384 results match your criteria lymphomatous polyposis

Multiple Lymphomatous Polyposis Associated With Mucosa-Associated Lymphoid Tissue Lymphoma of the Colon.

ACG Case Rep J 2021 Feb 26;8(2):e00503. Epub 2021 Feb 26.

Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Japan.

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February 2021

[A case of cap polyposis achieving complete remission by Helicobacter pylori eradication therapy].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(2):183-187

Department of Surgical Pathology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.

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February 2021

Synchronous Occurrence of Splenic Pleomorphic Mantle Cell Lymphoma and Esophageal Adenocarcinoma with Overexpression of BCL1 Protein.

Case Rep Oncol Med 2020 21;2020:8888829. Epub 2020 Dec 21.

Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA 71130, USA.

Synchronous occurrences of mantle cell lymphoma (MCL), or intermediate lymphocytic lymphoma, and other malignancies are rare. Such cases present diagnostic and especially therapeutic challenges, making them of particular interest to study. We report a case of synchronic MCL and an esophageal tumor in an elderly male patient. Read More

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December 2020

A case of multiple recurrent intussusceptions due to multiple lymphomatous polyposis associated with diffuse large B-cell lymphoma of gastrointestinal tract in a 15-year-old child: A rare case report.

Int J Surg Case Rep 2021 Feb 31;79:44-48. Epub 2020 Dec 31.

Department of Gastrointestinal and Hepatobiliary Surgery, CK Birla RBH Hospital, Jaipur, Rajasthan, India. Electronic address:

Introduction And Importance: Multiple lymphomatous polyposis (MLP) is a distinctive and rare entity of primary gastrointestinal (GI) lymphoma characterized by polypoid lymphomatous tissue in long segments of the gut and a strong tendency for spread throughout the GI tract. Although many cases of MLP presenting as intussusceptions in adults have been reported, we report a rare case of multiple recurrent intussusceptions due to MLP associated with high-grade Diffuse Large B-cell lymphoma (DLBCL) of the entire GI tract in a 15-year-old child.

Case Presentation: A 15-year-old child previously operated for acute intestinal obstruction, presented with intermittent abdominal pain, nausea and vomiting. Read More

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February 2021

BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.

Autophagy 2021 Jan 19:1-20. Epub 2021 Jan 19.

Department of Ophthalmology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.

Retinal ganglion cell axons are heavily myelinated (98%) and myelin damage in the optic nerve (ON) severely affects vision. Understanding the molecular mechanism of oligodendrocyte progenitor cell (OPC) differentiation into mature oligodendrocytes will be essential for developing new therapeutic approaches for ON demyelinating diseases. To this end, we developed a new method for isolation and culture of ON-derived oligodendrocyte lineage cells and used it to study OPC differentiation. Read More

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January 2021

A RAC-GEF network critical for early intestinal tumourigenesis.

Nat Commun 2021 01 4;12(1):56. Epub 2021 Jan 4.

CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.

RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon homeostasis, we reasoned that indirect targeting of RAC1 via RAC-GEFs might be effective. Transcriptional profiling of Apc deficient intestinal tissue identified Vav3 and Tiam1 as key targets. Read More

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January 2021

Gastric mucosa-associated lymphoid tissue lymphoma in conjunction with multiple lymphomatous polyposis in the context of Helicobacter pylori and Helicobacter suis superinfection.

Clin J Gastroenterol 2021 Apr 4;14(2):478-483. Epub 2021 Jan 4.

Department of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan.

A 53-year-old woman visited a doctor and complained of chest discomfort after meals. Esophagogastroduodenoscopy showed multiple granular elevations in the gastric body. After biopsies from the elevations, she was diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma. Read More

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Multiple lymphomatous polyposis: A presentation for mantle cell lymphoma.

Clin Case Rep 2020 Dec 17;8(12):3038-3042. Epub 2020 Sep 17.

Burrell College of Osteopathic Medicine Roswell New Mexico USA.

