13,129 results match your criteria main organs

[Recommendation for the recognition, management and follow up of cardiovascular compromise in patients with Pediatric Multisystemic Inflammatory Syndrome associated with COVID-19 (PIMS-CT). Position statement of Chilean Scientific Societies].

Rev Chil Pediatr 2020 Dec 8;91(6):982-990. Epub 2020 Oct 8.

Clínica Santa María, Santiago, Chile.

Since the onset of the SARS-CoV-2 pandemic, the pediatric population has been less affected by the disease both in frequency and severity. However, since April cases of variable presentation and severity characterized by inflammatory phenomena that affect multiple organs have been reported, a condition called Multisystem Inflammatory Syndrome in Children (MIS-C). The literature has reported frequent cardiac involvement, up to 80%. Read More

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December 2020

polyphenols: structural identification, antioxidant activity, immune function and inhibition of cancer cell proliferation.

Food Funct 2021 Apr 16. Epub 2021 Apr 16.

Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, 92 Xidazhi Street, Harbin, Nangang District, China.

Herein, polyphenols were extracted from Pinus koraiensis bark and characterized. Besides, the in vitro antioxidant activity, inhibition effect on cancer cells and the activity of the immune system were investigated. The results showed that the main component of Pinus koraiensis bark was 3,5,7,3',5'-pentahydroxydihydroflavone. Read More

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Chronic exposure to volcanic gaseous elemental mercury: using wild Mus musculus to unveil its uptake and fate.

Environ Geochem Health 2021 Apr 16. Epub 2021 Apr 16.

Faculdade de Ciências E Tecnologia, Universidade Dos Açores, Rua da Mãe de Deus, Apartado 1422, 9501-801, Ponta Delgada, Açores, Portugal.

Volcanoes are a natural source of gaseous elemental mercury (GEM) (Hg). Monitoring GEM releases of volcanic origin has been widely studied; however, few studies have been performed about the biomonitoring of species exposed to GEM, rendering an unknown risk to the worldwide populations living in the vicinity of an active volcano. In this pilot study, we used Mus musculus as a bioindicator species to understand to what extent lungs are the main route of mercury uptake in populations chronically exposed to active volcanic environments. Read More

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Large-Scale Screening of Lipase Acid Deficiency in at Risk Population.

Clin Chim Acta 2021 Apr 12. Epub 2021 Apr 12.

Normandie Univ, UNIROUEN, INSERM U1245, CHU Rouen, Department of Metabolic Biochemistry, 76000 Rouen, France. Electronic address:

Background: Lysosomal acid lipase deficiency (LALD, OMIM#278000) is a rare lysosomal disorder with an autosomal recessive inheritance. The main clinical manifestations are related to a progressive accumulation of cholesteryl esters, triglycerides or both within the lysosome in different organs such as the liver, spleen, and cardiovascular system. A wide range of clinical severity is associated with LALD including a severe very rare antenatal/neonatal/infantile phenotype named Wolman disease and a late-onset form named cholesteryl ester storage disease (CESD). Read More

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Aging drives organ-specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in mice.

FASEB J 2021 May;35(5):e21558

Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Jena, Germany.

Aging is accompanied by chronic, low-grade systemic inflammation, termed inflammaging, a main driver of age-associated diseases. Such sterile inflammation is typically characterized by elevated levels of pro-inflammatory mediators, such as cytokines, chemokines and reactive oxygen species causing organ damage. Lipid mediators play important roles in the fine-tuning of both the promotion and the resolution of inflammation. Read More

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Acute oral toxicity of a novel functional drink based on , and cocoa husk.

Toxicol Rep 2021 1;8:747-752. Epub 2021 Apr 1.

University of Antwerp, PPES, Epigenetic Signaling Lab, Faculty Biomedical Sciences, Prinsstraat 13, 2000, Wilrijk, Antwerp, Belgium.

A novel functional drink with nutraceutical properties was formulated from the aqueous extracts of , and leaves, and cocoa husks. This juice contains various bioactive compounds, such as phenolic compounds and methylxanthines, with antioxidant and stimulant properties of pharmacological interest. However, it is known whether herbal extracts' interaction may have adverse toxic effects on human health. Read More

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Identification and Regulation of Tomato Serine/Arginine-Rich Proteins Under High Temperatures.

