Search Our Scientific Publications & Authors

Ann Coloproctol 2021 Apr 22. Epub 2021 Apr 22.

Division of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology, and Pediatrics, University of Verona Hospital Trust, University of Verona, Italy.

Purpose: Laparoscopic complete mesocolic excision (CME) right colectomy is a technically demanding procedure infrequently employed in Western centers. This retrospective cohort study aims to analyze the safety of laparoscopic CME colectomy compared to standard colectomy for right-sided colon cancer in a Western series.

Methods: Prospectively collected data from 60 patients who underwent laparoscopic CME right colectomy were compared to the ones of 55 patients who underwent laparoscopic standard right colectomy. Read More

Eur J Cancer 2021 Apr 19;150:33-41. Epub 2021 Apr 19.

Department of Otorhinolaryngology, Region Hospital West Jutland, Holstebro, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus C, Denmark.

Background: We aimed to compare the predictive performance of pN-categories in oral squamous cell carcinoma (OSCC) encompassing the most recent 8th edition (TNM8), its predecessor (TNM7), and a newly proposed algorithm (pN-N), which classifies patients according to the number of positive lymph nodes and extranodal extension.

Methods: Consecutive, primary OSCC patients from seven previously published cohorts were included and classified according to the three pN-classifications: TNM7, TNM8 and pN-N. Overall survival probabilities were summarised with the Kaplan-Meier method. Read More

Eur J Cancer 2021 Apr 19;150:10-22. Epub 2021 Apr 19.

Department of Surgery, Yodogawa Christian Hospital, Yodogawa, Japan.

Background: The extended lymphadenectomy (D2) was recently introduced in several guidelines as the optimal treatment for gastric cancer, based only on the 15-year follow-up results of the Dutch randomised trial, while the British Medical Research Council (MRC) study failed to demonstrate a survival benefit over the more limited D1 dissection. The Italian Gastric Cancer Study Group randomised controlled trial (RCT) was also undertaken to compare D1 versus D2 gastrectomy, and a tendency to improve survival in patients with advanced resectable disease (pT > 1N+) was documented despite negative results in the entire patient population. Now we present the 15-year follow-up results of survival and gastric cancer-related mortality. Read More

Int J Surg 2021 Apr 19:105950. Epub 2021 Apr 19.

Department of General Surgery, Faculty of Medicine, Menoufia University, Egypt.

Background: Seroma is one of the most commonly encountered morbidities after inguinal lymph node dissection (ILND). It causes much nuisance to both patients and doctors and its presence can lead to many complications. This study aimed to evaluate the role and impact of using fibrin glue to decrease seroma formation in patients undergoing ILND. Read More

Acta Clin Belg 2021 Apr 22:1-6. Epub 2021 Apr 22.

Department of Internal Medicine and Infectious Diseases, Centre Hospitalier Universitaire (CHU), Liege, Belgium.

Opportunistic infections (OI) are common in patients with acquired immunodeficiency syndrome (AIDS). Cryptococcus neoformans and Mycobacterium avium complex (MAC) are frequently responsible of such infections. However, concurrent infection with these two pathogens is uncommon and underreported in the literature. Read More

Cell Cycle 2021 Apr 22:1-9. Epub 2021 Apr 22.

Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Recently, basic leucine zipper and the W2 domain-containing protein 1 (BZW1) are reported to be implicated in tumor progression. However, the role of BZW1 in prostate cancer remains unknown. This study is aimed to investigate the expression of BZW1 and its influence on cell proliferation in prostate cancer. Read More

Mol Pharm 2021 Apr 22. Epub 2021 Apr 22.

Immunobiology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, India.

We fabricated bilirubin-bovine serum albumin (BR-BSA) nanocomplexes as candidates for the delivery of 5-fluoro-2-deoxyuridine (5FUdr) against experimental murine lymphoma. BR was attached to 5FUdr via acid-labile ester bonds mimicking small-molecule drug conjugates. The construct was self-assembled with BSA through strong noncovalent interactions with high drug occupancy in the core and labeled with folic acid (FA) to target cancer cells. Read More

Vet Comp Oncol 2021 Apr 22. Epub 2021 Apr 22.

Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milan, Italy.

Tumor stage is a prognostic indicator for canine malignant head and neck tumors (MHNT). However, consensus is lacking on nodal staging in the absence of clinically apparent nodal disease (cN0 neck). This prospective observational study aims to determine the diagnostic accuracy of radiopharmaceutical and blue dye for sentinel lymph node biopsy (SLNB), to assess the correspondence between sentinel lymph node (SLN) and clinically expected regional lymph node (RLN) and the impact on staging of the procedure in dogs with MHNT and cN0 neck. Read More

Updates Surg 2021 Apr 22. Epub 2021 Apr 22.

Department of Advanced Biomedical Sciences, University of Naples "Federico II", Via Pansini n.5, 80131, Naples, Italy.

Seroma formation following mastectomy is one of the most experienced complications, with a very variable incidence ranging from 3 to 90%. In recent years, many publications have been realized to define an effective technique to prevent its formation and several approaches have been proposed. Given the potential of flap fixation in reducing seroma formation, we performed a meta-analysis of the literature to investigate the role of this approach as definitive gold standard in mastectomy surgery. Read More

J Robot Surg 2021 Apr 22. Epub 2021 Apr 22.

Department of Surgery, Osaka Rosai Hospital, 1179-3 Nagasone-kitaku, Sakai, Osaka, 591-8025, Japan.

It remains controversial whether the advantages of robotic-assisted surgery are beneficial for rectal cancer (RC). The study aimed to evaluate the short-term outcomes of robotic-assisted rectal surgery (RARS) compared with those of conventional laparoscopic-assisted rectal surgery. We retrospectively analyzed 539 consecutive patients with stage I-IV RC who had undergone elective surgery between January 2010 and December 2020, using propensity score-matched analysis. Read More

JAMA Oncol 2021 Apr 22. Epub 2021 Apr 22.

Ohio State University Comprehensive Cancer Center, Columbus.

Importance: Stereotactic body radiotherapy (SBRT) for oligometastases is hypothesized to improve survival and is increasingly used. Little evidence supports its safe use to treat patients with multiple metastases.

Objective: To establish safety of SBRT dose schedules in patients with 3 to 4 metastases or 2 metastases in close proximity to each other. Read More

Int J Biol Markers 2021 Apr 22:17246008211011177. Epub 2021 Apr 22.

Lithuanian University of Health Sciences, Kaunas, Lithuania.

Background: Genetic variations in oxidative stress-related genes may alter the coded protein level and impact the pathogenesis of breast cancer.

Methods: The current study investigated the associations of functional single nucleotide polymorphisms in the , , , and genes with the early-stage breast cancer clinicopathological characteristics and disease-free survival, metastasis-free survival, and overall survival. A total of 202 Eastern European (Lithuanian) women with primary I-II stage breast cancer were involved. Read More

Radiol Oncol 2021 Jan 12;55(1):35-41. Epub 2021 Jan 12.

Women's Health Institute José Botella Llusiá, Hospital Clínico San Carlos, Fundación de Investigación del Hospital Clínico San Carlos (IdISSC), Universidad Complutense, Madrid, Spain.

Background: The aim of the study was to determine if the endometrial tumor volume (TV) measured by magnetic resonance imaging (MRI-TV) is associated with survival in endometrial cancer and lymph nodes metastases (LN+).

Patients And Methods: We evaluated the MRI imaging and records of 341 women with endometrial cancer and preoperative MRI from 2008 to 2018. The MRI-TV was calculated using the ellipsoid formula measuring three perpendicular tumor diameters. Read More

Radiol Oncol 2020 Oct 8;55(1):50-56. Epub 2020 Oct 8.

Department of Surgery, Institute of Oncology Ljubljana, Ljubljana, Slovenia.

Background: Two prospective randomized studies analysing cutaneous melanoma (CM) patients with sentinel lymph node (SLN) metastases and rapid development of systemic adjuvant therapy have changed our approach to stage III CM treatment. The aim of this study was to compare results of retrospective survival analysis of stage III CM patients' treatment from Slovenian national CM register to leading international clinical guidelines.

