35,948 results match your criteria major fatty

Glutaminolysis-induced mTORC1 activation drives non-alcoholic steatohepatitis progression.

J Hepatol 2021 May 4. Epub 2021 May 4.

Universitat Rovira i Virgili, Department of Medicine and Surgery, Reus, Spain; Unitat de Recerca Biomèdica (URB-CRB), Hospital Universitari de Sant Joan, Institut d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Reus, Spain; The Campus of International Excellence Southern Catalonia, Tarragona, Spain. Electronic address:

Background & Aims: A holistic insight on the relationship between obesity and metabolic dysfunction-associated fatty liver disease is an unmet clinical need. Omics investigations can be used to investigate the multifaceted role of altered mitochondrial pathways to promote nonalcoholic steatohepatitis, a major risk factor for liver disease-associated death. There are no specific treatments but remission via surgery might offer an opportunity to examine the signaling processes that govern the complex spectrum of chronic liver diseases observed in extreme obesity. Read More

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Value of Visceral Fat Area and Resting Energy Expenditure in Assessment of Metabolic Characteristics in Obese and Lean Nonalcoholic Fatty Liver Disease.

Turk J Gastroenterol 2021 Feb;32(2):116-122

Department of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, Tianjin, China;Tianjin Institute of Hepatobiliary Disease, Tianjin, China;Artificial Cell Engineering Technology Research Center, Tianjin, China;The Third Central Clinical College of Tianjin Medical University, Tianjin, China.

Background: The high prevalence and incidence of non-alcoholic fatty liver disease (NAFLD) have become a global medical concern. Compared with obesity, metabolic abnormalities may be more critical. Currently, there is lack of relevant data for nutritional status and energy metabolic characteristics in patients with obese and lean NAFLD. Read More

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February 2021

Gut microbiome changes induced by a diet rich in fruits and vegetables.

Int J Food Sci Nutr 2020 Dec 1:1-5. Epub 2020 Dec 1.

College of Health Sciences, University of Memphis, Memphis, TN, USA.

Habitual dietary intake is a major determinant of the species composition and functional output of the trillions of microorganisms residing in the human gut. Diet influences which microbes will colonise, flourish or disappear throughout life. An increase in polyphenols, oligosaccharides and fibre, which are all components found in a fruit and vegetable-rich diet, have long been associated with decreased risk of chronic diseases. Read More

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December 2020

sp. nov., a new member of family isolated from sand fly rearing substrate.

Int J Syst Evol Microbiol 2021 May;71(5)

Department of Entomology and Plant Pathology, North Carolina State University, Raleigh, North Carolina, USA.

A Gram-stain-negative, rod-shaped, non-motile, non-spore-forming, aerobic bacterium, designated type strain SSI9, was isolated from sand fly ( Scopoli; ) rearing substrate and subjected to polyphasic taxonomic analysis. Strain SSI9 contained phosphatidylethanolamine as a major polar lipid, MK-7 as the predominant quinone, and Cω6/Cω, iso-C, iso-C 3-OH and C as the major cellular fatty acids. Phylogenetic analysis based on 16S rRNA gene sequences revealed that SSI9 represents a member of the genus , of the family Sphingobacteriaceae sharing 96. Read More

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Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes.

Ann Clin Transl Neurol 2021 May 6. Epub 2021 May 6.

Department of Neurology, University of Michigan, Ann Arbor, Michigan.

Objective: The global rise in type 2 diabetes is associated with a concomitant increase in diabetic complications. Diabetic polyneuropathy is the most frequent type 2 diabetes complication and is associated with poor outcomes. The metabolic syndrome has emerged as a major risk factor for diabetic polyneuropathy; however, the metabolites associated with the metabolic syndrome that correlate with diabetic polyneuropathy are unknown. Read More

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Compound heterozygous p. Arg949Trp and p. Gly970Ala mutations deteriorated the function of PEX1p: A study on PEX1 in a patient with Zellweger syndrome.

J Cell Biochem 2021 May 6. Epub 2021 May 6.

Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Postal Code 81746-73441, Iran.

