61 results match your criteria lymphoplasmacytic aggregates


Lesions associated with -like bacterium infection in a free-ranging, young-of-the-year raccoon from Prince Edward Island, Canada.

J Vet Diagn Invest 2021 Mar 19;33(2):362-365. Epub 2021 Jan 19.

Southeastern Cooperative Wildlife Disease Study and Warnell School of Forestry and Natural Resources, The University of Georgia, Athens, GA.

A young-of-the year, female raccoon was presented with clinical signs of weakness and tremors. The raccoon was euthanized, and autopsy findings included poor body condition, diffuse lymphadenopathy, and pale, firm kidneys with petechial hemorrhages throughout the renal cortex. Histologic lesions included systemic fibrinoid vascular necrosis and severe renal lesions, including lymphoplasmacytic interstitial nephritis and fibrinosuppurative glomerulonephritis. Read More

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Congenital erythropoietic protoporphyria and protoporphyric hepatopathy in a dog.

J Am Vet Med Assoc 2020 Dec;257(11):1148-1156

Case Description: A 6-month-old sexually intact male Clumber Spaniel was evaluated because of small stature, recurrent dermatitis of the head, and progressive pigmentary hepatopathy.

Clinical Findings: Clinicopathologic findings included nonanemic hypochromic microcytosis, hypocholesterolemia, persistently high serum liver enzyme activities, and anicteric hyperbilirubinemia. Histologic examination of liver biopsy specimens collected when the dog was 6 months and 2 years of age revealed expansion and bridging of portal tracts, occasional centrilobular parenchymal collapse, scattered lymphoplasmacytic infiltrates, and dark red to brown pigment within large aggregates of macrophages, engorged bile canaliculi, and hepatocytes. Read More

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December 2020

Rare Initial Manifestation of Lupus as Lobular Panniculitis of the Breast-A Case Report and Review of the Literature.

Am J Dermatopathol 2020 Nov 16. Epub 2020 Nov 16.

Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH.

Lupus mastitis is a rare complication of systemic or discoid lupus erythematosus with an uncommon initial presentation when limited to the breast. In this article, we report a 42-year-old woman who presented with constant pain and tenderness in her breasts. Ultrasound imaging of the left breast revealed a 14-mm oval mass, suspicious for malignancy; a needle core biopsy was performed. Read More

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November 2020

Rosai-Dorfman Disease of the Digestive System-Beware Vasculopathy: A Clinicopathologic Analysis.

Am J Surg Pathol 2019 12;43(12):1644-1652

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.

Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytic proliferation that occurs in nodal and extranodal sites. Rare examples of the disease involving the digestive system have been described. To characterize the digestive tract manifestations of this disease, 12 specimens from 11 patients with extranodal RDD affecting the digestive organs were analyzed. Read More

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December 2019

Investigation of chronic infection by Leptospira spp. in asymptomatic sheep slaughtered in slaughterhouse.

PLoS One 2019 23;14(5):e0217391. Epub 2019 May 23.

Post Graduate Program in Animal Science in the Tropics-Federal University of Bahia., Salvador,Bahia, Brazil.

The study aimed to evaluate the histopathological characteristics of renal lesions in chronically infected sheep and with low titers of anti-Leptospira antibodies from a slaughterhouse. In the serological analysis, 24.74% (48/194) presented seroreactivity with a titer equal to or greater than 100. Read More

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January 2020

Liver Fibrosis Helps to Distinguish Autoimmune Hepatitis from DILI with Autoimmune Features: A Review of Twenty Cases.

J Clin Transl Hepatol 2019 Mar 9;7(1):21-26. Epub 2019 Jan 9.

Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA.

Drug-induced liver injury with autoimmune features (AI-DILI) mimics the clinical presentation, and laboratory and pathologic features of idiopathic autoimmune hepatitis (AIH). We aimed to identify histopathologic hallmarks to differentiate these entities. All liver biopsies archived for the past 10 years were reviewed retrospectively to identify cases of recently detected liver injury associated with predominantly lymphoplasmacytic interphase hepatitis, positive markers for liver autoimmunity, and negative tests for viral hepatitis. Read More

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Syphilitic Aortitis Diagnosis in Clinical Setting.

