77,898 results match your criteria lupus erythematosus

Avoiding misclassification of thrombotic primary antiphospholipid syndrome as systemic lupus erythematosus (SLE): What are the best-performing SLE classification criteria?

Lupus 2021 Jul 22:9612033211033978. Epub 2021 Jul 22.

Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Background: Systemic lupus erythematosus (SLE) and Primary Antiphospholipid Syndrome (PAPS) overlap clinical and immunological features. Therefore, misclassification of PAPS patients as SLE is a concern. The ACR/EULAR 2019 SLE classification has never been studied in PAPS. Read More

View Article and Full-Text PDF

Induction and exacerbation of subacute cutaneous lupus erythematosus following messenger-RNA or adenoviral-vector based SARS-CoV-2 vaccination.

Clin Exp Dermatol 2021 Jul 22. Epub 2021 Jul 22.

Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten, Herdecke, Germany.

Accumulating evidence exists that COVID-19 vaccines might induce or exacerbate autoimmune rheumatic diseases. Currently available COVID-19 vaccines include messenger-RNA (mRNA) and recombinant adenoviral (AdV) vector vaccines, both encoding SARS-CoV-2 spike protein production as the primary target for neutralizing antibodies. We herein report a case of subacute cutaneous lupus erythematosus (SCLE) following mRNA vaccination with BNT162b2, and summarize the current literature on cutaneous lupus erythematosus occurring after COVID-19 vaccination. Read More

View Article and Full-Text PDF

Genetic Polymorphisms in Genes Involved in the Type I Interferon System (IFIH1/MDA-5, TNFAIP3/A20, and STAT4): Association with SLE Risk in Egyptian Children and Adolescents.

J Inflamm Res 2021 15;14:3349-3358. Epub 2021 Jul 15.

Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Purpose: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune inflammatory disease that is influenced by both genetic and environmental factors and associated with dysregulation of type I interferon (INF) response. This study aimed to investigate the effects of single nucleotide polymorphisms (SNPs) of the IFIH1, TNFAIP3, and STAT4 genes in the type I INF system on SLE risk in Egyptian children and adolescents.

Patients And Methods: We recruited 94 SLE individuals and 94 healthy subjects. Read More

View Article and Full-Text PDF

Myocardial infarctions, subtypes and coronary atherosclerosis in SLE: a case-control study.

Lupus Sci Med 2021 07;8(1)

Unit of Rheumatology, Karolinska University Hospital, Stockholm, Sweden.

Objective: Patients with SLE have increased risk of myocardial infarction (MI). Few studies have investigated the characteristics of SLE-related MIs. We compared characteristics of and risk factors for MI between SLE patients with MI (MI-SLE), MI patients without SLE (MI-non-SLE) and SLE patients without MI (non-MI-SLE) to understand underlying mechanisms. Read More

View Article and Full-Text PDF

The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases.

Med Res Rev 2021 Jul 21. Epub 2021 Jul 21.

Oesch-Tox Toxicological Consulting and Expert Opinions, Ingelheim, Germany and Institute of Toxicology,  Johannes Gutenberg University of Mainz, Mainz, Germany.

The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a comprehensive and timely overview of the literature regarding the immunosuppressive activity of artemisinin-type compounds toward inflammatory and autoimmune diseases. Read More

View Article and Full-Text PDF

Polyautoimmunity in systemic lupus erythematosus: secondary Sjogren syndrome.

Z Rheumatol 2021 Jul 21. Epub 2021 Jul 21.

Rheumatology Department, Complejo Asistencial Universitario de León, Calle Altos de nava, s/n, 24001, León, Spain.

Background: Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. It can be associated with other connective tissue diseases, including systemic lupus erythematosus (SLE).

Objective: This study aimed to determine the incidence of secondary SS (sSS) in patients diagnosed with SLE (SLE-SS) and compare the clinical and serological features of SLE-SS to SLE only. Read More

View Article and Full-Text PDF

Lupus retinopathy: epidemiology and risk factors.

