163 results match your criteria lymphoplasmacytic cholangitis

Challenging diagnostic work-up of a massive fluid-filled structure in the cranial abdomen of a cat.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Oct 12. Epub 2021 Oct 12.

Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation.

A 9-year-old female, neutered European shorthair cat was presented with acute vomiting, obvious jaundice and painful enlargement of the abdomen. Icteric skin and mucous membranes in addition to severe bilirubinaemia (mainly direct bilirubin) and a large increase in liver enzyme activities were the main findings at the initial examination. Radio- and ultrasonographic evaluation revealed a massive fluid-filled structure caudal to the liver displacing abdominal organs, in particular the stomach. Read More

View Article and Full-Text PDF
October 2021

IgG4-related hepatic inflammatory pseudotumor mimicking cholangiolocellular carcinoma.

Clin J Gastroenterol 2021 Sep 27. Epub 2021 Sep 27.

Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Inflammatory pseudotumor (IPT) is a benign tumor mass composed of chronic infiltration of inflammatory cells and fibrous tissue. IgG4-RD (related disease) in the hepatobiliary system has been widely recognized and includes IgG4-related hepatic IPT. This report describes a patient with IgG4-related hepatic IPT with sclerosing cholangitis. Read More

View Article and Full-Text PDF
September 2021

IgG4-related hepatic inflammatory pseudotumour: could MRI suggest the correct diagnosis?

BMJ Case Rep 2021 Aug 23;14(8). Epub 2021 Aug 23.

Radiology, Hospital Beatriz Ângelo, Loures, Portugal.

We report a case of a 62-year-old woman, HIV positive, with a 3-week history of jaundice and elevated cholestatic enzymes. Imaging studies displayed intrahepatic biliary dilatation and a central liver lesion. Pathology described lesions of active cholangitis, lymphoplasmacytic infiltration and fibrosis, suggesting a hepatic inflammatory pseudotumour (IPT) IgG4 related. Read More

View Article and Full-Text PDF

Autoimmune pancreatitis: Current perspectives.

Indian J Pathol Microbiol 2021 Jun;64(Supplement):S149-S159

Department of Pathology, GIPMER, New Delhi, India.

Over the last two decades, our knowledge and understanding regarding the pathogenesis and biology of autoimmune pancreatitis (AIP) have improved tremendously. Type 1 AIP or IgG4-related pancreatitis (IgG4-RP) is now believed to be the prototype of the multisystemic IgG4-related disease. In view of clinical features like obstructive jaundice and mass-forming lesions in the pancreas in elderly men, type 1 AIP often mimics pancreatic cancer. Read More

View Article and Full-Text PDF

Choledochal cyst with secondary cholangitis, choledochitis, duodenal papillitis, and pancreatitis in a young domestic shorthair cat.

J Vet Diagn Invest 2021 Jul 24;33(4):782-787. Epub 2021 May 24.

North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA.

Choledochal cysts, congenital segmental dilations of the common bile duct, have been reported in few cats, and histologic characterization is lacking. A 20-mo-old spayed female domestic shorthair cat was presented because of vomiting and weight loss. There was progressive elevation of liver enzyme activity (ALT > ALP, GGT) and hyperbilirubinemia. Read More

View Article and Full-Text PDF

Autoimmune hepatitis-is histology conclusive?

Ann Transl Med 2021 Apr;9(8):733

Department of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Liver biopsy is an essential and necessary element in the diagnosis and management of autoimmune hepatitis, and is of very special importance in the scoring system for diagnosis. Histopathology shows moderate to severe inflammatory infiltrates with abundant plasma cells in the enlarged portal tracts with interface hepatitis and moderate to severe necroinflammatory lesions in the lobules with lymphoplasmacytic reaction. Regeneration develops with rosette formation and regenerative nodules. Read More

View Article and Full-Text PDF

Clinical characteristics and histology of cholecystectomised dogs with nongravity-dependent biliary sludge: 16 cases (2014-2019).

J Small Anim Pract 2021 06 24;62(6):478-488. Epub 2021 Feb 24.

Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.