The peroxisome is responsible for a variety of vital pathways in primary metabolism, including the very long-chain fatty-acid oxidation and plasmalogen lipid biosynthesis. Autosomal recessive disorder of the Zellweger spectrum (ZSD) is a major subset of peroxisome biogenesis disorders (PBDs) that can be caused by mutations in any of the 14 PEX genes. Zellweger syndrome (ZS) is the foremost common and severe phenotype within the heterogeneous ZSD. Read More

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New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans.

Genetics 2020 Mar;214(3):669-690

Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250.

Temporal regulation of gene expression is a crucial aspect of metazoan development. In the roundworm Caenorhabditis elegans, the heterochronic pathway controls multiple developmental events in a time-specific manner. The most downstream effector of this pathway, the zinc-finger transcription factor LIN-29, acts in the last larval stage (L4) to regulate elements of the larval-to-adult switch. Read More

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Interdependent Oxidation of Eicosapentaenoic Acid and Docosahexaenoic Acid in Isada Krill Oil Encapsulated with Maltodextrin by Spray-drying.

J Oleo Sci 2021 ;70(5):633-635

Faculty of Bioenvironmental Science, Kyoto University of Advanced Science.

The major polyunsaturated fatty acids in krill oil extracted from Euphausia pacifica, known as Isada on the Sanriku coast, are eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) acid. A kinetic model was proposed to explain the relationship between the fractions of unoxidized EPA (Y ) and unoxidized DHA (Y ) in the oil spray-dried with maltodextrin and stored at 25, 50, and 70℃. The relationship between Y and Y during storage was independent of the temperature and could be expressed using the proposed model. Read More

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January 2021

[Molecular Mechanisms Underlying Toxic Actions of trans-Fatty Acids and Prevention of Related Diseases].

Yakugaku Zasshi 2021 ;141(5):675-679

Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University.

trans-Fatty acids (TFAs), including elaidic acid and linoelaidic acid, are unsaturated fatty acids that contain one or more carbon-carbon double bonds in trans configuration. TFAs are not synthesized in the human body, but are taken into the body from various foods, which are mainly produced during industrial food manufacturing. Recent epidemiological studies have revealed that TFA consumption is a major risk factor for various disorders, such as atherosclerosis, cardiovascular diseases, allergic diseases, and dementia. Read More

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January 2021

Obesity and Liver Cancer in Japan: A Comprehensive Review.

Anticancer Res 2021 May;41(5):2227-2237

The Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.

Lifestyle-related factors play a major role in the development of cancer. In recent years, obesity has become widespread in the world and has attracted attention not only as a cause of diabetes mellitus and atherosclerotic diseases but also as a factor in carcinogenesis. In Japan, the number of obesity-related malignancies has been increasing with the westernization of lifestyle. Read More

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Obesity Cardiomyopathy: Evidence, Mechanisms and Therapeutic Implications.

Physiol Rev 2021 05 5. Epub 2021 May 5.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital Fudan University, Shanghai, 200032 China

The prevalence of heart failure is on the rise and imposes a major health threat, in part, due to the rapidly increased prevalence of overweight and obesity. To this point, epidemiological, clinical and experimental evidence supports the existence of a unique disease entity termed "obesity cardiomyopathy", which develops independent of hypertension, coronary heart disease and other heart diseases. Our contemporary review evaluates the evidence for this pathological condition, examines putative responsible mechanisms, and discusses therapeutic options for this disorder. Read More

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Porphyran-derived oligosaccharides alleviate NAFLD and related cecal microbiota dysbiosis in mice.

FASEB J 2021 Jun;35(6):e21458

Key Laboratory of Marine Drugs of Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.

Porphyran and its derivatives possess a variety of biological activities, such as ameliorations of oxidative stress, inflammation, hyperlipemia, and immune deficiencies. In this study, we evaluated the potential efficacy of porphyran-derived oligosaccharides from Porphyra yezoensis (PYOs) in alleviating nonalcoholic fatty liver disease (NAFLD) and preliminarily clarified the underlying mechanism. NAFLD was induced by a high-fat diet for six months in C57BL/6J mice, followed by treatment with PYOs (100 or 300 mg/kg/d) for another six weeks. Read More

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Hymenobacter negativus sp. nov., bacteria isolated from mountain soil collected in South Korea.

