277,938 results match your criteria lymphoma


Neurocognitive Functions in Primary CNS Lymphoma.

Authors:
Denise D Correa

Neuro Oncol 2021 May 13. Epub 2021 May 13.

Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY.

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The value of bone marrow biopsy for staging of patients with primary CNS lymphoma.

Neuro Oncol 2021 May 13. Epub 2021 May 13.

Department of Neurology, Knappschaftskrankenhaus University of Bochum, In der Schornau 23-25, 44892 Bochum, Germany.

Background: In patients with presumed primary CNS lymphoma (PCNSL) a systemic manifestation is found only in a small minority. Although bone marrow biopsy (BMB) is recommended for staging, its diagnostic value is unclear.

Methods: A retrospective analysis of 392 patients with presumed PCNSL from three university hospitals and 33 patients with secondary CNS lymphoma (SCNSL) and initial CNS involvement from a multicentre Germany-wide prospective registry was performed. Read More

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Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds.

PLoS Genet 2021 May 13;17(5):e1009543. Epub 2021 May 13.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes with a poorly understood etiology in humans. A histologically and clinically similar counterpart affects flat-coated retrievers (FCRs) at unusually high frequency, with 20% developing the lethal disease. The similar clinical presentation combined with the closed population structure of dogs, leading to high genetic homogeneity, makes dogs an excellent model for genetic studies of cancer susceptibility. Read More

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Hyperglycaemia-Induced Contractile Dysfunction and Apoptosis in Cardiomyocyte-Like Pulsatile Cells Derived from Mouse Embryonic Stem Cells.

Cardiovasc Toxicol 2021 May 13. Epub 2021 May 13.

Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa.

Hyperglycaemia, a key metabolic abnormality in diabetes mellitus, is implicated in pathological cardiogenesis during embryological development. However, the underlying mechanisms and potential therapeutic targets remain unknown. We, therefore, studied the effect of hyperglycaemia on mouse embryonic stem cell (mESC) cardiac differentiation. Read More

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A new warhead in lymphoma therapy?

Authors:
Andrew McMillan

Blood 2021 May;137(19):2568-2570

Nottingham University Hospitals NHS Trust.

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Hodgkin Lymphoma Associated Retinopathy: Report of a Case.

Ocul Immunol Inflamm 2021 May 13:1-3. Epub 2021 May 13.

Université de Paris, Department of Ophthalmology, Hôpital Cochin, Paris, France.

: To report a case of Hodgkin lymphoma (HL) associated retinopathy.: Single-case, retrospective review of ophthalmological and systemic manifestations.: A bilateral panuveitis in a 17-year-old Caucasian woman led to the diagnosis of HL. Read More

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Hydroa vacciniforme-like lymphoproliferative disorder: A clinicopathological, immunohistochemical, and prognostic study of 24 cases in China.

J Dermatol 2021 May 13. Epub 2021 May 13.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD) is a rare cutaneous disease associated with Epstein-Barr virus infection. We retrospectively analyzed the clinical presentation, histopathological characteristics, and prognostic study of HV-LPD in 24 Chinese patients. All patients presented with recurrent papulovesicular and necrotic eruptions on the face, neck, and extremities, with 11 showing systemic symptoms. Read More

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A woman with visual loss, amenorrhoea and polyuria: the first reported case of nodular lymphocyte-predominant Hodgkin lymphoma presenting with hypopituitarism.

Endocrinol Diabetes Metab Case Rep 2021 May 1;2021. Epub 2021 May 1.

Department of Endocrinology and Diabetes, Royal Brisbane and Women's Hospital, Brisbane, Australia.

Summary: A 34-year-old woman presented 18 months post-partum with blurred vision, polyuria, amenorrhoea, headache and general malaise. Comprehensive clinical examination showed left superior temporal visual loss only. Initial investigations revealed panhypopituitarism and MRI demonstrated a sellar mass involving the infundibulum and hypothalamus. Read More

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[Effect of Dendrobium officinale superfine powder on stomach Yin deficiency model mice induced by "spicy overeating"].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1651-1657

Zhejiang Chinese Medical University Hangzhou 310053, China.

