23,260 results match your criteria mac

Pulmonary mycobacterium avium complex disease complicated by cancer: an 11-year survey at a single-center.

J Rural Med 2021 Apr 1;16(2):72-76. Epub 2021 Apr 1.

Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.

Pulmonary mycobacterium avium complex (MAC) disease is increasing significantly worldwide. Several studies have investigated the clinical features of pulmonary MAC disease in the setting of cancer. Here, we aimed to clarify the clinical characteristics of patients with cancer with recent onset of pulmonary MAC disease and the effect of cancer on the onset of this disease. Read More

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Successful Single-Lung Transplant for the Dominant Side: A Case Report.

Transplant Proc 2021 Apr 5. Epub 2021 Apr 5.

Department of Thoracic Surgery.

Although single-lung transplant on the side with better lung function is challenging in patients with significantly asymmetrical lung function between the right and left sides, it sometimes can be a realistic option because of the recipient's condition and from the viewpoint of organ sharing. We report our experience with a successful case of single-lung transplant on the side with a pulmonary perfusion ratio of 89%. The transplant was performed with the patient under central venoarterial extracorporeal membrane oxygenation through a clamshell incision, and the patient had an acceptable short- and long-term outcome with a remarkable improvement of lung function. Read More

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Clinical Features and Prognosis of Nontuberculous Mycobacterial Pleuritis: A Multicenter Retrospective Study.

Ann Am Thorac Soc 2021 Apr 8. Epub 2021 Apr 8.

Keio University School of Medicine, Department of Infectious Diseases, Shinjuku-ku, Tokyo, Japan;

Rationale: The clinical features and prognosis of nontuberculous mycobacterial (NTM) pleuritis and pleural effusion combined with NTM lung disease (NTM-LD) remain unclear.

Objectives: To investigate the clinical features and prognosis of NTM pleuritis.

Methods: This retrospective observational study included patients with NTM pleuritis from January 2001 to June 2018 across eight hospitals in Japan. Read More

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Improved Outcomes of Haploidentical Hematopoietic Cell Transplantation with Total Body Irradiation-Based Myeloablative Conditioning in Acute Lymphoblastic Leukemia.

Transplant Cell Ther 2021 Feb 11;27(2):171.e1-171.e8. Epub 2020 Dec 11.

Saint Antoine Hospital, INSERM UMR 938, Université Pierre et Marie Curie, Paris, France; European Society for Blood and Marrow Transplantation Paris Study Office/CEREST-TC, Paris, France.

The optimal myeloablative conditioning (MAC) for patients undergoing haploidentical hematopoietic cell transplantation (haplo-HCT) is unknown. We studied the outcomes of total body irradiation (TBI)-based versus chemotherapy (CT)-based MAC regimens in patients with acute lymphoblastic leukemia (ALL). The study included 427 patients who underwent first haplo-HCT with post-transplantation cyclophosphamide (PTCy), following TBI-based (n = 188; 44%) or CT-based (n = 239; 56%) MAC. Read More

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February 2021

An evaluation of the representativeness of a national spinal cord injury registry: a population-based cohort study.

Spinal Cord 2021 Apr 7. Epub 2021 Apr 7.

Hôpital du Sacré-Cœur de Montréal, Montréal, QC, Canada.

Study Design: Population-based cohort study for the western part of Quebec.

Objectives: To determine the impact of declining to participate in a national spinal cord injury (SCI) registry on patient outcomes and continuum of care.

Setting: Level-1 trauma center specialized in SCI care in Montreal, Canada. Read More

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Comparison of medical student performance in summative undergraduate paediatric examinations and a clinician-designed minimum accepted competency (MAC) assessment.

BMC Med Educ 2021 Apr 7;21(1):197. Epub 2021 Apr 7.

Department of paediatrics, RCSI, 123 St StephenIs Green, Dublin 2, Ireland.

Background: It is recognised that newly qualified doctors feel unprepared in many areas of their daily practice and that there is a gap between what students learn during medical school and their clinical responsibilities early in their postgraduate career. This study aimed to assess if undergraduate students and junior paediatric doctors met a Minimum Accepted Competency (MAC) of knowledge.

