14,410 results match your criteria maintenance duration


Systemic minoxidil as maintenance treatment in alopecia areata: a retrospective case-series of 24 patients.

Clin Exp Dermatol 2021 Dec 4. Epub 2021 Dec 4.

Sinclair Dermatology, Melbourne, Victoria, Australia.

Alopecia areata (AA) is a common, relapsing and remitting, T-cell mediated autoimmune disease. Relapse rates are low for patients with disease duration <6 months (13%), moderate for disease duration 6-12 months (65%) and high for disease duration ≥12 months (up to 100%). There is unmet need for safe and effective maintenance therapy that reduces the risk of AA relapse following initial regrowth. Read More

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December 2021

Immunosuppressants in Liver Transplant Recipients With Coronavirus Disease 2019: Capability or Catastrophe?-A Systematic Review and Meta-Analysis.

Front Med (Lausanne) 2021 11;8:756922. Epub 2021 Nov 11.

Department of Hepatobiliary Surgery & Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.

The probable impact of a maintenance immunosuppressant (IS) on liver transplant (LT) recipients with coronavirus disease 2019 (COVID-19) remains unexplored. Our specific aim was to approximate the prognosis of LT recipients with COVID-19 on the standard maintenance IS. We searched separate databases for the qualified studies in between December 2019 and June 25, 2021. Read More

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November 2021

Who to Involve and Where to Start Integrating Tuberculosis Screening into Routine Healthcare Services: Positive Cough of Any Duration as the First Step for Screening Tuberculosis in Ethiopia.

Risk Manag Healthc Policy 2021 25;14:4749-4756. Epub 2021 Nov 25.

Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Recent country surveys have shown an unacceptably high prevalence of confirmed tuberculosis (TB) even among those with a low duration of cough, and more than 50% of those with bacteriologically confirmed pulmonary tuberculosis (PTB) do not report symptoms that correspond to presumptive TB. Furthermore, there has been an increase in the incidence of smear-negative PTB patients who can serve as a source of infection. We investigated whether screening people who sought healthcare for cough of any duration can increase TB case detection in Ethiopia, and compiled the lessons learned and recommendations. Read More

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November 2021

Strategies for extended lifetime of implantable intraperitoneal insulin catheters.

J Control Release 2021 Nov 29. Epub 2021 Nov 29.

Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Road U3092, Storrs, CT 06269, USA. Electronic address:

Implantable insulin infusion systems using the intra-peritoneal route have dramatically changed the management of diabetes paving the way toward the realization of the potential "holy grail" of a fully implantable artificial pancreas. However, the wear duration of delivery catheters is compromised by the foreign body-mediated immune response. Both occlusion material present at the distal catheter tip end and fibrotic encapsulation surrounding the catheters influence the controlled and precise delivery of insulin, which eventually leads to the need for surgical intervention. Read More

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November 2021

A systematic review of the impact of carer interventions on outcomes for patients with eating disorders.

Eat Weight Disord 2021 Dec 1. Epub 2021 Dec 1.

Norfolk and Suffolk NHS Foundation Trust, Hellesdon Hospital, Drayton High Road, Norwich, NR6 5BE, UK.

Purpose: Eating disorder (ED) prevalence and illness severity is rapidly increasing. The complicated interplay of factors contributing to the maintenance of EDs, including family/carer influences, highlights the importance of carer interventions within ED treatment. Carer interventions demonstrate positive outcomes for carers themselves, though are also hypothesised to benefit the patient indirectly. Read More

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December 2021

Overall Survival and Safety With Pemetrexed/Platinum ± Anti-VEGF Followed by Pemetrexed ± Anti-VEGF Maintenance in Advanced Nonsquamous Non-Small-Cell Lung Cancer: A Pooled Analysis of 4 Randomized Studies.

Clin Lung Cancer 2021 Oct 25. Epub 2021 Oct 25.

Eli Lilly and Company, Indianapolis, IN.

Background: Before immune checkpoint blockade therapy, chemotherapy with pemetrexed maintenance was the standard of care for patients with advanced nonsquamous non-small-cell lung cancer (NSQ-NSCLC) and remains such where immunotherapy is not applicable. This pooled analysis aimed to characterize overall survival (OS) and safety of pemetrexed ± anti-VEGF maintenance, by treatment duration.