Antonie Van Leeuwenhoek 2021 May 4. Epub 2021 May 4.

Department of Food and Nutrition, Kookmin University, Seoul, 02707, Republic of Korea.

Two novel Gram-negative bacterial strains BT442 and BT584 were isolated from dry soil collected in mountains Busan and Guri, Korea during wintertime. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strains BT442 and BT584 both belong to a distinct lineage within the genus Hymenobacter (family Hymenobacteraceae, order Cytophagales, class Cytophagia). Strain BT442 was closely related to Hymenobacter soli PB17 (98. Read More

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Antimicrobial Power of Organic Acids and Nature-Identical Compounds against Two spp.: An In Vitro Study.

Microorganisms 2021 Apr 29;9(5). Epub 2021 Apr 29.

DIMEVET, Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell'Emilia, Italy.

Vibrosis is one of the major threats in aquaculture farming, and due to the increasing antimicrobial resistance of different species, there is an urgent need to replace conventional treatments with more sustainable solutions. Antimicrobial molecules such as organic acids (OA) and nature-identical compounds (NIC) are currently finding a central role in the infection management of terrestrial livestock, but little is known about their usage in aquaculture. The aim of this study was to perform a preliminary screening of the in vitro antimicrobial activity of a wide panel of OA and NIC against 2 species characteristic of the Mediterranean area, and , through minimal inhibitory/bactericidal concentration tests. Read More

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Gut Microbiota and NAFLD: Pathogenetic Mechanisms, Microbiota Signatures, and Therapeutic Interventions.

Microorganisms 2021 Apr 29;9(5). Epub 2021 Apr 29.

Czech Academy of Sciences, Institute of Microbiology, 142 20 Prague, Czech Republic.

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Its worldwide prevalence is rapidly increasing and is currently estimated at 24%. NAFLD is highly associated with many features of the metabolic syndrome, including obesity, insulin resistance, hyperlipidaemia, and hypertension. Read More

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Short chain fatty acids delay the development of hepatocellular carcinoma in HBx transgenic mice.

Neoplasia 2021 May 1;23(5):529-538. Epub 2021 May 1.

Department of Biology, College of Science and Technology, Philadelphia, PA, USA. Electronic address:

Chronic infection with hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma (HCC). The HBV encoded oncoprotein, HBx, alters the expression of host genes and the activity of multiple signal transduction pathways that contribute to the pathogenesis of HCC by multiple mechanisms independent of HBV replication. However, it is not clear which pathways are the most relevant therapeutic targets in hepatocarcinogenesis. Read More

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Maricaulis alexandrii sp. nov., a novel active bioflocculants-bearing and dimorphic prosthecate bacterium isolated from marine phycosphere.

Antonie Van Leeuwenhoek 2021 May 4. Epub 2021 May 4.

Department of Marine Chemistry, Zhejiang Ocean University, Zhoushan, China.

An aerobic, Gram-stain-negative, straight or curved rods and dimorphic prosthecate bacterium designated as strain LZ-16-1 was isolated from phycosphere microbiota of routinely laboratory-cultured and highly-toxic marine dinoflagellate Alexandrium catenella LZT09. Strain LZ-16-1 produces active bioflocculanting exopolysaccharides (EPS). Cells were dimorphic with non-motile prostheca, or non-stalked and motile by a single polar flagellum. Read More

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[New cardiac biomarkers for early detection of myocardial infarction in cardiac surgery].

Anaesthesist 2021 May 4. Epub 2021 May 4.

Klinik für Anästhesiologie, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

In-hospital mortality after cardiac surgery ranges from 2% to 8%. Many patients suffer from major adverse cardiovascular events, e.g. Read More

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In situ Detection of Fatty Acid C=C Positional Isomers by Coupling On-tissue mCPBA Epoxidation with IR-MALDESI Mass Spectrometry.