Arq Bras Oftalmol 2021 Jul-Aug;84(4):395-401

Ophthalmology Department, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Lupus retinopathy is a clinical manifestation of systemic lupus erythematosus in the visual system. It is generally asymptomatic; however, it can become a threatening condition. It is closely associated with the inflammatory activity and higher mortality of systemic lupus erythematosus. Read More

View Article and Full-Text PDF
December 2019

Adalimumab-Induced Rhupus Syndrome in a Female Patient Affected with Anti-Citrullinated Protein Antibody (ACPA)-Positive Rheumatoid Arthritis (RA): A Case Report and Review of Literature.

Clin Pract 2021 Jul 1;11(3):404-409. Epub 2021 Jul 1.

Primary Care Department, Casa Della Salute "Chiaravalle Centrale", Fragility Outpatient Clinic, Azienda Sanitaria Provinciale di Ca-tanzaro, Chiaravalle, 88064 Catanzaro, Italy.

We report a 38-year-old female patient affected with anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) who developed mild hemolytic anemia (Hb = 10.5 vs. >12 gr/dL), indolent oral ulceration, ANA (1:1280, homogeneous pattern), and anti-dsDNA antibody positivity following 8 months of therapy with an adalimumab biosimilar (GP2017). Read More

View Article and Full-Text PDF

Comprehension, Utility, and Acceptability of a Multi-Domain Physical Functioning Report for Systemic Lupus Erythematosus Patients and Their Providers.

Arthritis Care Res (Hoboken) 2021 Jul 19. Epub 2021 Jul 19.

Durham Veterans Affairs Geriatric Research Education and Clinical Center, Durham Veterans Affairs Health System, Department of Medicine, Duke University, Durham, North Carolina, USA.

Objective: Patient-provider discussions about functioning are often outside the scope of usual care for systemic lupus erythematosus (SLE), and tools to facilitate such discussions are lacking. We assessed the comprehension, utility, and acceptability of a novel, individualized functioning report, the purpose of which is to facilitate patient-provider communication about functioning, in a predominantly Black SLE patient population.

Methods: Individualized reports (including sections with pictorial representations of participants' measured activities of daily living, falls, physical performance, perceived physical functioning, and community mobility from a previous pilot study visit) and surveys were emailed or mailed to 59 SLE patients. Read More

View Article and Full-Text PDF

[Seroprevalence of infections among patients with autoimmune diseases].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Jun;33(3):305-307

Department of Laboratory Medicine, First People's Hospital of Yuhang District, Yuhang Branch of The Second Affiliated Hospital of Zhejiang University Medical School, Hangzhou 311100, China.

Objective: To understand the seroprevalence of infections among patients with autoimmune diseases, so as to provide the scientific evidence for the management of toxoplasmosis in patients with autoimmune diseases.

Methods: A total of 237 patients with definitive diagnosis of autoimmune disease were selected as the study subjects, including 79 cases with systemic lupus erythematosus, 71 cases with rheumatoid arthritis and 87 cases with inflammatory bowel disease, while 237 healthy volunteers served as controls. The serum anti- IgG antibody was detected using enzyme-linked immunosorbent assay (ELISA) in patients with autoimmune diseases and healthy controls, and the detection of serum IgG antibody against was compared between the autoimmune disease patients and healthy controls. Read More

View Article and Full-Text PDF

The Importance of Outcome Measures in the Management of Inflammatory Rheumatic Diseases.

Open Access Rheumatol 2021 12;13:191-200. Epub 2021 Jul 12.

Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Rheumatic inflammatory diseases include a diverse and heterogeneous group of multifaceted disorders in which clinical history and physical examination are essential to make treatment choices and for optimizing outcomes. Composite outcome measures have become very relevant in rheumatology to evaluate disease activity as they capture the most important dimensions of the disease into one single measure. Most outcome measures may include disease manifestations, laboratory data, physician examination as well as the patient perspective as different outcome dimensions of the disease into a simple index. Read More

View Article and Full-Text PDF

Altered expression of genes controlling metabolism characterizes the tissue response to immune injury in lupus.

