277,998 results match your criteria lymphoid tissues

Seneca Valley virus induces immunodepressionin suckling piglets by selective apoptosis of B lymphocytes.

Microb Pathog 2021 Jun 12:105022. Epub 2021 Jun 12.

Comparative Pathology Shared Resources Laboratory, Masonic Cancer Center, University of Minnesota, Saint Paul, MN, USA. Electronic address:

Seneca Valley virus (SVV) is the causative agent of an emerging infectious vesicular disease in swine that is clinically indistinguishable from other vesicular diseases of swine. This study utilized healthy suckling piglets (control) and SVV-naturally infected suckling piglets to determine the effects of SVV on lymphoid tissues and determined the SVV RNA load by quantitative RT-PCR (qRT-PCR). Furthermore, immunohistochemistry (IHC) analyses were performed to quantify the expression of T and B cell lymphocytes, natural killer cells, cleaved caspase 3, and ki-67. Read More

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Cytoplasmic expression of a model antigen with M Cell-Targeting moiety in lactic acid bacteria and implication of the mechanism as a mucosal vaccine via oral route.

Vaccine 2021 Jun 11. Epub 2021 Jun 11.

Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang-gun 25354, Republic of Korea; Institute of Green-Bio Science & Technology, Seoul National University, Pyeongchang-gun 25354, Republic of Korea; Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

Lactic acid bacteria (LAB) have been widely studied as mucosal vaccine delivery carriers against many infectious diseases for heterologous expression of protein antigens. There are three antigen expression strategies for LAB: cytoplasmic expression (CE), cell surface display (SD), and extracellular secretion (ES). Despite the generally higher protein expression level and many observations of antigen-specific immunogenicity in CE, its application as a mucosal vaccine has been overlooked relative to SD and ES because of the antigens enclosed by the LAB cell wall. Read More

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Maintenance of the human memory T cell repertoire by subset and tissue site.

Genome Med 2021 Jun 14;13(1):100. Epub 2021 Jun 14.

Department of Microbiology and Immunology, Columbia University, New York, NY, USA.

Background: Immune-mediated protection is mediated by T cells expressing pathogen-specific T cell antigen receptors (TCR) that are maintained at diverse sites of infection as tissue-resident memory T cells (TRM) or that disseminate as circulating effector-memory (TEM), central memory (TCM), or terminal effector (TEMRA) subsets in blood and tissues. The relationship between circulating and tissue resident T cell subsets in humans remains elusive, and is important for promoting site-specific protective immunity.

Methods: We analyzed the TCR repertoire of the major memory CD4 and CD8T cell subsets (TEM, TCM, TEMRA, and TRM) isolated from blood and/or lymphoid organs (spleen, lymph nodes, bone marrow) and lungs of nine organ donors, and blood of three living individuals spanning five decades of life. Read More

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RELT promotes the growth of esophageal squamous cell carcinoma by activating the NF-κB pathway.

Cell Cycle 2021 Jun 13:1-11. Epub 2021 Jun 13.

Department of Thoracic Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou, Henan, China.

The members of the tumor necrosis factor receptor (TNFR) family have been demonstrated to play critical roles in various cancers. However, little is known about the function of the Receptor Expressed in Lymphoid Tissues (RELT) in cancers, which is a member of the TNFR family, especially in the esophageal squamous cell carcinoma (ESCC). In this study, we found that RELT expression was increased in ESCC tissues and was consequently associated with poor overall survival of ESCC patients. Read More

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Primary Hodgkin lymphoma of the lung arising with hemoptysis and pulmonary consolidation: a case report.

Monaldi Arch Chest Dis 2021 Jun 10. Epub 2021 Jun 10.

Division of Thoracic Surgery, IRCCS Sacro Cuore-Don Calabria Hospital, Negrar (VR).

Classic Hodgkin lymphomas are neoplasms originating from lymphoid tissue. Primary extranodal classic Hodgkin lymphoma (PE-cHL) of the lung is rare. A 37-year-old Caucasian male was referred to our hospital for recurrent episodes of hemoptysis, cough and bronchitis. Read More

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Biomimetic nanotherapy: core-shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma.

