1,460 results match your criteria lupus erythematous

Systemic lupus erythematous presenting with hemorrhagic shock caused by gastric penetration of pancreatic pseudocyst: a case report.

J Med Case Rep 2021 Sep 18;15(1):460. Epub 2021 Sep 18.

Department of General Surgery, Honjoudaiichi Hospital, 110, Iwabuchishita, Yurihonnjou, Akita, 015-8567, Japan.

Background: Systemic lupus erythematous that causes various organ damage is rarely associated with pancreatic lesion. To the best of our knowledge, no cases presenting with hemorrhage shock caused by gastric penetration of pancreatic pseudocyst due to lupus pancreatitis have been reported. Herein, we report a case of hemorrhage shock caused by gastric penetration of pancreatic pseudocyst due to lupus pancreatitis. Read More

View Article and Full-Text PDF
September 2021

Tocilizumab for massive refractory pleural effusion in an adolescent with systemic lupus erythematosus.

Pediatr Rheumatol Online J 2021 Sep 16;19(1):144. Epub 2021 Sep 16.

Division of Rheumatology, ERN RITA center, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza Sant'Onofrio, 4-00165, Rome, Italy.

Background: Pleural effusion in systemic lupus erythematous (SLE) is a common symptom, and recent studies demonstrated that IL-6 has a pivotal role in its pathogenesis.

Case Presentation: We report a case of a 15 years old Caucasian boy with a history of persistent pleural effusion without lung involvement or fever. Microbiological and neoplastic aetiologies were previously excluded. Read More

View Article and Full-Text PDF
September 2021

A Case of C-ANCA Positive Systematic Lupus Erythematous and ANCA-Associated Vasculitis Overlap Syndrome Superimposed by COVID-19: A Fatal Trio.

Mod Rheumatol Case Rep 2021 Sep 4. Epub 2021 Sep 4.

Clinical Research Center and Development, Qom University of Medical Sciences, Qom, Iran.

Coronavirus disease 2019 (COVID-19) possesses a substantial challenge for rheumatologists and rheumatologic patients. They are concerned about the reciprocal interaction between connective tissue diseases, such as systemic lupus erythematosus (SLE), and the virus. Here, we report a 21-year-old female SLE patient presented to the emergency department with gastrointestinal symptoms and kidney involvement evidence. Read More

View Article and Full-Text PDF
September 2021

Lymphadenopathy as a prodrome for systemic lupus erythematous.

Curr Rheumatol Rev 2021 Sep 2. Epub 2021 Sep 2.

Division of Oncology, James J Peters VA Medical Center, Bronx, New York. United States.

A 41-year-old woman presented to the hospital with one month of fever, chills, lymphadenopathy, abdominal pain, a bilateral upper extremity rash, and malaise. The patient had no significant prior medical history and was physically active, kickboxing twice a week and working 16-hour days. She reported increased difficulty getting out of bed over the span of one month. Read More

View Article and Full-Text PDF
September 2021

SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center.

Cell Rep 2021 Aug;36(9):109624

Department of Surgery, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, NY 11203, USA; Department of Cell Biology, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, NY 11203, USA. Electronic address:

B cell tolerance prevents autoimmunity by deleting or deactivating autoreactive B cells that otherwise may cause autoantibody-driven disorders, including systemic lupus erythematosus (lupus). Lupus is characterized by immunoglobulin Gs carrying a double-stranded (ds)-DNA autospecificity derived mainly from somatic hypermutation in the germinal center (GC), pointing to a checkpoint breach of GC B cell tolerance that leads to lupus. However, tolerance mechanisms in the GC remain poorly understood. Read More

View Article and Full-Text PDF

Novel use of poly-L-lactic acid filler for the treatment of facial cutaneous atrophy in patients with connective tissue disease.

