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Patterns of Narcotic Utilization in Women Undergoing Hysterectomy for Benign Indications.

J Gynecol Obstet Hum Reprod 2021 Jun 12:102181. Epub 2021 Jun 12.

Department of Obstetrics and Gynecology, Division of Minimally Invasive Gynecologic Surgery, University of North Carolina School of Medicine, Chapel Hill, NC.

Objective: To determine whether perioperative narcotic utilization at the time of hysterectomy has decreased since 2012.

Study Design: Retrospective cohort study.

Setting: Academic university hospital. Read More

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In vivo bidirectional modulation of cannabinoid on the activity of globus pallidus in rats.

Neuroscience 2021 Jun 12. Epub 2021 Jun 12.

Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, China. Electronic address:

Endocannabinoids are bioactive substances which participate in central motor control. The globus pallidus (GP) is a major nucleus in the basal ganglia circuit, which plays an important function in movement regulation. Both cannabinoid receptor type 1 (CBR) and cannabinoid receptor type 2 (CBR) are expressed in the GP suggesting GP as a main action area of endocannabinoids. Read More

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Clinical Characteristics and Predictors of In-Hospital Mortality in Patients With Cardiogenic Shock: Results From the RESCUE Registry.

Circ Heart Fail 2021 Jun 15;14(6):e008141. Epub 2021 Jun 15.

Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center (J.H.Y., K.H.C., T.K.P., J.M.L., Y.B.S., J.-Y.H., S.-H.C., H.-C.G.), Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: In the current era of mechanical circulatory support, limited data are available on prognosis of cardiogenic shock (CS) caused by various diseases. We investigated the characteristics and predictors of in-hospital mortality in Korean patients with CS.

Methods: The RESCUE study (Retrospective and Prospective Observational Study to Investigate Clinical Outcomes and Efficacy of Left Ventricular Assist Device for Korean Patients With CS) is a multicenter, retrospective, and prospective registry of patients that presented with CS. Read More

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Comparison of Joint and Landmark Modeling for Predicting Cancer Progression in Men With Castration-Resistant Prostate Cancer: A Secondary Post Hoc Analysis of the PREVAIL Randomized Clinical Trial.

JAMA Netw Open 2021 Jun 1;4(6):e2112426. Epub 2021 Jun 1.

Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Importance: Dynamic prediction models may help predict radiographic disease progression in advanced prostate cancer.

Objective: To assess whether dynamic prediction models aid prognosis of radiographic progression risk, using ongoing longitudinal prostate-specific antigen (PSA) assessments.

Design, Setting, And Participants: This prognostic study used data from the PREVAIL study to compare dynamic models for predicting disease progression. Read More

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Childhood adiposity associated with expanded effector memory CD8 + and Vδ2 +Vγ9 + T cells.

J Clin Endocrinol Metab 2021 Jun 15. Epub 2021 Jun 15.

Department of Pediatrics, Sophia Children's Hospital, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Context: Adult obesity is associated with chronic low-grade inflammation and may give rise to future chronic disease. However, it is unclear whether adiposity-related inflammation is already apparent at young age.

Objective: To study associations between child's adiposity measures with circulating monocytes and naive and memory subsets in CD4, CD8, and γδ T-cell lineages. Read More

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Hyperglycemia and Hypo-HDL-cholesterolemia Are Primary Risk Factors for Age-related Cataract, and a Korean-style Balanced Diet has a Negative Association, based on the Korean Genome and Epidemiology Study.

J Korean Med Sci 2021 Jun 14;36(23):e155. Epub 2021 Jun 14.

Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, Korea.

Background: The prevalence of cataracts is steadily increasing among the middle-aged and elderly worldwide. We hypothesized that adults aged > 50 years with age-related cataracts (ARCs) have an association with metabolic syndrome (MS) and its components, and MS has interactions with different dietary patterns and lifestyles that affect ARC risk. We examined the hypothesis using the Korean Genome and Epidemiology Study (KoGES; a large-scale hospital-based cohort study), which collected data between 2004-2013. Read More

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Efficiency and Teamwork in Emergency Departments: Perception of Staff on Design Interventions.