Objectives: To report the available histology, biochemistry and clinical progression of dogs without classic overt biliary tract signs that underwent cholecystectomy for nongravity-dependent biliary sludge.

Materials And Methods: Case series of client-owned dogs for which a cholecystectomy was performed for nongravity-dependent biliary sludge. In six dogs, for which nongravity-dependent biliary sludge filled less than half of gall bladder volume, gall bladder ejection fractions were measured. Read More

View Article and Full-Text PDF

Evaluation and Pathologic Classification of Choledochal Cysts: Clinicopathologic Analysis of 84 Cases From the West.

Am J Surg Pathol 2021 05;45(5):627-637

Departments of Pathology.

Choledochal cyst (CC) is believed to be a mostly Asian disorder. As a clinically defined entity, its pathologic correlates are poorly characterized. Eighty-four resected CCs from the West were reanalyzed. Read More

View Article and Full-Text PDF

Immunoglobulin G4-related Disease Accompanied by Peripheral Neuropathy: A Report of Two Cases.

Intern Med 2021 Jun 15;60(12):1941-1947. Epub 2021 Jan 15.

Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan.

Due to its rarity and the limited literature, the clinicopathological characteristics of peripheral nerve involvement in immunoglobulin G4 (IgG4)-related disease are unknown. We present two cases of IgG4-related disease, accompanied by peripheral neuropathy, presenting as unilateral ptosis (case 1) and sclerosing cholangitis (case 2), respectively. In both cases, sural nerve biopsy indicated vasculitis as the underlying pathophysiology; the peripheral neuropathy was refractory to corticosteroid therapy. Read More

View Article and Full-Text PDF

The cytologic features of biliary diseases: A retrospective study.

Vet Clin Pathol 2020 Sep 6;49(3):440-450. Epub 2020 Sep 6.

IDEXX Laboratories Italia S.r.l., Brescia, Italy.

Background: Histologic examination, together with clinical data and instrument support, contributes to the recognition of biliary diseases. Although quantitative and qualitative changes in hepatic and biliary cells can occur, descriptions of cytologic samples from the liver affected by cholangiopathies are rare.

Objectives: This study aimed to describe the quantitative and qualitative changes in cholangiocytes, hepatocytes, and inflammatory cells in cytologic samples from dogs and cats affected by histologically confirmed cholangiopathies. Read More

View Article and Full-Text PDF
September 2020

Isolation of from free-range poultry with spotty liver disease in New Zealand.

N Z Vet J 2021 Jan 2;69(1):58-64. Epub 2020 Sep 2.

EpiLab, School of Veterinary Science, Massey University, Palmerston North, New Zealand.

In October 2019, a free-range egg laying flock suffering an outbreak of spotty liver disease was investigated. Eight 32-week-old hens were examined post-mortem. Five of the eight hens had sparse, focal, gross hepatic lesions typical of spotty liver disease. Read More

View Article and Full-Text PDF
January 2021

Histochemical and Immunohistochemical Characterizations of Hepatic Trematodiasis in Odontocetes.

Front Vet Sci 2020 30;7:336. Epub 2020 Jun 30.

Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.

Hepatic trematodiasis is a common condition in a number of free-ranging cetacean species, which occasionally result in severe hepatic and/or pancreatic lesions. However, even the basic pathological information of this disease is unknown for the majority of affected species. The current study describes and compares the histomorphology and immune reaction induced by hepatic trematodes of the family Brachycladiidae in the liver of the harbor porpoise ( = 8), Dall's porpoise ( = 8), and Hubbs' beaked whale ( = 2). Read More

View Article and Full-Text PDF

[Recent Updates of Immunoglobulin G4-related Pancreatobiliary Disease].

Korean J Gastroenterol 2020 05;75(5):257-263

Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Type 1 autoimmune pancreatitis and IgG4-related sclerosing cholangitis (IgG4-SC) are the pancreatobiliary manifestations of IgG4-related disease. IgG4-related disease is a newly named fibroinflammatory condition that is characterized by tumefactive lesions that contain dense lymphoplasmacytic infiltrates rich in IgG4-positive cells and often by elevated serum IgG4 concentrations. IgG4-related pancreatobiliary disease is often disguised as pancreatobiliary malignancies owing to its tumefactive nature and clinical presentations, such as obstructive jaundice. Read More

View Article and Full-Text PDF

Immunoglobulin G subtypes-1 and 2 differentiate immunoglobulin G4-associated sclerosing cholangitis from primary sclerosing cholangitis.