Rev Port Cir Cardiotorac Vasc 2017 Jul-Dec;24(3-4):166

Institute of Pathological Anatomy and Molecular Pathology of FMUC, Portugal.

Introduction: Cardiovascular syphilis can manifest as aortic aneurysms, aortic regurgitation and coronary ostial stenosis. Tertiary syphilis was the most commom reported cause of thoracic aortic aneurysm in the pre-antibiotic era, contributing to 5- 10% of cardiovascular deaths. However, in the 21st century, it has virtually disappered from the devoloping nations. Read More

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Pulmonary Pathologic Manifestations of Anti-Alanyl-tRNA Synthetase (Anti-PL-12)-Related Inflammatory Myopathy.

Arch Pathol Lab Med 2018 Feb 2;142(2):191-197. Epub 2017 Oct 2.

Context: - Patients with anti-aminoacyl-tRNA synthetase syndrome (ARS), a subset of idiopathic inflammatory myopathy, have a high prevalence of lung involvement. Autoantibodies directed against alanyl-tRNA synthetase (anti-PL-12 Abs) represent 1 of the 8 autoantibodies currently described under the rubric of ARS.

Objective: - To describe the clinical, radiographic, and pulmonary histopathologic findings in patients possessing anti-PL-12 autoantibodies. Read More

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February 2018

Concomitant lymphoplasmacytic lymphoma and plasma cell myeloma, a diagnostic challenge.

Am J Blood Res 2017 15;7(2):10-17. Epub 2017 Apr 15.

Department of Pathology and Laboratory Medicine, School of Medicine, Indiana UniversityIndianapolis, Indiana 46202, USA.

Background: Lymphoplasmacytic lymphoma and plasma cell myeloma are two B cell lymphoproliferative neoplasms derived from mature B-lymphocytes in different differentiation stages. The coexistence of these two tumors in the same patient is exceedingly rare and can be difficult to diagnose.

Case Presentation: A 76-year-old male presented with a pathologic fracture after a fall. Read More

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Clinicopathologic study of calcifying fibrous tumor of the gastrointestinal tract: a case series.

Hum Pathol 2017 04 30;62:199-205. Epub 2017 Jan 30.

Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD, 21231 USA.

Calcifying fibrous tumor (CFT) is a rare benign mesenchymal lesion known to arise at multiple body sites that may clinically mimic other more aggressive lesions in the gastrointestinal (GI) tract. In this study we describe the clinicopathologic findings of 28 GI tract CFTs. Tumors predominantly arose in middle-aged adults with a slight female predominance. Read More

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The pH of chemistry assays plays an important role in monoclonal immunoglobulin interferences.

Pract Lab Med 2015 Dec 9;3:8-16. Epub 2015 Oct 9.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

Objectives: Immunoglobulin paraproteins can interfere with multiple chemistry assays. We want to investigate the mechanisms of immunoglobulin interference.

Design And Methods: Serum samples containing paraproteins from the index patient and eight additional patients were used to investigate the interference with the creatinine and total protein assays on the Beckman Coulter AU5400/2700 analyzer, and to determine the effects of pH and ionic strength on the precipitation of different immunoglobulins in these patient samples. Read More

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December 2015

Clinicopathologic features of orbital immunoglobulin G4-related disease (IgG4-RD): a case series and literature review.

Graefes Arch Clin Exp Ophthalmol 2015 May 10;253(5):803-9. Epub 2015 Jan 10.

National Reporting Centre for Ophthalmic Pathology (NRCOP), Centre For Sight, Ashoka Capitol Building, Banjara Hills, Road No.2, Hyderabad, 500034, India,

Background: Involvement of orbital structures by immunoglobulin G4-related disease (IgG4-RD) is not uncommon. We conducted this study to evaluate the clinicopathologic features of orbital IgG4-RD.

Material/methods: This was a retrospective, clinicopathologic study. Read More

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Pulmonary pathologic manifestations of anti-glycyl-tRNA synthetase (anti-EJ)-related inflammatory myopathy.

J Clin Pathol 2014 Aug 2;67(8):678-83. Epub 2014 Jun 2.

Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Aims: Antisynthetase syndromes are a subset of the idiopathic inflammatory myopathies characterised by the presence of autoantibodies to aminoacyl transfer-RNA synthetases (ARS) and monotypic clinical features including Raynaud phenomenon, fever, non-erosive inflammatory arthritis and hyperkeratotic skin changes ('mechanic's hands'). Interstitial lung disease (ILD) is particularly common in ARS syndromes, affecting up to 90% of patients.

Methods: Four patients with ARS syndrome who possessed anti-glycyl-tRNA synthetase (anti-EJ) autoantibodies were retrieved from the University of Pittsburgh database. Read More

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Use of CD137 ligand expression in the detection of small B-cell lymphomas involving the bone marrow.

Hum Pathol 2014 May 21;45(5):1024-30. Epub 2014 Jan 21.

Department of Pathology, Stanford University School of Medicine, Stanford 94305, CA. Electronic address:

Staging for small B-cell lymphomas is important for prognostic and therapeutic decision making; however, the detection of lymphoid infiltrates in the bone marrow is often hampered by the lack of specific diagnostic markers. We recently described the hematopoietic tissue distribution patterns of CD137 and CD137 ligand (CD137L), which have shown promise as immunotherapeutic targets. CD137 expression was primarily confined to cells in the microenvironment, whereas CD137L was expressed in neoplastic cells in most B-cell lymphomas. Read More

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Fibro-adipose vascular anomaly: clinical-radiologic-pathologic features of a newly delineated disorder of the extremity.

J Pediatr Orthop 2014 Jan;34(1):109-17

*Divisions of Vascular and Interventional Radiology †Vascular Anomalies Center Departments of ‡Orthopedic Surgery ∥Plastic and Oral Surgery ¶Surgery #Anesthesiology **Radiology ‡‡Pathology ††Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA §Department of Diagnostic and Interventional Imaging, Memorial Hermann and Memorial Hermann Children's Hospital, Houston, TX.

Background: The diagnosis and management of vascular anomalies of the extremities can be challenging as these disorders are uncommon and may clinically overlap. The aim of this paper is to describe the clinical, radiologic, and histopathologic features of fibro-adipose vascular anomaly (FAVA), a previously unrecognized disorder of the limb.

Methods: The clinical, imaging, operative, and histopathologic data from patients with a unique intramuscular lesion of the extremities comprising dense fibrofatty tissue and slow-flow vascular malformations were retrospectively reviewed. Read More

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January 2014

Gastric calcifying fibrous tumor removed by endoscopic submucosal dissection.

World J Gastrointest Endosc 2013 Sep;5(9):457-60

Naotaka Ogasawara, Shinya Izawa, Mari Mizuno, Atsushi Tanabe, Tomonori Ozeki, Hisatsugu Noda, Makoto Sasaki, Kunio Kasugai, Department of Gastroenterology, Aichi Medical University School of Medicine, Aichi 480-1195, Japan.

The World Health Organization describes calcifying fibrous tumors (CFTs) as rare, benign lesions characterized by hypocellular, densely hyalinized collagenization with lymphoplasmacytic infiltration. These tumors rarely involve the gastrointestinal (GI) tract. A routine endoscopic upper gastrointestinal screen detected a 10-mm submucosal tumor (SMT) in the lesser curvature of the lower corpus of the stomach of an apparently healthy, 37-year-old woman with no history of Helicobacter pylori infection. Read More

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September 2013

Paratesticular rhabdomyoma: a morphologically distinct sclerosing variant.

Am J Surg Pathol 2013 Nov;37(11):1737-42

*Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA †Department of Pathology, University of Florida College of Medicine, Gainesville, FL ‡Department of Pathology, Institut Bergonie, Bordeaux, France.

Extracardiac rhabdomyomas, which currently are classified into fetal, adult, and genital types, are rare. We have identified 7 cases of a distinct morphologic variant of rhabdomyoma that affects mainly young men in the paratesticular region, seen in consultation between 2001 and 2011. The 7 male patients were adults (median age 24 y) and presented with tumors in paratesticular soft tissue (4 left-sided, 3 right-sided). Read More

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November 2013

Inflammatory angiomyolipoma of the liver: an unusual case suggesting relationship to IgG4-related pseudotumor.

Int J Clin Exp Pathol 2013 15;6(4):771-9. Epub 2013 Mar 15.

Institute of Pathology, University Hospital, Erlangen, Germany.