Methods: The knowledge of undergraduates and junior paediatric doctors was quantitatively assessed by their performance on a 30-item examination (the MAC examination). Read More

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Inferior outcomes with reduced intensity conditioning followed by allogeneic hematopoietic cell transplantation in fit individuals with acute lymphoblastic leukemia: a Canadian single-center study and a comparison to registry data.

Leuk Lymphoma 2021 Apr 8:1-9. Epub 2021 Apr 8.

Hans Messner Allogeneic Transplant Program, Princess Margaret Hospital Cancer Centre, University Health Network, Toronto, Canada.

Allogeneic hematopoietic cell transplantation (HCT) can offer cure to some patients with acute lymphoblastic leukemia (ALL). It remains unclear how conditioning intensity affects transplant outcomes in ALL. In this retrospective study, we compared outcomes between 27 patients <60 who received reduced intensity conditioning (RIC) at Princess Margaret Hospital Cancer Center (PMCC) and 226 Cell Therapy Transplant Canada (CTTC) age-matched controls who received myeloablative conditioning (MAC) between 2007 and 2018. Read More

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J Zoo Wildl Med 2021 Apr;52(1):327-331

Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Respiratory depression from isoflurane seems to be greater in birds than in mammals. Isoflurane respiratory anesthetic index (AI) has only been evaluated in ducks (), which indeed showed a lower AI compared to mammals, but the isoflurane AI for other avian species is not known. The aim of this study was to evaluate the isoflurane AI in chickens (). Read More

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a safe forage or hyper phytostabilizer species in copper contaminated soils.

Int J Phytoremediation 2021 Apr 7:1-10. Epub 2021 Apr 7.

Department of Agronomy and Plant Breeding, Faculty of Agriculture, University of Jiroft, Jiroft, Iran.

This study was carried out to evaluate Cu uptake, mobility, and accumulation in and define the physiological strategy it employs under copper stress conditions. The experiment was performed at concentration levels from 12, 100, 150, 200, 250, and 300 mg Cu/kg in pod soil. The metal concentrations in roots, tubers, and root organs and the translocation factor (TF), total soluble sugars (TSS), and biomass production were evaluated. Read More

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The impact of introducing a videolaryngoscope in the initial training of laryngoscopy for undergraduate medical students: a simulation randomized trial.

Braz J Anesthesiol 2021 Apr 3. Epub 2021 Apr 3.

CET/SBA da Santa Casa de São Paulo, São Paulo, SP, Brazil.

Introduction: Adequate and continuous airway management by health professionals is fundamental to ensure patient safety and protection. Among several techniques, laryngoscopy for orotracheal intubation is considered a basic skill, so it is taught and learned in medical school and used during the future years of professional practice. However, in some clinical scenarios, physical and anatomical characteristics can make laryngoscopy exceedingly difficult. Read More

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Salmonella nomenclature in the genomic era: a time for change.

Sci Rep 2021 Apr 5;11(1):7494. Epub 2021 Apr 5.

Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK.

Salmonella enterica nomenclature has evolved over the past one hundred years into a highly sophisticated naming convention based on the recognition of antigens by specific antibodies. This serotyping scheme has led to the definition of over 2500 serovars which are well understood, have standing in nomenclature and, for the majority, biological relevance. Therefore, it is highly desirable for any change in naming convention to maintain backwards compatibility with the information linked to these serovars. Read More

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Consensus on hemophilia in Mexico.

Gac Med Mex 2021 ;157(Suppl 1):S1-S35

Hematology department, Centro Médico Nacional 20 de Noviembre, ISSSTE, Mexico City. Mexico.

Hemophilia is a hemorrhagic disorder with a sex-linked inherited pattern, characterized by an inability to amplify coagulation due to a deficiency in coagulation factor VIII (hemophilia A or classic) or factor IX (hemophilia B). Sequencing of the genes involved in hemophilia has provided a description and record of the main mutations, as well as a correlation with the various degrees of severity. Hemorrhagic manifestations are related to levels of circulating factor, mainly affecting the musculoskeletal system and specifically the large joints (knees, ankles, and elbows). Read More

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January 2021

Managing Anxiety from Cancer (MAC): A pilot randomized controlled trial of an anxiety intervention for older adults with cancer and their caregivers.

