Int J Mol Sci 2021 Jul 5;22(13). Epub 2021 Jul 5.
Department of Biomedical, Experimental and Clinical Sciences, University of Firenze, 50134 Firenze, Italy.
(1) Background: Autophagy, the major cytoplasmic process of substrate turnover, declines with age, contributing to proteostasis decline, accumulation of harmful protein aggregates, damaged mitochondria and to ROS production. Accordingly, abnormalities in the autophagic flux may contribute to many different pathophysiological conditions associated with ageing, including neurodegeneration. Recent data have shown that extra-virgin olive oil (EVOO) polyphenols stimulate cell defenses against plaque-induced neurodegeneration, mainly, through autophagy induction. Read More