Front Plant Sci 2021 29;12:645689. Epub 2021 Mar 29.

Department of Biosciences, Molecular Cell Biology of Plants, Goethe University, Frankfurt am Main, Germany.

Alternative splicing is an important mechanism for the regulation of gene expression in eukaryotes during development, cell differentiation or stress response. Alterations in the splicing profiles of genes under high temperatures that cause heat stress (HS) can impact the maintenance of cellular homeostasis and thermotolerance. Consequently, information on factors involved in HS-sensitive alternative splicing is required to formulate the principles of HS response. Read More

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Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin.

mSphere 2021 04 14;6(2). Epub 2021 Apr 14.

Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a massive impact on human lives worldwide. While the airborne SARS-CoV-2 primarily affects the lungs, viremia is not uncommon. As placental trophoblasts are directly bathed in maternal blood, they are vulnerable to SARS-CoV-2. Read More

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Characterization and comparison of the digestive physiology of two scombrids, Katsuwonus pelamis and Sarda sarda, in the Gulf of Cádiz.

PLoS One 2021 14;16(4):e0249541. Epub 2021 Apr 14.

Aquaculture Research Group, Centro de Ciências do Mar do Algarve (CCMAR), Faro, Portugal.

Fish and other marine animals have a unique and intimate interaction with their surrounding environment. Diet type or trophic level play significant roles in modulating species digestive physiology. However, little is known about how the trophic niche influences digestive activity and gut microbiota in scombrids species. Read More

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Anti-Müllerian hormone in female reproduction.

Endocr Rev 2021 Apr 14. Epub 2021 Apr 14.

Sorbonne Paris Cité, Université Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l'Axe Gonadotrope U1133, Paris, France.

Anti-Müllerian hormone (AMH), also called Müllerian inhibiting substance, was shown to be synthesized by the ovary in the eighties. This article reviews the main findings of the past 20 years on the regulation of the expression of AMH and its specific receptor AMHR2 by granulosa cells, the mechanism of action of AMH, the different roles it plays in the reproductive organs, its clinical utility and its involvement in the principal pathological conditions affecting women. The findings in respect of regulation tell us that AMH and AMHR2 expression is mainly regulated by Bone Morphogenetic Proteins, gonadotropins and estrogens. Read More

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CT imaging of gold nanoparticle-labeled exosomes in a myocardial infarction mouse model.

Ann Transl Med 2021 Mar;9(6):504

Research Laboratory for Functional Nanomaterial, National Engineering Research Center for Nanotechnology, Shanghai, China.

Background: Acute myocardial infarction (MI) is the primary factor leading to cardiovascular diseases, which are the main causes of morbidity and mortality in developed countries. Mesenchymal stem cell (MSC)-derived exosomes have been reported to improve heart function after MI; however, the molecular mechanisms responsible for this are unknown. imaging can reveal the trafficking process and biodistribution of exosomes, which may provide an insight into the communication mechanisms and pharmacokinetics of exosomes. Read More

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Detection of circulating tumor cells: Advances and critical concerns.

Oncol Lett 2021 May 29;21(5):422. Epub 2021 Mar 29.

Clinical Medical Laboratory, Huai'an Maternity and Child Health Care Hospital, Huai'an, Jiangsu 223002, P.R. China.

Metastasis is the main cause of cancer-related death and the major challenge in cancer treatment. Cancer cells in circulation are termed circulating tumor cells (CTCs). Primary tumor metastasis is likely due to CTCs released into the bloodstream. Read More

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Hollow Fiber and Nanofiber Membranes in Bioartificial Liver and Neuronal Tissue Engineering.

Cells Tissues Organs 2021 Apr 13:1-30. Epub 2021 Apr 13.

Institute on Membrane Technology, National Research Council of Italy, CNR-ITM, Rende, Italy.