Dendrobium officinale is a traditional Chinese medicine for nourishing Yin and benefiting stomach. Its superfine powder has many advantages, such as good dissolution, high utilization rate, strong integrity and easy to use. However, the researches on effect of D. Read More

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Real-world evidence of cytomegalovirus reactivation in non-Hodgkin lymphomas treated with bendamustine-containing regimens.

Open Med (Wars) 2021 21;16(1):672-682. Epub 2021 Apr 21.

Hematology and Transplant Center, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, 84131, Italy.

Cytomegalovirus (CMV) reactivation during chemotherapy or after organ or hematopoietic stem cell transplantation is a major cause of morbidity and mortality, and the risk of reactivation increases with patients' age. Bendamustine, an alkylating agent currently used for treatment of indolent and aggressive non-Hodgkin lymphomas, can augment the risk of secondary infections including CMV reactivation. In this real-world study, we described an increased incidence of CMV reactivation in older adults (age >60 years old) with newly diagnosed and relapsed/refractory indolent and aggressive diseases treated with bendamustine-containing regimens. Read More

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Addition of BTK inhibitor orelabrutinib to rituximab improved anti-tumor effects in B cell lymphoma.

Mol Ther Oncolytics 2021 Jun 3;21:158-170. Epub 2021 Apr 3.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China.

Bruton tyrosine kinase (BTK) inhibitor ibrutinib has been validated as an effective drug to treat B cell malignancies. Combined therapies comprising ibrutinib and anti-CD20 antibodies like rituximab were designed as a backbone in many clinical trials. However, the off-target inhibition of ibrutinib on interleukin-2 (IL-2)-inducible T cell kinase (ITK) may reduce rituximab's antibody-dependent cellular cytotoxicity (ADCC) efficacy. Read More

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Circular RNA circPVT1 Contributes to Doxorubicin (DXR) Resistance of Osteosarcoma Cells by Regulating TRIAP1 via miR-137.

Biomed Res Int 2021 23;2021:7463867. Epub 2021 Apr 23.

Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun City, Jilin Province, China.

Background: Chemoresistance is a major obstacle to the treatment of osteosarcoma patients. Circular RNA (circRNA) circPVT1 has been reported to be related to the doxorubicin (DXR) resistance in osteosarcoma. This study is designed to explore the role and mechanism of circPVT1 in the DXR resistance of osteosarcoma. Read More

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Common Presentation of an Uncommon Small Intestinal Lymphoma: A Rare Case Entity.

Gastrointest Tumors 2021 Apr 17;8(2):47-51. Epub 2021 Feb 17.

Department of General Surgery, All India Institute of Medical Sciences, Jodhpur, India.

Primary gastrointestinal NHL accounts for 30-40% of all extranodal NHL. Primary gastrointestinal lymphomas constitute 5% of total gut neoplasms. Bowel perforation is a severe life-threatening complication and sometimes initial presentation of gastrointestinal lymphoma. Read More

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Adherence to Active Surveillance and Clinical Outcomes in Patients with Indeterminate Thyroid Nodules Not Referred for Thyroidectomy.

Eur Thyroid J 2021 Apr 6;10(2):168-173. Epub 2020 Aug 6.

Endocrine Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.

Objective: Outcomes of patients with cytologically indeterminate thyroid nodules not referred for thyroidectomy have hardly been investigated. We previously reported outcomes of 322 patients with thyroid nodules classified according to the Bethesda System of Reporting Thyroid Cytology (BSRTC) as indeterminate (B3/B4), of whom 123 (38.2%) underwent thyroidectomy. Read More

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Risks of Muscle Atrophy in Patients with Malignant Lymphoma after Autologous Stem Cell Transplantation.

Phys Ther Res 2021 13;24(1):69-76. Epub 2020 Nov 13.

Department of Orthopedics, Kurume University School of Medicine, Kurume, Japan.

