671,227 results match your criteria lymphocytic


Correlation between chest CT severity score and laboratory indicators in patients with Coronavirus disease 2019 (COVID-19).

Int J Clin Pract 2021 Sep 22:e14907. Epub 2021 Sep 22.

Clinical Laboratory, Affiliated Hospital of Putian University, Putian, 351100, China.

Objective: The association between computed tomography (CT) and clinical severity of COVID-19 has been demonstrated. However, there are few studies on CT and laboratory indicators in patients in COVID-19. Our aim was to explore the correlation between chest CT images and laboratory indicators of patients with COVID-19 pneumonia. Read More

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September 2021

Immune-related effects of compound astragalus polysaccharide and sulfated epimedium polysaccharide on newborn piglets.

Anim Biotechnol 2021 Sep 22:1-12. Epub 2021 Sep 22.

The Engineering Research Center of Ecology and Agricultural Use of Wetland, Ministry of Education, College of Animal Science, Yangtze University, Jingzhou, China.

This study aimed to evaluate the immune effects of compound astragalus polysaccharide and sulfated epimedium polysaccharide (APS-sEPS) on the peripheral blood lymphocyte and intestinal mucosa in newborn piglets. A total of 40 newborn piglets were randomly divided into four groups during a 25-day experiment, including APS-sEPS, APS, sEPS and control group. The results showed that supplementation with APS-sEPS to newborn piglets remarkably increased the physiological parameters, especially the WBC. Read More

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September 2021

Injectable Micelle-Incorporated Hydrogels for the Localized Chemo-Immunotherapy of Breast Tumors.

ACS Appl Mater Interfaces 2021 Sep 22. Epub 2021 Sep 22.

Advanced Materials Processing and Analysis and Department of Materials Science and Engineering, University of Central Florida, Orlando, Florida 32816, United States.

Although immune checkpoint blockade (ICB) holds potential for the treatment of various tumors, a considerable proportion of patients show a limited response to ICB therapy due to the low immunogenicity of a variety of tumors. It has been shown that some chemotherapeutics can turn low-immunogenic tumors into immunogenic phenotypes by inducing a cascade of immune responses. In this paper, we synthesized an injectable micelle-incorporated hydrogel, which was able to sequentially release the chemotherapeutic gemcitabine (GEM) and the hydrophobic indoleamine 2, 3-dioxygenase inhibitor, d-1-methyltryptophan (d-1MT) at tumor sites. Read More

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September 2021

Assessing the Prognostic Significance of Tumor-Infiltrating Lymphocytes in Patients With Melanoma Using Pathologic Features Identified by Natural Language Processing.

JAMA Netw Open 2021 Sep 1;4(9):e2126337. Epub 2021 Sep 1.

Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Importance: Although tumor-infiltrating lymphocytes (TILs) are an important histopathologic characteristic reflecting host immune response in patients with melanoma, their prognostic value remains controversial. Because manual review of medical records is labor intensive, a survival analysis using a large patient cohort with comprehensive clinical and histopathologic characteristics is lacking.

Objective: To assess the prognostic significance of TILs among patients with cutaneous melanoma using a large cohort established through natural language processing (NLP) algorithms. Read More

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September 2021

[Effects of neoadjuvant chemoradiotherapy on infiltrating immune cells in the tumor microenvironment of rectal cancer].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Aug;41(8):1270-1276

Department of Oncology, Xiangya Second Hospital of Central South University, Changsha 410011, China.

Objective: To detect the changes in the number and phenotype of tumor infiltrating immune cells in rectal cancer tissues before and after neoadjuvant concurrent chemoradiotherapy (CRT) and analyze their correlation with the clinicopathological parameters of the patients.

Methods: The protein expressions of CD3, CD4, CD8, CD56 and Foxp3 in biopsy specimens and postoperative pathological specimens collected from 20 rectal cancer patients before and after neoadjuvant CRT were detected using Elivision Plus immunohistochemistry, and the results were statistically analyzed.

Results: Compared with the measurements before the therapy, neoadjuvant CRT resulted in significant increments in CD3 (21. Read More

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Emerging insights into the immunological aspects of keloids.

