J Diabetes Res 2014 5;2014:727483. Epub 2014 Jun 5.
The Rogosin Institute, New York, NY 10021, USA ; NewYork-Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA.
We have previously described the use of a double coated agarose-agarose porcine islet macrobead for the treatment of type I diabetes mellitus. In the current study, the long-term viral safety of macrobead implantation into pancreatectomized diabetic dogs treated with pravastatin (n = 3) was assessed while 2 dogs served as nonimplanted controls. A more gradual return to preimplant insulin requirements occurred after a 2nd implant procedure (days 148, 189, and >652) when compared to a first macrobead implantation (days 9, 21, and 21) in all macrobead implanted animals. Read More