7,004 results match your criteria macular hole

Quantifying surgical skill in macular surgery.

Acta Ophthalmol 2021 Sep 22. Epub 2021 Sep 22.

Department of Ophthalmology, Rigshospitalet - Glostrup, Glostrup, Denmark.

Purpose: To evaluate the relationship between patient outcome and surgical experience by developing an objective quality measure of macular hole surgery based on forceps damage to the inner retina.

Methods: We retrospectively examined 3 macular hole case series >1 year after pars plana vitrectomy, internal limiting membrane peeling and gas tamponade. The patients were operated by (1) a novice surgeon (<20 cases), (2) an intermediate (150+ cases) and (3) an experienced surgeon (2000+ cases). Read More

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September 2021

Vitreous cytokine expression profiles in patients with retinal detachment.

J Fr Ophtalmol 2021 Sep 17. Epub 2021 Sep 17.

Department of Ophthalmology, Nancy University Hospital, Vandœuvre-lès-Nancy, France.

Purpose: To compare the expression profiles of various cytokines and chemokines in vitreous samples from patients with retinal detachment (RD) to those from controls and to analyze their association with various clinical features.

Methods: In this prospective study, undiluted vitreous fluid was obtained from 41 patients with primary RD and 33 controls with macular hole or vitreomacular traction. A multiplex bead immunoassay was performed to determine the expression of 27 inflammatory mediators. Read More

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September 2021


Retina 2021 Oct;41(10):2079-2087

Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea.

Purpose: To ascertain the pathogenesis of macular hole (MH) associated with age-related macular degeneration (AMD) and its surgical outcomes.

Methods: Patients with full-thickness MH associated with AMD (higher grades than intermediate) were enrolled. The mechanism of MH formation and closure rate after vitrectomy (surgical outcome) were determined using optical coherence tomography imaging. Read More

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October 2021

Displacement of the retina after idiopathic macular hole surgery with different internal limiting membrane peeling patterns.

Int J Ophthalmol 2021 18;14(9):1408-1412. Epub 2021 Sep 18.

Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.

Aim: To explore retinal displacement after surgical treatment for idiopathic macular hole (IMH) with different internal limiting membrane (ILM) peeling patterns.

Methods: Totally 22 eyes from 20 patients with IMH were randomly allocated into two groups, N-T group (11 eyes) and T-N group (11 eyes). For patients in N-T group, ILM was peeled off from nasal to temporal retina. Read More

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September 2021

"Shark Jaws" Sign in Macular Hole.

Asia Pac J Ophthalmol (Phila) 2021 Sep 14. Epub 2021 Sep 14.

Department of Vitreo-Retina, Netralaya super speciality eye hospital, Ahmedabad, Gujarat, India.

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September 2021

Two years outcomes of treating full-thickness macula hole associated with idiopathic macular telangiectasia type 2 by internal limiting membrane inverted flap technique: Case reports.

Medicine (Baltimore) 2021 Sep;100(36):e27078

Department of Ophthalmology, Akita University Graduate School of Medicine, Akita, Japan.

Rational: Macular telangiectasia (MacTel) is an uncommon ocular disorder that can lead to legal blindness. MacTel type 2 is characterized by a bilateral loss of macular transparency, the presence of white crystals on the retina, aberrant blood vessel growth, and neurodegeneration of the macula. Full-thickness macular holes (FTMHs) are a prominent cause of vision reduction in MacTel type 2, and the standard care for an FTMH is pars plana vitrectomy (PPV) to restore the FTMH and best-corrected visual acuity (BCVA). Read More

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September 2021

Surgical Treatment of Epiretinal Membrane.

Acta Med Okayama 2021 Aug;75(4):403-413

Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Epiretinal membrane (ERM) is a common retinal disease characterized by cellular proliferation and metaplasia that lead to the formation of a pathological fibrocellular membrane immediately superjacent to the inner retinal surface. The vast majority of ERMs are considered idiopathic. However, ERM formation can result from various primary intraocular diseases, including retinal breaks and detachment, retinal vascular diseases, and vitreoretinal inflammatory conditions. Read More

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En-face Imaging of Atypical Epiretinal Tissue in Lamellar Macular Hole.

Retina 2021 Sep 6. Epub 2021 Sep 6.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Ophthalmology, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea Department of Ophthalmology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

Purpose: To elucidate the significance of en-face optical coherence tomography (OCT) imaging of atypical epiretinal tissue (AET) in the lamellar macular hole (LMH).

Methods: This study involved 29 eyes of 29 patients who underwent surgical treatment for LMH with AET. Best-corrected visual acuity (BCVA), metamorphopsia assessment (M-score), and OCT were evaluated before and 6 months after surgery. Read More

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September 2021

Single-layer Inverted Internal Limiting Membrane Flap Versus Conventional Peel for Small- or Medium-sized Full-thickness Macular Holes.