J Cosmet Dermatol 2021 Aug 30. Epub 2021 Aug 30.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Patients with connective tissue disease (CTD) often suffer from facial cutaneous defects and resultant facial asymmetry. Unfortunately, these issues have been known to be difficult-to-treat, and concern exists regarding the use of cosmetic procedures in this patient population due to the theoretical risk of disease flare-up or reactivation. Injectable poly-L-lactic acid (PLLA) is one type of filler that has been used to treat skin atrophy in patients with morphea and lupus erythematous panniculitis. Read More

View Article and Full-Text PDF

Lupus cheilitis: An uncommon manifestation of systemic lupus erythematous.

Lupus 2021 Aug 28:9612033211038829. Epub 2021 Aug 28.

Department of Dermatology & Cosmetology, MEDENS Hospital, Panchkula, Haryana, India.

View Article and Full-Text PDF

Central nervous system melioidosis in systemic lupus erythematosus: A clinical vignette.

IDCases 2021 12;26:e01255. Epub 2021 Aug 12.

Rheumatology Unit, Department of Internal Medicine, Sarawak General Hospital, Ministry of Health, Malaysia.

Central nervous system melioidosis is an uncommon presentation of melioidosis infection. We report a case of a disseminated melioidosis infection with central nervous system, pulmonary, spleen, bone and cutaneous involvement in a patient with underlying systemic lupus erythematous. The diagnosis was confirmed based on positive blood and cerebrospinal fluid cultures coupled with radiological findings. Read More

View Article and Full-Text PDF

Usefulness of low-dose combined spinal epidural anesthesia for a woman with systemic lupus erythematosus, mechanical prosthesis in the mitral valve position, and worsening heart failure presenting for cesarean delivery.

Proc (Bayl Univ Med Cent) 2021 Sep 1;34(5):636-637. Epub 2021 Jun 1.

Department of Anesthesiology, Baylor Scott & White Medical Center - Temple, Temple, Texas.

A 31-year-old woman, gravida one, para zero, at 32 weeks, 4 days gestation, with a history of antiphospholipid antibody syndrome, mitral valve replacement requiring anticoagulation, chronic diastolic heart failure, and systemic lupus erythematous was admitted to the hospital for worsening cardiac decompensation with superimposed pneumonia. She was on warfarin for anticoagulation at the time of hospital admission and eventually started on an intravenous heparin infusion. Cesarean delivery was planned due to comorbidities and anticoagulation status. Read More

View Article and Full-Text PDF
September 2021

Cellular Response against Oxidative Stress, a Novel Insight into Lupus Nephritis Pathogenesis.

J Pers Med 2021 Jul 22;11(8). Epub 2021 Jul 22.

Department of Dermatology, Victor Babes Clinical Hospital of Tropical and Infectious Diseases, 030303 Bucharest, Romania.

The interaction of reactive oxygen species (ROS) with lipids, proteins, nucleic acids and hydrocarbonates promotes acute and chronic tissue damage, mediates immunomodulation and triggers autoimmunity in systemic lupus erythematous (SLE) patients. The aim of the study was to determine the pathophysiological mechanisms of the oxidative stress-related damage and molecular mechanisms to counteract oxidative stimuli in lupus nephritis. Our study included 38 SLE patients with lupus nephritis (LN group), 44 SLE patients without renal impairment (non-LN group) and 40 healthy volunteers as control group. Read More

View Article and Full-Text PDF

Bortezomib: a proteasome inhibitor for the treatment of autoimmune diseases.

Inflammopharmacology 2021 Aug 23. Epub 2021 Aug 23.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Autoimmune diseases (ADs) are conditions in which the immune system cannot distinguish self from non-self and, as a result, tissue injury occurs primarily due to the action of various inflammatory mediators. Different immunosuppressive agents are used for the treatment of patients with ADs, but some clinical cases develop resistance to currently available therapies. The proteasome inhibitor bortezomib (BTZ) is an approved agent for first-line therapy of people with multiple myeloma. Read More

View Article and Full-Text PDF

Radiation Toxicity in Patients With Collagen Vascular Disease: A Meta-analysis of Case-Control Studies.