Rapid Commun Mass Spectrom 2021 May 3:e9119. Epub 2021 May 3.

FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, NC, 27695.

Rationale: Unsaturated fatty acids (UFAs) play vital roles in regulating cellular functions. In-depth structural characterization of UFAs such as localizing carbon-carbon double bonds is fundamentally important but poses considerable challenges in mass spectrometry (MS) given that the most widely accessible ion activation method, low-energy collision-induced dissociation, primarily generates uninformative fragments (e.g. Read More

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Expression patterns of major genes in fatty acid synthesis, inflammation, oxidative stress pathways from colostrum to milk in Damascus goats.

Sci Rep 2021 May 3;11(1):9448. Epub 2021 May 3.

Department of Molecu1ar Biochemistry and Genetics, Institute of Health Sciences, Hatay Mustafa Kemal University, 31060, Hatay, Turkey.

The molecular regulation of milk secretion and quality in the transition period from colostrum to milk in goats is largely unknown. In the present study, mammary gland secretion of goats was collected in 0th, 4th, 7th, 14th and 28th days after parturition. In addition to composition and fatty acid profile of colostrum or milk, FASN, SCD, ACACA, COX-2, NRF2, TLR2, NF-kB, LTF and PTX3 genes expression patterns were determined from milk somatic cells. Read More

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Microalgae for high-value products: A way towards green nutraceutical and pharmaceutical compounds.

Chemosphere 2021 Apr 12;280:130553. Epub 2021 Apr 12.

Bioprocess and Bioenergy Laboratory, Department of Microbiology, Central University of Rajasthan, NH-8, Bandarsindri, Kishangarh, Ajmer, 305817, Rajasthan, India. Electronic address:

Microalgae is a renewable bioresource with the potential to replace the conventional fossil-based industrial production of organic chemicals and pharmaceuticals. Moreover, the microalgal biomass contains carotenoids, vitamins, and other biomolecules that are widely used as food supplements. However, the microalgal biomass production, their composition variations, energy-intensive harvesting methods, optimized bio-refinery routes, and lack of techno-economic analysis are the major bottleneck for the life-sized commercialization of this nascent bio-industry. Read More

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Membrane Lipids' Metabolism and Transcriptional Regulation in Maize Roots Under Cold Stress.

Front Plant Sci 2021 15;12:639132. Epub 2021 Apr 15.

Key Lab of Modern Agricultural Cultivation and Crop Germplasm Improvement of Heilongjiang Province, College of Agriculture, Heilongjiang Bayi Agricultural University, Daqing, China.

Low temperature is one of the major abiotic stresses that restrict the growth and development of maize seedlings. Membrane lipid metabolism and remodeling are key strategies for plants to cope with temperature stresses. In this study, an integrated lipidomic and transcriptomic analysis was performed to explore the metabolic changes of membrane lipids in the roots of maize seedlings under cold stress (5°C). Read More

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Hepatic Oxidative Stress, Apoptosis, and Inflammation in Broiler Chickens With Wooden Breast Myopathy.

Front Physiol 2021 14;12:659777. Epub 2021 Apr 14.

Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, National Experimental Teaching Demonstration Center of Animal Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.

Wooden breast (WB) syndrome has emerged as a global myopathy in modern commercial broiler chickens, mainly affecting the pectoralis major muscle. Recent evidence suggests that WB myopathy is a systemic disease, which might be accompanied by other physiological disparities and metabolic changes. This study was conducted to systemically investigate the potential physiological changes in liver tissues as well as the possible mechanisms involved to enhance the understanding of the etiology. Read More

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Validation and reproducibility of a short food frequency questionnaire for cardiovascular prevention.

Arch Cardiovasc Dis 2021 Apr 28. Epub 2021 Apr 28.

Service de Cardiologie, Université de Rennes, CHU Rennes, Inserm, LTSI U1099, 35000 Rennes, France.

Background: Diet strongly influences cardiovascular risk. Dietary evaluation is a major issue in cardiovascular prevention, but few simple tools are available. Our team previously validated a short food frequency questionnaire; a new version of this questionnaire (Cardiovascular Dietary Questionnaire 2 [CDQ-2]) is easier to complete and more reliable. Read More

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Treatment of clean in place (CIP) wastewater using microalgae: Nutrient upcycling and value-added byproducts production.