Multiple lymphomatous polyposis is an uncommon presentation of mantle cell lymphoma, and when exhibited should prompt clinicians to incorporate mantle cell lymphoma into their differential workup. Read More

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December 2020

Primary intestinal follicular lymphoma presenting as multiple lymphomatous polyposis.

BMJ Case Rep 2020 Dec 13;13(12). Epub 2020 Dec 13.

General Surgery Department, Dumfries and Galloway Royal Infirmary, Dumfries, UK.

Multiple lymphomatous polyposis (MLP) is a rare condition, described in the literature as a presentation of extranodal mantle cell lymphoma. We report a rare case of follicular lymphoma presenting as MLP in a young woman with a short history of haematochezia who underwent colonoscopy. Immunohistochemistry on colonic biopsies confirmed follicular lymphoma. Read More

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December 2020

Mantle cell lymphoma: A rare cause of colon polyposis.

Gastroenterol Hepatol 2020 Nov 9. Epub 2020 Nov 9.

Pathology Department, Centro Hospitalar de São João, Porto, Portugal.

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November 2020

Not your 'day-to-day' colonic polyps.

Gut 2020 Nov 2. Epub 2020 Nov 2.

Department of Pathology, Tan Tock Seng Hospital, Singapore.

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November 2020

Mantle cell lymphoma with gastrointestinal involvement and the role of endoscopic examinations.

PLoS One 2020 25;15(9):e0239740. Epub 2020 Sep 25.

Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: Studies on gastrointestinal (GI) tract involvement in mantle cell lymphoma (MCL) are lacking. We investigated the clinical characteristics and prognosis of MCL with GI tract involvement.

Methods: We retrospectively analyzed 64 patients diagnosed with MCL from January 2009 to April 2017. Read More

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November 2020

Colonic Mantle Cell Lymphoma with Multiple Lymphomatous Polyposis.

GE Port J Gastroenterol 2020 Jul 2;27(4):296-298. Epub 2020 Jan 2.

Division of Gastroenterology, Department of Medicine, University of Florida at Jacksonville, Jacksonville, Florida, USA.

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Haploinsufficiency of Casitas B-Lineage Lymphoma Augments the Progression of Colon Cancer in the Background of Adenomatous Polyposis Coli Inactivation.

Am J Pathol 2020 03 26;190(3):602-613. Epub 2020 Feb 26.

Department of Medicine, Boston University School of Medicine, Boston, Massachusetts; Veterans Affairs Boston Healthcare System, Boston, Massachusetts; Global Co-Creation Labs, Institute of Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts. Electronic address:

Casitas B-lineage lymphoma (c-Cbl) is a recently identified ubiquitin ligase of nuclear β-catenin and a suppressor of colorectal cancer (CRC) growth in cell culture and mouse tumor xenografts. We hypothesized that reduction in c-Cbl in colonic epithelium is likely to increase the levels of nuclear β-catenin in the intestinal crypt, augmenting CRC tumorigenesis in an adenomatous polyposis coli (APC) mouse model. Haploinsufficient c-Cbl mice (APC c-Cbl) displayed a significant (threefold) increase in atypical hyperplasia and adenocarcinomas in the small and large intestines; however, no differences were noted in the adenoma frequency. Read More

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Long-term Prognosis of Localized Lymphoid Hyperplasia of the Rectum.

Gut Liver 2021 Jan;15(1):77-84

Departments of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background/aims: Although localized lymphoid hyperplasia (LLH) of the rectum is occasionally observed, its clinical implications are unclear. This study aimed to investigate the clinical course and significance of LLH of the rectum.

Methods: We identified 65 patients diagnosed with LLH of the rectum using a histopathologic examination and who received follow-up endoscopies between January 2009 and June 2015. Read More

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January 2021

A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors.

Cancer Prev Res (Phila) 2020 03 12;13(3):291-298. Epub 2020 Feb 12.

Dana-Farber Cancer Institute, Boston, Massachusetts.