Patients And Methods: Since 2000, all Slovenian CM patients with primary tumour ≥ TIb are treated at the Institute of Oncology Ljubljana and data are prospectively collected into a national CM registry. Read More

J Minim Access Surg 2021 Apr 9. Epub 2021 Apr 9.

Department of Abdominal Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia; Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.

Radical surgery is the mainstay of treatment of colon cancer. Lymphatic drainage of splenic flexure colon cancer is variable, and the exact site of lymphatic dissection is uncertain. Hence, a true consensus of what kind of colectomy should be performed for tumours of the splenic flexure is lacking. Read More

J Minim Access Surg 2021 Mar 8. Epub 2021 Mar 8.

Department of Radiodiagnosis, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Minimally invasive esophagectomy (MIE) for oesophageal cancer has gained wide popularity in recent years due to its improved morbidity and mortality outcomes. We describe our modified technique of MIE in prone position with preservation of the arch of azygos vein. In our experience with 14 patients, the mean operative duration was 378 min (standard deviation [SD] 378 ± 59 min) and the mean blood loss was 390 ml (SD 390 ± 142 ml). Read More

J Vet Diagn Invest 2021 Apr 22:10406387211011024. Epub 2021 Apr 22.

Department of Veterinary Medicine, University of Milan, Lodi, Italy.

An 8-y-old spayed female Beagle dog was presented with peripheral lymphadenomegaly. Lymph node cytology and flow cytometry led to the diagnosis of large B-cell lymphoma (LBCL). We detected minimal percentages of LBCL cells in peripheral blood and bone marrow samples. Read More

Neoplasma 2021 Apr 23. Epub 2021 Apr 23.

Department of Pathology, Guangyuan Central Hospital, Guangyuan, Sichuan, China.

Gastric cancer is a common malignancy in the alimentary system. The laminin subunit gamma 1 (LAMC1) is an important oncogene in human cancers. However, how and whether LAMC1 takes part in gastric cancer progression is largely uncertain. Read More

Neoplasma 2021 Apr 23. Epub 2021 Apr 23.

Department of Emergency, Tianjin First Central Hospital, Tianjin, China.

Recently, leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a newly identified cancer stem cell marker and Wnt target gene. However, the role of LGR5 in gastric cancer (GC) remains uncertain. This study was performed to investigate the effect of LGR5 expression in GC. Read More

Histopathology 2021 Apr 21. Epub 2021 Apr 21.

Division of Gastroenterology, Department of Internal Medicine, 2-1-1, Shiwagun'yahabachou, 028-3695, Japan.

Aims: Recent studies have shown that the microenvironment can include cancer cells and cancer-associated fibroblasts (CAFs) and that both play important roles in the progression and metastasis of CRC. Here, we aimed to analyze the expression patterns of cancer cell- and CAF-related proteins in submucosal invasive colorectal cancer (SiCRC) and whether such markers are correlated with lymph node metastasis (LNM).

Methods And Results: Quantitative analysis was conducted for Ki-67, p53, β-catenin, and MMP7 to assess cancer cell markers. Read More

J Gastrointest Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie, 514-8507, Japan.

Background: Perihilar cholangiocarcinoma often involves the adjacent vasculature, including the portal vein and hepatic artery. Combined vascular resection and reconstruction of the portal vein is more common than vascular resection and reconstruction of the hepatic artery. Herein, we aimed to elucidate the long-term outcomes in patients who underwent vascular resection and reconstruction for perihilar cholangiocarcinoma. Read More

J Mol Histol 2021 Apr 21. Epub 2021 Apr 21.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

PD-1, PD-L1, CTLA-4, TIM-3, and LAG-3, crucial immune checkpoint molecules in the tumor microenvironment, identify as key targets for cancer immunotherapy. There is a correlation between immune cells and epithelial-mesenchymal transition (EMT)-related genes expression in varies human cancers. In this study, we aimed to investigate the probable association between expression of immune checkpoints and EMT in esophageal squamous cell carcinoma (ESCC) with clinical treats for providing the new therapeutic targets and prognostic value for the disease. Read More

Arch Dermatol Res 2021 Apr 21. Epub 2021 Apr 21.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

While having a thin melanoma (defined as AJCC 8 T1 stage tumor ≤ 1.0 mm) with negative sentinel lymph node biopsy (SLNB) provides an excellent prognosis, some patients still develop recurrence and die. To determine risk factors for any recurrence (local/in-transit, nodal, distant) in thin melanoma patients with negative SLNB and assess survival outcomes. Read More

J Cancer Res Clin Oncol 2021 Apr 21. Epub 2021 Apr 21.

