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Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy.

Anim Genet 2021 May 10. Epub 2021 May 10.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, North Carolina State University, A227, Main CVM, 1060 William Moore Drive, Raleigh, NC, 27607, USA.

Hypertrophic cardiomyopathy (HCM) is the most common cause of heart disease in the domestic cat with a genetic predisposition in a few breeds. In the Maine Coon and Ragdoll breeds, two variants associated with the HCM phenotype have been identified in the cardiac myosin binding protein C gene (MYBPC3; p.Ala31Pro and p. Read More

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Nine Seasons of a Bronchiolitis Observation Unit and Home Oxygen Therapy Protocol.

J Hosp Med 2021 May;16(5):261-266

Department of Pediatrics, Division of Inpatient Medicine, University of Utah, Salt Lake City, Utah.

Background: We implemented an observation unit and home oxygen therapy (OU-HOT) protocol at our children's hospital during the 2010-2011 winter season to facilitate earlier discharge of children hospitalized with bronchiolitis. An earlier study demonstrated substantial reductions in inpatient length of stay and costs in the first year after implementation.

Objective: Evaluate long-term reductions in length of stay and cost. Read More

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Relationship between a plant-based 'vegan' pet food and clinical manifestation of multiple nutrient deficiencies in two cats.

J Anim Physiol Anim Nutr (Berl) 2021 Mar 3. Epub 2021 Mar 3.

Nutrition Department, Ecole Nationale Vétérinaire de Toulouse ENVT, Toulouse, France.

A topical subject in human nutrition is the steadily growing number of people choosing to limit or completely avoid all animal-derived food products either for moral dilemma, health concerns or both. To meet people's will of applying their dietary choices to their domestic animals, the pet food industry answered by launching on the market some plant-based diets. This leads to concerns about whether these diets are adequately formulated to satisfy the target species nutritional requirements, especially for cats which are still considered strict carnivores. Read More

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Survival Following Traumatic Brain Injury in Is Increased by Heterozygosity for a Mutation of the NF-κB Innate Immune Response Transcription Factor Relish.

Genetics 2020 12 27;216(4):1117-1136. Epub 2020 Oct 27.

Department of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53706

Traumatic brain injury (TBI) pathologies are caused by primary and secondary injuries. Primary injuries result from physical damage to the brain, and secondary injuries arise from cellular responses to primary injuries. A characteristic cellular response is sustained activation of inflammatory pathways commonly mediated by nuclear factor-κB (NF-κB) transcription factors. Read More

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December 2020

Analyzing factors affecting quality of life in patients hospitalized with chronic wound.

Wound Repair Regen 2021 01 20;29(1):70-78. Epub 2020 Nov 20.

Wound Center of the First Affiliated Hospital, School of Medicine, Shihezi University, Xinjiang, China.

Background: Studies have reported associations between health-related quality of life (HRQOL), social support, and mental stress of patients with chronic wound, while the causal relationship is unclear and little is known about the HRQOL of hospitalized them. We therefore investigated the status of HRQOL of hospitalized patients with chronic wound and the causal relationships among social support, mental stress (anxiety and depression) and HRQOL of which.

Methods: A cross-sectional survey was conducted and the demographic and disease characteristics, HRQOL, perceived social support and mental stress of 216 hospitalized patients with chronic wound was surveyed through questionnaires collected by face to face interview. Read More

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January 2021

Comparison of As-Needed and Scheduled Posthospitalization Follow-up for Children Hospitalized for Bronchiolitis: The Bronchiolitis Follow-up Intervention Trial (BeneFIT) Randomized Clinical Trial.

JAMA Pediatr 2020 09 8;174(9):e201937. Epub 2020 Sep 8.

Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.

Importance: Posthospitalization follow-up visits are prescribed frequently for children with bronchiolitis. The rationale for this practice is unclear, but prior work has indicated that families value these visits for the reassurance provided. The overall risks and benefits of scheduled visits have not been evaluated. Read More

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September 2020

Are the Yellow and Red Marked Club-Tail the Same Species?

Insects 2020 Jun 24;11(6). Epub 2020 Jun 24.

Yunnan Key Laboratory of International Rivers and Transboundary Eco-security, Yunnan University, Kunming 650500, China.

(Fabricius, 1793) is currently comprised of ten subspecies, which were originally described under two names, and before 1909, when they were combined as one species. The main difference between them is the colour of abdomen and hindwing subterminal spots-yellow in and red in . Wing morphology, male and female genitalia, and molecular evidence (DNA barcodes) were analysed for multiple subspecies of and three other species-, , and . Read More

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The role of rare compound heterozygous events in autism spectrum disorder.

Transl Psychiatry 2020 06 22;10(1):204. Epub 2020 Jun 22.