Am J Ophthalmol 2021 Sep 9. Epub 2021 Sep 9.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan. Electronic address:

Purpose: To compare the outcomes of using an internal limiting membrane (ILM) flap and the conventional ILM peel technique for small- or medium-sized full-thickness macular hole (FTMH) repair.

Design: Retrospective, interventional case series.

Methods: Eyes with an FTMH ≤ 400 µm that underwent vitrectomy with either a single-layer inverted ILM flap (flap group, 55 eyes) or an ILM peel (peel group, 62 eyes) were enrolled. Read More

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September 2021

Indications and outcomes for intravitreal injection of CF gas for symptomatic vitreomacular traction.

Sci Rep 2021 Sep 10;11(1):18089. Epub 2021 Sep 10.

Eye Clinic, Cantonal Hospital Sankt Gallen, Rorschacherstrasse 95, 9007, Sankt Gallen, Switzerland.

To evaluate the indications and outcomes of perfluoropropane (C3F8) gas injection for symptomatic vitreomacular traction (VMT). A retrospective analysis of eyes with VMT treated with 0.3 mL of C3F8 gas was performed. Read More

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September 2021

Macular Hole as a Complication Following Laser Photocoagulation for Retinopathy of Prematurity.

Ophthalmic Surg Lasers Imaging Retina 2021 Sep 1;52(9):510-512. Epub 2021 Sep 1.

Complications after laser photocoagulation for retinopathy of prematurity (ROP) are rare but do occur. To the best of our knowledge, we report a previously unreported case of a unilateral macular hole that developed after resolution of an exudative retinal detachment that resulted from laser photocoagulation for ROP. Confluent laser patterns in ROP in infants who have previously received intravitreal anti-vascular endothelial growth factor may result in adverse outcomes such as exudative retinal detachments. Read More

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September 2021

Surgical Management of Recurrent and Persistent Macular Holes: A Practical Approach.

Ophthalmol Ther 2021 Sep 7. Epub 2021 Sep 7.

Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, i-32, Cleveland, OH, 44195, USA.

Primary surgery for macular hole (MH) closure has a high success rate with current methods of pars plana vitrectomy and internal limiting membrane (ILM) peeling. When primary surgery fails, there are several options available for secondary repair, including extension of the ILM peel, creation of an ILM flap, pedunculated ILM flap, lens capsule flap transplantation, autologous retinal transplantation, use of a human amniotic membrane plug, adjuvant autologous platelet concentrate, induction of macular detachments with subretinal blebs, and creation of retinal incisions. In this review, we discuss the practical approach to each of these surgical techniques for the management of recurrent or persistent MHs. Read More

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September 2021

The Association in Myopic Tractional Maculopathy With Myopic Atrophy Maculopathy.

Front Med (Lausanne) 2021 20;8:679192. Epub 2021 Aug 20.

Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

To investigate the relationship between myopic tractional maculopathy (MTM) and myopic atrophy maculopathy (MAM). Two hundred and six eyes with definitive myopic retinoschisis were assessed in the retrospective observational case series study and the atrophic and tractional features were further evaluated. Atrophic changes were analyzed according to the atrophic component in the ATN classification and the occurrence of gamma zones and delta zones. Read More

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Flap technique-assisted surgeries for advanced retinitis pigmentosa complicated with macular hole: a case report and literature review.

BMC Ophthalmol 2021 Sep 6;21(1):322. Epub 2021 Sep 6.

Department of Ophthalmology, National Taiwan University Hospital, Medical College, National Taiwan University, 7 Chung-Shan S. Road, Taipei, Taiwan.

Background: Full-thickness macular hole (FTMH) is a rare complication in retinitis pigmentosa (RP) patients and may increase intraoperative challenges. Furthermore, lens capsular flap transplantation and inverted internal limiting membrane (ILM) flap were reported to close complicated FTMH successfully. Here, we present a case of bilateral advanced RP complicated by a FTMH treated with a novel lens capsular flap transplantation and inverted internal limiting membrane flap. Read More

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September 2021

Ocriplasmin for Treatment of Vitreomacular Traction and Macular Hole A Systematic Literature Review and Individual Participant Data Meta-Analysis of Randomized, Controlled, Double-Masked Trials.

Surv Ophthalmol 2021 Sep 1. Epub 2021 Sep 1.

Xintera bv, Ghent, Belgium.

Ocriplasmin is used to treat vitreomacular traction (VMT), with or without full-thickness macular hole (MH). We systematically reviewed the evidence on ocriplasmin's effect on vitreomacular adhesion resolution (VMAR), MH closure, vitrectomy, and best-corrected visual acuity (BCVA) and investigated the effect of baseline covariates on outcome. We applied individual participant data meta-analyses to the entire population and to subgroups defined by MH or epiretinal membrane (ERM) presence. Read More

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September 2021

Atypical macular hole formation after Anti-VEGF therapy for neovascular age-related macular degeneration: Coincidence or consequence?

