94,624 results match your criteria lupus

Is Lupus Anticoagulant a Significant Feature of COVID-19? A Critical Appraisal of the Literature.

Semin Thromb Hemost 2021 Jun 15. Epub 2021 Jun 15.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

The term "lupus anticoagulant (LA)" identifies a form of antiphospholipid antibodies (aPLs) causing prolongation of clotting tests in a phospholipid concentration-dependent manner. LA is one of the laboratory criteria identified in patients with antiphospholipid (antibody) syndrome (APS). The presence of LA in patients with APS represents a significant risk factor for both thrombosis and pregnancy morbidity. Read More

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COVID-19 and Antiphospholipid Antibodies: Time for a Reality Check?

Semin Thromb Hemost 2021 Jun 15. Epub 2021 Jun 15.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

Antiphospholipid antibodies (aPL) comprise a panel of autoantibodies that reflect a potential prothrombotic risk in several autoimmune conditions, most notably antiphospholipid (antibody) syndrome (APS). aPL can be divided into those that form part of the laboratory criteria for APS, namely, lupus anticoagulant (LA), as well as anticardiolipin antibodies (aCL) and anti-β2-glycoprotein I antibodies (aβ2GPI) of the immunoglobulin G and M classes, and those that form a group considered as "noncriteria antibodies." The noncriteria antibodies include, for example, antiphosphatidylserine antibodies (aPS), antiprothrombin antibodies (aPT), and antiphosphatidylserine/prothrombin complex antibodies (aPS/PT). Read More

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Artificial Intelligence and Cellular Segmentation in Tissue Microscopy Images.

Am J Pathol 2021 Jun 12. Epub 2021 Jun 12.

Department of Radiology and Committee on Medical Physics, University of Chicago, Chicago, IL, USA, 60637. Electronic address:

With applications in object detection, image feature extraction, image classification, and image segmentation, artificial intelligence is enabling high-throughput analysis of image data in a variety of biomedical imaging disciplines, ranging from radiology and pathology to cancer biology and immunology. Specifically, a growth in research surrounding deep learning has led to widespread application of computer vision techniques to analyze and mine data from biomedical images. The availability of open-source software packages and the development of novel, trainable deep neural network architectures has led to an increase in accuracy of cell detection and segmentation algorithms. Read More

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ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody.

JCI Insight 2021 Jun 15. Epub 2021 Jun 15.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, United States of America.

The blood-brain barrier (BBB) prevents antibodies from penetrating the CNS and limits conventional antibody-based approaches to brain tumors. We now show that ENT2, a transporter that regulates nucleoside flux at the BBB, may offer an unexpected path to circumventing this barrier to allow targeting of brain tumors with an anti-DNA autoantibody. Deoxymab-1 (DX1) is a DNA-damaging autoantibody that localizes to tumors and is synthetically lethal to cancer cells with defects in the DNA damage response. Read More

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Neurotrophic factors in systemic lupus erythematosus: markers of disease activity.

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Locomotor System, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

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Soluble ST2 is increased in systemic lupus erythematous and is a potential marker of lupus nephritis.

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, Belgium.

Objectives: To investigate the role of the interleukin IL-33/ST2 axis in systemic lupus erythematosus (SLE).

Methods: Serum concentrations of IL-33 and sST2 were measured by sandwich ELISA in SLE patients (n=111) compared to sex- and age-matched healthy controls (n=36). The serum concentrations of IL-33 and sST2 were correlated with various clinical and biological parameters. Read More

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Reliable detection of subtypes of nailfold capillary haemorrhages in childhood-onset systemic lupus erythematosus.

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Internal Medicine, Ghent University, and Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.

Objectives: In systemic lupus erythematosus (SLE), it is necessary to obtain biomarkers that predict cardiovascular complications due to premature atherosclerosis, which is related to endothelial dysfunction. Nailfold capillary abnormalities might be a biomarker for endothelial dysfunction. In adults and children with SLE, nailfold capillary haemorrhages have shown to be significantly correlated with disease activity. Read More

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Osteopontin: another piece in the systemic lupus erythematosus immunopathology puzzle.

Clin Exp Rheumatol 2021 May 5. Epub 2021 May 5.

Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Guadalajara; UDG-CA-703, Inmunología y Reumatología, Guadalajara, and Hospital Civil de Guadalajara Dr Juan I. Menchaca, División de Medicina Interna, Servicio de Reumatología, CONACyT PNPC, Guadalajara, Mexico.