Hepatic angiomyolipoma (AML) is rare. Based on its wide histomorphological range, several distinctive histological variants have been delineated. However, hepatic AML displaying predominantly or exclusively inflammatory pattern closely mimicking inflammatory pseudotumor (IPT) is exceptionally rare with only 7 cases reported so far. Read More

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October 2013

[Extranodal Rosai-Dorfman disease of upper respiratory tract: a clinicopathologic study].

Zhonghua Bing Li Xue Za Zhi 2012 Jan;41(1):11-5

Department of Pathology, Eye and Ear Nose Throat Hospital of Fudan University, Shanghai 200031, China.

Objective: To study the clinicopathologic features and differential diagnosis of extranodal Rosai-Dorfman disease (RDD) of the upper respiratory tract.

Methods: The clinical, pathologic and immunohistochemical features of 10 cases of RDD were evaluated.

Results: Among the 10 cases studied, there were 3 males and 7 females. Read More

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January 2012

Facial paralysis and lymphocytic facial neuritis in a rhesus macaque (Macaca mulatta) positive for simian retrovirus type D2.

Comp Med 2011 Dec;61(6):538-45

Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA; Laboratory Animal Resources Unit, College of Veterinary Medicine, North Carolina State, Raleigh, North Carolina, USA.

Simian retrovirus type D (SRVD) is a naturally occurring betaretrovirus in nonhuman primates of the genus Macaca. Infection can lead to a variety of clinical, hematologic, and histopathologic abnormalities. We report an unusual clinical presentation of facial paralysis and histologic lymphocytic neuritis in an SRVD type 2 (SRVD2)-infected rhesus macaque (Macaca mulatta) with a catheter-associated vena caval thrombus, anemia, thrombocytopenia, and multisystemic lymphoid hyperplasia. Read More

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December 2011

Cutaneous colesional acquired immunodeficiency syndrome associated Kaposi sarcoma and cryptococcosis.

Am J Dermatopathol 2010 Dec;32(8):780-6

Department of Anatomical Pathology, University of KwaZulu Natal, Durban, KwaZulu Natal, South Africa.

The clinicopathologic features of 4 AIDS patients with cutaneous colesional Kaposi sarcoma (KS) and cryptococcosis, a rare phenomenon, are described. Biopsies from 3 patients who were highly active antiretroviral therapy (HAART)-naive demonstrated predominant KS with a conspicuous spindle cell component and small aggregates of cryptococcal yeasts in 2 biopsies and predominant gelatinous cryptococcosis with attenuated KS spindle cells in 1 biopsy. One patient was HAART exposed. Read More

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December 2010

Morphological factors as indicators of malignancy of squamous cell carcinomas in cattle exposed naturally to bracken fern (Pteridium aquilinum).

J Comp Pathol 2011 Jan 9;144(1):48-54. Epub 2010 Jun 9.

Programa de Pós-Graduação em Medicina Veterinária, UFSM, Jaguari, RS, Brazil.

Squamous cell carcinomas (SCCs) of the upper digestive tract (UDT) of cattle have been associated with chronic bracken fern (Pteridium aquilinum) toxicity and infection with bovine papillomavirus type-4. These tumours share some morphological similarities with human head and neck SCCs. In this study, morphological changes were correlated with the biological behaviour of 40 alimentary SCCs in cattle grazing on pastures with high bracken content. Read More

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January 2011

Calcifying fibrous tumor of the stomach: clinicopathologic and molecular study of seven cases with literature review and reappraisal of histogenesis.

Am J Surg Pathol 2010 Feb;34(2):271-8

Institute of Pathology, University Hospital, Erlangen, Germany.

Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor composed of hyalinized fibrous tissue with interspersed bland fibroblastic spindled cells, scattered psammomatous, and/or dystrophic calcifications and variably prominent mononuclear inflammatory infiltrate. CFTs show a predilection for the abdominal cavity and soft tissue. To date, 6 gastric and 3 intestinal CFTs have been reported. Read More

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February 2010

Oncocytic variant of papillary thyroid carcinoma associated with Hashimoto's thyroiditis: a case report and review of the literature.

Diagn Cytopathol 2009 Aug;37(8):600-6

Department of Pathology, University of California, San Diego, California 92103-8720, USA.