Palliat Support Care 2021 Apr 5:1-11. Epub 2021 Apr 5.

Weill Cornell Medicine,New York, NY.

Objective: Anxiety is common in older adults with cancer (OACs) and their caregivers and is associated with poor outcomes including worse physical symptoms, poor treatment adherence and response, and longer hospitalizations. This study examined the feasibility, acceptability, adherence, and preliminary efficacy of a cognitive-behavioral therapy (CBT) intervention for OACs and their caregivers.

Method: Patients with active cancer age 65 years and older and their caregivers were randomized to Managing Anxiety from Cancer (MAC), a seven-session CBT-based psychotherapy intervention delivered over the telephone or usual care. Read More

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Metabolic Profile Reveals the Immunosuppressive Mechanisms of Methionyl-Methionine in Lipopolysaccharide-Induced Inflammation in Bovine Mammary Epithelial Cell.

Animals (Basel) 2021 Mar 16;11(3). Epub 2021 Mar 16.

College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

Our previous transcriptomic study found that methionyl-methionine (Met-Met) exerts an anti-inflammatory effect in the bovine mammary epithelial cell (MAC-T) at a molecular level. However, evidence of whether the metabolic production of Met-Met confers protection was scarce. To investigate the inflammatory response and metabolite changes of Met-Met in lipopolysaccharide (LPS)-induced inflammation of MAC-T, mass spectrometry-based metabolomics and qPCR were conducted. Read More

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Genetic Involvement of Complex in the Regulation and Manipulation of Innate Immune Functions of Host Cells.

Int J Mol Sci 2021 Mar 16;22(6). Epub 2021 Mar 16.

Department of Microbiology and Institute for Immunology and Immunological Diseases, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.

complex (MAC), a collection of mycobacterial species representing nontuberculous mycobacteria, are characterized as ubiquitous and opportunistic pathogens. The incidence and prevalence of infectious diseases caused by MAC have been emerging globally due to complications in the treatment of MAC-pulmonary disease (PD) in humans and the lack of understating individual differences in genetic traits and pathogenesis of MAC species or subspecies. Despite genetically close one to another, mycobacteria species belonging to the MAC cause diseases to different host range along with a distinct spectrum of disease. Read More

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Curcumin Alleviates LPS-Induced Oxidative Stress, Inflammation and Apoptosis in Bovine Mammary Epithelial Cells via the NFE2L2 Signaling Pathway.

Toxins (Basel) 2021 Mar 12;13(3). Epub 2021 Mar 12.

Key Laboratory of Zoonosis Research, Ministry of Education, Department of Animal Science, College of Animal Sciences, Jilin University, Changchun 130062, China.

Lipopolysaccharide (LPS) is an endotoxin, which may cause immune response and inflammation of bovine mammary glands. Mastitis impairs animal health and results in economic loss. Curcumin (CUR) is a naturally occurring diketone compound, which has attracted widespread attention as a potential anti-inflammatory antioxidant. Read More

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Thrombin-Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis.

Int J Mol Sci 2021 Mar 4;22(5). Epub 2021 Mar 4.

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.

Fibrinogen is a well-known risk factor for arterial and venous thrombosis. Its function is not restricted to clot formation, however, as it partakes in a complex interplay between thrombin, soluble plasma fibrinogen, and deposited fibrin matrices. Fibrinogen, like thrombin, participates predominantly in hemostasis to maintain vascular integrity, but executes some important pleiotropic effects: firstly, as observed in thrombin generation experiments, fibrin removes thrombin from free solution by adsorption. Read More

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Improving Accurate Blood Pressure Cuff Allocation in Patients with Obesity: A Quality Improvement Initiative.

Healthcare (Basel) 2021 Mar 13;9(3). Epub 2021 Mar 13.

Department of Anaesthesia and Perioperative Medicine, The Royal Brisbane and Women's Hospital, Herston 4006, Australia.

