Plastic Surgery, Columbia University Irving Medical Center Columbia University Medical School, New York, NY.

Background: An increasing number of women are choosing to undergo contralateral prophylactic mastectomy with immediate bilateral breast reconstruction. Operating on the contralateral noncancer side is not without its own set of risks. We sought to compare complication rates between the cancerous and contralateral prophylactic breasts. Read More

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The Triangular Dart Flap: A Reconstructive Option for Soft Tissue Defects.

Ann Plast Surg 2021 Apr 5. Epub 2021 Apr 5.

From the Department of Plastic and Reconstructive Surgery, Wake Forest School of Medicine; Winston-Salem, NC.

Introduction: Reconstruction of soft tissue defects after skin cancer excision remains a challenge. Options for reconstruction are numerous, including primary repair, local tissue rearrangement, and skin grafts, among others. In this series, the authors present a novel technique: The triangular dart flap. Read More

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Maxillomandibular advancement versus multilevel surgery for treatment of obstructive sleep apnea: A systematic review and meta-analysis.

Sleep Med Rev 2021 Mar 17;57:101471. Epub 2021 Mar 17.

Department of Oral and Maxillofacial Surgery, Amsterdam UMC Location AMC and Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, Amsterdam, the Netherlands.

Multilevel surgery (MLS) and maxillomandibular advancement surgery (MMA) are two established options in surgical management of obstructive sleep apnea (OSA), which target different levels of airway obstruction. The objective of this review was to comparatively evaluate the clinical efficacy and safety of MMA and MLS in the treatment of OSA. MEDLINE and Embase databases were searched for studies on MMA and/or MLS in OSA patients. Read More

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Existence and features of the myodural bridge in Gentoo penguins: A morphological study.

PLoS One 2021 8;16(4):e0244774. Epub 2021 Apr 8.

Department of Anatomy, College of Basic Medicine, Dalian Medical University, Dalian, China.

Recent studies have evidenced that the anatomical structure now known as the myodural bridge (MDB) connects the suboccipital musculature to the cervical spinal dura mater (SDM). In humans, the MDB passes through both the posterior atlanto-occipital and the posterior atlanto-axial interspaces. The existence of the MDB in various mammals, including flying birds (Rock pigeons and Gallus domesticus) has been previously validated. Read More

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Immunolocalization of Epidermal Differentiation Complex proteins reveals distinct molecular compositions of cells that control structure and mechanical properties of avian skin appendages.

J Morphol 2021 Apr 8. Epub 2021 Apr 8.

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

The EDC (Epidermal Differentiation Complex) is a cluster of genes that encode structural proteins of skin derivatives with variable mechanical performances, from the scales of reptiles and birds to the hard claws and beaks, and to the flexible but resistant corneous material of feathers. Corneous proteins with or without extended beta-regions are produced from avian genomes, and include the largely prevalent corneous beta proteins (CβPs, formerly indicated as beta-keratins), and minor contribution from histidine-rich proteins, trichohyalin-like proteins (scaffoldin), loricrin, and other proteins rich in cysteine or other types of amino acids. The light-microscopic and ultrastructural immunolocalization of major and minor EDC-proteins in avian skin (feather CβPs, EDKM, EDWM, EDMTFH, EDDM and scaffoldin) suggests that each specific appendage consists of a particular mix of these proteins in addition to the main proteins containing a peculiar beta-region of 34 amino acids, indicated as feather/scale/claw/beak CβPs (fCβPs, sCβPs, cCβPs, bCβPs). Read More

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Evaluation of Pre-peritoneal (Sublay) Mesh Repair for Treatment of Ventral Hernia.

Mymensingh Med J 2021 Apr;30(2):453-457

Dr Nelema Jahan, Associate Professor, Department of Surgery, Dhaka Dental College, Dhaka, Bangladesh; E-mail:

Ventral hernia after abdominal surgery is a common complication. Several techniques for the repair of ventral hernia have been described from time to time and it is a great challenge for a surgeon. The mesh placement by sublay technique authorized by Rives and Stoppa in Europe has been reported to be effective with low recurrence rate. Read More

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Orthodontic appliances and MR image artefacts: An exploratory in vitro and in vivo study using 1.5-T and 3-T scanners.

Imaging Sci Dent 2021 Mar 29;51(1):63-71. Epub 2021 Jan 29.

Department of Oral and Maxillofacial Radiology, Faculty of Odontology, Malmö University, Malmö, Sweden.

