14,918 results match your criteria lyme

An -like operon and its relationship to riboflavin utilization and mammalian.

Infect Immun 2021 Jul 26:IAI0030721. Epub 2021 Jul 26.

Department of Microbiology, UT Southwestern Medical Center, Dallas, TX, USA.

Riboflavin is an essential micronutrient, but its transport and utilization has remained largely understudied among pathogenic spirochetes. Here we show that , the zoonotic spirochete that causes Lyme disease, is able to import riboflavin via products of its -like operon as well as synthesize flavin mononucleotide and flavin adenine dinucleotide despite lacking canonical genes for their synthesis. Additionally, a mutant deficient in the -like operon is resistant to the antimicrobial effect of roseoflavin, a natural riboflavin analog, and is attenuated in a murine model of Lyme borreliosis. Read More

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Case 292: Lyme Neuroborreliosis.

Radiology 2021 Aug;300(2):484-488

From the Departments of Ophthalmology (V.P.D., K.A.A.D., B.K.C.) and Radiology (K.L.R.), Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston, MA 02114; and Department of Neurology, Neuro-Ophthalmology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (B.K.C.).

History A 24-year-old right-handed woman presented to a neuro-ophthalmology clinic in Massachusetts in the summer with acute binocular diplopia when looking down and to the left, which started about 1 month earlier. Her medical history was notable for Raynaud syndrome, recurrent streptococcal pharyngitis, and an allergy to amoxicillin. Three days prior to developing diplopia, she presented to an outside emergency department due to fever, chills, and back pain. Read More

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An Exploration of COVID-19 Management Policies across Nine African Countries.

Myron O Odingo

East Afr Health Res J 2020 26;4(2):113-117. Epub 2020 Nov 26.

Keele University, School of Pharmacy, Hornbeam Building, ST5 5BG, Newcastle Under-Lyme, Staffordshire, United Kingdom.

Background: The Coronavirus disease 2019 (COVID-19) has registered more than 16 million cases and has been declared a global pandemic. Social distancing measures have been recommended as part of health policies aimed at reducing the transmission of the disease. These have resulted in adverse social and economic implications; many countries are therefore discussing exit strategies for the relaxation of COVID-19 restrictions. Read More

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November 2020

To the Editor-Phase-4 RBBB in Lyme carditis?

HeartRhythm Case Rep 2021 Jul 30;7(7):506. Epub 2021 Apr 30.

Heart Institute, Hadassah University Hospital, Jerusalem, Israel.

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Author's Reply-Phase-4 RBBB in Lyme carditis?

HeartRhythm Case Rep 2021 Jul 29;7(7):506. Epub 2021 Apr 29.

Department of Medicine, Queen's University, Kingston, Ontario, Canada.

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[Lobular panniculitis in a patient with Lyme borreliosis].

Zhonghua Nei Ke Za Zhi 2021 Aug;60(8):764-767

Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

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Antigenic sites in SARS-CoV-2 spike RBD show molecular similarity with pathogenic antigenic determinants and harbors peptides for vaccine development.

Immunobiology 2021 Jul 13;226(5):152091. Epub 2021 Jul 13.

Genome & Computational Biology Lab, Department of Biotechnology, Mohanlal Sukhadia University, Udaipur 313001, Rajasthan, India. Electronic address:

The spike protein of coronavirus is key target for drug development and other pharmacological interventions. In current study, we performed an integrative approach to predict antigenic sites in SARS-CoV-2 spike receptor binding domain and found nine potential antigenic sites. The predicted antigenic sites were then assessed for possible molecular similarity with other known antigens in different organisms. Read More

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COVID-19 and the Consequences of Anchoring Bias.

Emerg Infect Dis 2021 Aug;27(8):2235-2236

Suspicion of coronavirus disease in febrile patients might lead to anchoring bias, causing misdiagnosis of other infections for which epidemiologic risks are present. This bias has potentially severe consequences, illustrated by cases of human granulocytic anaplasmosis and Lyme disease in a pregnant woman and human granulocytic anaplasmosis in another person. Read More

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Comparison of Lyme Disease in the United States and Europe.