Sci Rep 2021 Jul 20;11(1):14789. Epub 2021 Jul 20.

AMPEL BioSolutions, LLC and RILITE Research Institute, Charlottesville, VA, USA.

To compare lupus pathogenesis in disparate tissues, we analyzed gene expression profiles of human discoid lupus erythematosus (DLE) and lupus nephritis (LN). We found common increases in myeloid cell-defining gene sets and decreases in genes controlling glucose and lipid metabolism in lupus-affected skin and kidney. Regression models in DLE indicated increased glycolysis was correlated with keratinocyte, endothelial, and inflammatory cell transcripts, and decreased tricarboxylic (TCA) cycle genes were correlated with the keratinocyte signature. Read More

View Article and Full-Text PDF

The relationship between the modified National Institute of Health activity and chronicity scoring system, and the long-term prognosis for lupus nephritis: A retrospective single-center study.

Lupus 2021 Jul 20:9612033211034234. Epub 2021 Jul 20.

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan.

Background: The revision of International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification guidelines for lupus nephritis (LN) was suggested by a working group, who recommended a modified National Institute of Health (NIH) activity and chronicity scoring system to evaluate active and chronic LN lesions. However, whether this approach was useful for estimating long-term prognosis for LN patients is unclear.

Methods: We conducted a retrospective cohort study in Japanese subjects with biopsy-proven LN, between 1977 and 2018. Read More

View Article and Full-Text PDF

Impact of the first wave of the COVID-19 pandemic on systemic lupus erythematosus patients: Results from a multi-center prospective cohort.

Lupus 2021 Jul 20:9612033211033981. Epub 2021 Jul 20.

Division of Rheumatology/Department of Medicine, Hospital for Special Surgery and Weill Cornell Medicine, New York, USA.

Objective: The aim of this study was to evaluate the initial impact of the COVID-19 pandemic on individuals with systemic lupus erythematosus (SLE).

Methods: Patients with SLE participating in a multi-center longitudinal cohort study in New York and Boston were invited to complete a supplemental web-based questionnaire in the summer of 2020. Participants completed standardized patient-reported outcome (PRO) measures and a combination of Likert scale and open-ended questions exploring the impact of the COVID-19 pandemic on their health and access to health care. Read More

View Article and Full-Text PDF

Methyl donor micronutrients, CD40-ligand methylation and disease activity in systemic lupus erythematosus: A cross-sectional association study.

Lupus 2021 Jul 20:9612033211034559. Epub 2021 Jul 20.

Medical Faculty, Dept. & Hiller Research Unit for Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany.

Objective: Hypomethylation of CD40-ligand (CD40L) in T-cells is associated with increased disease activity in systemic lupus erythematosus (SLE). We therefore investigated possible associations of dietary methyl donors and products with CD40L methylation status in SLE.

Methods: Food frequency questionnaires were employed to calculate methyl donor micronutrients in 61 female SLE patients (age 45. Read More

View Article and Full-Text PDF

Ophthalmologic manifestations in patients with antiphospholipid antibodies: Beware of iatrogenic complications.

Lupus 2021 Jul 20:9612033211033988. Epub 2021 Jul 20.

Université de Lorraine, Inserm UMR_S 1116 DCAC and CHRU de Nancy, Vascular Medicine Division And Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases, F-54000 Nancy, France.

Background: Antiphospholipid syndrome (APS) is characterized by several clinical manifestations such as venous and arterial thrombosis associated with persistent antiphospholipid antibodies (aPL). Several studies confirmed that retinal vein occlusion was the most common APS ocular manifestation. The purpose of this study was to identify ophthalmologic manifestations in a homogeneous cohort of well-defined persistently aPL-positive patients and to determine variables associated with these manifestations. Read More

View Article and Full-Text PDF

Belimumab in subacute cutaneous lupus erythematosus.