To date, the creation of biomimetic devices for the regeneration and repair of injured or diseased tissues and organs remains a crucial challenge in tissue engineering. Membrane technology offers advanced approaches to realize multifunctional tools with permissive environments well-controlled at molecular level for the development of functional tissues and organs. Membranes in fiber configuration with precisely controlled, tunable topography, and physical, biochemical, and mechanical cues, can direct and control the function of different kinds of cells toward the recovery from disorders and injuries. Read More

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Clinical guidelines for the treatment of congenital diaphragmatic hernia.

Pediatr Int 2021 Apr 13. Epub 2021 Apr 13.

Department of Pediatric Surgery, Osaka Women's and Children's Hospital, Izumi, Japan.

Congenital diaphragmatic hernia (CDH) is a birth defect of the diaphragm in which abdominal organs herniate through the defect into the thoracic cavity. The main pathophysiology is respiratory distress and persistent pulmonary hypertension because of pulmonary hypoplasia caused by compression of the elevated organs. Recent progress in prenatal diagnosis and postnatal care has led to an increase in the survival rate of patients with CDH. Read More

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Production of petaloid phenotype in the reproductive organs of compound flowerheads by the co-suppression of class-C genes in hexaploid Chrysanthemum morifolium.

Planta 2021 Apr 13;253(5):100. Epub 2021 Apr 13.

Institute of Vegetable and Floriculture Science, National Agriculture and Food Research Organization (NARO), Fujimoto 2-1, Tsukuba, Ibaraki, 305-0852, Japan.

Main Conclusion: Functional suppression of two types of class-C genes caused transformation of pistils and stamens into petaloid organs that exhibit novel phenotypes, which gives a distinct gorgeous impression in the florets of chrysanthemum. The multiple-petal trait is a breeding objective for many horticultural plants. The loss of function of class-C genes causes the multiple-petal trait in several plant species. Read More

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Anticipating the impact of COVID19 and comorbidities on the South African healthcare system by agent-based simulations.

Sci Rep 2021 04 12;11(1):7901. Epub 2021 Apr 12.

Next Generation Mobility Group, Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17, 37077, Göttingen, Germany.

Tuberculosis (TB) is the 10th leading cause of death worldwide, and since 2007 it has been the main cause of death from a single infectious agent, ranking above HIV/AIDS. The current COVID-19 is a pandemic which caused many deaths around the world. The danger is not only a coinfection as observed for TB and HIV for a long time, but that both TB and SARS-CoV-2 affect the respiratory organs and thus potentiate their effect or accelerate the critical course. Read More

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Current concepts on diffuse choroidal hemangioma in Sturge Weber syndrome.

Ophthalmic Genet 2021 Apr 12:1-8. Epub 2021 Apr 12.

Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Sapienza University of Rome, Faculty of Medicine and Psychology, St. Andrea Hospital, Rome, Italy.

: Diffuse choroidal hemangioma (DCH) is a benign vascular tumor that is characteristically found in the Sturge-Weber syndrome (SWS). Recent genetic discoveries demonstrate that DCH occurs sporadically from an activating mutation in at codon . Mutations in or result in dysregulation of the mitogen-activated protein kinase, which influences gene transcription and results in cellular proliferation. Read More

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The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations.

Brain Behav Immun Health 2021 Jul 3;14:100251. Epub 2021 Apr 3.

Institute of Biomedical Research (BIOMED), UCA-CONICET, Av. Alicia Moreau de Justo 1600, C1107AFF, Buenos Aires, Argentina.

Although our current knowledge of the pathophysiology of COVID-19 is still fragmentary, the information so far accrued on the tropism and life cycle of its etiological agent SARS-CoV-2, together with the emerging clinical data, suffice to indicate that the severe acute pulmonary syndrome is the main, but not the only manifestation of COVID-19. Necropsy studies are increasingly revealing underlying endothelial vasculopathies in the form of micro-haemorrhages and micro-thrombi. Intertwined with defective antiviral responses, dysregulated coagulation mechanisms, abnormal hyper-inflammatory reactions and responses, COVID-19 is disclosing a wide pathophysiological palette. Read More

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Major Stress-Related Symptoms During the Lockdown: A Study by the Italian Society of Psychophysiology and Cognitive Neuroscience.

Front Public Health 2021;9:636089. Epub 2021 Mar 26.

Neurology Unit, Bambino Gesù Hospital, Roma, Italy.