Osteopontin (OPN) is a phosphoglycoprotein involved in bone remodelling, wound healing, cell adhesion, tissue remodelling, and immune response that is distributed widely in normal adult tissues. OPN biological activity is regulated by thrombin and matrix metalloproteinases (MMPs) cleavage, where the full-length (OPN-FL) protein and the cleaved OPN-N are associated with autoimmune diseases such as systemic lupus erythematosus (SLE). OPN overexpression has been associated with a predisposition to SLE and bad prognosis since OPN could mediate a sustained polyclonal B cell activation that besides to intracellular OPN (iOPN) form, promote the T follicular helper (TFH) cells and enhance anti-nuclear antibody production. Read More

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Meant to B: B cells as a therapeutic target in systemic lupus erythematosus.

J Clin Invest 2021 Jun;131(12)

Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, New York, USA.

B cells have a prominent role in the pathogenesis of systemic lupus erythematosus (SLE). They are mediators of inflammation through the production of pathogenic antibodies that augment inflammation and cause direct tissue and cell damage. Multiple therapeutic agents targeting B cells have been successfully used in mouse models of SLE; however, these preclinical studies have led to approval of only one new agent to treat patients with SLE: belimumab, a monoclonal antibody targeting B cell-activating factor (BAFF). Read More

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Variants in BANK1 are associated with lupus nephritis of European ancestry.

Genes Immun 2021 Jun 14. Epub 2021 Jun 14.

Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

The genetic background of lupus nephritis (LN) has not been completely elucidated. We performed a case-only study of 2886 SLE patients, including 947 (33%) with LN. Renal biopsies were available from 396 patients. Read More

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The other connective tissue disease-associated interstitial lung diseases: Sjogren's syndrome, mixed connective tissue disease, and systemic lupus erythematosus.

Curr Opin Pulm Med 2021 Jun 14. Epub 2021 Jun 14.

Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA.

Purpose Of Review: We review the clinical manifestations of three less common connective tissue disease (CTD)-associated interstitial lung diseases (ILDs): Sjogren's syndrome (SjS), mixed CTD (MCTD), and systemic lupus erythematosus (SLE).

Recent Findings: SjS is classically associated with lymphocytic interstitial pneumonia and cystic lung disease, but the most common type of ILD in Sjogren's patients is nonspecific interstitial pneumonia. ILD is prevalent in MCTD and associated with worse survival. Read More

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Impact of a commercially available DOAC absorbent on two integrated procedures for lupus anticoagulant detection.

Thromb Res 2021 Jun 5;204:32-39. Epub 2021 Jun 5.

Ospedale Maggiore Cremona, Italy.

Background: Lupus anticoagulant (LA)-detection in anticoagulated patients is an unmet need, which becomes even more cogent with the introduction of direct oral anticoagulants (DOAC) that may lead to false-positive results.

Aims: We aimed to investigate the effect of a commercially available DOAC absorbent on residual drug concentrations, and on integrated procedures for LA-detection.

Methods: Blood from patients treated for atrial fibrillation with either dabigatran (n = 39), rivaroxaban (n = 55), apixaban (n = 47) or edoxaban (n = 47) were collected at peak and trough, and centralized for testing with two LA integrated procedures [i. Read More

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Depletion of Fractalkine ameliorates renal injury and Treg cell apoptosis via the p38MAPK pathway in lupus-prone mice.

Exp Cell Res 2021 Jun 11:112704. Epub 2021 Jun 11.

Department of Nephrology, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi Zhuang Autonomous Region, China. Electronic address:

Fractalkine (FKN) is a chemokine with several roles, including chemotaxis; adhesion; and immune damage, which also participates in cell inflammation and apoptosis and responds to the pathogenesis of autoimmune diseases. Given the involvement of regulatory T cells (Treg) cells in autoimmune diseases, this study investigated the regulatory mechanism of FKN in renal injury and Treg apoptosis via the p38 mitogen-activated protein kinase (p38MAPK) signaling pathway in lupus-prone mice. Lupus was induced in BALB/c female mice by injection of pristane, followed by isolation of CD4CD5 Treg cells from the spleen of lupus model mice. Read More

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A Review of COVID-19 Chilblains-like Lesions and Their Differential Diagnoses.

Adv Skin Wound Care 2021 Jul;34(7):348-354

General Purpose: To familiarize wound care practitioners with the differential diagnoses of chilblains-like lesions that could be associated with the complications of COVID-19.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After participating in this educational activity, the participant will:1. Read More

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Cholinergic anti-inflammatory pathway and connective tissue diseases.