Objective: Muscle atrophy is associated with autologous stem cell transplantation (ASCT)-related outcomes in patients with malignant lymphoma (ML). However, the impact of ASCT on muscle mass remains unclear in patients with ML. The aims of this study were to investigate changes in muscle mass and risk profiles for muscle atrophy after ASCT. Read More

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November 2020

Preliminary evaluation of probiotic effects on gastrointestinal signs in dogs with multicentric lymphoma undergoing multi-agent chemotherapy: A randomised, placebo-controlled study.

Vet Rec Open 2021 Dec 29;8(1):e2. Epub 2021 Mar 29.

Department of Clinical Sciences College of Veterinary Medicine Kansas State University Manhattan Kansas USA.

Background: Gastrointestinal (GI) toxicity is a major dose-limiting factor in dogs undergoing chemotherapy. A proposed mechanism of GI toxicity includes chemotherapy-driven GI dysbiosis. This study was designed to determine the effects of probiotic administration on GI side-effects in dogs receiving multi-agent chemotherapy. Read More

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December 2021

Primary Pancreatic Lymphoma: Recommendations for Diagnosis and Management.

J Blood Med 2021 5;12:257-267. Epub 2021 May 5.

Hematology and Bone Marrow Transplant Unit, Department of Medicine, University of Verona, Verona, Italy.

Background: Primary pancreatic lymphoma (PPL) is a rare disease representing 0.1% of all malignant lymphomas, which lacks well-defined diagnostic and therapeutic protocols. We conducted a systematic review to analyze demographic, diagnostic and therapeutic features of PPL. Read More

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A comprehensive retrospective cohort study of the journey of B-cell lymphoma in Taiwan.

Sci Rep 2021 May 12;11(1):10069. Epub 2021 May 12.

Global Epidemiology, Janssen Research & Development, 2 Science Park Drive, Singapore, 118222, Singapore.

Complete disease journey and risk factors for poor outcomes are needed to facilitate effectiveness evaluations of new therapies and clinical decision-making in B-cell Non-Hodgkin lymphoma (B-NHL), particularly in Asia where such data are lacking. This retrospective cohort study used electronic medical records from a regional medical centre in southern Taiwan to follow-up 441 patients newly diagnosed with common B-NHL subtypes: Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma (CLL/SLL), Marginal Zone Lymphoma (MZL), Mantle Cell Lymphoma (MCL), and Waldenström macroglobulinemia (WM), between 01-Jan-2008 and 31-Dec-2013, until 31-Dec-2017. Treatment pathways were modelled using a Markov approach. Read More

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Circular RNA circ_0000712 regulates high glucose-induced apoptosis, inflammation, oxidative stress, and fibrosis in (DN) by targeting the miR-879-5p/SOX6 axis.

Endocr J 2021 May 11. Epub 2021 May 11.

Department of Endocrinology, Affliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, 442008, Hubei, P.R.China.

Diabetic nephropathy (DN), a frequent diabetes complication, has complex pathogenesis. Circular RNAs (circRNAs) circ_0000712 has been reported to be upregulated in kidney tissues and high glucose (HG)-inducted Mesangial cells (MCs). This study is designed to explore the role and mechanism of circ_0000712 in the HG-inducted MCs injury in DN. Read More

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Patterns and Trends of Childhood Cancer Incidence (0-14 Years) in Delhi, India: 1990-2014.

Indian Pediatr 2021 May;58(5):430-435

Department of Radiotherapy, Dr BRAIRCH, AIIMS, New Delhi, India.

Objectives: To investigate the patterns and temporal trends of childhood cancer incidence (0-14 years) in Delhi from 1990 to 2014.

Methods: The new childhood cancer cases diagnosed between 1990 and 2014 were extracted from the Delhi population-based cancer registry (PBCR). Joinpoint regression analysis was performed to assess the temporal behaviour of new childhood cancer. Read More

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EGR1 addiction in diffuse large B cell lymphoma.

Mol Cancer Res 2021 May 12. Epub 2021 May 12.