Prior small reports have postulated a link between gastrointestinal polyposis and childhood and young adulthood cancer (CYAC) treatment (therapy-associated polyposis; TAP), but this remains a poorly understood phenomenon. The aim of this study was to describe the phenotypic spectrum of TAP in a multi-institutional cohort. TAP cases were identified from eight high-risk cancer centers. Read More

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Practical Approach to the Histologic Diagnosis of Gastrointestinal Lymphomas Through the First-line Marker Battery of CD20, CD3, CD30, and Epstein-Barr Virus-encoded RNAs.

Adv Anat Pathol 2020 Mar;27(2):75-86

Department of Pathology, Yonsei University College of Medicine, Severance Hospital, Seoul.

The gastrointestinal (GI) tract is a prevalent site for extranodal lymphomas. Some subtypes of GI tract lymphomas are aggressive and have dismal clinical outcomes. Therefore, prompt histopathologic detection of such types can be very important. Read More

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Primary colon mantle lymphoma: a misleading macroscopic appearance!

Rev Esp Enferm Dig 2019 Dec;111(12):965-967

Department of Gastroenterology, Hospital da Senhora da Oliveira - Guimarães , Portugal.

Mantle cell lymphoma (MCL) of the colon is a rare entity, usually presenting as lymphomatous polyposis. We report the case of a 43-year-old male with an unusual colonic MCL in the form of a single exophytic and ulcerous lesion with necrotic areas associated with an ileo-cecal intussusception. The endoscopic appearance suggested adenocarcinoma. Read More

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December 2019

Synchronous colonic adenoma and intestinal marginal zone B-cell lymphoma associated with Crohn's disease: a case report and literature review.

BMC Cancer 2019 Oct 17;19(1):966. Epub 2019 Oct 17.

Department of Surgical Oncology, Mohamed I University, 30050, Oujda, Morocco.

Background: Lymphoma and dysplasia are rare complications of long-standing Crohn's disease. We report an exceptional case of a synchronous intestinal marginal zone B-cell lymphoma (MALT lymphoma) and colonic adenoma in a Crohn's disease patient.

Case Presentation: A 50-year-old male patient presented with right lower quadrant for the last 9 months. Read More

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October 2019

Burkitt-like lymphoma in a pediatric patient with familial adenomatous polyposis.

Cancer Genet 2019 11 4;239:33-35. Epub 2019 Sep 4.

Department of Pediatrics, University of California Los Angeles Mattel Children's Hospital, Los Angeles, CA, United States; Division of Pediatric Hematology and Oncology, University of California Los Angeles Mattel Children's Hospital, Los Angeles, CA, United States; Jonsson Comprehensive Cancer Center, University of California Los Angeles, United States; Children's Discovery and Innovation Institute, University of California Los Angeles Hospital, Los Angeles, CA, United States. Electronic address:

Familial adenomatous polyposis (FAP) is an autosomal dominant condition that predisposes to multiple malignancies, most commonly colorectal carcinoma, but has rarely been associated with lymphoma. We discuss one patient found to have Burkitt-like Lymphoma (BLL) with 11q aberration in the setting of previously undiagnosed FAP. We review the literature of FAP and associated malignancies and the provisional WHO classification of Burkitt-like lymphoma with 11q aberration. Read More

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November 2019

ALK-positive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis: A case report and literature review.

World J Clin Cases 2019 Aug;7(15):2049-2057

Department of Surgical Pathology, Asahikawa Medical University Hospital (formerly Department of Cancer Pathology, Hokkaido University, Faculty of Medicine), Asahikawa 0788510, Japan.

Background: Anaplastic large cell lymphoma (ALCL) is a type of T-cell lymphoma that can be divided into two categories: anaplastic lymphoma kinase-positive (ALK+) and ALK-negative. Gastrointestinal ALK+ ALCL is rare. Multiple lymphomatous polyposis (MLP) is thought to be a representative form of gastrointestinal lesion in mantle cell lymphoma, and T-cell lymphomas seldom show this feature. Read More

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Pseudotumor lymphomatous polyposis of the ileum in a patient with gastrointestinal MALT lymphoma.