Inflammopharmacology 2021 Jun 14. Epub 2021 Jun 14.

Immunology Research Center, Tabriz University of Medical Sciences, Golgasht St, Postcode: 5166614766, Tabriz, Iran.

Connective tissue diseases (CTDs) consist of an extensive range of heterogeneous medical conditions, which are caused by immune-mediated chronic inflammation and influences the various connective tissues of the body. They include rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, vasculitis, Sjögren's syndrome, Behcet's disease, and many other autoimmune CTDs. To date, several anti-inflammatory approaches have been developed to reduce the severity of inflammation or its subsequent organ manifestations. Read More

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Diffusion tensor imaging of renal cortex in lupus nephritis.

Jpn J Radiol 2021 Jun 14. Epub 2021 Jun 14.

Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura, 13551, Egypt.

Purpose: To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes.

Methods: Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Read More

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Current Status of the Evaluation and Management of Lupus Patients and Future Prospects.

Front Med (Lausanne) 2021 28;8:682544. Epub 2021 May 28.

Ampel BioSolutions and Re-Imagine Lupus Investigation, Treatment and Education Research Institute, Charlottesville, VA, United States.

The vastly diverse nature of systemic lupus erythematosus (SLE) poses great challenges to clinicians and patients, as well as to research and drug development efforts. Precise management of lupus patients would be advanced by the ability to identify specific abnormalities operative in individual patients at the time of encounter with the clinician. Advances in new technologies and bioinformatics have greatly improved the understanding of the pathophysiology of SLE. Read More

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Metformin Reverses Hashimoto's Thyroiditis by Regulating Key Immune Events.

Front Cell Dev Biol 2021 28;9:685522. Epub 2021 May 28.

Department of Endocrinology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Background: Hashimoto's thyroiditis (HT) is a common autoimmune disease characterized by high levels of thyroid peroxidase antibody (TPOAb) and thyroid globulin antibody (TgAb) as well as infiltration of lymphocytes in thyroid. In recent years, metformin has been proven to be effective in a variety of autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis.

Methods: This study systematically explored the therapeutic effect of metformin on HT and its underlying mechanism by comprehensively utilizing methods including animal model, cell culture and differentiation, mRNA sequencing and 16S rRNA sequencing. Read More

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An Interesting Presentation of Testosterone-Induced Arterial Thrombosis.

Cureus 2021 May 11;13(5):e14972. Epub 2021 May 11.

Internal Medicine, Oak Hill Hospital, Brooksville, USA.

Testosterone replacement therapy (TRT) is an industry on the rise in large part due to an increase in direct-to-customer advertising targeting middle-aged men with non-specific symptoms. The biggest problem with unnecessary prescribing is that testosterone therapy is not without side effects. One of the more common adverse effects is erythrocytosis with subsequent thrombosis. Read More

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Acquired White Oral Lesions with Specific Patterns: Oral Lichen Planus and Lupus Erythematosus.

Dermatol Pract Concept 2021 May 20;11(3):e2021074. Epub 2021 May 20.

Dermatology Clinic, Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Background: Diagnosis of oral white lesions might be challenging. These lesions represent a wide spectrum of diseases with different etiology and prognosis. Oral white lesions can be categorized into two major groups, congenital and acquired, according to their development, and in four subgroups: lesions which can be scraped off or not and lesions with special pattern or not. Read More

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Juvenile Systemic Lupus Erythematosus Presenting with Esophagitis and Severe Oral Mucositis.

Case Rep Rheumatol 2021 2;2021:5868655. Epub 2021 Jun 2.

Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Rheumatology, Chicago, IL, USA.

We present a case of a previously healthy adolescent female who developed severe oral mucositis and acute esophagitis as her presenting symptoms of juvenile systemic lupus erythematosus. Mucositis involving the lips is infrequently reported in systemic lupus erythematosus, and to our knowledge, this is the first reported case of acute, non-infectious esophagitis as a presenting symptom in a pediatric systemic lupus erythematosus patient. Read More

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Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis.

Front Immunol 2021 28;12:691559. Epub 2021 May 28.

Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China.

Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases. Compared with other IL-17 cytokine family members, IL-25 has relatively low sequence similarity to IL-17A and exhibits a distinct function from other IL-17 cytokines. Read More

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Autoantibody Discovery, Assay Development and Adoption: Death Valley, the Sea of Survival and Beyond.

Front Immunol 2021 27;12:679613. Epub 2021 May 27.