J Nanobiotechnology 2021 Jun 13;19(1):179. Epub 2021 Jun 13.

Department of Blood Transfusion, Qilu Hospital of Shandong University, Jinan, 250012, People's Republic of China.

Background: Non-Hodgkin's lymphoma (NHL) is a malignant disease of lymphoid tissue. At present, chemotherapy is still the main method for the treatment of NHL. R-CHOP can significantly improve the survival rate of patients. Read More

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Mesenchymal Stem Cells: A Novel Therapeutic Approach to Enhance Protective Immunomodulation and Erythropoietic Recovery in Malaria.

Stem Cell Rev Rep 2021 Jun 12. Epub 2021 Jun 12.

Parasite-Host Biology, National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, 110077, India.

Mesenchymal stem cells (MSCs) are self-renewing, multi-potent heterogeneous stem cells that display strong tissue protective and restorative properties by differentiating into cells of the mesodermal lineages. In addition to multi-lineage differentiation capacity, MSCs play important roles in regulating immune responses, inflammation, and tissue regeneration. MSCs play a role in the outcome of the pathogenesis of several infectious diseases. Read More

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Establishment of risk prediction nomogram for ipsilateral axillary lymph node metastasis in T1 breast cancer.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Feb;50(1):81-89

Department of Breast Surgery,Zhejiang University Lishui Hospital,Lishui 323000,Zhejiang Province,China.

:To establish and verify a risk prediction nomogram for ipsilateral axillary lymph node metastasis in breast cancer stage T1 (mass ≤ 2 cm). :The clinicopathological data of 907 patients with T1 breast cancer who underwent surgical treatment from January 2010 to June 2015 were collected,including 573 cases from the Second Affiliated Hospital of Zhejiang University School of Medicine (modeling group) and 334 cases from Zhejiang University Lishui Hospital (verification group). The risk factors of ipsilateral axillary lymph node metastasis were analyzed by univariate and multivariate logistic regression. Read More

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February 2021

Stromal Cells Underlining the Paths From Autoimmunity, Inflammation to Cancer With Roles Beyond Structural and Nutritional Support.

Front Cell Dev Biol 2021 25;9:658984. Epub 2021 May 25.

Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, United States.

Stromal cells provide structural support and nutrients in secondary lymphoid organs and non-lymphoid tissues. However, accumulating evidence suggests that a complex relationship exists between stromal cells and immune cells. Interactions between immune cells and stromal cells have been shown to influence the pathology of both autoimmunity and cancer. Read More

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Serum free culture for the expansion and study of type 2 innate lymphoid cells.

Sci Rep 2021 Jun 10;11(1):12233. Epub 2021 Jun 10.

Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.

Type 2 innate lymphoid cells (ILC2s) were discovered approximately ten years ago and their clinical relevance is gaining greater importance. However, their successful isolation from mammalian tissues and in vitro culture and expansion continues to pose challenges. This is partly due to their scarcity compared to other leukocyte populations, but also because our current knowledge of ILC2 biology is incomplete. Read More

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Efficacy of low-dose radiotherapy (2 Gy × 2) in the treatment of marginal zone and mucosa-associated lymphoid tissue lymphomas.

Br J Radiol 2021 Jul 16;94(1123):20210012. Epub 2021 Jun 16.

Department of Oncology, University of Torino, Torino, Italy.

Objectives: To investigate the efficacy of a schedule of low-dose radiotherapy (LDRT) with 4 Gy (2 Gy x 2) in a cohort of unselected MALT or MZL patients.

Methods: We retrospectively collected all patients receiving LDRT, either for cure or palliation, for a stage I-IV histologically proven MALT or MZL between 2016 and 2020. Response to LDRT was evaluated with the Lugano criteria. Read More

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[Experimental study on the structure and immune cell phenotypes of the lymphoid tissues in oral lichenoid lesions].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):113-119

College of Stomatology, Weifang Medical University. Weifang 261021, Shandong Province, China.