HERD 2021 Jun 15:19375867211023156. Epub 2021 Jun 15.

College of Architecture and Environmental Design, Kent State University, OH, USA.

Objectives: The goal of this study is twofold: (1) identifying design strategies that enhance efficiency and support teamwork in emergency departments (EDs) and (2) identifying design features that contribute to the spread of COVID-19, based on staff perception.

Background: Due to increasing ED visits annually, an efficient work environment has become one of the main concerns in designing EDs. According to the literature, an efficient work environment and teamwork improve healthcare outcomes and positively impact staff satisfaction. Read More

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Impact of Air-frying on The Plasmalogens Deterioration and Oxidation in Oyster Revealed by Mild Acid Hydrolysis and HILIC-MS based Lipidomics Analysis.

Electrophoresis 2021 Jun 14. Epub 2021 Jun 14.

Collaborative Innovation Center of Seafood Deep Processing, Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, P. R. China.

Oyster is rich in plasmalogens which are ether phospholipids with biological functions to human body. Air-frying is a popular technique for preparing delicious oyster but makes the plasmalogens vulnerable to oxidation. In this study, the effect of air-frying processing on plasmalogens oxidation was studied by lipidomic approach. Read More

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Second-order division in sectors as a prepattern for sensory organs in vertebrate development.

Theory Biosci 2021 Jun 15. Epub 2021 Jun 15.

Laboratoire Matière et Systèmes Complexes, UMR 7057, Université de Paris/CNRS, 10 rue Alice Domont et Léonie Duquet, 75013, Paris, France.

We present in vivo observations of chicken embryo development which show that the early chicken embryo presents a principal structure made out of concentric rings and a secondary structure composed of radial sectors. During development, physical forces deform the main rings into axially directed, antero-posterior tubes, while the sectors roll up to form cylinders that are perpendicular to the antero-posterior axis. As a consequence, the basic structure of the chicken embryo is a series of encased antero-posterior tubes (gut, neural tube, body envelope, amnion, chorion) decorated with smaller orifices (ear duct, eye stalk, nasal duct, gills, mouth) forming at right angles to the main body axis. Read More

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The effect of pair housing on dairy calf health, performance, and behavior.

J Dairy Sci 2021 Jun 11. Epub 2021 Jun 11.

Department of Ethology, Institute of Animal Science, Přátelství 815, 104 00 Prague-Uhřínevěs, Czech Republic; Department of Ethology and Companion Animal Science, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences, Kamýcká 129, 165 21 Prague 6, Czech Republic.

Individual housing of dairy calves prevails in Europe and North America despite its negative effects on calf development. One of the main reasons is that farmers find individual housing of calves more practical than group housing. A compromise between practice and welfare could be housing calves in pairs. Read More

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The bacterial community composition and its environmental drivers in the rivers around eutrophic Chaohu Lake, China.

BMC Microbiol 2021 Jun 14;21(1):179. Epub 2021 Jun 14.

Taihu Laboratory for Lake Ecosystem Research, State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, 210008, Nanjing, China.

Background: Bacterial community play a key role in environmental and ecological processes in river ecosystems. Rivers are used as receiving body for treated and untreated urban wastewaters that brings high loads of sewage and excrement bacteria. However, little is known about the bacterial community structure and functional files in the rivers around the eutrophic Chaohu Lake, the fifth largest freshwater lake in China, has been subjected to severe eutrophication and cyanobacterial blooms over the past few decades. Read More

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[Clinical and genetic characteristics of different types of non-obstructive hypertrophic cardiomyopathy].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):593-600

Department of Cardiomyopathy, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China State Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

To analyze the clinical and genetic characteristics of clinical subtypes of non-obstructive hypertrophic cardiomyopathy (HCM). It was a cohort study. Patients with non-obstructive HCM admitted to Fuwai Hospital, Chinese Academy of Medical Sciences, from January 1999 to April 2019 were enrolled. Read More

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Metabolomics analysis underlay mechanisms in the renal impairment of mice caused by combination of aflatoxin M1 and ochratoxin A.