Medicine, University of Wisconsin School of Medicine and Public Health

Early growth response gene (EGR1) is a transcription factor known to be a downstream effector of B cell receptor signaling and Janus kinase 1 (JAK1) signaling in diffuse large B cell lymphoma (DLBCL). While EGR1 is characterized as a tumor suppressor in leukemia and multiple myeloma, the role of EGR1 in lymphoma is unknown. Here we demonstrate that EGR1 is a potential oncogene that promotes cell proliferation in DLBCL. Read More

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Reversible renal-limited thrombotic microangiopathy due to gemcitabine-dexamethasone-cisplatin therapy: a case report.

BMC Nephrol 2021 May 12;22(1):175. Epub 2021 May 12.

Department of Hematology, Kobe City Medical Center General Hospital, 2-1-1 Minami-machi, Minatojima, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Background: Gemcitabine and cisplatin are chemotherapeutic agents used for treating multiple cancers, and these agents are sometimes used in combination. Drug-induced thrombotic microangiopathy (TMA) is a rare but potentially fatal complication. It typically presents as a systemic disease with the classical triad of hemolytic anemia, thrombocytopenia, and organ damage. Read More

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Metabolic differences among newborns born to mothers with a history of leukemia or lymphoma.

J Matern Fetal Neonatal Med 2021 May 12:1-8. Epub 2021 May 12.

Department of Epidemiology, University of Iowa, Iowa City, IA, USA.

Background: Leukemia and lymphoma are cancers affecting children, adolescents, and young adults and may affect reproductive outcomes and maternal metabolism. We evaluated for metabolic changes in newborns of mothers with a history of these cancers.

Methods: A cross-sectional study was conducted on California births from 2007 to 2011 with linked maternal hospital discharge records, birth certificate, and newborn screening metabolites. Read More

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Non-Hodgkin's Plasmablastic Lymphoma as Initial Presentation of Human Immunodeficiency Virus.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211014689

UCLA at Kern Medical Center, Bakersfield, CA, USA.

Plasmablastic lymphoma (PBL) is a subtype of non-Hodgkin's lymphoma that manifests in patients with the diagnosis of human immunodeficiency virus (HIV), more prominently in the head, neck, and oral mucosal region. The diagnosis of this rare lymphoma serves as a concomitant diagnosis of acquired immunodeficiency syndrome. The case is of a 33-year-old previously healthy male, with an unknown diagnosis of HIV with a painful right mandibular mass. Read More

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[Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma involving the small intestine: a case report].

Zhonghua Xue Ye Xue Za Zhi 2021 Apr;42(4):346

Department of Hematology, Affiliated Hospital of Nantong University, Nantong 226001, China.

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[Rituximab-induced acute thrombocytopenia in a patient with splenic marginal zone lymphoma: a case report and literature review].

Zhonghua Xue Ye Xue Za Zhi 2021 Apr;42(4):338-342

Department of Hematology, Institute of Hematology, The First Affiliated Hospital of Naval Medical University, Changhai Hospital, Shanghai 200433, China.

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[Clinical features and treatment outcome of patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis].

Zhonghua Xue Ye Xue Za Zhi 2021 Apr;42(4):324-331

Department of Hematology, Huadong Hospital, Fudan University, Shanghai 200040, China.

To investigate the clinical features and effect of prognostic factors in patients with different pathological types of non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis. We collected and analyzed the clinical data of 89 patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis who were treated at Huadong Hospital from March 2013 to May 2020. The data were analyzed via log-rank and Cox multivariate analyses. Read More

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Clinicopathological Characteristics and Surgical Outcomes of Crohn Disease-Associated Colorectal Malignancy.

Ann Coloproctol 2021 Apr 30;37(2):101-108. Epub 2021 Apr 30.

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Carcinoma arising from Crohn disease (CD) is rare, and there is no clear guidance on how to properly screen for at-risk patients and choose appropriate care. This study aimed to evaluate the clinicopathological characteristics, treatment, and oncologic outcomes of CD patients diagnosed with colorectal cancer (CRC).

Methods: Using medical records, we retrospectively enrolled a single-center cohort of 823 patients who underwent abdominal surgery for CD between January 2006 and December 2015. Read More

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