Lupus 2021 Jul 20:9612033211033989. Epub 2021 Jul 20.

Rheumatology Department, Hospital Consorci Sanitari Alt Penedès Garraf (CSAPG), Vilafranca del Penedès, Spain Dermatology Department, Hospital Consorci Sanitari Alt Penedès Garraf (CSAPG), Vilafranca del Penedès, Spain.

View Article and Full-Text PDF

Expression characteristics of interferon-stimulated genes and possible regulatory mechanisms in lupus patients using transcriptomics analyses.

EBioMedicine 2021 Jul 17;70:103477. Epub 2021 Jul 17.

Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, 28 Fuxing Road, Haidian District, Beijing 100853, China. Electronic address:

Background: Type I interferon signature is one of the most important features of systemic lupus erythematosus (SLE), which indicates an active immune response to antigen invasion. Characteristics of type I interferon-stimulated genes (ISGs) in SLE patients have not been well described thus far.

Methods: We analyzed 35,842 cells of PBMC single-cell RNA sequencing data of five SLE patients and three healthy controls. Read More

View Article and Full-Text PDF

Psoriasis successfully treated with guselkumab in a patient with systemic lupus erythematosus and acquired hemophilia A.

Ital J Dermatol Venerol 2021 Jul 20. Epub 2021 Jul 20.

Dermatology Unit, Department of Medical, Surgical and Neurological sciences, Santa Maria alle Scotte Hospital, Siena University, Siena, Italy.

View Article and Full-Text PDF

Different cerebral functional segregation in Sjogren's syndrome with or without systemic lupus erythematosus revealed by amplitude of low-frequency fluctuation.

Acta Radiol 2021 Jul 20:2841851211032441. Epub 2021 Jul 20.

Department of Radiology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, PR China.

Background: Sjögren's syndrome (SjS) associated with systemic lupus erythematosus (SjS-SLE) was considered a standalone but often-overlooked entity.

Purpose: To assess altered spontaneous brain activity in SjS-SLE and SjS using amplitude of low-frequency fluctuation (ALFF).

Material And Methods: Sixteen patients with SjS-SLE, 17 patients with SjS, and 17 matched controls underwent neuropsychological tests and subsequent resting-state functional magnetic resonance imaging (fMRI) examinations. Read More

View Article and Full-Text PDF

Axonal dysfunction is associated with interferon-γ levels in childhood-onset systemic lupus erythematosus: a multivoxel magnetic resonance spectroscopy study.

Rheumatology (Oxford) 2021 Jul 20. Epub 2021 Jul 20.

Rheumatology Lab, School of Medical Sciences, University of Campinas.

Objective: Axonal/neuronal damage has been shown to be a pathological finding that precedes neuropsychiatric manifestations in systemic lupus erythematosus (SLE). Therefore, the objective of this study was to determine the presence of axonal dysfunction in childhood-onset SLE patients (cSLE) and to determine clinical, immunological, and treatment features associated with its occurrence.

Methods: We included 86 consecutive cSLE patients [median age 17 years (range 5-28)] and 71 controls [median age 18 years (5-28)]. Read More

View Article and Full-Text PDF

Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease.

Nat Commun 2021 07 19;12(1):4379. Epub 2021 Jul 19.

Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

The transcription factor IRF5 has been implicated as a therapeutic target for the autoimmune disease systemic lupus erythematosus (SLE). However, IRF5 activation status during the disease course and the effects of IRF5 inhibition after disease onset are unclear. Here, we show that SLE patients in both the active and remission phase have aberrant activation of IRF5 and interferon-stimulated genes. Read More

View Article and Full-Text PDF

IRF-8/miR-451a regulates M-MDSC differentiation via the AMPK/mTOR signal pathway during lupus development.