Toxicology 2021 Jun 11:152835. Epub 2021 Jun 11.

Key Laboratory of Quality & Safety Control for Milk and Dairy Products of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China; Laboratory of Quality and Safety Risk Assessment for Dairy Products of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China; Milk and Milk Products Inspection Center of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. Electronic address:

Aflatoxin M1 (AFM1) and ochratoxin A (OTA) are pernicious mycotoxins widely co-existing in the environment. However, nephrotoxicity and underlying mechanism induced by AFM1 coupled with OTA still remain to be explored. In this study, CD-1 mice were treated with 3. Read More

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Climate change and neurodegenerative diseases.

Environ Res 2021 Jun 11:111511. Epub 2021 Jun 11.

Scuola Superiore Sant'Anna and Centre for Climate Change Studies and Sustainable Actions (3CSA), Pisa, Italy.

The climate change induced global warming, and in particular the increased frequency and intensity of heat waves, have been linked to health problems. Among them, scientific works have been reporting an increased incidence of neurological diseases, encompassing also neurodegenerative ones, such as Dementia of Alzheimer's type, Parkinson's Disease, and Motor Neuron Diseases. Although the increase in prevalence of neurodegenerative diseases is well documented by literature reports, the link between global warming and the enhanced prevalence of such diseases remains elusive. Read More

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Definition, prevalence, and risk factors of low sex hormone-binding globulin in US adults.

Yutang Wang

J Clin Endocrinol Metab 2021 Jun 14. Epub 2021 Jun 14.

School of Science, Psychology and Sport, Federation University Australia, Ballarat, VIC, Australia.

Context: Lower sex hormone-binding globulin (SHBG) is associated with many diseases including cardiovascular disease, cancer, polycystic ovarian syndrome, arthritis, and liver disease. However, the definition of low SHBG and its prevalence in US adults are unknown.

Objective: To define low SHBG and to determine its prevalence and risk factors in US adults. Read More

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Cholinergic anti-inflammatory pathway and connective tissue diseases.

Inflammopharmacology 2021 Jun 14. Epub 2021 Jun 14.

Immunology Research Center, Tabriz University of Medical Sciences, Golgasht St, Postcode: 5166614766, Tabriz, Iran.

Connective tissue diseases (CTDs) consist of an extensive range of heterogeneous medical conditions, which are caused by immune-mediated chronic inflammation and influences the various connective tissues of the body. They include rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, vasculitis, Sjögren's syndrome, Behcet's disease, and many other autoimmune CTDs. To date, several anti-inflammatory approaches have been developed to reduce the severity of inflammation or its subsequent organ manifestations. Read More

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Association Between Childhood Consumption of Ultraprocessed Food and Adiposity Trajectories in the Avon Longitudinal Study of Parents and Children Birth Cohort.

JAMA Pediatr 2021 Jun 14:e211573. Epub 2021 Jun 14.

Public Health Policy Evaluation Unit, Imperial College London, London, United Kingdom.

Importance: Reports of associations between higher consumption of ultraprocessed foods (UPF) and elevated risks of obesity, noncommunicable diseases, and mortality in adults are increasing. However, associations of UPF consumption with long-term adiposity trajectories have never been investigated in children.

Objective: To assess longitudinal associations between UPF consumption and adiposity trajectories from childhood to early adulthood. Read More

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Digital radiograph rejection analysis during "Coronavirus disease 2019 (COVID-19) pandemic" in a tertiary care public sector hospital in Khyber Pakhtunkhwa Province of Pakistan.

Chin J Acad Radiol 2021 Jun 7:1-8. Epub 2021 Jun 7.

Department of Radiology, Lady Reading Hospital (Medical Teaching Institute) Peshawar, Soekarno Rd, PTCL Colony, Peshawar, 25000 Pakistan.

Background: Evaluation of X-ray reject analysis is an important quality parameter in diagnostic facility. The aim of this study was to find out the radiograph rejection and its causes during the coronavirus disease 2019 (COVID-19) pandemics as there was fear of coronavirus disease infection among the technical staff from the incoming patients in a busy, high volume public sector tertiary care hospital.