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

The identification of genetic variants underlying autism spectrum disorders (ASDs) may contribute to a better understanding of their underlying biology. To examine the possible role of a specific type of compound heterozygosity in ASD, namely, the occurrence of a deletion together with a functional nucleotide variant on the remaining allele, we sequenced 550 genes in 149 individuals with ASD and their deletion-transmitting parents. This approach allowed us to identify additional sequence variants occurring in the remaining allele of the deletion. Read More

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PLIN2 Functions As a Novel Link Between Progesterone Signaling and Metabolism in Uterine Leiomyoma Cells.

J Clin Endocrinol Metab 2019 12;104(12):6256-6264

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Context: Uterine leiomyoma (fibroids) are the most common tumors in women. Recently, perilipin-2 (PLIN2) was identified as a critical target gene of the progesterone receptor; however, its function in the pathogenesis of fibroids is unknown.

Objective: To determine the function of PLIN2 in leiomyoma cells. Read More

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December 2019

Lineage: Visualizing Multivariate Clinical Data in Genealogy Graphs.

IEEE Trans Vis Comput Graph 2019 03 6;25(3):1543-1558. Epub 2018 Mar 6.

The majority of diseases that are a significant challenge for public and individual heath are caused by a combination of hereditary and environmental factors. In this paper we introduce Lineage, a novel visual analysis tool designed to support domain experts who study such multifactorial diseases in the context of genealogies. Incorporating familial relationships between cases with other data can provide insights into shared genomic variants and shared environmental exposures that may be implicated in such diseases. Read More

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Effects of urbanization on the population structure of freshwater turtles across the United States.

Conserv Biol 2018 10 1;32(5):1150-1161. Epub 2018 Aug 1.

Department of Biology, Rogers State University, 1701 W. Will Rogers Boulevard, Claremore, OK 74017, U.S.A.

Landscape-scale alterations that accompany urbanization may negatively affect the population structure of wildlife species such as freshwater turtles. Changes to nesting sites and higher mortality rates due to vehicular collisions and increased predator populations may particularly affect immature turtles and mature female turtles. We hypothesized that the proportions of adult female and immature turtles in a population will negatively correlate with landscape urbanization. Read More

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October 2018

RANKL/RANK Pathway and Its Inhibitor RANK-Fc in Uterine Leiomyoma Growth.

J Clin Endocrinol Metab 2018 05;103(5):1842-1849

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Context: Uterine leiomyomas are the most common type of gynecologic tumor in women.

Objective: To determine the role of the cytokine receptor activator of nuclear factor κ-Β ligand (RANKL); its receptor, receptor activator of nuclear factor κ-Β (RANK); and the RANKL/RANK pathway inhibitor RANK-Fc in leiomyoma growth.

Design: Messenger RNA (mRNA) or protein levels of RANKL, RANK, and proliferation markers cyclin D1 and Ki67 were assessed in various leiomyoma tissues and cell populations. Read More

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Temporal Trends in Gender-Affirming Surgery Among Transgender Patients in the United States.

JAMA Surg 2018 07;153(7):609-616

Center for Transgender Health, Johns Hopkins Medicine, Baltimore, Maryland.

Importance: Little is known about the incidence of gender-affirming surgical procedures for transgender patients in the United States.

Objectives: To investigate the incidence and trends over time of gender-affirming surgical procedures and to analyze characteristics and payer status of transgender patients seeking these operations.

Design, Setting, And Participants: In this descriptive observational study from 2000 to 2014, data were analyzed from the National Inpatient Sample, a representative pool of inpatient visits across the United States. Read More

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Paediatric overdiagnosis modelled by coronary abnormality trends in Kawasaki disease.

Arch Dis Child 2018 10 22;103(10):937-941. Epub 2018 Feb 22.

Department of Pediatrics, Division of Hospital Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Objective: Compare trends in coronary artery (CA) abnormality diagnoses to trends in adverse cardiac outcomes among American children with Kawasaki disease (KD) to assess the fit of detection of CA abnormalities to an established model of overdiagnosis.

Design: Multicenter retrospective cohort.

Setting: 48 US children's hospitals in the Paediatric Health Information System database. Read More

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October 2018

Real-time detection and discrimination of visual perception using electrocorticographic signals.

J Neural Eng 2018 06 23;15(3):036001. Epub 2018 Jan 23.

Guger Technologies OG, Graz, Austria. Department of Computational Perception, Johannes Kepler University, Linz, Austria.

Objective: Several neuroimaging studies have demonstrated that the ventral temporal cortex contains specialized regions that process visual stimuli. This study investigated the spatial and temporal dynamics of electrocorticographic (ECoG) responses to different types and colors of visual stimulation that were presented to four human participants, and demonstrated a real-time decoder that detects and discriminates responses to untrained natural images.