Purpose: To evaluate the existence of tertiary lymphoid structures(TLS) in oral lichenoid lesions and its compositional characteristics of immune cells.

Methods: Tissue samples of normal oral mucosa, oral lichen planus (OLP) and oral lichenoid tissue reaction(OLTR) were collected, thirty cases in each group. Hematoxylin-eosin(H-E) staining was performed to identify the TLS-like structures, and immunohistochemistry (IHC) staining was applied to assess the structure and amount of infiltrating CD3+ T cells, CD19+, CD20+ B cells, CD21+ follicular dendritic cells (FDC), Bcl-6+ germinal centers, CD34+ PNAd+ venules and CD34+ Gp36+ micro lymphatic vessels in TLS of OLL. Read More

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[A case of metastatic gastric cancer showing long-term control with nivolumab after pseudoprogression].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(6):549-554

Department of Gastroenterological Surgery and Oncology, Tazuke Kofukai Medical Research Institute, Kitano Hospital.

The Japanese guidelines for the treatment of gastric cancer recommend nivolumab as third-line chemotherapy for metastatic gastric adenocarcinoma. We report a case in which long-term control of metastatic gastric adenocarcinoma was achieved with nivolumab after pseudoprogression. A man in his late 70s with advanced HER2-negative gastric cancer and liver metastasis underwent total gastrectomy to control tumor bleeding. Read More

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GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair.

Immunity 2021 Jun;54(6):1123-1136.e8

Department of Geriatrics, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China; Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China; CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei 230027, China. Electronic address:

Neutrophils migrate rapidly to damaged tissue and play critical roles in host defense and tissue homeostasis. Here we investigated the mechanisms whereby neutrophils participate in tissue repair. In an intestinal epithelia injury model, neutrophil depletion exacerbated colitis and associated with reduced interleukin (IL)-22 and limited activation of type 3 innate lymphoid cells (ILC3s). Read More

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ILC damage, and I'll repair it.

Immunity 2021 Jun;54(6):1097-1099

Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institute and University Hospital Solna, 171 76 Stockholm, Sweden. Electronic address:

In this issue of Immunity, Wang et al. report that the recognition of lysophosphatidyl serine via the receptor GPR43 confers type 3 innate lymphoid cells with the capacity to sense damage-induced cell death, which in turn triggers interleukin-22-dependent tissue repair. Read More

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[Therapeutic Effect of Spleen Low Molecular Weight Extracts on Leukopenia Caused by Epirubicin in Mice and Its Mechanism].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):969-974

Department of Immunology, School of Basic Medicine, Peking University, Beijing 100191,

Objective: To investigate the therapeutic effect of spleen low molecular weight extracts on epileptics hydrochloride-induced leukopenia in mice and explore its mechanism.

Methods: The model of leukopenia in mice was established by the injection of epirubicin hydrochloride (10 mg/kg). After the injection of chemotherapeutic drugs, leukocytopenia mice were treated with different doses of spleen low molecular weight extract, Ganoderma oral solution and recombinant granulocyte colony stimulating factor (rhG-CSF). Read More

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[The Value of CD44 Mononuclear Cells and Spleen Stiffness Measurement in Minimal Residual Disease in Acute Myeloid Leukemia and Its Prognosis].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):715-719

Department of Hematology, Hebei Petro China Center Hospital, Langfang 065000, Hebei Province, China.

Objective: To investigate the value of CD44 mononuclear cells (MNC) and spleen stiffness measurement (SSM) in minimal residual disease (MRD) in acute myeloid leukemia (AML) and its prognosis.

Methods: Flow cytometry was used to detected the proportion of CD44 and CD24 MNC in 44 AML patients after induction chemotherapy. The SSM was tested by FS. Read More

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Pulmonary sarcoidosis masquerading as metastatic breast cancer: a case report.

Pan Afr Med J 2021 8;38:245. Epub 2021 Mar 8.

Department of Radiology, Alexis Multispecialty Hospital, Nagpur, Maharashtra, India.