Accurate noninvasive blood pressure (NIBP) measurement requires use of an appropriately sized cuff. We aimed to improve the perioperative allocation of NIBP cuffs in patients with Class II-III obesity. In the baseline evaluation, we measured the mid-arm circumference (MAC) of 40 patients with BMI > 35 kg/m, documenting the corresponding cuff allocated by pre-operative nurses. Read More

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Packet Flow Based Reinforcement Learning MAC Protocol for Underwater Acoustic Sensor Networks.

Sensors (Basel) 2021 Mar 24;21(7). Epub 2021 Mar 24.

Department of Electronic Engineering, University of York, York YO10 5DD, UK.

Medium access control (MAC) is one of the key requirements in underwater acoustic sensor networks (UASNs). For a MAC protocol to provide its basic function of efficient sharing of channel access, the highly dynamic underwater environment demands MAC protocols to be adaptive as well. Q-learning is one of the promising techniques employed in intelligent MAC protocol solutions, however, due to the long propagation delay, the performance of this approach is severely limited by reliance on an explicit reward signal to function. Read More

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Quality of Life in Women Subjected to Surgical Treatment of Breast Cancer Depending on the Procedure Performed within the Breast and Axillary Fossa-A Single-Center, One Year Prospective Analysis.

J Clin Med 2021 Mar 24;10(7). Epub 2021 Mar 24.

Department of Surgical Oncology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, Poland.

The aim of this study was to evaluate the quality of life of patients undergoing surgical treatment of breast cancer depending on the type of procedure involving the breast (mastectomy vs. breast conserving treatment) and axillary fossa (sentinel lymph node biopsy vs. axillary lymph node dissection). Read More

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Supplementing with L-Tryptophan Increases Medium Protein and Alters Expression of Genes and Proteins Involved in Milk Protein Synthesis and Energy Metabolism in Bovine Mammary Cells.

Int J Mol Sci 2021 Mar 9;22(5). Epub 2021 Mar 9.

Department of Animal Science and Technology, Konkuk University, Seoul 05029, Korea.

The objective of this study was to investigate the effects of supplementing with L-tryptophan (L-Trp) on milk protein synthesis using an immortalized bovine mammary epithelial (MAC-T) cell line. Cells were treated with 0, 0.3, 0. Read More

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Role of C5aR1 and C5L2 Receptors in Ischemia-Reperfusion Injury.

J Clin Med 2021 Mar 2;10(5). Epub 2021 Mar 2.

Department of Nephrology, Parc de Salut Mar, 08003 Barcelona, Spain.

The role of C5a receptors (C5aR1 and C5L2) in renal ischemia-reperfusion injury (IRI) is uncertain. We generated an in vitro model of hypoxia/reoxygenation with human proximal tubule epithelial cells to mimic some IRI events. C5aR1, membrane attack complex (MAC) and factor H (FH) deposits were evaluated with immunofluorescence. Read More

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Immunoglobulins and Transcription Factors in Otitis Media.

Int J Mol Sci 2021 Mar 21;22(6). Epub 2021 Mar 21.

Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University, Seoul 02447, Korea.

The causes of otitis media (OM) involve bacterial and viral infection, anatomo-physiological abnormalities of the Eustachian canal and nasopharynx, allergic rhinitis, group childcare centers, second-hand smoking, obesity, immaturity and defects of the immune system, formula feeding, sex, race, and age. OM is accompanied by complex and diverse interactions among bacteria, viruses, inflammatory cells, immune cells, and epithelial cells. The present study summarizes the antibodies that contribute to immune reactions in all types of otitis media, including acute otitis media, otitis media with effusion, and chronic otitis media with or without cholesteatoma, as well as the transcription factors that induce the production of these antibodies. Read More

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Design of New Polyacrylate Microcapsules to Modify the Water-Soluble Active Substances Release.

Polymers (Basel) 2021 Mar 6;13(5). Epub 2021 Mar 6.

Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.