United European Gastroenterol J 2020 06 29;8(5):584-593. Epub 2020 Apr 29.

Department for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Background: Autoimmune pancreatitis is a special form of chronic pancreatitis with strong lymphocytic infiltration and two histopathological distinct subtypes, a lymphoplasmacytic sclerosing pancreatitis and idiopathic duct centric pancreatitis. Immunoglobulin G4-associated cholangitis may be present at the time of autoimmune pancreatitis type 1 diagnosis or occur later over the course of the disease. Immunoglobulin G4 is considered reliable but not an ideal marker for diagnosis of autoimmune pancreatitis type 1 with reported sensitivity between 71-81%. Read More

View Article and Full-Text PDF

Immunoglobulin G4-related disease mimicking gallbladder cancer with associated choledochal cyst: A case report of a malignant masquerade.

JGH Open 2019 Dec 22;3(6):536-539. Epub 2019 Feb 22.

Division of Surgical Gastroenterology, Department of General Surgery Postgraduate Institute of Medical Education and Research Chandigarh India.

Immunoglobulin G4 (IgG4)-related disease is a recently described autoimmune disease that can involve diverse organ systems, causing pancreatitis, cholangitis, retroperitoneal fibrosis, and thyroiditis to name a few. Key histological features include storiform fibrosis, obliterative venulitis, and intense inflammatory infiltrate composed of lymphoplasmacytic cells. The disease has a tendency to present with mass-forming lesions, often difficult to differentiate from malignant processes. Read More

View Article and Full-Text PDF
December 2019

Autoimmune Pancreatitis and IgG4-Related Disease: The Storiform Discovery to Treatment.

Kazuichi Okazaki

Dig Dis Sci 2019 09;64(9):2385-2394

Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Shinmachi, Hirakata, Osaka, 573-1197, Japan.

Autoimmune pancreatitis (AIP) is an entity that has been recognized since 1961. Prior to the discovery of elevated serum IgG4 as a useful biomarker for its diagnosis, Dr. Yoshida in 1995 first described the entity of AIP, which in retrospect closely resembles the current concept of type 1 AIP. Read More

View Article and Full-Text PDF
September 2019

Immunoglobulin G4-related hepatobiliary disease.

Semin Diagn Pathol 2019 Nov 24;36(6):423-433. Epub 2019 Jul 24.

Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

Immunoglobuline G4-related disease (IgG4-RD) is a systemic disease that can involve virtually any organs including the biliary tract and liver. The biliary tract involvement of IgG4-RD is known as IgG4-sclerosing cholangitis (IgG4-SC) and may or may not present with an inflammatory pseudotumor. Large bile ducts such as extrahepatic, hilar, and perihilar ducts are typically affected and demonstrate marked bile duct wall thickening and develop strictures. Read More

View Article and Full-Text PDF
November 2019

Diagnosis and management of IgG4-related disease.

Frontline Gastroenterol 2019 Jul 31;10(3):275-283. Epub 2018 Oct 31.

Department of Gastroenterology, St James University Hospital, Leeds, UK.

IgG subclass 4-related disease (IgG4-RD) is a rare but increasingly recognised fibroinflammatory condition known to affect multiple organs. IgG4-RD is characterised by unique histological features of lymphoplasmacytic infiltration, storiform fibrosis and obliterative phlebitis. In this review we describe the pancreaticobiliary manifestations of IgG4-RD, with particular emphasis on type 1 autoimmune pancreatitis (AIP) and IgG4-related sclerosing cholangitis (IgG4-SC). Read More

View Article and Full-Text PDF

[Paying attention to the diagnosis and treatment of IgG4-related sclerosing cholangitis].

