127,004 results match your criteria lung tissues

Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters.

Clin Infect Dis 2021 Sep 18. Epub 2021 Sep 18.

State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

Background: The effect of low environmental temperature on viral shedding and disease severity of COVID-19 is uncertain.

Methods: We investigated the virological, clinical, pathological, and immunological changes in hamsters housed at room (21 oC), low (12-15 oC), and high (30-33 oC) temperature after challenge by 10 5 plaque-forming units of SARS-CoV-2.

Results: The nasal turbinate, trachea, and lung viral load and live virus titre were significantly higher (~0. Read More

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September 2021

Immunotherapy and Prevention of Cancer by Nanovaccines Loaded with Whole-Cell Components of Tumor Tissues or Cells.

Adv Mater 2021 Sep 18:e2104849. Epub 2021 Sep 18.

Department of Pharmaceutics, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, P. R. China.

Tumor tissues/cells are the best sources of antigens to prepare cancer vaccines. However, due to the difficulty of solubilization and delivery of water-insoluble antigens in tumor tissues/cells, including water-insoluble antigens into cancer vaccines and delivering such vaccines efficiently to antigen-presenting cells (APCs) remain challenging. To solve these problems, herein, water-insoluble components of tumor tissues/cells are solubilized by 8 m urea and thus whole components of macrometer-sized tumor cells are reasssembled into nanosized nanovaccines. Read More

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September 2021

Accurate diagnosis of lung tissues for 2D Raman spectrogram by deep learning based on short-time Fourier transform.

Anal Chim Acta 2021 Sep 2;1179:338821. Epub 2021 Jul 2.

State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China.

Multivariate statistical analysis methods have an important role in spectrochemical analyses to rapidly identify and diagnose cancer and the subtype. However, utilizing these methods to analyze lager amount spectral data is challenging, and poses a major bottleneck toward achieving high accuracy. Here, a new convolutional neural networks (CNN) method based on short-time Fourier transform (STFT) to diagnose lung tissues via Raman spectra readily is proposed. Read More

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September 2021

Heterotopic Ossifications after Fractures of the Anterior Pelvic Segment: Overview of Morphology and Clinical Correlations.

Acta Chir Orthop Traumatol Cech 2021 ;88(4):253-259

Centre for Integrated Studies of the Pelvis, Third Faculty of Medicine, Charles University, Prague.

PURPOSE OF THE STUDY In certain patients after treated pelvic fractures, heterotopic ossifications can be observed in the area of the pubic bone, which protrude ventrally, and often also laterally and distally into surrounding soft tissues of the groin or even medially into the proximal thigh. These ossifications are shaped like sharp spikes of various lengths, which is why the authors refer to them as "spicules". In some patients, these ossifications are also associated with pain. Read More

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January 2021

, negatively regulated by miR-128-3p, promotes the progression of non-small-cell lung cancer.

Per Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Thoracic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, 201308, China.

To investigate the effects of SKA3 on cell proliferation and metastasis in non-small-cell lung cancer (NSCLC) and its underlying mechanism. Immunohistochemistry was employed to analyze the expression of SKA3 in NSCLC. CCK-8 assay, EdU assay, Transwell assay and flow cytometry analysis were employed to assess cell proliferation, metastatic potential and apoptosis , respectively. Read More

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September 2021

Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of Mice.

J Am Heart Assoc 2021 Sep 17:e020441. Epub 2021 Sep 17.

Vascular Biology Section Evans Department of Medicine Whitaker Cardiovascular InstituteBoston University School of Medicine Boston MA.

Background Persistent activation of endoplasmic reticulum stress and the unfolded protein response (UPR) induces vascular cell apoptosis, contributing to atherogenesis. Aging and hypercholesterolemia are 2 independent proatherogenic factors. How they affect vascular UPR signaling remains unclear. Read More

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September 2021

miRNA-218/FANCI is associated with metastasis and poor prognosis in lung adenocarcinoma: a bioinformatics analysis.

Ann Transl Med 2021 Aug;9(16):1298

Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: In this study, tumor microarray analysis was used to screen the key messenger RNAs (mRNAs) and microRNAs related to the progression of lung adenocarcinoma (LUAD), in order to provide a theoretical basis for early diagnosis, therapeutic targets, and prognosis evaluation of patients with LUAD.

Methods: The mRNA and miRNA expression datasets came from the Gene Expression Omnibus (GEO) project database. Differentially expressed genes (DEGs) and microRNAs (DEMs) between LUAD tissues and adjacent lung tissue were obtained using GEO2R. Read More

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Downregulation of LINC00115 inhibits the proliferation and invasion of lung cancer cells and .

Ann Transl Med 2021 Aug;9(15):1256

Department of Medical Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: Lung cancer is a common malignant tumor in clinical practice. Its morbidity and mortality rank first among malignant tumors. However, the pathogenesis of lung cancer has not been fully clarified. Read More

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Circular RNA _0015278 inhibits the progression of non-small cell lung cancer through regulating the microRNA 1278/SOCS6 gene axis.