Patients And Methods: Data from 4 randomized clinical trials (PARAMOUNT, PRONOUNCE, PointBreak, JVBL) of patients with NSQ-NSCLC receiving pemetrexed ± anti-VEGF maintenance therapy were pooled as 2 groups (Group A: pemetrexed-only maintenance, n = 486; and Group B: pemetrexed + anti-VEGF maintenance, n = 329). Read More

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October 2021

Treatment of tuberculous meningitis in adults: Is the duration of intensive-phase therapy adequate?

S Afr Med J 2021 Apr 30;111(5):412-415. Epub 2021 Apr 30.

Department of Neurology, Inkosi Albert Luthuli Central Hospital, Durban, South Africa.

Tuberculous meningitis (TBM) results in considerable morbidity and mortality, especially in developing countries such as South Africa. Treatment regimens have been extrapolated from treatment for pulmonary tuberculosis, and the intensive-phase duration of 2 months may be inadequate for treatment of patients with TBM. We highlight this situation with a case report of a patient with TBM whose illness progressed after institution of the maintenance phase of treatment. Read More

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Virological outcomes with dolutegravir plus either lamivudine or two NRTIs as switch strategies: a multi-cohort study.

J Antimicrob Chemother 2021 Nov 28. Epub 2021 Nov 28.

Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC Malattie Infettive, Rome, Italy.

Objectives: To compare the efficacy of dolutegravir plus lamivudine dual therapy (DT) with that of dolutegravir plus two NRTIs triple therapy (TT) as switch strategies.

Methods: A multicentre cohort of HIV-positive, HBsAg-negative patients with viral suppression (HIV-RNA ≤50 copies/mL) switching to DT or TT was retrospectively selected from the ARCA database. The effect of DT versus TT on virological failure (VF; defined as two consecutive HIV-RNA values >50 copies/mL or one HIV-RNA value ≥200 copies/mL) was evaluated by multivariable Cox regression models, overall and after stratifying for the presence of NRTI resistance-associated mutations (RAMs). Read More

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November 2021

Final Results of the Prospective ADVATE Immune Tolerance Induction Registry (PAIR) Study with Plasma- and Albumin-Free Recombinant Factor VIII.

J Blood Med 2021 20;12:991-1001. Epub 2021 Nov 20.

Centre for Outcomes and Experience Research in Children's Health Illness and Disability (ORCHID), Great Ormond Street Hospital, London, UK.

Introduction: Neutralizing antibodies to coagulation factor VIII (FVIII) remain a major complication associated with FVIII replacement therapy.

Aim: To assess safety and efficacy of immune tolerance induction (ITI) therapy with ADVATE (antihemophilic factor [recombinant] [rAHF]) in patients who participated in the Prospective ADVATE Immune Tolerance Induction Registry (PAIR) study.

Methods: The PAIR study was an international, multicenter, open-label, prospective, observational study in patients with hemophilia A and inhibitors, prescribed rAHF ITI therapy in clinical practice. Read More

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November 2021

High-power short-duration versus standard-power standard-duration settings for repeat atrial fibrillation ablation.

Heart Vessels 2021 Nov 30. Epub 2021 Nov 30.

Department of Medicine, Jefferson Heart Institute, Thomas Jefferson University Hospital, 925 Chestnut Street, Mezzanine level, Philadelphia, PA, 19107, USA.

Introduction: High-power short-duration (HPSD) ablation is a novel strategy using contact force-sensing catheters optimized for radiofrequency ablation for atrial fibrillation (AF). No study has directly compared HPSD versus standard-power standard-duration (SPSD) contact force-sensing settings in patients presenting for repeat ablation with AF recurrence after initial ablation.

Methods: We studied consecutive cases of patients with AF undergoing repeat ablation with SPSD or HPSD settings after their initial pulmonary vein isolation (PVI) with temperature controlled non-contact force, SPSD or HPSD settings between 6/23/14 and 3/4/20. Read More

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November 2021

Odds of Testing Positive for SARS-CoV-2 Following Receipt of 3 vs 2 Doses of the BNT162b2 mRNA Vaccine.

JAMA Intern Med 2021 Nov 30. Epub 2021 Nov 30.

Public Health Modeling Unit, Yale School of Public Health, Yale University, New Haven, Connecticut.