Materials And Method: This descriptive study was conducted at Radiology Department, Lady Reading Hospital, Peshawar from August to November, 2020. Read More

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Review on Pneumococcal Infection in Children.

Cureus 2021 May 9;13(5):e14913. Epub 2021 May 9.

Paediatrics, Base Hospital, Mahaoya, LKA.

Childhood pneumococcal infection is a growing concern among paediatricians especially, in countries where there is no routine vaccination program against . The disease is associated with significant morbidity and mortality in young children particularly those who are under the age of two years. Its main virulent factors include polysaccharide capsule, autolysin, pneumolysin, choline-binding Protein A, the higher chance for genetic transformation, and the presence of pilli that facilitate enhanced binding of bacteria to host cellular surfaces. Read More

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The Immediate Effects of Foam Rolling and Stretching on Iliotibial Band Stiffness: A Randomized Controlled Trial.

Int J Sports Phys Ther 2021 Jun 1;16(3):651-661. Epub 2021 Jun 1.

Texas Tech University Health Sciences Center, Lubbock, TX.

Background: Iliotibial Band Syndrome (ITBS) is a common clinical condition likely caused by abnormal compressive forces to the iliotibial band (ITB). Stretching interventions are common in ITBS treatment and may predominantly affect tensor fascia latae (TFL). Another ITBS treatment is foam rolling, which may more directly affect the ITB. Read More

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Areca Nut Chewing: Initiation, Addiction, and Harmful Effects Emphasizing the Barriers and Importance of Cessation.

J Addict 2021 3;2021:9967097. Epub 2021 Jun 3.

Centre for Research in Oral Cancer, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.

Areca nut is a highly addictive substance with carcinogenic properties and causes many harmful effects to the human body. Alkaloids are the major chemicals found in areca nut, and their mechanism of action has been studied for several years. About 600 million people around the world use areca nut, and its usage is higher in Asian countries. Read More

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Clinical Observation of Intraosseous Anesthesia in Percutaneous Kyphoplasty.

J Healthc Eng 2021 1;2021:5528073. Epub 2021 Jun 1.

The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China.

Objective: Percutaneous kyphoplasty (PKP) is an effective minimally invasive technique in spine surgery in recent years. General anesthesia and local anesthesia are the main ways of anesthesia in PKP, and epidural anesthesia is also applied to PKP to some extent. However, all these three anesthetic methods have their respective advantages and disadvantages. Read More

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High Serum Anti-Müllerian Hormone Concentrations Are Associated With Poor Pregnancy Outcome in Fresh IVF/ICSI Cycle but Not Cumulative Live Birth Rate in PCOS Patients.

Front Endocrinol (Lausanne) 2021 26;12:673284. Epub 2021 May 26.

Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: To investigate the association between baseline serum Anti-Müllerian hormone (AMH) levels and IVF/ICSI outcomes in women with polycystic ovary syndrome (PCOS).

Design: Retrospective study.

Setting: Reproductive medicine center in a hospital. Read More

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The Effect of Anti-seizure Medications on the Propagation of Epileptic Activity: A Review.

Front Neurol 2021 27;12:674182. Epub 2021 May 27.

Department of Neurology, Rambam Health Care Campus, Haifa, Israel.

The propagation of epileptiform events is a highly interesting phenomenon from the pathophysiological point of view, as it involves several mechanisms of recruitment of neural networks. Extensive and research has been performed, suggesting that multiple networks as well as cellular candidate mechanisms govern this process, including the co-existence of wave propagation, coupled oscillator dynamics, and more. The clinical importance of seizure propagation stems mainly from the fact that the epileptic manifestations cannot be attributed solely to the activity in the seizure focus itself, but rather to the propagation of epileptic activity to other brain structures. Read More

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A Critical Review of Spatial Abilities in Down and Williams Syndromes: Not All Space Is Created Equal.

Front Psychiatry 2021 28;12:669320. Epub 2021 May 28.