Rev Esp Enferm Dig 2019 Jun;111(6):483-484

Medicina de Aparato Digestivo, Hospital Universitario 12 de Octubre, España.

A 46-year-old male presented with anemia, vitamin B12 deficiency and a positive fecal occult blood test. Ileocolonoscopy was performed, which identified multiple large (up to 5 cm) edematous, polypoid lesions at the terminal ileum. Read More

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Nasolacrimal Duct Management During Endoscopic Sinus and Skull Base Surgery.

Ann Otol Rhinol Laryngol 2019 Oct 14;128(10):932-937. Epub 2019 May 14.

1 Department of Otolaryngology-Head and Neck Surgery, New York University Langone Health, NY, USA.

Objective: To evaluate rates of epiphora after transection and marsupialization of the nasolacrimal duct (NLD) during endoscopic sinus and skull base surgery.

Introduction: The nasolacrimal canal forms part of the medial wall of the maxillary sinus. Transecting the NLD is sometimes necessary for tumor resection or surgical access to maxillary sinus and infratemporal fossa pathology. Read More

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October 2019

Mantle cell lymphoma presenting as diffuse esophageal, gastric, and duodenal bulb polyposis.

Ann Gastroenterol 2019 May-Jun;32(3):317. Epub 2019 Jan 23.

Sanford Gastroenterology, University of South Dakota, Sanford School of Medicine, Sioux Falls, SD, USA (Charoen Mankongpaisarnrung).

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January 2019

Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/β-catenin pathway by sponging miR-135b-5p to elevate expression of APC.

Cell Death Dis 2019 03 15;10(4):252. Epub 2019 Mar 15.

Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.

Diffuse large B cell lymphoma (DLBCL) is a common and fatal hematological malignancy. Long noncoding RNAs (lncRNAs) have emerged as crucial biomarkers and regulators in many cancers. Novel lncRNA biomarker in DLBCL needs to be investigated badly, as well as its function and molecular mechanism. Read More

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Images of the Month: Multiple lymphomatous polyposis incidentally found after acute sigmoid diverticulitis.

Am J Gastroenterol 2018 06;113(6)

Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.

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High prevalence of advanced colorectal neoplasia and serrated polyposis syndrome in Hodgkin lymphoma survivors.

Cancer 2019 03 18;125(6):990-999. Epub 2018 Dec 18.

Department of Gastroenterology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Background: Hodgkin lymphoma (HL) survivors treated with abdominal radiotherapy and/or alkylating chemotherapy have an increased risk of colorectal cancer (CRC). This study was aimed at evaluating the prevalence of colorectal neoplasia in HL survivors.

Methods: This multicenter cohort study assessed the diagnostic yield of advanced colorectal neoplasia detected by a first surveillance colonoscopy among HL survivors treated with abdominal radiotherapy and/or procarbazine. Read More

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Immunohistochemical detection of ALK protein identifies APC mutated medulloblastoma and differentiates the WNT-activated medulloblastoma from other types of posterior fossa childhood tumors.

Brain Tumor Pathol 2019 Jan 6;36(1):1-6. Epub 2018 Dec 6.

Department of Experimental and Clinical Pathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, A. Pawińskiego 5 Street, 02-106, Warsaw, Poland.

Expression of the ALK gene strongly correlates with the WNT-activated medulloblastomas, which are routinely identified by detection of CTNNB1 mutation. However, some tumors have mutations in other than CTNNB1 genes. Therefore, we investigated if ALK expression may identify WNT-activated tumors without CTNNB1 mutation. Read More

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January 2019

Mantle cell lymphoma with involvement of the digestive tract.

Rev Gastroenterol Mex 2019 Oct - Dec;84(4):434-441. Epub 2018 Sep 11.

Departamento de Endoscopia Gastrointestinal, Instituto Nacional de Cancerología, Secretaría de Salud, Ciudad de México, México.

Introduction And Aim: Mantle cell lymphoma is an aggressive subtype of B-cell non-Hodgkin lymphoma and its incidence is 0.5/100,000 inhabitants. Gastrointestinal involvement at diagnosis is 15-30%. Read More

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