The clinical effects of the Covid-19 pandemic are now the subject of numerous studies worldwide. But what are the effects of the quarantine imposed by the states that implemented the measures of lockdown? The present research aims to explore, in a preliminary way, the major stress-related symptoms during the lockdown, due to Covid-19, in the Italian population. Subjects were asked to fill out a survey, that traced a line identifying the most relevant psychophysiological symptoms that took into account factors such as perceived stress, body perception, perceived pain, quality of sleep, perceptive variations (i. Read More

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Proteomic Characterization, Biodistribution, and Functional Studies of Immune-Therapeutic Exosomes: Implications for Inflammatory Lung Diseases.

Front Immunol 2021 25;12:636222. Epub 2021 Mar 25.

Department of Periodontics, Dental College of Georgia at Augusta University, Augusta, GA, United States.

Dendritic cell (DC)-derived exosomes (DC EXO), natural nanoparticles of endosomal origin, are under intense scrutiny in clinical trials for various inflammatory diseases. DC EXO are eobiotic, meaning they are well-tolerated by the host; moreover, they can be custom-tailored for immune-regulatory or -stimulatory functions, thus presenting attractive opportunities for immune therapy. Previously we documented the efficacy of immunoregulatory DCs EXO (regDCs EXO) as immunotherapy for inflammatory bone disease, in an model. Read More

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Oleuropein Attenuates Lipopolysaccharide-Induced Acute Kidney Injury and by Regulating Toll-Like Receptor 4 Dimerization.

Front Pharmacol 2021 24;12:617314. Epub 2021 Mar 24.

College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.

Acute kidney injury (AKI) is a common critical illness that involves multiple systems and multiple organs with a rapid decline in kidney function over short period. It has a high mortality rate and presents a great treatment challenge for physicians. Oleuropein, the main active constituent of Hook. Read More

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Acute Decompensation and Acute-on-Chronic Liver Failure.

Clin Liver Dis 2021 May 10;25(2):419-430. Epub 2021 Mar 10.

Department for Internal Medicine I, University Hospital, Goethe University, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany; European Foundation for the Study of Chronic Liver Failure, Travesera de Gracia 11, 08021 Barcelona, Spain. Electronic address:

Liver cirrhosis is a major healthcare problem. Acute decompensation, and in particular its interplay with dysfunction of other organs, is responsible for the majority of deaths in patients with cirrhosis. Acute decompensation has different courses, from stable decompensated cirrhosis over unstable decompensated cirrhosis to pre-acute-on-chronic liver failure and finally acute-on-chronic liver failure, a syndrome with high short-term mortality. Read More

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Occurrence, mitigation and in vitro cytotoxicity of nivalenol, a type B trichothecene mycotoxin - updates from the last decade (2010-2020).

Food Chem Toxicol 2021 Apr 7:112182. Epub 2021 Apr 7.

Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100, Valencia, Spain.

The present review aims to give an overview of the literature of the last decade (2010-2020) concerning the occurrence of the type B trichothecene mycotoxin nivalenol (NIV) and its in vitro toxicity, with the purpose of updating information regarding last researches on this mycotoxin. The most recent studies on the possible methods for preventing Fusarium spp. growth and NIV production are also discussed. Read More

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SARS-CoV-2 and Human Immunodeficiency Virus: Pathogen Pincer Attack.

HIV AIDS (Auckl) 2021 31;13:361-375. Epub 2021 Mar 31.

Texas Tech University Health Sciences Center, Department of Immunology & Molecular Microbiology, Lubbock, TX, USA.

Paramount efforts worldwide are seeking to increase understanding of the basic virology of SARS-CoV-2, characterize the spectrum of complications associated with COVID-19, and develop vaccines that can protect from new and recurrent infections with SARS-CoV-2. While we continue learning about this new virus, it is clear that 1) the virus is spread via the respiratory route, primarily by droplets and contact with contaminated surfaces and fomites, as well as by aerosol formation during invasive respiratory procedures; 2) the airborne route is still controversial; and 3) that those infected can spread the virus without necessarily developing COVID-19 (ie, asymptomatic). With the number of SARS-CoV-2 infections increasing globally, the possibility of co-infections and/or co-morbidities is becoming more concerning. Read More

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Mechanisms of human drug-induced anaphylaxis.