J Dermatol 2021 Sep 21. Epub 2021 Sep 21.

Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China.

A special kind of scar, keloid, sometimes grows huge, disturbing patients in different ways. We discussed the pathogenesis of keloids and found researches about fibroblasts and collagen disorders, with little emphasis on immunity. Coupled with few effective treatments in keloid at present, we have focused on the immunological mechanisms of keloids with an aim to unravel some new therapeutic approaches in the future. Read More

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September 2021

Impact of rituximab on COVID-19 outcomes.

Ann Hematol 2021 Sep 22. Epub 2021 Sep 22.

Tisch Cancer Institute, New York, NY, USA.

Rituximab is associated with prolonged B-cell depletion and secondary hypogammaglobulinemia and is associated with a dampened humoral response and increased infectious complications. To describe the potential impact of prior rituximab therapy on clinical outcomes from SARS-CoV-2 infection and development of COVID-19 antibodies, we conducted a retrospective study of adults across the Mount Sinai Health System diagnosed with COVID-19 who received rituximab for any indication from February 2019 to October 2020. Patients' baseline characteristics, markers of disease severity, clinical outcomes, and antibody development were examined. Read More

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September 2021

Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Dyslipidemia.

Int J Gen Med 2021 14;14:5573-5579. Epub 2021 Sep 14.

Division of Hematology, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People's Republic of China.

Objective: In order to evaluate the effect of dyslipidemia on cellular or humoral immunity in patients, changes in the absolute number of lymphocyte subsets were detected.

Methods: Flow cytometry was applied to determine the absolute value of lymphocyte subsets: B cell, NK cell, CD4 T cell including the functional subset (CD4CD28), native subset (CD4CD45RACD62L), memory T cell subset (CD4CD45RA), CD8 T cell including the functional subset (CD8CD28) and activated subsets (CD8CD38 and CD8DR). The relationship between lymphocyte subsets and hypercholesterolemia and hypertriglyceridemia was analyzed. Read More

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September 2021

DNA methylation-based signature of CD8+ tumor-infiltrating lymphocytes enables evaluation of immune response and prognosis in colorectal cancer.

J Immunother Cancer 2021 Sep;9(9)

Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Background: Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, can be used for predicting immunotherapy responsiveness and survival outcome. However, the evaluation of CD8+ TILs currently relies on histopathological methodology with high variability. We therefore aimed to develop a DNA methylation signature for CD8+ TILs (CD8+ MeTIL) that could evaluate immune response and prognosis in colorectal cancer (CRC). Read More

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September 2021

Efficacy of clarithromycin in patients with mild COVID-19 pneumonia not receiving oxygen administration: protocol for an exploratory, multicentre, open-label, randomised controlled trial (CAME COVID-19 study).

BMJ Open 2021 Sep 21;11(9):e053325. Epub 2021 Sep 21.

Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.

Introduction: The COVID-19 pandemic has emerged worldwide. Although several medications have been approved for treating moderate-to-severe COVID-19, very few treatment strategy has been established for patients with mild COVID-19 who do not require oxygen administration. Clarithromycin is a macrolide antimicrobial agent that has been widely used for bacterial respiratory infectious diseases. Read More

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September 2021

The human liver microenvironment shapes the homing and function of CD4 T-cell populations.

Gut 2021 Sep 21. Epub 2021 Sep 21.

Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK

Objective: Tissue-resident memory T cells (T) are vital immune sentinels that provide protective immunity. While hepatic CD8 T have been well described, little is known about the location, phenotype and function of CD4 T.

Design: We used multiparametric flow cytometry, histological assessment and novel human tissue coculture systems to interrogate the ex vivo phenotype, function and generation of the intrahepatic CD4 T-cell compartment. Read More

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September 2021

Pembrolizumab-induced autoimmune haemolytic anemia in a patient with chronic lymphocytic leukaemia successfully treated with ibrutinib.

BMJ Case Rep 2021 Sep 21;14(9). Epub 2021 Sep 21.

Division of Hematology, Oncology, and Stem Cell Transplant, Rush University Medical Center, Chicago, Illinois, USA.