Emerg Infect Dis 2021 08;27(8):2017-2024

Lyme disease, or Lyme borreliosis, is the most common tickborne disease in the United States and Europe. In both locations, Ixodes species ticks transmit the Borrelia burgdorferi sensu lato bacteria species responsible for causing the infection. The diversity of Borrelia species that cause human infection is greater in Europe; the 2 B. Read More

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Modeling future climate suitability for the western blacklegged tick, Ixodes pacificus, in California with an emphasis on land access and ownership.

Ticks Tick Borne Dis 2021 Jul 13;12(5):101789. Epub 2021 Jul 13.

University of California Division of Agriculture and Natural Resources, University of California, Berkeley, 130 Hilgard Way, Berkeley, CA 95449 USA. Electronic address:

In the western United States, Ixodes pacificus Cooley & Kohls (Acari: Ixodidae) is the primary vector of the agents causing Lyme disease and granulocytic anaplasmosis in humans. The geographic distribution of the tick is associated with climatic variables that include temperature, precipitation, and humidity, and biotic factors such as the spatial distribution of its primary vertebrate hosts. Here, we explore (1) how climate change may alter the geographic distribution of I. Read More

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Upregulated Intrathecal Expression of VEGF-A and Long Lasting Global Upregulation of Proinflammatory Immune Mediators in Vaccine Breakthrough Tick-Borne Encephalitis.

Front Cell Infect Microbiol 2021 1;11:696337. Epub 2021 Jul 1.

Laboratory for Diagnostic of Zoonoses and World Health Organization (WHO) Center, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Although anti-TBE vaccines are highly effective, vaccine breakthrough (VBT) cases have been reported. With increasing evidence for immune system involvement in TBE pathogenesis, we characterized the immune mediators reflecting innate and adaptive T and B cell responses in neurological and convalescent phase in VBT TBE patients. At the beginning of the neurological phase, VBT patients have significantly higher serum levels of several innate and adaptive inflammatory cytokines compared to healthy donors, reflecting a global inflammatory state. Read More

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A transwell assay method to evaluate Borrelia burgdorferi sensu stricto migratory chemoattraction toward tick saliva proteins.

Ticks Tick Borne Dis 2021 Jul 12;12(5):101782. Epub 2021 Jul 12.

Bacterial Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States. Electronic address:

We developed a transwell assay to quantify migration of the Lyme disease agent, Borrelia burgdorferi sensu stricto (s.s.), toward Ixodes scapularis salivary gland proteins. Read More

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Surveillance of Borrelia miyamotoi-carrying ticks and genomic analysis of isolates in Inner Mongolia, China.

Parasit Vectors 2021 Jul 17;14(1):368. Epub 2021 Jul 17.

Department of Bacteriology-I, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo, 162-8640, Japan.

Background: Borrelia miyamotoi is a newly described relapsing fever spirochete transmitted by ixodid tick species. Little is known about the prevalence of B. miyamotoi infections in humans and ticks in Inner Mongolia, China. Read More

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Risk of transfusion-transmitted Babesia microti in Canada.

Transfusion 2021 Jul 17. Epub 2021 Jul 17.

Medical Microbiology, Héma-Québec, Montreal, Quebec, Canada.

Background: Babesia microti has gained a foothold in Canada as tick vectors become established in broader geographic areas. B. microti infection is associated with mild or no symptoms in healthy individuals but is transfusion-transmissible and can be fatal in immunocompromised individuals. Read More

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Electrocardiogram as a Lyme Disease Screening Test.

J Pediatr 2021 Jul 12. Epub 2021 Jul 12.

Division of Emergency Medicine, Boston Children's Hospital Boston, MA.

Objective: To examine the association between electrocardiographic (ECG) evidence of carditis at the time of Lyme disease evaluation and a diagnosis of Lyme disease.