Importance: With the evidence of waning immunity of the mRNA vaccine BNT162b2 (Pfizer-BioNTech), a nationwide third-dose (booster) vaccination campaign was initiated in Israel during August 2021; other countries have begun to administer a booster shot as well.

Objective: To evaluate the initial short-term additional benefit of a 3-dose vs a 2-dose regimen against infection of SARS-CoV-2.

Design, Setting, And Participants: This preliminary retrospective case-control study used 2 complementary approaches: a test-negative design and a matched case-control design. Read More

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November 2021

Epicardial adipose tissue radiodensity is associated with all-cause mortality in patients undergoing hemodialysis.

Sci Rep 2021 Nov 29;11(1):23090. Epub 2021 Nov 29.

Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.

The radiodensity and volume of epicardial adipose tissue (EAT) on computed tomography angiography (CTA) may provide information regarding cardiovascular risk and long-term outcomes. EAT volume is associated with mortality in patients undergoing incident hemodialysis. However, the relationship between EAT radiodensity/volume and all-cause mortality in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis remains elusive. Read More

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November 2021

Decreased reward-related brain function prospectively predicts increased substance use.

J Abnorm Psychol 2021 Nov;130(8):886-898

Department of Psychology, Temple University.

Substance use and addiction are prominent global health concerns and are associated with abnormalities in reward sensitivity. Reward sensitivity and approach motivation are supported by a fronto-striatal neural circuit including the orbitofrontal cortex (OFC), ventral striatum (VS), and dorsal striatum (DS). Although research highlights abnormalities in reward neural circuitry among individuals with problematic substance use, questions remain about whether such use arises from excessively high, or excessively low, reward sensitivity. Read More

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November 2021

Dyspepsia in Montenegrin chronic kidney disease patients undergoing hemodialysis: endoscopic and histopathological features.

Int Urol Nephrol 2021 Nov 27. Epub 2021 Nov 27.

Faculty of Medical Sciences, Department of Social Medicine, University of Kragujevac, Kragujevac, Serbia.

Purpose: The main purpose of this study was to analyze the characteristics of dyspepsia and contributing factors in Montenegrin maintenance hemodialysis patients.

Methods: The study included 43 patients undergoing hemodialysis with symptoms of dyspepsia and 40 control dyspeptic subjects with preserved kidney function. All subjects underwent an interview about dyspeptic symptoms, physical and biochemical examination, and upper gastrointestinal endoscopy with pathohistological analysis of biopsy specimens. Read More

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November 2021

Transient Waterlogging Events Impair Shoot and Root Physiology and Reduce Grain Yield of Durum Wheat Cultivars.

Plants (Basel) 2021 Nov 1;10(11). Epub 2021 Nov 1.

Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.

Durum wheat ( L. subsp. (Desf. Read More

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November 2021

An Updated View on the Antiviral Therapy of Hepatitis C in Chronic Kidney Disease.

Pathogens 2021 Oct 26;10(11). Epub 2021 Oct 26.

Division of Nephrology, Dialysis, and Kidney Transplant, Ca' Granda IRCCS Foundation and Maggiore Policlinico Hospital, 20122 Milano, Italy.

Background: Hepatitis C virus infection remains common in patients with chronic kidney disease, including those on maintenance dialysis. The relationship between hepatitis C virus infection and chronic kidney disease is bi-directional; in fact, HCV is both a cause and consequence of chronic kidney disease. According to a systematic review with meta-analysis of observational studies ( = 23 studies) ( = 574,081 patients on long-term dialysis), anti-HCV positive serologic status was an independent and significant risk factor for death in patients with advanced chronic kidney disease on long-term dialysis. Read More

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October 2021

Discrimination of Acoustic Stimuli and Maintenance of Graded Alarm Call Structure in Captive Meerkats.

Animals (Basel) 2021 Oct 27;11(11). Epub 2021 Oct 27.

Department of Bioscience Education and Zoo Biology, Goethe-University Frankfurt, Max-von-Laue-Str. 13, 60438 Frankfurt, Germany.

Animals living in human care for several generations face the risk of losing natural behaviors, which can lead to reduced animal welfare. The goal of this study is to demonstrate that meerkats () living in zoos can assess potential danger and respond naturally based on acoustic signals only. This includes that the graded information of urgency in alarm calls as well as a response to those alarm calls is retained in captivity. Read More

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October 2021

[KDIGO 2021 guideline glomerulonephritis - focus on ANCA-associated vasculitides and anti-glomerular basement membrane glomerulonephritis].

