114,949 results match your criteria lymphoid

Stromal Cells Underlining the Paths From Autoimmunity, Inflammation to Cancer With Roles Beyond Structural and Nutritional Support.

Front Cell Dev Biol 2021 25;9:658984. Epub 2021 May 25.

Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, United States.

Stromal cells provide structural support and nutrients in secondary lymphoid organs and non-lymphoid tissues. However, accumulating evidence suggests that a complex relationship exists between stromal cells and immune cells. Interactions between immune cells and stromal cells have been shown to influence the pathology of both autoimmunity and cancer. Read More

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Ankylosing spondylitis: an autoimmune or autoinflammatory disease?

Nat Rev Rheumatol 2021 Jun 10. Epub 2021 Jun 10.

Dipartimento di Medicina di Precisione, Università della Campania L. Vanvitelli, Naples, Italy.

Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike other systemic autoimmune diseases, in AS, the innate immune system has a dominant role characterized by aberrant activity of innate and innate-like immune cells, including γδ T cells, group 3 innate lymphoid cells, neutrophils, mucosal-associated invariant T cells and mast cells, at sites predisposed to the disease. The intestine is involved in disease manifestations, as it is at the forefront of the interaction between the mucosal-associated immune cells and the intestinal microbiota. Read More

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Serum free culture for the expansion and study of type 2 innate lymphoid cells.

Sci Rep 2021 Jun 10;11(1):12233. Epub 2021 Jun 10.

Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.

Type 2 innate lymphoid cells (ILC2s) were discovered approximately ten years ago and their clinical relevance is gaining greater importance. However, their successful isolation from mammalian tissues and in vitro culture and expansion continues to pose challenges. This is partly due to their scarcity compared to other leukocyte populations, but also because our current knowledge of ILC2 biology is incomplete. Read More

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Efficacy of low-dose radiotherapy (2 Gy × 2) in the treatment of marginal zone and mucosa-associated lymphoid tissue lymphomas.

Br J Radiol 2021 Jun 11:20210012. Epub 2021 Jun 11.

Department of Oncology, University of Torino, Torino, Italy.

Objectives: To investigate the efficacy of a schedule of low dose radiotherapy (LDRT) with 4 Gy (2 Gy x 2) in a cohort of unselected MALT or MZL patients.

Methods: We retrospectively collected all patients receiving LDRT, either for cure or palliation, for a stage I-IV histologically proven MALT or MZL between 2016 and 2020. Response to LDRT was evaluated with the Lugano criteria. Read More

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Longitudinal assessment of PD-L1 expression and gene expression profiles in patients with head and neck cancer reveals temporal heterogeneity.

Oral Oncol 2021 Jun 7;119:105368. Epub 2021 Jun 7.

Department of Medical Oncology, Centre Léon Bérard, Lyon, France; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon 69008, France. Electronic address:

Background: Programmed death-ligand 1 (PD-L1) is the most validated predictive biomarker used for the treatment of head and neck squamous cell carcinoma (HNSCC) with immune checkpoint inhibitors (ICI). Several gene expression-based signatures surrogate of the activation of IFN-gamma pathway and of the presence of tertiary lymphoid structures (TLS) have also been proposed as potential biomarkers. While they may have a potential therapeutic implication, the longitudinal changes of either PD-L1 or gene expression profiles between the initial and recurrent HNSCC lesions is unknown. Read More

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Modeling leukemia with pediatric acute leukemia patient-derived iPSCs.

Stem Cell Res 2021 May 25;54:102404. Epub 2021 May 25.

Department of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology, Shanghai 200127, China. Electronic address:

Objective: ediatric acute leukemia (AL) is the most common hematological malignancy in childhood. However, the limitation of clinical specimens hindered the progress of research. Therefore, new research platforms are urgently needed to establish and clarify the pathogenesis of pediatric AL, and it is necessary to try to find novel targeted therapies for the clinical use. Read More

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MiR-130b and miR-128a are essential lineage-specific co-drivers of t(4;11) MLL-AF4 acute leukemia.

Blood 2021 Jun 10. Epub 2021 Jun 10.

University of Edinburgh, Edinburgh, United Kingdom.

t(4;11) MLL-AF4 acute leukemia is one of the most aggressive malignancies in the infant and pediatric population, yet we have little information on the molecular mechanisms responsible for disease progression. This impairs the development of therapeutic regimens that can address the aggressive phenotype and lineage plasticity of MLL-AF4-driven leukemogenesis. This study highlights novel mechanisms of disease development by focusing on two microRNAs upregulated in leukemic blasts from primary patient samples: miR-130b and miR-128a. Read More

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Pulmonary Hypertension in Patients with Common Variable Immunodeficiency.