J Allergy Clin Immunol 2021 Apr;147(4):1133-1142

Department "Auto-immunité et Hypersensibilités," DMU BioGeM, APHP, Hôpital Bichat, Paris, France; "Inflammation, Microbiome and Immunosurveillance" INSERM UMR 996, Faculté de Pharmacie, Université Paris-Saclay, Châtenay-Malabry, France. Electronic address:

Drug-induced anaphylaxis is a hyperacute reaction affecting multiple organs that can be of fatal consequence. Its incidence is increasing, consistent with a global increased sensitization to various allergens and drugs in the population. Few risk factors and mechanisms have been identified from human studies due to the rarity of anaphylactic events and their unpredictability. Read More

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[The Clinical Effectiveness of Neural Network-based Boundary Recognition of Upper Abdominal Organs on CT Images].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Mar;52(2):306-310

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To assess the clinical effectiveness of boundary recognition of upper abdomen organs on CT images based on neural network model and the combination of different slices.

Methods: A total of 2 000 patients who underwent upper abdomen enhanced CT scans from March 2018 to March 2019 were included in the study. The quality of the CT images met the requirements for clinical diagnosis. Read More

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Mobile shielding evaluation on the fetal dose during a breast radiotherapy using Monte Carlo simulation.

Phys Med 2021 Apr 4;84:24-32. Epub 2021 Apr 4.

Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.

Purpose: Evaluation of the out-of-field dose is an important aspect in radiotherapy. Due to the fetus radiosensitivity, this evaluation becomes even more conclusive when the patient is pregnant. In this work, a linear accelerator Varian Clinac 2100c operating at 6 MV, a pregnant anthropomorphic phantom (Maria), and different shields added above the abdominal region of the phantom were used for the analysis based on MCNPX. Read More

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Functional validation of epitope-tagged ATF5 knock-in mice generated by improved genome editing of oviductal nucleic acid delivery (i-GONAD).

Cell Tissue Res 2021 Apr 7. Epub 2021 Apr 7.

Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo, 192-0392, Japan.

Activating transcription factor 5 (ATF5) is a stress-responsive transcription factor that belongs to the cAMP response element-binding protein (CREB)/ATF family, and is essential for the differentiation and survival of sensory neurons in murine olfactory organs. However, the study of associated proteins and target genes for ATF5 has been hampered due to the limited availability of immunoprecipitation-grade ATF5 antibodies. To overcome this issue, we generated hemagglutinin (HA)-tag knock-in mice for ATF5 using CRISPR/Cas9-mediated genome editing with one-step electroporation in oviducts (i-GONAD). Read More

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a safe forage or hyper phytostabilizer species in copper contaminated soils.

Int J Phytoremediation 2021 Apr 7:1-10. Epub 2021 Apr 7.

Department of Agronomy and Plant Breeding, Faculty of Agriculture, University of Jiroft, Jiroft, Iran.

This study was carried out to evaluate Cu uptake, mobility, and accumulation in and define the physiological strategy it employs under copper stress conditions. The experiment was performed at concentration levels from 12, 100, 150, 200, 250, and 300 mg Cu/kg in pod soil. The metal concentrations in roots, tubers, and root organs and the translocation factor (TF), total soluble sugars (TSS), and biomass production were evaluated. Read More

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Insight into Canary Island pine physiology provided by stable isotope patterns of water and plant tissues along an altitudinal gradient.

Tree Physiol 2021 Apr 6. Epub 2021 Apr 6.

Swiss Federal Institute for Forest, Snow and Landscape Research WSL, 8903 Birmensdorf, Switzerland.

The Canary Islands, an archipelago east of Morocco's Atlantic coast, present steep altitudinal gradients covering various climatic zones from hot deserts to subalpine Mediterranean, passing through fog-influenced cloud forests. Unlike the majority of the Canarian flora, Pinus canariensis grow along most of these gradients, allowing the study of plant functioning in contrasting ecosystems. Here we assess the water sources (precipitation, fog) of P. Read More

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