2 results match your criteria maintains trpc4

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Differential PI(4,5)P sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.

Sci Rep 2019 02 12;9(1):1849. Epub 2019 Feb 12.

Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.

Transient receptor potential canonical (TRPC) 4 and TRPC5 channels are modulated by the Gα-PLC pathway. Since phosphatidylinositol 4,5-bisphosphate (PI(4,5)P) maintains TRPC4 and TRPC5 channel function, the Gα-PLC pathway inhibits channel activity by depleting PI(4,5)P. Here we investigated the difference in PI(4,5)P sensitivity between homomeric and heteromeric TRPC channels. Read More

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February 2019

Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle.

Am J Physiol Gastrointest Liver Physiol 2003 Jun;284(6):G1074-83

Department of Medicine, The University of Western Ontario, London, Ontario N6A 4V2, Canada.

Transient receptor potential channel (TRPC) genes encode Ca(2+)-permeable channels mediating capacitative Ca(2+) entry (CCE), which maintains intracellular Ca(2+) stores. We compared TRPC gene expression and CCE in human esophageal body (EB) and lower esophageal sphincter (LES), because these smooth muscles have distinct contractile functions that are likely associated with different Ca(2+) regulatory mechanisms. Circular layer smooth muscle cells were grown in primary culture. Read More

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