J Clin Immunol 2021 Jun 10. Epub 2021 Jun 10.

Assistance Publique - Hôpitaux de Paris (AP-HP), Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Purpose: Common variable immunodeficiency (CVID) is known to cause infectious, inflammatory, and autoimmune manifestations. Pulmonary hypertension (PH) is an unusual complication of CVID with largely unknown characteristics and mechanisms.

Methods: We report the clinical, functional, hemodynamics, radiologic and histologic characteristics, and outcomes of CVID-associated PH patients from the French PH Network. Read More

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BCL-2 Inhibition as Treatment for Chronic Lymphocytic Leukemia.

Curr Treat Options Oncol 2021 Jun 10;22(8):66. Epub 2021 Jun 10.

Bone Marrow Transplantation Unit, Hospital Israelita Albert Einstein, Av. Albert Einstein (SP), São Paulo, 627/520, Brazil.

Opinion Statement: At the end of the 1990s, with the advent of imatinib for chronic myeloid leukemia and rituximab for B cell lymphoproliferative diseases with CD20 expression, there was a great conceptual evolution in the treatment of onco-hematological diseases. Researchers from around the world and the pharmaceutical industry began to focus their efforts on the so-called target therapy used alone or associated with classic chemotherapeutic drugs. In chronic lymphocytic leukemia, the development of second-generation anti-CD20 antibodies, biosimilars, PI3K (phosphatidylinositol 3-kinases) inhibitors, BTK (Bruton's tyrosine kinase) inhibitors, and anti-bcl 2 drugs represented mainly by venetoclax brought new, broader, and more effective opportunities in the treatment of this disease. Read More

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Vaccination against COVID-19: a challenge in CLL.

Blood 2021 Jun;137(23):3153-3154

University of Cologne; Center for Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf.

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[Experimental study on the structure and immune cell phenotypes of the lymphoid tissues in oral lichenoid lesions].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):113-119

College of Stomatology, Weifang Medical University. Weifang 261021, Shandong Province, China.

Purpose: To evaluate the existence of tertiary lymphoid structures(TLS) in oral lichenoid lesions and its compositional characteristics of immune cells.

Methods: Tissue samples of normal oral mucosa, oral lichen planus (OLP) and oral lichenoid tissue reaction(OLTR) were collected, thirty cases in each group. Hematoxylin-eosin(H-E) staining was performed to identify the TLS-like structures, and immunohistochemistry (IHC) staining was applied to assess the structure and amount of infiltrating CD3+ T cells, CD19+, CD20+ B cells, CD21+ follicular dendritic cells (FDC), Bcl-6+ germinal centers, CD34+ PNAd+ venules and CD34+ Gp36+ micro lymphatic vessels in TLS of OLL. Read More

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Spontaneous (Hashimoto-like) chronic lymphocytic thyroiditis in a rhesus macaque ().

Primate Biol 2021 1;8(1):37-42. Epub 2021 Jun 1.

Zentrallabor, Universitätsklinikum Frankfurt, Frankfurt, Germany.

A case of a female, 10-year-old rhesus macaque () with spontaneous chronic lymphocytic thyroiditis is presented. At necropsy, the thyroid gland was slightly enlarged, with up to 2 mm large, round, confluent, beige foci on the surface of both lobes. Histopathologic features resembled human Hashimoto's thyroiditis: multifocally, the interstitium was infiltrated by lymphocytes and variably sized lymphoid follicles. Read More

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TLR7 Signaling Drives the Development of Sjögren's Syndrome.

Front Immunol 2021 24;12:676010. Epub 2021 May 24.

Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.

Sjögren's syndrome (SS) is a chronic systemic autoimmune disease that affects predominately salivary and lacrimal glands. SS can occur alone or in combination with another autoimmune disease like systemic lupus erythematosus (SLE). Here we report that TLR7 signaling drives the development of SS since TLR8-deficient (TLR8ko) mice that develop lupus due to increased TLR7 signaling by dendritic cells, also develop an age-dependent secondary pathology similar to associated SS. Read More

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Integration of With Disease-Gene Network Reveals Common Cellular Mechanisms Between IMIDs and Drug Repurposing Strategies.

Front Immunol 2021 24;12:669400. Epub 2021 May 24.

Division Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, Netherlands.