Cell Death Discov 2021 Jul 16;7(1):179. Epub 2021 Jul 16.

The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, 210093, PR China.

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease. Myeloid-derived suppressor cells (MDSCs) have been found to be involved in the regulation of SLE development. However, little is known about the association between MDSC subsets and the factors that draw MDSCs into abnormal expansion. Read More

View Article and Full-Text PDF

Immune-Related Urine Biomarkers for the Diagnosis of Lupus Nephritis.

Int J Mol Sci 2021 Jul 1;22(13). Epub 2021 Jul 1.

GENYO, Centre for Genomics and Oncological Research Pfizer, University of Granada, Andalusian Regional Government, PTS, 18016 Granada, Spain.

The kidney is one of the main organs affected by the autoimmune disease systemic lupus erythematosus. Lupus nephritis (LN) concerns 30-60% of adult SLE patients and it is significantly associated with an increase in the morbidity and mortality. The definitive diagnosis of LN can only be achieved by histological analysis of renal biopsies, but the invasiveness of this technique is an obstacle for early diagnosis of renal involvement and a proper follow-up of LN patients under treatment. Read More

View Article and Full-Text PDF

Systemic Lupus Erythematosus Research: A Bibliometric Analysis over a 50-Year Period.

Malcolm Koo

Int J Environ Res Public Health 2021 Jul 2;18(13). Epub 2021 Jul 2.

Graduate Institute of Long-term Care, Tzu Chi University of Science and Technology, Hualien City, Hualien 970046, Taiwan.

Bibliometric analysis is a well-established approach to quantitatively assess scholarly productivity. However, there have been few assessments of research productivity on systemic lupus erythematosus (SLE) to date. The aim of this study was to analyze global research productivity through original articles published in journals indexed by the Web of Science from 1971 to 2020. Read More

View Article and Full-Text PDF

International Consensus For The Dosing Of Corticosteroids In Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis.

Arthritis Rheumatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Pediatrics, Sao Paulo State University (UNESP), Botucatu, Brazil.

Objective: To develop a Standardized Steroid dosing Regimen (SSR) by physicians treating childhood-onset systemic lupus erythematosus (cSLE) complicated by lupus nephritis (LN), using consensus formation methodology.

Methods: Parameters influencing corticosteroid (CS) dosing were identified (Step-1). Data from children with proliferative LN were used to generate Patient Profiles (PP) (Step-2). Read More

View Article and Full-Text PDF

Liver Abnormalities in Systemic Lupus Erythematosus: A Prospective Observational Study.

Cureus 2021 Jun 16;13(6):e15691. Epub 2021 Jun 16.

Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IND.

Objectives In this study, we aimed to examine and analyze liver abnormalities among patients with systemic lupus erythematosus (SLE), including both newly diagnosed patients and those being followed up, as well as the prevalence of lupus hepatitis. Methods This was a prospective observational study. Clinical data, liver function tests (LFTs), and the findings from the ultrasonography of the abdomen among the patients were prospectively recorded and evaluated. Read More

View Article and Full-Text PDF

A Case of COVID-19 Mimicking Acute Appendicitis in Multi-System Inflammatory Syndrome.

Cureus 2021 Jun 11;13(6):e15600. Epub 2021 Jun 11.

Clinical Curriculum Integration & Assessment, Lake Erie College of Osteopathic Medicine (LECOM) - Bradenton, Bradenton, USA.

Children's naive immune systems allow for a unique course of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus when compared to adults. In multi-system inflammatory syndrome in children (MIS-C), a current or recent SARS-CoV-2 infection can cause fever and elevated inflammatory markers in individuals under the age of 21. Similar to Kawasaki disease, Kikuchi disease, systemic lupus erythematosus, toxic shock syndrome (TSS), and macrophage activation syndrome (MAS), there is an influx of inflammation associated with MIS-C that creates this pathologic state. Read More

View Article and Full-Text PDF