Approach: ECoG signals from the participants were recorded while they were shown colored and greyscale versions of seven types of visual stimuli (images of faces, objects, bodies, line drawings, digits, and kanji and hiragana characters), resulting in 14 classes for discrimination (experiment I). Read More

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The effect of sexual maturity and egg production on skeletal muscle (pectoralis major and gastrocnemius) protein turnover in broiler breeder pure lines.

Poult Sci 2018 Feb;97(2):531-539

University of Arkansas, Center of Excellence for Poultry Science, Fayetteville, Arkansas 72701.

A study was conducted to evaluate the effect of sexual maturity on pectoralis major and gastrocnemius muscle protein turnover in broiler breeder pure lines. Protein turnover in skeletal muscle tissue was determined in 4 broiler breeder pure lines (Line A, Line B, Line C and Line D) at 22, 27, 33, 37, 44, and 50 wk of age. A completely randomized design with a factorial arrangement 4 × 6 (4 lines and 6 time periods (ages)) was used. Read More

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February 2018

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder.

Nat Neurosci 2017 09 17;20(9):1217-1224. Epub 2017 Jul 17.

Division of Genetics and Genomics, Manton Center for Orphan Disease Research and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts, USA.

We systematically analyzed postzygotic mutations (PZMs) in whole-exome sequences from the largest collection of trios (5,947) with autism spectrum disorder (ASD) available, including 282 unpublished trios, and performed resequencing using multiple independent technologies. We identified 7.5% of de novo mutations as PZMs, 83. Read More

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September 2017

Proteomic analysis reveals changes in carbohydrate and protein metabolism associated with broiler breast myopathy.

Poult Sci 2017 Aug;96(8):2992-2999

Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas.

White Striping (WS) and Woody Breast (WB) are 2 conditions that adversely affect consumer acceptance as well as quality of poultry meat and meat products. Both WS and WB are characterized with degenerative myopathic changes. Previous studies showed that WS and WB in broiler fillets could result in higher ultimate pH, increased drip loss, and decreased marinade uptake. Read More

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Paracrine Pathways in Uterine Leiomyoma Stem Cells Involve Insulinlike Growth Factor 2 and Insulin Receptor A.

J Clin Endocrinol Metab 2017 05;102(5):1588-1595

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.

Context: Uterine leiomyomas (fibroids) are the most common benign tumors in women. Recently, three populations of leiomyoma cells were discovered on the basis of CD34 and CD49b expression, but molecular differences between these populations remain unknown.

Objective: To define differential gene expression and signaling pathways in leiomyoma cell populations. Read More

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Evidence of selection signatures that shape the Persian cat breed.

Mamm Genome 2016 Apr 8;27(3-4):144-55. Epub 2016 Mar 8.

Department of Animal Science, Iowa State University, Ames, IA, USA.

The Persian cat is mainly characterized by an extremely brachycephalic face as part of the standard body conformation. Despite the popularity, world-wide distribution, and economic importance of the Persian cat as a fancy breed, little is known about the genetics of their hallmark morphology, brachycephaly. Over 800 cats from different breeds including Persian, non-Persian breeds (Abyssinian, Cornish Rex, Bengal, La Perm, Norwegian Forest, Maine Coon, Manx, Oriental, and Siamese), and Persian-derived breeds (British Shorthair, Scottish Fold, Selkirk Rex) were genotyped with the Illumina 63 K feline DNA array. Read More

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Estrogen receptor β regulates endometriotic cell survival through serum and glucocorticoid-regulated kinase activation.

Fertil Steril 2016 05 28;105(5):1266-1273. Epub 2016 Jan 28.

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois. Electronic address:

Objective: To determine the expression and biological roles of serum and glucocorticoid-regulated kinase (SGK1) in tissues and cells from patients with endometriosis and from healthy control subjects.

Design: Case-control.

Setting: University research setting. Read More

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Contralateral bone widening and transfer for limb sparing in a cat.

Vet Comp Orthop Traumatol 2016 25;29(2):174-80. Epub 2016 Jan 25.

Massimo Petazzoni, Clinica Veterinaria Milano Sud, Via della Liberazione 26, 20068, Peschiera, Borromeo (Mi), Italy, Phone: +39 02 55 30 55 68 , Fax: +39 02 55 30 62 88, E-mail:

Objective: To report on a novel surgical procedure to treat a long segmental tibial defect in a five-year-old 5 kg spayed female Main Coon cat using transverse distraction osteogenesis in the contralateral tibia to create a free autograft.

Methods: A long free bone segment was created from the cranial half of the normal tibia. A circular external fixator was constructed to give the segment 7 mm of cranial distraction. Read More

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December 2016

Geographical and temporal changes of anthropometric traits in historical Yemen.