B L Li J C Xiao

Zhonghua Wai Ke Za Zhi 2019 Jul;57(7):508-512

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

IgG4-related sclerosing cholangitis (IgG4-SC) is characterized by biliary strictures and obstructive jaundice.Elevated levels of serum IgG4 and a multifocal IgG4-rich lymphoplasmacytic infiltration of affected organs are also the characteristics of IgG4-SC. Prednisone is recommended in the initial treatment of IgG4-SC. Read More

View Article and Full-Text PDF

Immunoglobulin G4-related sclerosing cholangitis.

Atsushi Tanaka

J Dig Dis 2019 Jul 2;20(7):357-362. Epub 2019 Jul 2.

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Immunoglobulin (Ig)G4-related sclerosing cholangitis (IgG4-SC) is a biliary tract manifestation of IgG4-related diseases (IgG4-RD); a subgroup of SC defined as a condition with progressive stenosis and destruction of the bile ducts due to diffuse inflammation and fibrosis. IgG4-SC is clinically characterized by the (a) chronic elevation of cholestatic enzyme levels, (b) significant elevation of serum IgG4 levels, (c) diffuse or segmental narrowing of intra and/or extra hepatic bile ducts with thickening of the bile duct wall in imaging studies, (d) marked lymphoplasmacytic and IgG4-positive plasma cell infiltration and fibrosis in histology, (e) presence of IgG4-RD in other organs, mainly involving autoimmune pancreatitis, and (f) excellent response to corticosteroids. The diagnosis of IgG4-SC is based on a combination of these findings. Read More

View Article and Full-Text PDF

[Clinicopathological characteristics and diagnosis of IgG4related sialadenitis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):1-3

Department of Oral Radiology, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated disease and one of immunoglobulin G4-related diseases (IgG4-RD). Our multidisciplinary research group investigated the clinicopathological characteristics and diagnosis of IgG4-RS during the past 10 years. Clinically, it showed multiple bilateral enlargement of major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands. Read More

View Article and Full-Text PDF
February 2019

[Research status and challenges in immunoglobulin G4-related hepatobiliary disease].

Q X Wang X Ma

Zhonghua Gan Zang Bing Za Zhi 2018 Jun;26(6):401-403

Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai 200001, China.

IgG4-associated hepatobiliary diseases are group of autoimmune diseases characterized by lymphoplasmacytic infiltrates with an elevated serum IgG4 levels, affecting pancreas and biliary tract. In addition, it mainly includes IgG4-related sclerosing cholangitis, IgG4-related autoimmune pancreatitis and IgG4-related autoimmune hepatitis. An accurate diagnosis helps to avoid unnecessary surgery. Read More

View Article and Full-Text PDF

IgG4-Related Sclerosing Cholangitis Involving the Intrahepatic Bile Ducts Diagnosed with Liver Biopsy.

Case Rep Pathol 2018 16;2018:2309293. Epub 2018 Sep 16.

Department of Pathology, Odense University Hospital, Odense, Denmark.

IgG4-related disease is characterized by lymphoplasmacytic inflammation and fibrosis, often leading to mass-forming lesions in different organs. When IgG4-related disease affects the bile ducts, it is called IgG4-related sclerosing cholangitis. A 74-year-old male complained of dysphagia and abdominal pain. Read More

View Article and Full-Text PDF
September 2018

Immunoglobulin G4 Sclerosing Cholangitis: An Unusual Cause of Obstructive Jaundice-Case Report and Literature Review.

Case Rep Rheumatol 2018 23;2018:9602373. Epub 2018 Aug 23.

Department of Medicine, Reading Hospital-Tower Health System, West Reading, PA 19611, USA.

IgG4-related sclerosing cholangitis (IgG4-SC) is one of the most common extra-pancreatic manifestation of IgG4-related disease (IgG4-RD) and is clinically distinct from primary sclerosing cholangitis (PSC). IgG4-RD is an increasingly recognized immune-mediated fibroinflammatory systemic disease, mostly affecting middle-aged and older male populations that can affect multiple organs. The presence of extra-biliary clinical manifestations of IgG4-RD, such as parotid and lacrimal swelling, lymphadenopathy, autoimmune pancreatitis, and retroperitoneal fibrosis, if present could provide important clues to diagnosis. Read More

View Article and Full-Text PDF

Difficulty Achieving a Preoperative Diagnosis of IgG4-Related Sclerosing Cholangitis.