Department of Gynecology and Obstetrics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Background: Neuropilin-1 (NRP-1) is a transmembrane protein that acts as a multifunctional non-tyrosine kinase receptor with an established role in development and immunity. NRP-1 also regulates tumor biology, and high expression levels of tissue NRP-1 have been associated with a poor prognosis. Recently, ELISA-based quantification of soluble NRP-1 (sNRP-1) has become available, but little is known about the prognostic value of sNRP-1 in malignancies. Read More

Dis Esophagus 2021 Mar 17. Epub 2021 Mar 17.

Department of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.

The 11th edition of the "Japanese Classification of Esophageal Cancer" by the Japan Esophageal Society (JES) and the 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) "Cancer Staging Manual" are two separate classification systems both widely used for the clinical and pathological staging of esophageal cancer. Furthermore, the lymph node stations from these classification systems are combined for research purposes in the multinational TIGER study, which investigates the distribution pattern of lymph node metastases. The existing classification systems greatly differ with regard to number, location and anatomical boundaries of locoregional lymph node stations. Read More

Nanoscale Horiz 2021 Apr 22. Epub 2021 Apr 22.

Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.

A significant barrier to the application of nanoparticles for precision medicine is the mononuclear phagocyte system (MPS), a diverse population of phagocytic cells primarily located within the liver, spleen and lymph nodes. The majority of nanoparticles are indiscriminately cleared by the MPS via macropinocytosis before reaching their intended targets, resulting in side effects and decreased efficacy. Here, we demonstrate that the biodistribution and desired tissue accumulation of targeted nanoparticles can be significantly enhanced by co-injection with polymeric micelles containing the actin depolymerizing agent latrunculin A. Read More

Biomed Res Int 2021 2;2021:5519144. Epub 2021 Apr 2.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Objectives: To explore the application of computed tomography (CT) texture analysis in differentiating lymphomas from other malignancies of the small bowel.

Methods: Arterial and venous CT images of 87 patients with small bowel malignancies were retrospectively analyzed. The subjective radiological features were evaluated by the two radiologists with a consensus agreement. Read More

J Surg Case Rep 2021 Apr 14;2021(4):rjab025. Epub 2021 Apr 14.

Department of General Surgery, Government Stanley Medical College, Tamil Nadu Dr. M.G.R. Medical University, Chennai, Tamil Nadu, India.

Malignant adnexal tumours are a very rare and highly aggressive primary skin neoplasms. Among them, malignant hidradenocarcinoma is a particularly aggressive tumour that arises from the intradermal duct of eccrine sweat glands. It more commonly arises and rarely from a pre-existing hidradenoma. Read More

J Surg Case Rep 2021 Apr 14;2021(4):rjab018. Epub 2021 Apr 14.

Department of Breast Oncology and Surgery, Tokyo Medical University, Tokyo, Japan.

A 52-year-old woman with a strong family history of breast cancer was diagnosed as having triple-negative breast cancer (TNBC) in her right breast. Neoadjuvant chemotherapy (NAC; four cycles of epirubicin/cyclophosphamide/5-fluorouracil) was performed, followed by breast-conserving surgery and axillary lymph node dissection. Histopathological analysis of the surgical specimens demonstrated a few focal tumor cells remaining in the stroma, but not a pathological complete response (pCR). Read More

Iran J Parasitol 2020 Oct-Dec;15(4):576-586

Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: We aimed to compare parasite burden in BALB/c mice, using three methods including the direct fluorescent microscopic using recombinant expressing an enhanced green fluorescent protein, limiting dilution assay, and real-time PCR technique.

Methods: The current study was carried out in 2018, to induce stable enhanced green fluorescent protein (EGFP) production. Initially, the linearized DNA expression cassette (pLEXSY-egfp-sat2) was integrated into the ssu locus of . Read More