We present a unique case of a patient with a long-standing history of indolent chronic lymphocytic leukaemia (CLL) who suddenly developed autoimmune haemolytic anaemia after starting immune checkpoint inhibitor therapy for bladder cancer. He had no clear indication to start CLL-directed treatment based on current clinical practice guidelines; however, targeted treatment of CLL with ibrutinib proved to be effective in treating the haemolytic anaemia. Read More

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September 2021

Integrated safety analysis of umbralisib, a dual PI3Kδ/CK1ε inhibitor, in relapsed/refractory lymphoid malignancies.

Blood Adv 2021 Sep 21. Epub 2021 Sep 21.

TG Therapeutics, Inc., New York, New York, United States.

Phosphoinositide 3-kinase-delta (PI3Kδ) inhibitors are active in lymphoid malignancies, though associated toxicities can limit their use. Umbralisib is a dual inhibitor of PI3Kδ and casein kinase-1ε (CK1ε). This study analyzed integrated comprehensive toxicity data from 4 open-label, phase 1 and 2 studies that included 371 adult patients (median age, 67 years) with relapsed/refractory non-Hodgkin lymphoma (follicular lymphoma [n = 147]; marginal zone lymphoma [n = 82]; diffuse large B-cell lymphoma/mantle cell lymphoma [n = 74]; chronic lymphocytic leukemia [n = 43]; and other [n = 25]) who were treated with recommended phase 2 dose of umbralisib 800 mg or higher once daily. Read More

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September 2021

The application of machine learning algorithms in predicting the length of stay following femoral neck fracture.

Int J Med Inform 2021 Sep 13;155:104572. Epub 2021 Sep 13.

International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Department of Orthopedics, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, China. Electronic address:

Purpose: Femoral neck fracture is a frequent cause of hospitalization, and length of stay is an important marker of hospital cost and quality of care provided. As an extension of traditional statistical methods, machine learning provides the possibility of accurately predicting the length of hospital stay. The aim of this paper is to retrospectively identify predictive factors of the length of hospital stay (LOS) and predict the postoperative LOS by using machine learning algorithms. Read More

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September 2021

Peripheral Blood Monocyte to Lymphocyte Ratio for Prediction of Tuberculous Pleuritis.

Int J Infect Dis 2021 Sep 18. Epub 2021 Sep 18.

Division of Pulmonary, Critical Care, and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Objective: To examine the peripheral monocytes to lymphocytes ratio (ML ratio) of patients with tuberculous pleuritis and the ML ratio changes after treatment.

Methods: Clinical and laboratory information of patients with lymphocytic exudative pleural effusion admitted to Chiang Mai University Hospital from 2013 to 2019 were collected. We compared the ML ratios between tuberculous pleuritis and other diagnoses. Read More

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September 2021

Development of PI3K inhibitors: advances in clinical trials and new strategies (Review).

Pharmacol Res 2021 Sep 18:105900. Epub 2021 Sep 18.

Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of Nanomedicine and Nano formulations, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055, P. R. China; University of Chinese Academy of Sciences Beijing 100049, P.R. China. Electronic address:

Phosphatidylinositol 3-kinases (PI3Ks) are the family of vital lipid kinases widely distributed in mammalian cells. The overexpression of PI3Ks leads to hyperactivation of the PI3K/AKT/mTOR pathway, which is considered a pivotal pathway in the occurrence and development of tumors. Hence, PI3Ks are viewed as promising therapeutic targets for anti-cancer therapy. Read More

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September 2021

Biological activities of some species.

Z Naturforsch C J Biosci 2021 Sep 20. Epub 2021 Sep 20.

Department of Biology, Faculty of Necatibey Education, Balikesir University, Balıkesir, Turkey.

In this study, total phenolic, flavonoid and protein contents, antiradical capacities, antibacterial and cytotoxic properties of five different species ( Boiss., Rech.f. Read More

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September 2021

Exploration of severe Covid-19 associated risk factor in China: meta-analysis of current evidence.

Int J Clin Pract 2021 Sep 21:e14900. Epub 2021 Sep 21.