Purpose: The aim of this study was to assess the artefacts of 12 fixed orthodontic appliances in magnetic resonance images obtained using 1.5-T and 3-T scanners, and to evaluate different imaging sequences designed to suppress metal artefacts.

Materials And Methods: In vitro, study casts of 1 adult with normal occlusion were used. Read More

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Coronavirus Disease 2019-Challenges Today and Tomorrow in Orthodontic Practice: A Review.

Turk J Orthod 2021 1;34(1):61-67. Epub 2021 Mar 1.

Department of Orthodontics & Dentofacial Orthopaedics, Al-Badar Rural Dental College & Hospital, Gulbarga, India.

From the start of 2020, the world has witnessed the biggest health and humanitarian crisis in the modern century named coronavirus disease 2019. The rapid spread of infection created chaos and confusion across the globe. Like all other health professions, a timely and major reorganization of orthodontic services is challenging. Read More

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Cross-modal music integration in expert memory: Evidence from eye movements.

J Eye Mov Res 2018 Dec 12;11(2). Epub 2018 Dec 12.

LEAD, University of Bourgogne Dijon, France.

The study investigated the cross-modal integration hypothesis for expert musicians using eye tracking. Twenty randomized excerpts of classical music were presented in two modes (auditory and visual), at the same time (simultaneously) or successively (sequentially). Musicians (N = 53, 26 experts and 27 non-experts) were asked to detect a note modified between the auditory and visual versions, either in the same major/minor key or violating the key. Read More

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December 2018

Autoantibodies in the Diagnosis, Monitoring, and Treatment of Membranous Nephropathy.

Front Immunol 2021 22;12:593288. Epub 2021 Mar 22.

Department of Nephrology, 1st Faculty of Medicine, General University Hospital, Charles University, Prague, Czechia.

The discovery of anti-podocyte antibodies in primary membranous nephropathy (MN) has revolutionized our approach toward the diagnosis and treatment of this disease. Evaluation of serum levels of anti-podocyte antibodies paved the way for non-invasive diagnosis and helped distinguish between primary and secondary MN although the relationship between anti-podocyte antibodies and cancer remains to be elucidated. Serum levels of anti-PLA2R antibodies directed against the major podocyte autoantigen are related to MN activity and the decrease in serum levels of anti-PLA2R antibodies in response to treatment (immunologic remission) also serves as an early indicator of the later putative proteinuric remission, enabling personalization of the treatment. Read More

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Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation.

World J Gastroenterol 2021 Mar;27(12):1161-1181

Department of Gastroenterology, Division of Liver and Gastrointestinal Transplant, Hospital das Clinicas, University of São Paulo School of Medicine, São Paulo 05402-000, Brazil.

Background: The impact of perioperative blood transfusion on short- and long-term outcomes in pediatric living donor liver transplantation (PLDLT) must still be ascertained, mainly among young children. Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.

Aim: To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT. Read More

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Past climate variations recorded in needle-like aragonites correlate with organic carbon burial efficiency as revealed by lake sediments in Croatia.

Sci Rep 2021 Apr 7;11(1):7568. Epub 2021 Apr 7.

Croatian Geological Survey, Sachsova 2, 10000, Zagreb, Croatia.

The drivers of organic carbon (OC) burial efficiency are still poorly understood despite their key role in reliable projections of future climate trends. Here, we provide insights on this issue by presenting a paleoclimate time series of sediments, including the OC contents, from Lake Veliko jezero, Croatia. The Sr/Ca ratios of the bulk sediment are mainly derived from the strontium (Sr) and calcium (Ca) concentrations of needle-like aragonite in Core M1-A and used as paleotemperature and paleohydrology indicators. Read More

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Parthenogenetic mosaicism: generation via second polar body retention and unmasking of a likely causative PER2 variant for hypersomnia.

Clin Epigenetics 2021 Apr 7;13(1):73. Epub 2021 Apr 7.

Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Background: Parthenogenetic mosaicism is an extremely rare condition identified only in five subjects to date. The previous studies indicate that this condition is mediated by parthenogenetic activation and is free from a specific phenotype ascribed to unmaking of a maternally inherited recessive variant in the parthenogenetic cell lineage.

Results: We examined a 28-year-old Japanese 46,XX female with Silver-Russell syndrome and idiopathic hypersomnia. Read More

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Chronic type C3 distal humeral fracture associated with massive bone defects treated by open reduction and internal fixation with iliac crest autografts: a case report.

BMC Musculoskelet Disord 2021 Apr 7;22(1):338. Epub 2021 Apr 7.

Department of Orthopedic Trauma, Beijing Jishuitan Hospital, No.31 Xinjiekou East Street, Xicheng District, Beijing, 100035, China.