Sci Total Environ 2021 Apr 24;785:147337. Epub 2021 Apr 24.

National Food Institute, Technical University of Denmark, Kemitorvet Building 204, 2800 Kgs. Lyngby, Denmark.

CIP wastewater is one of the major wastewater streams from the food industry, and its treatment is generally expensive, requiring a large effort to reduce its typically high nitrogen (N), and phosphorus (P) contents. Microalgae-based wastewater treatment is increasingly explored as a more sustainable alternative to the conventional methods, due to the added benefit of nutrient upcycling and value-added biomass production. For the first time, four microalgae species were used to treat CIP wastewater high in N (565. Read More

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γ-Oryzanol improves exercise endurance and muscle strength by upregulating PPARδ and ERRγ activity in aged mice.

Mol Nutr Food Res 2021 May 1:e2000652. Epub 2021 May 1.

Natural Materials and Metabolism Research Group, Korea Food Research Institute, Wanju, 55365, Republic of Korea.

Scope: γ-Oryzanol, a well-known antioxidant, has been used by body builders and athletes to boost strength and increase muscle gain, without major side effects. However, the effect of γ-oryzanol on sarcopenia and the underlying molecular mechanism is poorly understood.

Results: Aged mice fed with the γ-oryzanol diet did not show significant changes in muscle weight, but showed increased running endurance as well as improved grip strength. Read More

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4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-α.

Clin Transl Med 2021 Apr;11(4):e379

National Center for Liver Cancer, Second Military Medical University, Shanghai, China.

Background And Aims: 4-phenylbutyric acid (4-PBA) is a low molecular weight fatty acid that is used in clinical practice to treat inherited urea cycle disorders. In previous reports, it acted as a chemical chaperone inhibiting endoplasmic reticulum (ER) stress and unfolded protein response signaling. A few studies have suggested its function against hepatic fibrosis in mice models. Read More

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Plasma lipidome profiling of newborns with antenatal exposure to Zika virus.

PLoS Negl Trop Dis 2021 Apr 30;15(4):e0009388. Epub 2021 Apr 30.

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.

The 2015-2016 Zika virus (ZIKV) outbreak in Brazil was remarkably linked to the incidence of microcephaly and other deleterious clinical manifestations, including eye abnormalities, in newborns. It is known that ZIKV targets the placenta, triggering an inflammatory profile that may cause placental insufficiency. Transplacental lipid transport is delicately regulated during pregnancy and deficiency on the delivery of lipids such as arachidonic and docosahexaenoic acids may lead to deficits in both brain and retina during fetal development. Read More

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Efficient -mediated stable genetic transformation of green microalgae, .

3 Biotech 2021 Apr 26;11(4):196. Epub 2021 Mar 26.

Centre for Energy, Indian Institute of Technology Guwahati, Guwahati, Assam 781039 India.

The green oleaginous microalgae, , is a highly productive species and a potential host for the production of biofuel, nutraceuticals, and recombinant therapeutic proteins. The lack of a stable and efficient genetic transformation system is the major bottleneck in improving this species. We report an efficient and stable -mediated transformation system for the first time in . Read More

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Associations of Arachidonic Acid Synthesis with Cardiovascular Risk Factors and Relation to Ischemic Heart Disease and Stroke: A Univariable and Multivariable Mendelian Randomization Study.

Nutrients 2021 Apr 28;13(5). Epub 2021 Apr 28.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Arachidonic acid (AA), a major long-chain omega-6 polyunsaturated fatty acid, is associated with ischemic heart disease (IHD) and stroke. We assessed bi-directional associations of AA synthesis reflected by plasma phospholipid AA with CVD risk factors, and identified mediators of associations of AA with IHD and stroke using Mendelian randomization (MR). We used two-sample MR to assess bi-directional associations of AA synthesis with lipids, blood pressure, adiposity, and markers of inflammation and coagulation. Read More

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