Arch Soc Esp Oftalmol (Engl Ed) 2021 Sep 21;96(9):455-461. Epub 2021 May 21.

Baskent University, Faculty of Medicine, Department of Ophthalmology, Ankara Hospital, Ankara, Turkey.

Introduction And Objectives: Age-related macular degeneration (AMD) is the primary cause of blindness in developed countries, particularly in older adults. Anti-vascular endothelial growth factor (anti-VEGF) intravitreal injection is the current standard treatment for neovascular form of AMD. Studies reporting macular hole (MH) formation following anti-VEGF treatment are limited, and the exact pathogenesis is still under discussion. Read More

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September 2021

Combined fovea-sparing internal limiting membrane peeling with internal limiting membrane flap technique for progressive myopic traction maculopathy.

Graefes Arch Clin Exp Ophthalmol 2021 Sep 3. Epub 2021 Sep 3.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Background: To present the anatomical and functional outcomes of combined fovea-sparing internal limiting membrane peeling (FSIP) with internal limiting membrane flap (ILMF) for myopic traction maculopathy (MTM).

Methods: This is a retrospective, observational study. Included were 66 eyes of 62 patients who underwent vitrectomy with combined FSIP and ILMF (or modified ILMF) for MTM with a minimal follow-up of 6 months. Read More

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September 2021

Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy.

Acta Ophthalmol 2021 Sep 3. Epub 2021 Sep 3.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: To investigate the expression of CD146 and its role in proliferative diabetic retinopathy (PDR).

Methods: Enzyme linked immunosorbent assay was performed to analyse the expression and relationship of sCD146, vascular endothelial growth factor (VEGF), sVEGFR1 and sVEGFR2 in vitreous specimens from PDR and idiopathic epiretinal membranes (IERM) or idiopathic macular hole patients. The location of CD146 in ERMs was detected by immunofluorescence. Read More

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September 2021

Optical Coherence Tomography based indices in predicting functional outcome of macular hole surgery: A retrospective chart review.

Pak J Med Sci 2021 Sep-Oct;37(5):1504-1508

Dr. Shiraz Hashmi, MBBS, M.Sc Section of Ophthalmology, Department of Surgery, The Aga Khan University, Karachi, Pakistan.

Objectives: The objective of this study was to assess the utility of novel macular hole indices of Optical Coherence Tomography (OCT) and predicting the functional outcome of surgery.

Methods: This was a retrospective chart review of 28 eyes who underwent surgery for idiopathic Full Thickness Macular Hole (FTMH) at The Aga Khan University Hospital (AKUH), Karachi from January 2016 to March 2020. Data of preoperative OCTs were recovered from data server of OCT machine. Read More

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January 2021

Sequential multimodal imaging of isolated necrotic full-thickness macular hole secondary to toxoplasma retinochoroiditis.

Am J Ophthalmol Case Rep 2021 Sep 12;23:101193. Epub 2021 Aug 12.

Department of Uvea, Aravind Eye Hospital, Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.

Purpose: To describe the sequential multimodal imaging features of an isolated necrotic macular hole secondary to Toxoplasma retinochoroiditis.

Observation: A 23-year-old male was referred for surgical management of an idiopathic macular hole following sudden decrease in vision in his right eye. Right eye examination showed best-corrected visual acuity of 20/200, mild anterior segment inflammation, and a full thickness non operculated macular hole (MH) with ill-defined ragged margins and surrounding strip of pallid edema. Read More

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September 2021

Case series of scleral patch grafts during COVID-19 pandemic.

Indian J Ophthalmol 2021 Sep;69(9):2530-2532

Chief Consultant, Department of Vitreo Retinal Services, Modern Retina Centre, Nellore, Andhra Pradesh, India.

Scleral graft is done for clinical conditions as scleral melt post pterygium surgery, immune or infection related scleral melt, for covering the tubes of Ahmed glaucoma valve implant, for covering the orbital implants post enucleation, etc. A review of literature revealed the use of sclera for corneal perforations in the past, but became obsolete after the cornea being used for patch grafts. Now in this COVID-19 time, due to scarcity of corneal tissue, this technique of scleral patch grafts can be considered as an alternative to corneal patch grafts, which serves well the tectonic/therapeutic purpose and helps salvage the eye. Read More

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September 2021

A Case of Idiopathic Dense Vitreous Hemorrhage: Suspected Rupture of a Large Retinal Arterial Macroaneurysm on the Optic Disc.

Case Rep Ophthalmol 2021 May-Aug;12(2):634-639. Epub 2021 Jul 16.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.