Background: Chronic intercondylar fractures of the distal humerus with massive bone defects and severe comminution in the metaphysis are rare and complex injuries that are challenging for surgeons to treat, as reconstructing the triangular structure of the distal humerus is difficult and may have a severe impact on functional outcomes, especially in young patients, for whom total elbow arthroplasty is usually not a suitable option due to significant impairment in upper limb strength. Here, we report a patient in such scenario who was young and active and was treated by structural iliac bone autografting and internal fixation.

Case Presentation: A 26-year-old male patient experienced a major car accident and was diagnosed with an open fracture (Gustilo-Anderson type IIIB) of the right distal humerus with massive bone defects and severe intra-articular involvement, without neurovascular injuries or other associated injuries. Read More

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Multicolor-FISH Characterization of a Prenatal Mosaicism for a Chromosomal Rearrangement Undetected by Molecular Cytogenetics.

Cytogenet Genome Res 2021 Apr 7:1-10. Epub 2021 Apr 7.

Service de Cytogénétique et Biologie Cellulaire, CHU Rennes, Rennes, France.

Fetal mosaicism for chromosomal rearrangements remains a challenge to diagnose, even in the era of whole-genome sequencing. We present here a case of fetal mosaicism for a chromosomal rearrangement explored in amniocytes and fetal muscle, consisting of a major cell population (95%) with partial monosomy 4q and a minor population (5%) with additional material replacing the 4qter deleted segment. Molecular techniques (MLPA, array-CGH) failed to assess the origin of this material. Read More

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Molecular Configuration of Human Genome Neighboring Megabase-Sized Large Deletions Induced by X-Ray Irradiation.

Radiat Res 2021 Apr 7. Epub 2021 Apr 7.

Ibaraki University, Mito, Ibaraki 310-8512, Japan.

The genomic landscape neighboring large deletions including the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus on human X chromosome in 6-thioguanine-resistant mutants originating from immortalized human fibroblast cells exposed to X rays was characterized by real-time quantitative PCR (qPCR)-based analyses. Among the 13 mutant clones with large deletions extending over several Mb, including the HPRT locus, revealed by 10 conventional sequence-tagged site (STS) markers, three clones bearing the largest deletions were selected for further qPCR analysis using another 21 STS markers and 15 newly designed PCR primer pairs. The results indicated that the major deletions were in very specific regions between the 130-Mb and 140-Mb positions containing the HPRT locus on the X chromosome and, contrary to our initial expectations, additional minor deletions were distributed in a patchwork pattern. Read More

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An extended catalogue of tandem alternative splice sites in human tissue transcriptomes.

PLoS Comput Biol 2021 Apr 7;17(4):e1008329. Epub 2021 Apr 7.

Skolkovo Institute for Science and Technology, Moscow, Russia.

Tandem alternative splice sites (TASS) is a special class of alternative splicing events that are characterized by a close tandem arrangement of splice sites. Most TASS lack functional characterization and are believed to arise from splicing noise. Based on the RNA-seq data from the Genotype Tissue Expression project, we present an extended catalogue of TASS in healthy human tissues and analyze their tissue-specific expression. Read More

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Uninterrupted Oral Anticoagulant Therapy in Patients Undergoing Unplanned Percutaneous Coronary Intervention.

JACC Cardiovasc Interv 2021 Apr;14(7):754-763

Department of Cardiology and Department of Health, Medicine and Caring Sciences, Unit of Cardiovascular Sciences, Linköping University, Linköping, Sweden.

Objectives: This study sought to compare interrupted and uninterrupted oral anticoagulant therapy (I-OAC vs. U-OAC) in patients on OAC undergoing percutaneous coronary intervention.

Background: There is a paucity of data regarding the optimal peri-procedural management of OAC-treated patients. Read More

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Risks of Macrosomia Associated with Catechol--Methyltransferase Genotypes and Genetic-Epigenetic Interactions among Children with and without Gestational Diabetes Exposure.

Child Obes 2021 Apr 6. Epub 2021 Apr 6.

Department of Preventive Medicine, Center for Global Oncology, Institute for Global Health, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Gestational diabetes mellitus (GDM) is a major macrosomia risk factor. Variations in the catechol--methyltransferase (COMT; rs4680) genotypes are associated with heightened susceptibility to environmental exposures and nutritional conditions. However, macrosomia risks associated with COMT genetics, epigenetics, and the interaction between genetic and epigenetics among children with and without exposure to GDM are unknown. Read More

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