Research and Development, Inova Diagnostics, San Diego, CA, United States.

Dating to the discovery of the Lupus Erythematosus (LE) cell in 1948, there has been a dramatic growth in the discovery of unique autoantibodies and their cognate targets, all of which has led to the availability and use of autoantibody testing for a broad spectrum of autoimmune diseases. Most studies of the sensitivity, specificity, commutability, and harmonization of autoantibody testing have focused on widely available, commercially developed and agency-certified autoantibody kits. However, this is only a small part of the spectrum of autoantibody tests that are provided through laboratories world-wide. Read More

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Association of Circulating Vascular Endothelial Growth Factor Levels With Autoimmune Diseases: A Systematic Review and Meta-Analysis.

Front Immunol 2021 27;12:674343. Epub 2021 May 27.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: Autoimmune diseases (ADs) are characterized by immune-mediated tissue damage, in which angiogenesis is a prominent pathogenic mechanism. Vascular endothelial growth factor (VEGF), an angiogenesis modulator, is significantly elevated in several ADs including rheumatoid arthritis (RA), systemic sclerosis (SSc), and systemic lupus erythematosus (SLE). We determined whether circulating VEGF levels were associated with ADs based on pooled evidence. Read More

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Immune Response to  in Lupus Patients Is Associated With a Subset of Lupus-Associated Autoantibodies.

Front Immunol 2021 28;12:635072. Epub 2021 May 28.

Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Interactions between gut microbes and the immune system influence autoimmune disorders like systemic lupus erythematosus (SLE). Recently, , a gram-positive commensal gut bacterium, was implicated as a candidate pathobiont in SLE. The present study was undertaken to evaluate the influence of exposure on clinical parameters of SLE. Read More

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Nanoparticles Engineered as Artificial Antigen-Presenting Cells Induce Human CD4 and CD8 Tregs That Are Functional in Humanized Mice.

Front Immunol 2021 26;12:628059. Epub 2021 May 26.

Department of Medicine, University of California Los Angeles, Los Angeles, CA, United States.

Artificial antigen-presenting cells (aAPCs) are synthetic versions of naturally occurring antigen-presenting cells (APCs) that, similar to natural APCs, promote efficient T effector cell responses . This report describes a method to produce acellular tolerogenic aAPCs made of biodegradable poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) and encapsulating IL-2 and TGF-β for a paracrine release to T cells. We document that these aAPCs can induce both human CD4 and CD8 T cells to become FoxP3 T regulatory cells (Tregs). Read More

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Frequency and risk factors for hydroxychloroquine retinopathy among patients with systemic lupus erythematosus.

Egypt J Intern Med 2021 8;33(1):18. Epub 2021 Jun 8.

Department of Medicine Division of Rheumatology, Ain Shams University, Cairo, Egypt.

Background: Hydroxychloroquine (HCQ) is an antimalarial drug, recently used in COVID-19 treatment. Also it is considered over many years the cornerstone in treating systemic lupus erythematosus (SLE) in adults and children. The incidence of retinal affection and retinal toxicity from hydroxychloroquine is rare, but even after the HCQ is stopped, loss of vision may not be reversible and may continue to progress. Read More

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Correlation between irreversible organ damage and the quality of life of patients with systemic lupus erythematosus: The Kyoto Lupus Cohort survey.

Lupus 2021 Jun 14:9612033211025614. Epub 2021 Jun 14.

Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Objectives: It is important to clarify the relationship between irreversible organ damage and the quality of life (QOL) by considering the unique factors of patients with systemic lupus erythematosus (SLE). We aimed to clarify their correlation using SLE-specific QOL assessment tools. We also aimed to identify which type of organ damage is adversely correlated with the QOL. Read More

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An engineering perspective on the development and evolution of implantable cardiac monitors in free-living animals.

Philos Trans R Soc Lond B Biol Sci 2021 Aug 14;376(1830):20200217. Epub 2021 Jun 14.

Department of Surgery, University of Minnesota, B172 Mayo, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA.

The latest technologies associated with implantable physiological monitoring devices can record multiple channels of data (including: heart rates and rhythms, activity, temperature, impedance and posture), and coupled with powerful software applications, have provided novel insights into the physiology of animals in the wild. This perspective details past challenges and lessons learned from the uses and developments of implanted biologgers designed for human clinical application in our research on free-ranging American black bears (). In addition, we reference other research by colleagues and collaborators who have leveraged these devices in their work, including: brown bears (), grey wolves (), moose (), maned wolves () and southern elephant seals (). Read More

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