Dtsch Med Wochenschr 2021 Nov 26;146(23):1552-1558. Epub 2021 Nov 26.

Medizinische Klinik und Poliklinik IV, Nephrologisches Zentrum, LMU Klinikum, Campus Großhadern.

In 2021 new KDIGO (Kidney Disease: Improving Global Outcomes) guidelines for the management of glomerular diseases were published.For ANCA-associated glomerulonephritis the new recommendations comprise a more rapid steroid taper during induction treatment with cyclophosphamide or rituximab, the advice against routine use of plasma exchange, the choice of drug for and duration of maintenance treatment in accordance with predictors of relapse. A kidney transplant should be performed after at least 6 months of remission irrespective of the ANCA titer in ANCA-associated disease, and 6 months after absence of anti-GBM-antibodies in anti-GBM-disease. Read More

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November 2021

Description of on-farm treatment compliance and risk factors for culling in sows.

Porcine Health Manag 2021 Nov 25;7(1):59. Epub 2021 Nov 25.

Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, 1920 Coffey Rd, Columbus, OH, 43210, USA.

Background: In commercial pig farming, sick or injured sows are often treated by producers or hired staff. To date, limited quantitative data exists on treatment compliance and the possible effect on sow longevity post-treatment. The objective of the study was to quantify on-farm compliance of treatment selection, frequency, and dosage, as well as to investigate the association between body condition scores (BCS) and other sow-level factors on post-treatment cull risk. Read More

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November 2021

Moderate evidence for heritability in the duet contributions of a South American primate.

J Evol Biol 2021 Nov 25. Epub 2021 Nov 25.

Animal Behavior Graduate Group, University of California, Davis, Davis, CA, 95616, USA.

Acoustic signals are ubiquitous across mammalian taxa. They serve a myriad of functions related to the formation and maintenance of social bonds, and can provide conspecifics information about caller condition, motivation, and identity. Disentangling the relative importance of evolutionary mechanisms that shape vocal variation is difficult, and little is known about heritability of mammalian vocalizations. Read More

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November 2021

Long-term individual retention with cenobamate in adults with focal seizures: Pooled data from the clinical development program.

Epilepsia 2021 Nov 23. Epub 2021 Nov 23.

Epilepsy Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Objective: We determined retention on open-label cenobamate therapy in the clinical development program to assess the long-term efficacy and tolerability of adjunctive cenobamate in individuals with uncontrolled focal seizures.

Methods: Data from two randomized, controlled cenobamate studies and one open-label safety and pharmacokinetic study were pooled. Based on the percentage of participants remaining on treatment, retention rates were estimated using Kaplan-Meier survival analyses. Read More

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November 2021

A Smartphone-Based Self-Management Intervention for Individuals with Bipolar Disorder (LiveWell): Qualitative Study on User Experiences of the Behavior Change Process.

JMIR Ment Health 2021 Nov 22;8(11):e32306. Epub 2021 Nov 22.

Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.

Background: Bipolar disorder is a severe mental illness characterized by recurrent episodes of depressed, elevated, and mixed mood states. The addition of psychotherapy to pharmacological management can decrease symptoms, lower relapse rates, and improve quality of life; however, access to psychotherapy is limited. Mental health technologies such as smartphone apps are being studied as a means to increase access to and enhance the effectiveness of adjunctive psychotherapies for bipolar disorder. Read More

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November 2021

Sequencing of Novel Therapies for Mantle Cell Lymphoma.

Curr Treat Options Oncol 2021 11 23;22(12):118. Epub 2021 Nov 23.

Department of Hematology and Medical Oncology, Winship Cancer Institute At Emory University, Atlanta, GA, USA.

Opinion Statement: There is no standard approach to sequencing novel therapies in mantle cell lymphoma (MCL). For initial treatment, intensive induction chemotherapy followed by autologous stem cell transplant and rituximab maintenance remains our preferred approach in young, fit patients. We consider bendamustine plus rituximab or lenalidomide plus rituximab in patients who are ineligible for intensive chemotherapy-based approaches. Read More

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November 2021

Trajectories of stroke recovery of impairment, function, and quality of life in response to 12-month mobility and fitness intervention.

NeuroRehabilitation 2021 Nov 15. Epub 2021 Nov 15.

Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.

Background: Gait deficits and functional disability are persistent problems for many stroke survivors, even after standard neurorehabilitation. There is little quantified information regarding the trajectories of response to a long-dose, 12-month intervention.

Objective: We quantified treatment response to an intensive neurorehabilitation mobility and fitness program. Read More

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November 2021

Oral Antidiabetics and Sleep Among Type 2 Diabetes Patients: Data From the UK Biobank.

Front Endocrinol (Lausanne) 2021 3;12:763138. Epub 2021 Nov 3.

Department of Neuroscience (Sleep Science, Biomedicinskt centrum (BMC)), Uppsala University, Uppsala, Sweden.

Previous small-scale studies have found that oral antidiabetic therapy is associated with sleep difficulties among patients with type 2 diabetes (T2D). Here, we used data from 11 806 T2D patients from the UK Biobank baseline investigation to examine the association of oral antidiabetic therapy with self-reported difficulty falling and staying asleep and daily sleep duration. As shown by logistic regression adjusted for, e. Read More

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November 2021

Real-World Data of Tigecycline-Associated Drug-Induced Liver Injury Among Patients in China: A 3-year Retrospective Study as Assessed by the Updated RUCAM.

Front Pharmacol 2021 2;12:761167. Epub 2021 Nov 2.

Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, China.

Tigecycline, a glycylcycline antibiotic, is increasingly used clinically for the treatment of severe infections caused by multidrug-resistant bacteria, but it is also associated with hepatotoxicity. However, the incidence and risk factors of tigecycline-associated drug-induced liver injury (DILI) are unclear. We conducted this study to investigate the incidence, characteristics and risk factors of tigecycline-associated DILI in the real-world clinic setting. Read More

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November 2021

Elevated Cow's Milk-Specific IgE Levels Prior to Oral Immunotherapy Decrease the Likelihood of Reaching the Maintenance Dose.

J Allergy Clin Immunol Pract 2021 Nov 15. Epub 2021 Nov 15.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.

Background: Food desensitization via oral immunotherapy (OIT) is gaining acceptance in clinical practice. Owing to adverse reactions, the duration of the buildup phase until a maintenance dose is achieved may be prolonged, and in a minority of cases, OIT is stopped.

Objective: We aimed to assess factors associated with the probability of reaching the maintenance dose in cow's milk (CM) OIT. Read More

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November 2021

Fatty Liver and the Coronavirus Disease 2019 Pandemic: Health Behaviors, Social Factors, and Telemedicine Satisfaction in Vulnerable Populations.

Hepatol Commun 2021 Nov 18. Epub 2021 Nov 18.

Division of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

The coronavirus disease 2019 (COVID-19) pandemic has impacted health-related behaviors that influence fatty liver disease (FLD) management. We evaluated the impact of the pandemic on FLD management and satisfaction with care delivery in this population. In the San Francisco safety-net hepatology clinics, we evaluated health-related behaviors and factors associated with self-reported weight gain during the COVID-19 pandemic as well as satisfaction with telemedicine in adults with FLD by using multivariable modeling. Read More

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November 2021

Identification of a genetic signature enriching for response to ibrutinib in relapsed/refractory follicular lymphoma in the DAWN phase 2 trial.

Cancer Med 2021 Nov 17. Epub 2021 Nov 17.

Division of Medical Oncology, Department of Medicine, The University of Washington, Seattle, Washington, USA.

Background: The single-arm DAWN trial (NCT01779791) of ibrutinib monotherapy in patients with relapsed/refractory follicular lymphoma (FL) showed an overall response rate (ORR) of 20.9% and a median response duration of 19.4 months. Read More

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November 2021

Efficacy and safety of tocilizumab in Behçet's syndrome with refractory arterial lesions: A single-centre observational cohort study in China.

Rheumatology (Oxford) 2021 Nov 15. Epub 2021 Nov 15.

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.

Objective: To assess the effectiveness and safety of interleukin-6-receptor inhibitor tocilizumab (TCZ) in Behçet's syndrome (BS) with refractory arterial involvement via an observational cohort study.

Methods: Ten patients admitted to the Rheumatology and Immunology Department of Peking University People's Hospital between January 2014 and December 2019 were enrolled. Patients met the BS international criteria and exhibited severe arterial impairments. Read More

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November 2021