Int J Radiat Oncol Biol Phys 2021 Aug 19. Epub 2021 Aug 19.

Loyola University Chicago, Stritch School of Medicine, Department of Radiation Oncology, Maywood, Illinois.

Purpose: Several retrospective series have reported that patients with collagen vascular disease (CVD) are at increased risk of radiation (RT) toxicity. However, the evidence is mixed, and many series lack control groups. We performed a meta-analysis including only case-cohort or randomized studies that examined the risk of RT toxicity for patients with CVD compared with controls. Read More

View Article and Full-Text PDF

Squamous cell carcinoma arising within discoid lupus erythematous lesions: A systematic review.

JAAD Int 2021 Mar 30;2:1-4. Epub 2020 Nov 30.

Department of Dermatology, University of Toronto, Toronto, Ontario, Canada.

View Article and Full-Text PDF

Utilization of Rituximab for Refractory Rowell Syndrome.

Case Rep Rheumatol 2021 29;2021:2727382. Epub 2021 Jul 29.

Division of Rheumatology, Department of Medicine, University of Florida Health Jacksonville, Jacksonville, FL, USA.

Rowell syndrome describes the occurrence of erythema multiforme-like lesions in patients with cutaneous lesions of lupus erythematosus. The clinical picture of atypical erythema multiforme-like lesions, presence of chilblains, speckled ANA pattern, anti-Ro/SSA, or anti-La/SSB antibodies, and absence of infectious or pharmacologic triggers in a patient with systemic lupus erythematosus are some of the classic clinical and serologic features. Histopathologic and serologic findings can help differentiate this process from erythema multiforme. Read More

View Article and Full-Text PDF

[Hydroxychloroquine: An Essential Drug in Dermatology and Its Controversial Use in COVID-19].

Actas Dermosifiliogr 2021 Aug 2. Epub 2021 Aug 2.

Dermik. Clínica Dermatológica Multidisciplinar, Barcelona, España.

Hydroxychloroquine is an antimalarial drug with immunomodulatory, anti-inflammatory, antibacterial, and antiviral properties. It has a good safety profile, can be used in children and in pregnant and breastfeeding women, and does not suppress the immune system. Regular screening for retinopathy, one of the drug's most feared adverse effects, is necessary. Read More

View Article and Full-Text PDF

Sjogren's Syndrome Presenting with Solely Cutaneous Features.

Diagnostics (Basel) 2021 Jul 14;11(7). Epub 2021 Jul 14.

University of Cincinnati, Cincinnati, OH 45267, USA.

Sjogren's syndrome is classically characterized by symptoms of keratoconjunctivitis sicca and xerostomia, secondary to lymphocytic infiltration of the salivary and lacrimal glands. Cutaneous findings of this disease are infrequently discussed and thus rarely considered among patients without the typical symptomatology. However, these patients can develop xerosis, alopecia, vitiligo, papular or nodular lesions, or cutaneous vasculitis. Read More

View Article and Full-Text PDF

Clinical and peculiar immunological manifestations of SARS-CoV-2 infection in systemic lupus erythematosus patients.

Rheumatology (Oxford) 2021 Aug 5. Epub 2021 Aug 5.

Lupus Clinic, Clinical Rheumatology Unit, ASST Pini-CTO, Milan, Italy.

Objectives: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with systemic lupus erythematosus (SLE) remains unclear and data on clinical manifestations after infection are lacking. The aim of this multicentre study is to describe the effect of SARS-CoV-2 in SLE patients.

Methods: SLE patients referring to 4 Italian centres were monitored between February 2020 and March 2021. Read More

View Article and Full-Text PDF

COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series.

Anesth Pain Med 2021 Apr 18;11(2):e113760. Epub 2021 Apr 18.

Department of MESVA, University of L'Aquila, L'Aquila, Italy.