Department of Orthopaedics, Zibo Central Hospital, 54 West Gongqingtuan Road, Zibo, 255036, Shandong province, China.

Aim: This meta-analysis aimed to explore potential risk factors for severe Covid-19.

Methods: We systemically and comprehensively retrieved the eligible study evaluating clinical differences between severe versus non-severe Covid-19. Main effect sizes were demographic characteristics, comorbidities, signs and symptoms, laboratory findings as well as radiological features of chest CT. Read More

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September 2021

Clinical features of drug-induced hypersensitivity syndrome to BRAF inhibitors with and without previous immune checkpoint inhibition: a review.

Support Care Cancer 2021 Sep 21. Epub 2021 Sep 21.

Department of Dermatology, Stanford University Medical Center and Cancer Institute, 780 Welch Road, CJ220F, Palo Alto, CA, 94304-5779, USA.

Purpose: Cutaneous reactions to BRAF inhibitors are common, but severe reactions resembling or consistent with drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) are relatively rare. Several reports suggest that cutaneous reactions including DRESS/DIHS to BRAF inhibitors are more frequent and severe in the setting of previous immune checkpoint inhibition (ICI).

Methods: To characterize existing literature on these reports, we queried the PubMed/MEDLINE database for cases of DIHS/DRESS to BRAF inhibitors. Read More

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September 2021

AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression.

Immunol Rev 2021 Sep 20. Epub 2021 Sep 20.

Department of Pathology, University of Chicago, Chicago, IL, USA.

The emergence of antigen receptor diversity in clonotypic lymphocytes drove the evolution of a novel gene, Aire, that enabled the adaptive immune system to discriminate foreign invaders from self-constituents. AIRE functions in the epithelial cells of the thymus to express genes highly restricted to alternative cell lineages. This somatic plasticity facilitates the selection of a balanced repertoire of T cells that protects the host from harmful self-reactive clones, yet maintains a wide range of affinities for virtually any foreign antigen. Read More

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September 2021

Lipid specificity of the immune effector perforin.

Faraday Discuss 2021 Sep 21. Epub 2021 Sep 21.

London Centre for Nanotechnology, University College London, 19 Gordon Street, London WC1H 0AH, UK.

Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during the immune response. During the response, the lymphocyte membrane becomes refractory to perforin function by accumulating densely ordered lipid rafts and externalizing negatively charged lipid species. The dense membrane packing lowers the capacity of perforin to bind, and the negatively charged lipids scavenge any residual protein before pore formation. Read More

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September 2021

New Perspective on the Geographic Distribution and Evolution of Lymphocytic Choriomeningitis Virus, Central Europe.

Emerg Infect Dis 2021 Oct;27(10):2638-2647

Lymphocytic choriomeningitis virus (LCMV) is an Old World mammarenavirus found worldwide because of its association with the house mouse. When LCMV spills over to immunocompetent humans, the virus can cause aseptic meningitis; in immunocompromised persons, systemic infection and death can occur. Central Europe is a strategic location for the study of LCMV evolutionary history and host specificity because of the presence of a hybrid zone (genetic barrier) between 2 house mouse subspecies, Mus musculus musculus and M. Read More

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October 2021

[Flow cytometry evaluation of the rhesus monkey cellular immunity following the Zaire ebolavirus (Filoviridae; Ebolavirus: Zaire ebolavirus) experimental infection].

Vopr Virusol 2021 Sep 18;66(4):289-298. Epub 2021 Sep 18.

Directorate of the Chief of the Radiation, Chemical, and Biological Defence Troops of the Armed Forces of the Ministry of Defence of the Russian Federation.

Introduction: The outbreaks of the Zaire ebolavirus (ZE) disease (ZED) that have arisen in the last decade determine the need to study the infection pathogenesis, the formation of specific immunity forming as well as the development of effective preventive and therapeutic means. All stages of fight against the ZED spread require the experimental infection in sensitive laboratory animals, which are rhesus monkeys in case of this disease .The aim of the study is to evaluate the rhesus monkey cellular immunity following the ZE experimental infection by the means of flow cytometry (cytofluorimetry). Read More

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September 2021

Immune and cellular damage biomarkers to predict COVID-19 mortality in hospitalized patients.