Despite the poor photochemical stability of capsules walls, polyacrylate is one of the most successful polymers for microencapsulation. To improve polyacrylate performance, the combined use of different acrylate-based polymers could be exploited. Herein butyl methacrylate (BUMA)-based lattices were obtained via free radical polymerization in water by adding (i) methacrylic acid (MA)/methyl methacrylate (MMA) and (ii) methacrylamide (MAC) respectively, as an aqueous phase in Pickering emulsions, thanks to both the excellent polymer shells' stability and the high encapsulation efficiency. Read More

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Deploying an NFV-Based Experimentation Scenario for 5G Solutions in Underserved Areas.

Sensors (Basel) 2021 Mar 8;21(5). Epub 2021 Mar 8.

Instituto Nacional de Telecomunicações, Santa Rita do Sapucaí 37540-000, Brazil.

Presently, a significant part of the world population does not have Internet access. The fifth-generation cellular network technology evolution (5G) is focused on reducing latency, increasing the available bandwidth, and enhancing network performance. However, researchers and companies have not invested enough effort into the deployment of the Internet in remote/rural/undeveloped areas for different techno-economic reasons. Read More

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Efficient Implementation of NIST LWC ESTATE Algorithm Using OpenCL and Web Assembly for Secure Communication in Edge Computing Environment.

Sensors (Basel) 2021 Mar 11;21(6). Epub 2021 Mar 11.

Department of Financial Information Security, Kookmin University, Seoul 02707, Korea.

In edge computing service, edge devices collect data from a number of embedded devices, like sensors, CCTVs (Closed-circuit Television), and so on, and communicate with application servers. Since a large portion of communication in edge computing services are conducted in wireless, the transmitted data needs to be properly encrypted. Furthermore, the application servers (resp. Read More

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MK801 regulates the expression of key osteoarthritis factors in osteoarthritis synovial fibroblasts through complement C5.

Res Vet Sci 2021 Mar 3;136:377-384. Epub 2021 Mar 3.

Department of Anesthesiology, Guizhou Medical University, Guiyang 550002, PR China. Electronic address:

Background: Osteoarthritis is currently one of the most common chronic diseases. As life expectancy increases, its prevalence and incidence are expected to rise. At present, more and more evidences prove the correlation between the complement system and osteoarthritis (OA). Read More

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The Impact of Opportunistic Salpingectomy on Ovarian Cancer Mortality and Healthcare Costs: A Call For Universal Insurance Coverage.

Am J Obstet Gynecol 2021 Mar 30. Epub 2021 Mar 30.

University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, OH.

Background: Opportunistic salpingectomy at the time of hysterectomy, or as an alternative to bilateral tubal ligation may reduce the incidence of ovarian cancer as it has been demonstrated that most serous ovarian cancers begin in the fallopian tubes. However, salpingectomy at the time of sterilization is not always financially covered by third party payers and this represents a barrier to adoption. Routine salpingectomy has become more common but is not always practiced at the time of hysterectomy. Read More

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Anatomic classification of mitral annular calcification for surgical and transcatheter mitral valve replacement.

J Card Surg 2021 Apr 2. Epub 2021 Apr 2.

Department of Cardiovascular Surgery, Mount Sinai Medical Center, New York, New York, USA.

BACKGROUND AND AIM OF THE STUDY: A systematic approach to quantify mitral annular calcification (MAC) in all-comers by multidetector computed tomography (MDCT) is essential to guide treatment, but lacking.

Methods: From September 2015 to July 2019, 82 patients with MAC underwent MDCT at two institutions to evaluate for surgical mitral valve replacement (SMVR), transcatheter mitral valve replacement (TMVR), or medical management. Type 1 MAC was defined as <270° annular calcium and Type 2 as ≥270°. Read More

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First report of detection of IgA anti-Acanthamoeba antibodies among Saudi population and amoeba isolation from their surroundings.

Trop Biomed 2021 Mar;38(1):73-80

College of Arts and Sciences, Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al-Mouz, Nizwa, 616, Sultanate of Oman.

Acanthamoeba is an opportunistic protozoan pathogen which is found in diverse environment worldwide. Being ubiquitous nature of this amoeba we come across it in our daily life. Acanthamoeba species are recognized as human pathogens; that may cause blinding keratitis and rare but fatal granulomatous encephalitis involving central nervous system. Read More

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