Background: A variety of skin manifestations have been associated with COVID-19 infection. Acral lesions on hands and feet, closely resembling chilblains, have been reported in association with COVID-19, which are nonspecific. These acro-ischemic painful lesions have been described mainly in asymptomatic and mildly symptomatic pediatric COVID-19 positive patients, without a precise pathogenetic mechanism. Read More

View Article and Full-Text PDF

Neuropsychiatric Lupus: A Challenging Journey of a Patient With Pulmonary Tuberculosis.

Cureus 2021 Jun 29;13(6):e16018. Epub 2021 Jun 29.

Critical Care, Hamad Medical Corporation, Doha, QAT.

Systemic lupus erythematosus (SLE) is a disease that affects multiple systems in the body. Due to its variable manifestations, it can at times pose challenges for physicians to hold SLE as the culprit behind an affected system. This is most true when encountering patients with neuropsychiatric manifestations of SLE. Read More

View Article and Full-Text PDF

An unusual presentation to the burn' unit - a cautionary tale.

J Burn Care Res 2021 Jul 29. Epub 2021 Jul 29.

Reconstructive Surgery and Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea.

We report a case of a 34-year old female with systemic lupus erythematosus (SLE) and lupus nephritis who was referred to the regional burns service with a suspected contact burn to the left flank and hypogastrium from a hot water bottle. The patient had been applying a hot-water bottle to the area at night for pain relief and after 3-days she noticed a localised area of erythema which became larger and began to blister over a period of 5-days. The blistered areas were erythematous and wet, however the capillary refill time was sluggish. Read More

View Article and Full-Text PDF

Disseminated Herpes Zoster on a Child with Systemic Lupus Erythematosus and Lupus Nephritis.

Infect Drug Resist 2021 20;14:2777-2785. Epub 2021 Jul 20.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya/ Dr. Saiful Anwar Regional Hospital, Malang, Indonesia.

Introduction: Disseminated herpes zoster (DHZ) is a complication of herpes zoster (HZ) associated with an immunocompromised state. Immunocompromised conditions in systemic lupus erythematosus (SLE) and lupus nephritis increase the incidence of DHZ.

Case: A 14-year-old girl was consulted with a complaint of painful reddish blisters for the previous 4 days. Read More

View Article and Full-Text PDF

Chinese Herbal Medicine for Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis of Randomized, Placebo-Controlled Trials.

Chin J Integr Med 2021 Jul 28. Epub 2021 Jul 28.

Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.

Objective: To provide evidence on the efficacy and safety of Chinese herbal medicine (CHM) as interventions for systemic lupus erythematosus (SLE).

Methods: Seven electronic databases, including the Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), Chinese Biomedical Literature Service System (SinoMed), Wanfang, Embase, and PubMed, were comprehensively searched, from their inception to August 16, 2020, for all randomized controlled trials (RCTs) that focused on CHM used alone or in combination with conventional medicine for SLE. Outcomes were SLE activity index (SLEDAI), traditional Chinese medicine symptom/syndrome score (TCMSS), dosage of glucocorticoids, main serological testing, and incidence of adverse events. Read More

View Article and Full-Text PDF

A case of psoriasis and systemic lupus erythematous successfully treated with ustekinumab.

Eur J Dermatol 2021 Jun;31(3):429-431

Department of Dermatology, Centro Hospitalar Universitário do Porto, Porto, Portugal, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.

View Article and Full-Text PDF

Hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis.

Med Mycol Case Rep 2021 Sep 24;33:18-20. Epub 2021 Jun 24.

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Histoplasmosis-associated hemophagocytic lymphohistiocytosis is a rate but lethal disease in immunocompromised hosts. Unusual clinical presentations make diagnosing invasive fungal infection even more challenging. Here we present a case of hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis in a patient with systemic lupus erythematous. Read More

View Article and Full-Text PDF
September 2021

The Spectrum of C4d Deposition in Renal Biopsies of Lupus Nephritis Patients.