Curr Res Immunol 2021 Sep 16. Epub 2021 Sep 16.

Department of Pulmonary Medicine, Thoracic Disease Research Unit, Mayo Clinic, Rochester, USA.

Early prediction of COVID-19 in-hospital mortality relies usually on patients' preexisting comorbidities and is rarely reproducible in independent cohorts. We wanted to compare the role of routinely measured biomarkers of immunity, inflammation, and cellular damage with preexisting comorbidities in eight different machine-learning models to predict mortality, and evaluate their performance in an independent population. We recruited and followed-up consecutive adult patients with SARS-Cov-2 infection in two different Italian hospitals. Read More

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September 2021

Development an Inflammation-Related Factor-Based Model for Predicting Organ Failure in Acute Pancreatitis: A Retrospective Cohort Study.

Mediators Inflamm 2021 10;2021:4906768. Epub 2021 Sep 10.

Pancreas Center, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu Province, China.

Several inflammation-related factors (IRFs) have been reported to predict organ failure of acute pancreatitis (AP) in previous clinical studies. However, there are a few shortcomings in these models. The aim of this study was to develop a new prediction model based on IRFs that could accurately identify the risk for organ failure in AP. Read More

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September 2021

Protein Kinase D3 Promotes the Reconstruction of OSCC Immune Escape Niche Via Regulating MHC-I and Immune Inhibit Molecules Expression.

J Immunother 2021 Sep 21. Epub 2021 Sep 21.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, People's Republic of China.

Protein kinase D3 (PKD3) has been involved in various aspects of tumorigenesis and progression in many kinds of cancer types. However, whether PKD3 regulates immune escape in tumor microenvironment is rarely reported. Here, we explored the function and mechanism of PKD3 in reconstructing the immune escape niche of oral squamous cell carcinoma (OSCC). Read More

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September 2021

Curious case of the unexplained exudative pleural effusion.

BMJ Case Rep 2021 Sep 20;14(9). Epub 2021 Sep 20.

Respiratory Medicine, West Hertfordshire Hospitals NHS Trust, Watford, UK.

We report a case of a 74-year-old male patient who was referred to the respiratory clinic with an incidental finding of a left sided pleural effusion. He was initially being treated by the general practitioner for chest infection with productive cough that had limited resolution after course of oral antibiotics. At the pleural clinic, 1. Read More

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September 2021

Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis.

BMJ Case Rep 2021 Sep 20;14(9). Epub 2021 Sep 20.

Shiraishi Internal Medicine Clinic, Nogata, Japan.

The most common neurological manifestation of eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is mononeuritis multiplex caused by small-vessel vasculitis. In contrast, central nervous system involvement is rare. Among EGPA-associated central nervous system disorders, there are only a few reported cases of hypertrophic pachymeningitis (HP). Read More

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September 2021

The neutrophil-to-lymphocyte ratio as a marker of vasculitis activity, severe infection and mortality in anca-associated vasculitis: A retrospective study.

Nefrologia 2021 May-Jun;41(3):321-328

Division of Nephrology and Renal Transplantation, Department of Medicine. Centro Hospitalar Universitário Lisboa Norte, EPE. Av. Prof. Egas Moniz, 1649-035 Lisboa, Portugal.

Introduction: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a multisystemic disease. Despite the improvement in mortality rate since the introduction of immunosuppression, long-term prognosis is still uncertain not only because of the disease activity but also due to treatment associated adverse effects. The neutrophil-to-lymphocyte ratio (NLR) has been demonstrated as an inflammatory marker in multiple settings. Read More

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Erratum: "Toxicological evaluation of dextran stabilized iron oxide nanoparticles in human peripheral blood lymphocytes" [Biointerphases 11, 04B302 (2016)].

Biointerphases 2021 09 20;16(5):058601. Epub 2021 Sep 20.

Division of Toxicology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Thiruvananthapuram 695 012, Kerala, India.

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September 2021