Homo 2016 Feb 28;67(1):11-22. Epub 2015 Sep 28.

Università di Cagliari, Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Antropologia, Monserrato 09042, Italy.

This study investigates secular changes of anthropometric variables among four geographic groups in historical Yemen, to evaluate possible regional differences in the evolution of living standards. Nineteen somatic and cephalic measures collected by Coon in 1939, and 8 anthropometric indices in 1244 Yemenite adult males were analyzed. The individuals were divided into 10-year age groups. Read More

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February 2016

Dystocia in the cat evaluated using an insurance database.

J Feline Med Surg 2017 01 10;19(1):42-47. Epub 2016 Jul 10.

1 Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.

Objectives The aim of this study was to describe the incidence of feline dystocia with respect to breed. Methods The data used were reimbursed claims for veterinary care insurance and/or life insurance claims in cats registered in a Swedish insurance database from 1999-2006. Results The incidence rates for dystocia were about 22 cats per 10,000 cat-years at risk, 67 per 10,000 for purebred cats and seven per 10,000 for domestic shorthair cats. Read More

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January 2017

The effects of spatial filtering and artifacts on electrocorticographic signals.

J Neural Eng 2015 Oct 13;12(5):056008. Epub 2015 Aug 13.

School of Mechanical Engineering, Beijing Institute of Technology, Beijing, People's Republic of China. National Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department of Health, Albany, NY, USA.

Objective: Electrocorticographic (ECoG) signals contain noise that is common to all channels and noise that is specific to individual channels. Most published ECoG studies use common average reference (CAR) spatial filters to remove common noise, but CAR filters may introduce channel-specific noise into other channels. To address this concern, scientists often remove artifactual channels prior to data analysis. Read More

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October 2015

Comparison of dietary supplement product knowledge and confidence between pharmacists and health food store employees.

J Am Pharm Assoc (2003) 2015 Mar-Apr;55(2):161-8

Objectives: To determine pharmacists' and health food store employees' knowledge about the safety and efficacy of common, nonvitamin, nonmineral dietary supplements in a retail setting and confidence in discussing, recommending, and acquiring knowledge about complementary and alternative medicine (CAM).

Design: Cross-sectional survey.

Setting: Central and western New York in May and June 2012. Read More

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October 2015

Human uterine leiomyoma stem/progenitor cells expressing CD34 and CD49b initiate tumors in vivo.

J Clin Endocrinol Metab 2015 Apr 6;100(4):E601-6. Epub 2015 Feb 6.

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology (P.Y., M.O., M.B.M., J.S.C.V., A.N., D.M., M.T.D., S.A.D., S.S.M., W.Q., D.C., J.J.K., S.E.B.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; and Department of Molecular and Cellular Biochemistry (V.A.S.), The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.

Context: Uterine leiomyoma is the most common benign tumor in reproductive-age women. Using a dye-exclusion technique, we previously identified a side population of leiomyoma cells exhibiting stem cell characteristics. However, unless mixed with mature myometrial cells, these leiomyoma side population cells did not survive or grow well in vitro or in vivo. Read More

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Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT).

J Clin Endocrinol Metab 2015 Jan;100(1):E30-40

Department of Obstetrics and Gynecology (E.J.S., H.X., P.Y., M.D., J.C.), Division of Maternal-Fetal Medicine and/or Division of Reproductive Science in Medicine, and Department of Pathology (L.M.E.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; and Department of Pediatrics (K.N.F., K.K.M.), Division of Neonatology, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611.

Context: Fetal growth restriction with abnormal umbilical artery Doppler velocimetry (FGRadv), reflective of elevated fetoplacental vascular resistance, is associated with increased risks of fetal morbidity and mortality even in comparison to those of growth-restricted fetuses with normal placental blood flow. One major cause of this abnormally elevated fetoplacental vascular resistance is the aberrantly formed, thin, elongated villous vessels that are seen in FGRadv placentas.

Objective: The purpose of this study was to determine the role of fetoplacental endothelial cells (ECs) in angiogenesis in normal pregnancies and in those complicated by FGRadv. Read More

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January 2015

Activation-induced cell death drives profound lung CD4(+) T-cell depletion in HIV-associated chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2014 Oct;190(7):744-55

1 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Rationale: As overall survival improves, individuals with HIV infection become susceptible to other chronic diseases, including accelerated chronic obstructive pulmonary disease (COPD).

Objectives: To determine whether individuals with HIV-associated COPD exhibit dysregulated lung mucosal T-cell immunity compared with control subjects.

Methods: Using flow cytometry, we evaluated peripheral blood and lung mucosal T-cell immunity in 14 HIV(+)COPD(+), 13 HIV(+)COPD(-), and 7 HIV(-)COPD(+) individuals. Read More

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October 2014