Study Design: We performed an eight-center prospective cohort study of children undergoing emergency department evaluation for Lyme disease limited to those who had an ECG obtained by their treating clinicians. The study cardiologist reviewed all ECGs flagged as abnormal by the study sites to assess for ECG evidence of carditis. Read More

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PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi.

PLoS Pathog 2021 Jul 15;17(7):e1009725. Epub 2021 Jul 15.

Department of Medicine, UConn Health, Farmington, Connecticut, United States of America.

In this study, we examined the relationship between c-di-GMP and its only known effector protein, PlzA, in Borrelia burgdorferi during the arthropod and mammalian phases of the enzootic cycle. Using a B. burgdorferi strain expressing a plzA point mutant (plzA-R145D) unable to bind c-di-GMP, we confirmed that the protective function of PlzA in ticks is c-di-GMP-dependent. Read More

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Comparison of the clinical practice guidelines for Lyme disease from the Infectious Diseases Society of America: 2000, 2006, and 2020.

Diagn Microbiol Infect Dis 2021 Jun 4;101(2):115446. Epub 2021 Jun 4.

Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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Relations of peri-residential temperature and humidity in tick-life-cycle-relevant time periods with human Lyme disease risk in Pennsylvania, USA.

Sci Total Environ 2021 Jul 1;795:148697. Epub 2021 Jul 1.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Population Health Sciences, Geisinger, Danville, PA, USA; Johns Hopkins School of Medicine, Department of Medicine, Baltimore, MD, USA. Electronic address:

How weather affects tick development and behavior and human Lyme disease remains poorly understood. We evaluated relations of temperature and humidity during critical periods for the tick lifecycle with human Lyme disease. We used electronic health records from 479,344 primary care patients in 38 Pennsylvania counties in 2006-2014. Read More

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The tick fauna in Istanbul, Turkey, from 2013 to 2017 and identification of their pathogens by multiplex PCR: an epidemiological study.

Exp Appl Acarol 2021 Jul 12. Epub 2021 Jul 12.

Cerrahpasa Medical Faculty, Department of Medical biology, Istanbul University-Cerrahpasa, Zemin kat, Kocamustafapasa, 34098, Istanbul, Turkey.

Ticks may carry several pathogens as vectors and their pathogen load may vary due to differences in geography, climate and vegetation. In this study, we collected ticks from 39 districts of Istanbul (Turkey) between May and October, from 2013 to 2017, and identified them under stereo-microscope. In addition, we investigated the pathogens that the ticks carry (Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, Rickettsia sp. Read More

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Lyme Carditis in Hospitalized Children and Adults, a Case Series.

Open Forum Infect Dis 2021 Jul 23;8(7):ofab140. Epub 2021 Mar 23.

Division of Infectious Diseases, Maine Medical Center, Portland, Maine, USA.

Background: Lyme carditis is an uncommon manifestation of Lyme disease. This report compares Lyme carditis presentation, management, and outcomes in pediatric and adult populations.

Methods: Charts of pediatric and adult patients with heart block (PR interval >300 ms) and positive Lyme serologies hospitalized in Portland, Maine, between January 2010 and December 2018 were analyzed. Read More

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Comparisons of hematologic results for juvenile versus adult shelter dogs presented for ovariohysterectomy or castration.

J Am Vet Med Assoc 2021 Aug;259(3):275-282

Objective: To compare hematologic results for juvenile versus adult dogs from shelters that outwardly appeared healthy and were presented for ovariohysterectomy or castration.

Animals: 138 dogs from 13 regional shelters.

Procedures: Each dog underwent a physical examination (including use of a flea comb), age estimation by dental eruption characteristics, PCV, CBC, and tests for antigen and , and antibodies. Read More

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Detection Limits of Trinitrotoluene and Ammonium Nitrate in Soil by Raman Spectroscopy.