Pulmonary lesions on imaging are presumed to be metastatic lesions in patients with breast cancer. Here, we report an interesting case of a 63-year-old lady with breast carcinoma showing pulmonary lesions on imaging suggestive of pulmonary metastases. Detailed evaluation of pulmonary lesions confirmed the presence of co-existing pulmonary sarcoidosis. Read More

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Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir.

Nat Commun 2021 06 8;12(1):3453. Epub 2021 Jun 8.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.

A once every eight-week cabotegravir (CAB) long-acting parenteral is more effective than daily oral emtricitabine and tenofovir disoproxil fumarate in preventing human immunodeficiency virus type one (HIV-1) transmission. Extending CAB dosing to a yearly injectable advances efforts for the elimination of viral transmission. Here we report rigor, reproducibility and mechanistic insights for a year-long CAB injectable. Read More

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Georgian Med News 2021 Apr(313):139-146

Higher State Educational Institution of Ukraine Bukovinian State Medical University, Chernivtsi, Ukraine.

The aim of the research was to study experimentally the morphologic peculiarities of the granular tissue around the elements of the reticular allotransplant of the muscular aponeurotic layer of the anterior abdominal wall when using postoperative distant gamma therapy. The experiment has been done on 168 laboratory rats which were implanted with a prolenic mesh allograft into the tissues of muscular aponeurotic layer of the anterior abdominal wall. From the 13th to 19th day after the implantation of the reticular allograft, animals from the main group (96 rats) received irradiation of the site of the last one. Read More

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Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma.

J Immunother Cancer 2021 Jun;9(6)

Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA

Background: Tertiary lymphoid structures (TLSs) are immune aggregates in peripheral tissues that may support adaptive immune responses. Their presence has been associated with clinical response to checkpoint blockade therapy (CBT), but it is unknown whether TLS have prognostic significance independent of CBT in melanoma. We hypothesized that TLS in melanoma metastases would be associated with increased intratumoral lymphocyte infiltration, but that the intra-TLS immunological milieu would be distinct from the intratumoral immunological milieu. Read More

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[Application of endobronchial ultrasound in children: an analysis of 4 cases].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):511-515

Department No. 2 of Respiratory Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To investigate the feasibility, clinical efficacy and safety of endobronchial ultasound (EBUS) in children. The radiological features, EBUS images, pathological results and intraoperative and postoperative complications of 3 cases who underwent EBUS examination and 1 case who underwent EBUS guided transbronchial needle aspiration (EBUS-TBNA) were retrospectively analyzed. Among the 4 cases, 2 were males and 2 were females, with the onset age of 7. Read More

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[Analysis of correlation factors of contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma with lateral cervical lymph node metastasis].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):502-506

Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

To examine the correlation factors of contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma with lateral cervical lymph node metastasis. The clinical data of patients with unilateral papillary thyroid carcinoma who underwent total thyroidectomy and bilateral central lymph node dissection and ipsilateral cervical lymph node dissection from June 2016 to June 2018 at Department of Thyroid Surgery, West China Hospital, Sichuan University were analyzed retrospectively. A total of 317 patients, including 87 males and 230 females, aged (41. Read More

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A Comparative Study of Kimura's Disease and IgG4-related Disease: Similarities, Differences and Overlapping Featuress.

Histopathology 2021 Jun 8. Epub 2021 Jun 8.

Department of Pathology, Shenzhen Hospital of Peking University, Shenzhen, China.

Aim: To compare the fibroinflammatory diseases Kimura's disease (KD) and IgG4-related disease (IgG4RD) and to explore their possible relationship.

Methods And Results: 46 cases of KD and 29 IgG4RD of our institution diagnosed from 2011 to 2020 were studied. They were compared with each other on clinical, pathological and immunohistological features. Read More

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Mantle cell lymphoma, malt lymphoma, small lymphocytic lymphoma and follicular lymphoma of the oral cavity: an update.

J Oral Pathol Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.