We report a novel case of vitreous hemorrhage associated with suspected rupture of 2-disc-diameter retinal arterial macroaneurysm on the optic disc. A 90-year-old woman presented with blurred vision (sudden onset) in her left eye. Examination of the fundus revealed acute onset vitreous hemorrhage of unknown origin without retinal detachment. Read More

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The impact of the COVID-19 pandemic lockdown on rhegmatogenous retinal detachment services-Experiences from the Tongren eye center in Beijing.

PLoS One 2021 19;16(8):e0254751. Epub 2021 Aug 19.

Department of Ophthalmology, Mid & South Essex NHS Foundation Trust, Southend University Hospital, Anglia Ruskin University, Cambridge, United Kingdom.

Purpose: To investigate the impact on services for rhegmatogenous retinal detachment (RRD) patients during the COVID-19 (2019coronal virus disease) pandemic in one tertiary center in Beijing.

Methods: A retrospective cohort study. Two reviewed consecutive RRD patients cohorts of the same length were treated during two different periods: the COVID-19 pandemic and the pre-COVID-19 group. Read More

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PRO Study Report No. 7: Macular Hole in RRD.

Dhananjay Shukla

Ophthalmic Surg Lasers Imaging Retina 2021 Aug 1;52(8):418. Epub 2021 Aug 1.

Ratan Jyoti Netralaya, India.

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Reply to Letter to the Editor: PRO Study Report No. 7: Macular Hole in RRD.

Ophthalmic Surg Lasers Imaging Retina 2021 Aug 1;52(8):418-419. Epub 2021 Aug 1.

VitreoRetinal Surgery, Minneapolis, Minnesota.

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Inverted Internal Limiting Membrane Flap Technique: Is It the Best Option for Macular Holes?

Clin Ophthalmol 2021 8;15:3295-3303. Epub 2021 Aug 8.

Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, 4099-001, Portugal.

Surgical treatment is generally necessary to repair full-thickness macular holes (FTMH). Although vitrectomy with or without internal limiting membrane (ILM) peeling remains the standard surgical technique, the inverted ILM flap procedure has increasingly assumed a role in the primary surgical repair of FTMHs. Some vitreoretinal surgeons reserve this technique to treat large or myopic holes, whereas others use it routinely in all cases. Read More

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Outcomes of a novel bubble ultra-wide field viewing system for vitreoretinal surgery.

Acta Ophthalmol 2021 Aug 17. Epub 2021 Aug 17.

Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.

Purpose: To report the clinical outcomes and evaluate the efficacy of a novel bubble ultra-wide field viewing system for vitreoretinal surgery.

Design: Prospective, noncomparative, interventional case series.

Participants: One hundred and fifty-one eyes of 146 consecutive patients with proliferative diabetic retinopathy (PDR), vitreous haemorrhage originating from retinal vein occlusion (VH-RVO), epiretinal membrane (EM), macular hole (MH) or retinal detachment (RD) who underwent vitreoretinal surgery using the bubble ultra-wide field viewing system were included. Read More

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Conversion from type 2 to type 1 macular hole closure after surgery in high myopia.

BMJ Case Rep 2021 Aug 10;14(8). Epub 2021 Aug 10.

Departemnt of Retina and Vitreous, Narayana Nethralaya, Bengaluru, Karnataka, India.

We describe a case of spontaneous conversion from type 2 macular hole (MH) closure to type 1 closure following MH surgery in high myopia. A 42-year-old male patient with myopia was diagnosed with full-thickness MH and localised neurosensory detachment. His best-corrected vision in the right eye was 20/120, N18. Read More

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[Profile of macular holes in Cotonou].

J Fr Ophtalmol 2021 Aug 5. Epub 2021 Aug 5.

Centre national hospitalier et universitaire Hubert Koutoukou Maga, Cotonou, Bénin.

Purpose: To establish the epidemiological and tomographic profile of macular holes in the Beninese subject.

Patients And Methods: This cross-sectional study included consecutive patients seen for macular testing during the period from January 2016 to August 2017 at the St. Anthony of Padua Retinal Testing Center in Cotonou (Benin). Read More

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Development and validation of a deep learning system to classify aetiology and predict anatomical outcomes of macular hole.

Br J Ophthalmol 2021 Aug 4. Epub 2021 Aug 4.

Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

Aims: To develop a deep learning (DL) model for automatic classification of macular hole (MH) aetiology (idiopathic or secondary), and a multimodal deep fusion network (MDFN) model for reliable prediction of MH status (closed or open) at 1 month after vitrectomy and internal limiting membrane peeling (VILMP).

Methods: In this multicentre retrospective cohort study, a total of 330 MH eyes with 1082 optical coherence tomography (OCT) images and 3300 clinical data enrolled from four ophthalmic centres were used to train, validate and externally test the DL and MDFN models. 266 eyes from three centres were randomly split by eye-level into a training set (80%) and a validation set (20%). Read More

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