Case Rep Gastroenterol 2018 May-Aug;12(2):425-431. Epub 2018 Aug 21.

Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.

A 75-year-old male was admitted to our hospital because of bile duct stenosis. He had no medical history of autoimmune disease. The level of tumor markers, serum IgG, and IgG4 were within normal ranges. Read More

View Article and Full-Text PDF


J Wildl Dis 2018 10 23;54(4):782-789. Epub 2018 May 23.

4   California Animal Health & Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California-Davis, 105 W Central Ave., San Bernardino, California 92408, USA.

In Argentina there is little information about diseases that affect exotic ungulates and the health risks that they pose to native wildlife, livestock, and humans. The aim of this study was to evaluate the health status of red deer ( Cervus elaphus) in the Nahuel Huapi National Park and surrounding areas in Patagonia, Argentina. During three consecutive hunting seasons, necropsies were performed on 101 red deer, and tissues were examined histologically. Read More

View Article and Full-Text PDF
October 2018

Primary Biliary Cholangitis and Autoimmune Hepatitis.

Surg Pathol Clin 2018 Jun;11(2):329-349

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Avenue South, C-3316 MCN, Nashville, TN 37232-2561, USA.

Primary biliary cholangitis and autoimmune hepatitis are common autoimmune diseases of the liver. Both have typical clinical presentations, including certain autoantibodies on serologic testing. Histologic features are also often typical: primary biliary cholangitis shows bile duct destruction (sometimes with granulomas), and autoimmune hepatitis shows prominent portal and lobular lymphoplasmacytic inflammation. Read More

View Article and Full-Text PDF

Hilar cholangiocarcinoma associated with immunoglobulin G4-positive plasma cells and elevated serum immunoglobulin G4 levels.

Hepatol Commun 2018 04 28;2(4):349-353. Epub 2018 Feb 28.

Division of Gastroenterology and Hepatology University of California San Francisco San Francisco CA.

Immunoglobulin G4 (IgG4)-related disease is a fibroinflammatory systemic disorder with multiorgan involvement. Proximal bile duct involvement results in IgG4-related sclerosing cholangitis, which is characterized by a lymphoplasmacytic infiltrate with abundant IgG4-positive plasma cells and fibrosis. Differentiating between cholangiocarcinoma and IgG4-sclerosing cholangitis can present a diagnostic dilemma. Read More

View Article and Full-Text PDF

IgG4-related disease: with emphasis on the biopsy diagnosis of autoimmune pancreatitis and sclerosing cholangitis.

Virchows Arch 2018 Apr 1;472(4):545-556. Epub 2017 Dec 1.

Department of Pathology, Consultation Center of Pancreatic and Endocrine Tumors, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany.

In 2011, chronic fibroinflammatory processes occurring simultaneously or metachronously in various organs and associated with elevated IgG4 serum levels and/or tissue infiltration with IgG4-positive plasma cells have been recognized as manifestations of a systemic disorder called IgG4-related disease (IgG4-RD). The histologic key findings are lymphoplasmacytic infiltration rich in IgG4-positive plasma cells combined with storiform fibrosis and obliterative phlebitis. Among the organs mainly affected by IgG4-RD are the pancreas and the extrahepatic bile ducts. Read More

View Article and Full-Text PDF

IgG4-Related Cholangiopathy and Its Mimickers: A Case Report and Review Highlighting the Importance of Early Diagnosis.

Int J Surg Pathol 2018 Apr 14;26(2):165-173. Epub 2017 Sep 14.

1 University of Illinois at Chicago, IL, USA.

Immunoglobulin (Ig) G4 (IgG4)-related disease is a recently described clinical entity that can involve multiple organs. It is an autoimmune disorder characterized by a dense lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis. A key distinguishing factor is its dramatic response to steroid therapy. Read More

View Article and Full-Text PDF