Although uncommon, mature small B-cell lymphomas may arise in the oral/maxillofacial area and oral pathologists must be aware of the key characteristics of these neoplasms to perform an accurate diagnosis. In this manuscript we attempted to integrate the currently available data on the clinicopathological features of Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT-L), and Chronic Lymphocytic Leukaemia/ Small Lymphocytic Lymphoma (CLL/SLL) affecting these anatomical regions. An updated descriptive literature review was carried out and a detailed electronic search was done in multiple databases to gather all cases affecting the oral/maxillofacial region and palatine tonsils. Read More

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Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma.

Nat Immunol 2021 Jun 7. Epub 2021 Jun 7.

Innate Pharma Research Labs, Marseille, France.

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little about their underlying mechanisms or whether they could be clinically relevant or targeted to improve patient outcomes. Here, we found that high ILC2 infiltration in human melanoma was associated with a good clinical prognosis. Read More

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The role of lymph node dissection and a new N-staging system for intrahepatic cholangiocarcinoma: a study from the SEER database.

J Int Med Res 2021 Jun;49(6):3000605211012209

Department of Hepatobiliary Surgery, National Clinical Research Center for Cancer Hospital, Beijing, China.

Background: Although the National Comprehensive Cancer Network guidelines recommend routine lymph node dissection (LND) in intrahepatic cholangiocarcinoma (ICC), the role of LND remains controversial, and the node (N) stage is oversimplified.

Methods: Patients were identified from the Surveillance, Epidemiology, and End Results research data 18 (SEER 18). Propensity score matching (PSM) was used to reduce bias, and Kaplan-Meier curves and Cox proportional hazards models were used to compare overall survival (OS). Read More

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Expression of leukocyte immunoglobulin-like receptor subfamily B expression on immune cells in hepatocellular carcinoma.

Mol Immunol 2021 Jun 4;136:82-97. Epub 2021 Jun 4.

Clinical Research Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Zhong Fu Road, Gulou District, Nanjing, Jiangsu, 210003, PR China; Department of Hepatobiliary Surgery, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Zhong Fu Road, Gulou District, Nanjing, Jiangsu, 210003, PR China. Electronic address:

Background: Leukocyte immunoglobulin-like receptor subfamily B (LILRB) is a group of inhibitory receptors involved in innate immune mainly expressed on lymphoid and myelomonocytic cells. LILRB is proposed to serve as immune checkpoint like PD-1 and CTLA-4 for tumor treatment. We recently reported that the expression of LILRB2 in CD1c mDC from tumor tissue might suppress immune for HCC patients. Read More

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The fibroblast: An emerging key player in thymic T cell selection.

Immunol Rev 2021 Jun 6. Epub 2021 Jun 6.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Fibroblasts have recently attracted attention as a key stromal component that controls the immune responses in lymphoid tissues. The thymus has a unique microenvironment comprised of a variety of stromal cells, including fibroblasts and thymic epithelial cells (TECs), the latter of which is known to be important for T cell development because of their ability to express self-antigens. Thymic fibroblasts contribute to thymus organogenesis during embryogenesis and form the capsule and medullary reticular network in the adult thymus. Read More

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Spatiotemporal Analysis of B Cell- and Antibody Secreting Cell-Subsets in Human Melanoma Reveals Metastasis-, Tumor Stage-, and Age-Associated Dynamics.

Front Cell Dev Biol 2021 21;9:677944. Epub 2021 May 21.

Laboratory of Molecular Dermato-Oncology and Tumor Immunology, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

The role of tumor-associated B cells in human cancer is only starting to emerge. B cells typically undergo a series of developmental changes in phenotype and function, however, data on the composition of the B cell population in human melanoma are largely absent including changes during tumor progression and their potential clinical significance. In this study, we compared the number and distribution of six major B cell and antibody secreting cell subpopulations outside tertiary lymphoid structures in whole tumor sections of 154 human cutaneous melanoma samples (53 primary tumors without subsequent metastasis, 44 primary tumors with metastasis, 57 metastatic samples) obtained by seven color multiplex immunohistochemistry and automated tissue imaging and analysis. Read More

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