Front Immunol 2021 1;12:654652. Epub 2021 Jul 1.

Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.

Objectives: This study aimed to determine the prevalence and localization of complement factor C4d in renal biopsies from patients with lupus nephritis (LN), as well as its associations with the disease's clinico-pathological features. The correlation between arteriolar C4d deposition and renal microvascular lesions (RVLs) was further analyzed.

Methods: A total of 325 biopsy-proven LN patients were enrolled, and their clinico-pathological data were collected. Read More

View Article and Full-Text PDF

Distinct Microbiomes of Gut and Saliva in Patients With Systemic Lupus Erythematous and Clinical Associations.

Front Immunol 2021 1;12:626217. Epub 2021 Jul 1.

Department of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.

Alterations in the microbiome of the gut and oral cavity are involved in the etiopathogenesis of systemic lupus erythematosus (SLE). We aimed to assess whether both microbiome compositions in feces and saliva were specific in patients with SLE. A total of 35 patients with SLE, as well as sex- and age-matched asymptomatic subjects as healthy control (HC) group were recruited. Read More

View Article and Full-Text PDF
September 2021

Periorbital hypopigmentation and telangiectasias: Clues to diagnosing neonatal lupus in skin of color.

Pediatr Dermatol 2021 Jul 11. Epub 2021 Jul 11.

Department of Dermatology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.

Neonatal lupus erythematosus (NLE) is an autoimmune disease characterized by a periorbital erythematous rash. Although post-inflammatory hypopigmentation and telangiectasias are known possible sequelae, these features may be particularly noticeable in skin of color. Herein, we describe two infants with skin of color in whom periorbital hypopigmentation and telangiectasias were clues to the diagnosis of NLE. Read More

View Article and Full-Text PDF

Case Report: Psychopathological Syndromes in the Course of Lupus Erythematosus and the Co-occurrence of Lupus Erythematous With Mental Disorders.

Front Psychiatry 2021 24;12:668050. Epub 2021 Jun 24.

Second Department of Psychiatry, Medical University of Lublin, Lublin, Poland.

Systemic lupus erythematosus (SLE) is an autoimmune disease that leads to a chronic inflammatory process in tissues and organs. The neuropsychiatric systemic lupus erythematosus (NPSLE) is a set of neuropsychiatric symptoms that derive from the central and peripheral nervous system and are observed in the course of SLE. A diagnostic and therapeutic process in a patient with the signs and symptoms of SLE and bipolar disorder (BD) has been described. Read More

View Article and Full-Text PDF

Rheumatological complications of Covid 19.

Autoimmun Rev 2021 Sep 5;20(9):102883. Epub 2021 Jul 5.

Louise Coote Lupus Unit, Guy's Hospital, London SE1 9RT, UK. Electronic address:

Introduction: COVID-19 has caused unprecedented hardships in the 21st century with more than 150 million infections. Various immunological phenomena have been described during the course of the infection, and this infection has also triggered autoimmunity. Rheumatological illnesses have been described following resolution of the acute infection; hence we sought to conduct a review of the rheumatological complications of COVID-19. Read More

View Article and Full-Text PDF
September 2021

Chronic inflammatory diseases and coronary heart disease: Insights from cardiovascular CT.

J Cardiovasc Comput Tomogr 2021 Jun 24. Epub 2021 Jun 24.

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Epidemiological and clinical studies have demonstrated a consistent relationship between increased systemic inflammation and increased risk of cardiovascular events. In chronic inflammatory states, traditional risk factors only partially account for the development of coronary artery disease (CAD) but underestimate total cardiovascular risk likely due to the residual risk of inflammation. Computed coronary tomography angiography (CCTA) may aid in risk stratification by noninvasively capturing early CAD, identifying high risk plaque morphology and quantifying plaque at baseline and in response to treatment. Read More

View Article and Full-Text PDF