Institute of Psychology, University of Lausanne, Lausanne, Switzerland.

Down syndrome (DS, Trisomy 21) and Williams syndrome (WS) are two neurodevelopmental disorders of genetic origin that are accompanied by mild to moderate intellectual disability but exhibit distinct cognitive profiles. In this review we discuss our recent work characterizing the real-world spatial learning and memory abilities of adult individuals with DS and WS. We used several different paradigms in which participants locomote freely and have access to coherent input from all sensory modalities to investigate their fundamental egocentric (body-centered or viewpoint-dependent) and allocentric (world-centered or viewpoint-independent) spatial abilities. Read More

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ZhiJingSan Inhibits Osteoclastogenesis via Regulating RANKL/NF-κB Signaling Pathway and Ameliorates Bone Erosion in Collagen-Induced Mouse Arthritis.

Front Pharmacol 2021 28;12:693777. Epub 2021 May 28.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Bone erosion is the most evident pathological condition of rheumatoid arthritis (RA), which is the main cause of joint deformities and disability in RA patients. At present, the conventional RA drugs have not achieved satisfactory effect in improving bone erosion. ZhiJingSan (ZJS), which is a traditional Chinese prescription composed of scolopendra (dried body of , ) and scorpion (dried body of ), exhibits anti-rheumatism, analgesic and joint deformities improvement effects. Read More

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Pharmacokinetic Study of Oral C-Radiolabeled Hyzetimibe, A New Cholesterol Absorption Inhibitor.

Front Pharmacol 2021 28;12:665372. Epub 2021 May 28.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.

Hyzetimibe is a candidate drug being investigated as the second-in-class cholesterol absorption inhibitor; it lowers plasma levels of low-density lipoprotein cholesterol (LDL-C) by blocking the Niemann-Pick C1-like 1 protein, a transporter mainly expressed in the intestine that allows dietary cholesterol to enter the body from the intestinal lumen. Previous studies on the metabolism of hyzetimibe in healthy volunteers were not enough to show the biotransformation and excretion pathway; in particular, whether hyzetimibe maintains pharmacological action for duration sufficient to pass through the hepatic-intestinal circulation remains unknown. Furthermore, it remains unclear whether the differences between the chemical structures of ezetimibe and hyzetimibe would result in different pharmacokinetic characteristics. Read More

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Association of Angiotensin-Converting Enzyme gene polymorphism in Pakistani women with the atypical steroidogenesis in Polycystic ovarian syndrome: A case-control study.

Saudi J Biol Sci 2021 Jun 14;28(6):3483-3489. Epub 2021 Mar 14.

Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.

Background: Polymorphism in the angiotensin-converting enzyme gene (ACE) is responsible for elevated ACE concentrations in plasma. High ACE levels induce insulin resistance and hyperandrogenism, which are the main attributes of polycystic ovary syndrome (PCOS). Therefore, it was hypothesized that I/D polymorphism plays a role in the pathogenesis of PCOS. Read More

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Cardioprotective properties of natural medicine in isoproterenol induced myocardial damage in the male Albino rats.

Saudi J Biol Sci 2021 Jun 20;28(6):3169-3175. Epub 2021 Apr 20.

Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam bin Abdul Aziz University, Al Kharj, Saudi Arabia.

The main aim of this study is to investigate cardioprotective properties of natural medicine inmyocardial damage induced male Albino rats. The aqueous extractof was used for the determination of phenolic compounds and flavonoids. The amount of phenol (1. Read More

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Endophytic microbes from Nigerian ethnomedicinal plants: a potential source for bioactive secondary metabolites-a review.

Bull Natl Res Cent 2021 8;45(1):103. Epub 2021 Jun 8.

Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria.

Background: Endophytes are highly beneficial species of microbes that live in symbiosis with plant tissues in the setting. Endophytes are difficult to isolate in their natural environment, and they are understudied despite being a rich source of bioactive molecules. There are varieties of new infectious diseases emerging across the world, necessitating a constant and expanded search for newer and more efficient bioactive molecules. Read More

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