Objective: Development and progression of immune-mediated inflammatory diseases (IMIDs) involve intricate dysregulation of the disease-associated genes (DAGs) and their expressing immune cells. Identifying the crucial disease-associated cells (DACs) in IMIDs has been challenging due to the underlying complex molecular mechanism.

Methods: Using transcriptome profiles of 40 different immune cells, unsupervised machine learning, and disease-gene networks, we constructed the Disease-gene IMmune cell Expression (DIME) network and identified top DACs and DAGs of 12 phenotypically different IMIDs. Read More

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Author Correction: Significance of abnormal 53BP1 expression as a novel molecular pathologic parameter of follicular-shaped B-cell lymphoid lesions in human digestive tract.

Sci Rep 2021 Jun 9;11(1):12536. Epub 2021 Jun 9.

Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1‑12‑4 Sakamoto, Nagasaki, 852-8523, Japan.

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[Clinical trials in lymphoid malignancies: current status, and future issues].

Hirokazu Nagai

Rinsho Ketsueki 2021 ;62(5):424-428

National Hospital Organization Nagoya Medical Center.

The standard of care for lymphoid tumors has been established and is continually being updated, using the evidence generated through clinical research and development, including multicenter phase III trials. The Japan Clinical Oncology Group-Lymphoma Study Group is a multicenter research group that has been developing treatments for lymphoid malignancies for >40 years. This group is fully equipped with a system that guarantees a high level of scientific accuracy and quality and has produced considerable evidence based on the results of phase III trials. Read More

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Mol Cancer Ther 2021 Jun 9. Epub 2021 Jun 9.

Dept. of Medicine,, University of Virginia

The peripheral T-cell lymphomas (PTCL) could be considered the prototypical epigenetic disease. As a disease, they are uniquely sensitive to histone deacetylase (HDAC) and DNA methyltransferase (DNMT) inhibitors, both alone and in combination, are characterized by a host of mutations in epigenetic genes, and can develop spontaneously in genetically engineered murine models predicated on established recurring mutations in (RHOAG17V) and TET2, an epigenetic gene governing DNA methylation. Given the clinical benefit of HDAC inhibitors (HDACi) and hypomethlyation agents (HMA) alone and in combination in PTCL, we sought to explore a mechanistic basis for these agents in PTCL. Read More

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1,3-Butadiene, styrene and lymphohaematopoietic cancers among North American synthetic rubber polymer workers: exposure-response analyses.

Occup Environ Med 2021 Jun 9. Epub 2021 Jun 9.

Epidemiology, The University of Alabama at Birmingham School of Public Health, Birmingham, Alabama, USA.

Objective: To evaluate exposure-response between 1,3-butadiene, styrene and lymphohaematopoietic cancers in an updated cohort of workers at six North American plants that made synthetic rubber polymers.

Methods: Employees were followed from 1943 through 2009 to determine mortality outcomes. Cox regression analyses estimated rate ratios (RRs) and 95% CIs by quartile of cumulative exposure to butadiene or styrene, measured in parts per million-years (ppm-years), and exposure-response trends for all leukaemia, lymphoid leukaemia, myeloid leukaemia, acute myeloid leukaemia, non-Hodgkin's lymphoma (NHL), multiple myeloma and all B-cell malignancies. Read More

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Characteristics and spatially-defined immune (micro)landscapes of early-stage PD-L1-positive triple-negative breast cancer.

Clin Cancer Res 2021 Jun 9. Epub 2021 Jun 9.

Division of Medical Oncology, Mayo Clinic.

Purpose: PD-(L)1-targeted therapies have shown modest survival benefit in triple-negative breast cancer (TNBC). PD-L1+ microenvironments in TNBC are not well-characterized and may inform combinatorial immune therapies. Herein, we characterized clinicopathologic features, RNA-based immune signatures and spatially-defined protein-based immune microenvironments (TIME) in early-stage PD-L1+ and PD-L1- TNBC. Read More

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GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair.

Immunity 2021 Jun;54(6):1123-1136.e8

Department of Geriatrics, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China; Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China; CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei 230027, China. Electronic address:

Neutrophils migrate rapidly to damaged tissue and play critical roles in host defense and tissue homeostasis. Here we investigated the mechanisms whereby neutrophils participate in tissue repair. In an intestinal epithelia injury model, neutrophil depletion exacerbated colitis and associated with reduced interleukin (IL)-22 and limited activation of type 3 innate lymphoid cells (ILC3s). Read More

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ILC damage, and I'll repair it.