Identification of Hürthle cells on fine-needle aspiration (FNA) of the thyroid leads to a wide differential diagnosis including benignand malignant entities. We report the cytological and histological findings of a patient with an oncocytic variant of papillary thyroid carcinoma (PTC) with concurrent Hashimoto's thyroiditis. FNA revealed a lymphoplasmacytic infiltrate with Hürthle cells demonstrating abnormal chromatin patterns, nuclear enlargement, pleomorphism, intranuclear cytoplasmic invaginations, and foci of papillary aggregates. Read More

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Biopsy of osteoporotic vertebral compression fractures during kyphoplasty: unsuspected histologic findings of chronic osteitis without clinical evidence of osteomyelitis.

Spine (Phila Pa 1976) 2009 Jun;34(14):1486-91

Department of Orthopaedic Surgery, University of California, San Diego, CA 92103-8894, USA.

Study Design: Retrospective case series.

Objective: To evaluate biopsy results obtained during vertebral augmentation (kyphoplasty) for presumed/confirmed osteoporotic vertebral compression fractures (VCFs).

Summary Of Background Data: Kyphoplasty to augment vertebrae in osteoporotic VCFs is well established. Read More

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Oral calcifying fibrous pseudotumor: case analysis and review.

Head Neck Pathol 2008 Dec 30;2(4):343-7. Epub 2008 Aug 30.

Department of Pathology, Unit 85, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

Calcifying fibrous pseudotumor (CFT) is a rare distinct soft-tissue lesion characterized histologically by lymphoplasmacytic aggregates in a rich collagenized background with abundant psammomatous and dystrophic calcifications. Occurring most often in children and young adults, CFTs are clinically benign lesions that can form over a broad anatomic distribution, including in subcutaneous and deep soft tissues, as well as in serosal and visceral locations. The cause and mechanisms of pathogenesis of CFT are unknown. Read More

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December 2008

Immunoglobulin derived depositions in the nervous system: novel mass spectrometry application for protein characterization in formalin-fixed tissues.

Lab Invest 2008 Oct 18;88(10):1024-37. Epub 2008 Aug 18.

Department of Laboratory Medicine and Pathology, Research Center, Mayo Clinic, Rochester, MN 55905, USA.

Proteinaceous deposits are occasionally encountered in surgically obtained biopsies of the nervous system. Some of these are amyloidomas, although the precise nature of other cases remains uncertain. We studied 13 cases of proteinaceous aggregates in clinical specimens of the nervous system. Read More

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October 2008

Ocular adnexal IgG4-related disease has uniform clinicopathology.

Pathol Int 2008 Aug;58(8):465-70

Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

IgG4-related disease is a recently proposed clinical entity with several unique clinicopathological features. Ocular adnexal IgG4-related disease, however, has not well been clarified. The purpose of the present study was to examine 21 patients (10 men, 11 women; age range, 39-86 years) with ocular adnexal IgG4-related disease. Read More

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An immunohistochemical investigation of canine idiopathic granulomatous scleritis.

Vet Ophthalmol 2008 Jan-Feb;11(1):11-7

Division of Veterinary Pathology, Infection and Immunity, School of Clinical Veterinary Science, University of Bristol, Langford BS40 5 DU, UK.

The clinical, histopathologic and immunohistochemical findings in three dogs with granulomatous scleritis are reported. The lesions of granulomatous scleritis were characterized by vasculitis, collagenolysis, granulomatous inflammation and perivascular lymphoplasmacytic aggregation. There was evidence of vascular immune complex deposition, and the inflammatory aggregates contained T lymphocytes, IgG plasma cells and macrophages expressing class II molecules of the major histocompatibility complex (MHC). Read More

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Renal lesions in IgG4-related systemic disease.

Intern Med 2007 3;46(17):1365-71. Epub 2007 Sep 3.

Department of Internal Medicine, Nagaoka Red Cross Hospital.

Objective: Recently, a new concept of IgG4-related systemic disease including autoimmune pancreatitis, characterized by a high serum IgG4 level and tissue infiltration by IgG4-positive plasma cells, has been proposed. Our aim was to investigate the renal involvement in this condition.

Patients And Methods: We investigated the results of laboratory and imaging studies of the kidneys in 7 patients with IgG4-related systemic disease, and examined the renal histology in four of them. Read More

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September 2007