ACS Omega 2021 Jun 15;6(25):16316-16323. Epub 2021 Jun 15.

U.S. Army Engineer Research and Development Center, Cold Regions Research and Engineering Lab, 72 Lyme Road, Hanover, New Hampshire 03755, United States.

The detection limit of 2,4,6-trinitrotoluene (TNT) and ammonium nitrate (AN) in mixtures of Ottawa sand (OS) was studied using a Raman microscope applying conventional calibration curves, Pearson correlation coefficients, and two-sample -tests. By constructing calibration curves, the conventionally defined detection limits were estimated to be 1.9 ± 0. Read More

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In vitro efficacy of antibiotics against different Borrelia isolates.

Acta Microbiol Immunol Hung 2021 Jul 6. Epub 2021 Jul 6.

1Group for Medical Entomology, Centre of Excellence for Food and Vector Borne Zoonoses, Institute for Medical Research, University of Belgrade, Belgrade, Serbia.

In the present study, the effectiveness of six antimicrobial agents have been tested against 24 borrelia strains isolated from Ixodes ricinus ticks (11 Borrelia lusitaniae, eight Borrelia afzelii, three Borrelia garinii and two Borrelia valaisiana) and one B. lusitaniae strain isolated from human skin. The minimum inhibitory concentration range of antimicrobial agents was as follows: amoxicillin, 0. Read More

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Ceftriaxone and Doxycycline induced Seroconversion in Previously Seronegative Patient with Clinically Suspected Disseminated Lyme Disease: Case Report.

Infect Chemother 2021 Mar 23. Epub 2021 Mar 23.

Department of Physiology, Pathophysiology and Immunology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

We present a case of middle-aged woman whose health problems began 3 months after a registered tick bite in endemic area of Lyme borreliosis. First symptoms included fatigue, chills, cervical lymphadenopathy, neck pain and stiffness. Patient was afebrile. Read More

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Lyme arthritis: linking infection, inflammation and autoimmunity.

Nat Rev Rheumatol 2021 Aug 5;17(8):449-461. Epub 2021 Jul 5.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

Infectious agents can trigger autoimmune responses in a number of chronic inflammatory diseases. Lyme arthritis, which is caused by the tick-transmitted spirochaete Borrelia burgdorferi, is effectively treated in most patients with antibiotic therapy; however, in a subset of patients, arthritis can persist and worsen after the spirochaete has been killed (known as post-infectious Lyme arthritis). This Review details the current understanding of the pathogenetic events in Lyme arthritis, from initial infection in the skin, through infection of the joints, to post-infectious chronic inflammatory arthritis. Read More

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Southern Tick-Associated Rash Illness: Florida's Lyme Disease Variant.

Cureus 2021 May 28;13(5):e15306. Epub 2021 May 28.

Internal Medicine, University of Central Florida College of Medicine, Ocala, USA.

Southern tick-associated rash illness (STARI) is an emerging zoonotic disease causing an annular rash with central clearing that is almost identical to erythema migrans seen in Lyme disease. It is spread by tick bite. Although it is still debatable, this zoonotic disease is thought to be caused by spirochete. Read More

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An atypical presentation of borrelial lymphocytoma in 4 children.

Ann Dermatol Venereol 2021 Jul 1. Epub 2021 Jul 1.

Pediatric dermatology unit, departments of dermatology & venereology and pediatrics, university hospital Lausanne, university of Lausanne, 1011 Lausanne, Switzerland.

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Seroprevalence of babesiosis in immunocompetent and immunocompromised individuals.

Pol Merkur Lekarski 2021 Jun;49(291):193-197

National Medical University, Kharkiv, Ukraine.

Interest in Babesia species is gaining an increasing attention as an emerging tick-borne pathogen. Infection is primarily transmitted through Ixodes ticks, and alternatively by blood transfusions from asymptomatic donors.

Aim: The aim of the study was detection of Babesia seroprevalence in different groups of population with the usage of experimental B. Read More

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