Immunity 2021 Jun;54(6):1097-1099

Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institute and University Hospital Solna, 171 76 Stockholm, Sweden. Electronic address:

In this issue of Immunity, Wang et al. report that the recognition of lysophosphatidyl serine via the receptor GPR43 confers type 3 innate lymphoid cells with the capacity to sense damage-induced cell death, which in turn triggers interleukin-22-dependent tissue repair. Read More

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Diffuse Large B-Cell Lymphoma. Reply.

N Engl J Med 2021 06;384(23):2262

Memorial Sloan Kettering Cancer Center, New York, NY.

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New drugs and pharmacological interactions in real life.

Hematol Oncol 2021 Jun;39 Suppl 1:78-82

New Drugs Development Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

A high number of new drugs have entered clinical development and many of them have recently been approved for patients with lymphoid malignancies. The availability of new drugs offers additional treatment options, but it also requires particular attention for the emergence of adverse events. In addition, new drugs may also have interactions with other drugs, which could further increase the risk of toxicities or result in decreased efficacy. Read More

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Molecular diagnostics and reporting in lymphoid malignancies: Current status and beyond.

Hematol Oncol 2021 Jun;39 Suppl 1:73-77

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

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Genetic changes and evolutionary analysis of canine circovirus.

Arch Virol 2021 Jun 8. Epub 2021 Jun 8.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.

Canine circovirus (canineCV) has been found to be associated with vasculitis, hemorrhage, hemorrhagic enteritis, and diarrhea of canines. CanineCV, like other circoviruses, may also be associated with lymphoid depletion and immunosuppression. This circovirus has been detected worldwide in different countries and species. Read More

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Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors.

Oncoimmunology 2021 May 23;10(1):1929724. Epub 2021 May 23.

Predictive Oncology Laboratory, "Equipe Labellisée Ligue Contre Le Cancer", Centre De Recherche En Cancérologie De Marseille (CRCM), Institut Paoli-Calmettes, INSERM UMR1068, CNRS UMR725, Aix-Marseille Université, Marseille, France.

. Anti-PD1/PDL1 immune checkpoint inhibitors (ICIs) showed promising results in breast cancer, and exploration of additional actionable immune checkpoints is ongoing. Inflammatory breast cancer (IBC) is an aggressive form of disease, the immune tumor microenvironment (TME) of which is poorly known. Read More

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Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer.

Oncoimmunology 2021 May 18;10(1):1915574. Epub 2021 May 18.

Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Immunotherapy that block PD-1-PD-L1 pathway can induce durable tumor control and result in the long-term survival of patients with advanced bladder cancers. However, these responses only occur in a subset of patients. We study gene expression profiles in 1763 muscle-invasive bladder cancers (MIBCs) and 11,835 solid tumors from TCGA. Read More

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Linguistic-Cognitive Outcomes in Children with Acute Lymphoid Leukemia: An Exploratory Study.

J Multidiscip Healthc 2021 1;14:1285-1295. Epub 2021 Jun 1.

School of Medicine, University of São Paulo, São Paulo, Brazil.

Background: Acute lymphoid leukemia (ALL) is the most prevalent cancer of childhood. Impairment in linguistic and memory skills is a possible late sequela in cancer survivors that can limit their quality of life and the overall performance of the individual in society. There is evidence that survivors of ALL treated exclusively with chemotherapy demonstrate significant differences in long-term linguistic and memory functions and also changes in neuroanatomical integrity. Read More

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Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir.

Nat Commun 2021 06 8;12(1):3453. Epub 2021 Jun 8.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.

A once every eight-week cabotegravir (CAB) long-acting parenteral is more effective than daily oral emtricitabine and tenofovir disoproxil fumarate in preventing human immunodeficiency virus type one (HIV-1) transmission. Extending CAB dosing to a yearly injectable advances efforts for the elimination of viral transmission. Here we report rigor, reproducibility and mechanistic insights for a year-long CAB injectable. Read More

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Georgian Med News 2021 Apr(313):139-146

Higher State Educational Institution of Ukraine Bukovinian State Medical University, Chernivtsi, Ukraine.

The aim of the research was to study experimentally the morphologic peculiarities of the granular tissue around the elements of the reticular allotransplant of the muscular aponeurotic layer of the anterior abdominal wall when using postoperative distant gamma therapy. The experiment has been done on 168 laboratory rats which were implanted with a prolenic mesh allograft into the tissues of muscular aponeurotic layer of the anterior abdominal wall. From the 13th to 19th day after the implantation of the reticular allograft, animals from the main group (96 rats) received irradiation of the site of the last one. Read More

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