Ann Transl Med 2021 Aug;9(15):1255

Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, China.

Background: Non-small cell lung cancer (NSCLC) is one of the most lethal malignancies worldwide. Deepening understanding of the pathogenesis of NSCLC is quite important for its treatment. Circular (circ) RNA_0015278 has been found to be downregulated in NSCLC, but its role in NSCLC and the underlying regulatory mechanism is unknown. Read More

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BTLA-HVEM Couple in Health and Diseases: Insights for Immunotherapy in Lung Cancer.

Front Oncol 2021 31;11:682007. Epub 2021 Aug 31.

Cancer Research Center in Marseille (CRCM), INSERM U1068, CNRS U7258, Aix Marseille University (AMU), Paoli Calmette Institute (IPC), Marseille, France.

Lung cancer is the leading cause of cancer deaths worldwide. Immunotherapies (IT) have been rapidly approved for lung cancer treatment after the spectacular results in melanoma. Responses to the currently used checkpoint inhibitors are strikingly good especially in metastatic diseases. Read More

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Synergistic effects of arsenic trioxide combined with in treating the advanced hepatocellular carcinoma in rat models.

J Gastrointest Oncol 2021 Aug;12(4):1732-1742

Department of Interventional Radiology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: To evaluate the safety and efficacy of arsenic trioxide (ATO) combined with VNP20009 in treating the advanced hepatocellular carcinoma (HCC).

Methods: The proliferation assay, migration assay and real-time PCR analyses were performed to assess the impact of ATO combined with VNP20009 on the McA-RH7777 cells. Forty Buffalo rats were orthotopically implanted with HCC in the livers and randomly divided into four groups: (A) ATO plus VNP20009; (B) ATO; (C) VNP20009; and (D) control. Read More

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Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.

Front Immunol 2021 31;12:721030. Epub 2021 Aug 31.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Poly (ADP-ribose) polymerases-1 (PARP1) alterations are associated with PARP1 inhibitor resistance, regulating the function of Treg cells and PDL1 expression in tumor cells, and high PARP1 expression is significantly associated with aggressive behavior and chemotherapeutic resistance in several tumors. However, a comprehensive analysis of the predictive values of PARP1 alteration for immune checkpoint inhibitor (ICI) effectiveness in tumors remains unclear, and the associations between its expression and immunotherapy signatures also needs to be explored further.

Methods: We performed some analyses with the cBioPortal online database (https://www. Read More

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CircPTCH1 Promotes Migration in Lung Cancer by Regulating MYCN Expression Through miR-34c-5p.

Onco Targets Ther 2021 10;14:4779-4789. Epub 2021 Sep 10.

Pulmonology and Critical Care Medicine Department, The Third Xiangya Hospital of Central South University, Changsha, 410013, People's Republic of China.

Background: The incidence rate and mortality rate of lung cancer are the highest in the world. Therefore, further studies are needed to reveal the molecular mechanism of lung cancer progression and development. Previous study demonstrated that the deregulation of circRNAs can regulate cell biological functions in tumorigenesis and development. Read More

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September 2021

Analysis of the Electrophoretic Profiles of Prion Protein in Carcinous and Pericarcinous Lysates of Six Different Types of Cancers.

Biomed Environ Sci 2021 Sep;34(9):683-692

State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;Center for Global Public Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China;Wuhan Institute of Virology, Chinese Academy of Science, Wuhan 430071, Hubei China;China Academy of Chinese Medical Sciences, Beijing 100700, China.

Objective: To find the different electrophoretic profiles of prion protein in carcinous and individual pericarcinous tissues in lysates of gastric, colon, liver, lung, thyroid, and laryngeal cancers.

Methods: Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot were used to test the amounts and electrophoretic patterns of total PrP and the tolerance of PK (protease K) digestion among six various cancer tissue types.

Results: A mass of PrP signals with a large molecular weight were identified in the homogenates of peripheral tissues. Read More

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September 2021

Ultra- and micro-structural changes of respiratory tracts in SARS-CoV-2 infected Syrian hamsters.

Vet Res 2021 Sep 16;52(1):121. Epub 2021 Sep 16.

Laboratory of Veterinary Pathology, College of Veterinary Medicine, Jeonbuk National University, Iksan, 54596, South Korea.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a global crisis. It is still unresolved. Although many therapies and vaccines are being studied, they are still in their infancy. Read More

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September 2021

MicroRNA-214 promotes alveolarization in neonatal rat models of bronchopulmonary dysplasia via the PlGF-dependent STAT3 pathway.

Mol Med 2021 Sep 16;27(1):109. Epub 2021 Sep 16.

Department of Neonatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, No. 261, Huansha Road, Hangzhou, 310000, Zhejiang Province, People's Republic of China.

Background: Recently, the role of several microRNAs (miRNAs or miRs) in pulmonary diseases has been described. The molecular mechanisms by which miR-214 is possibly implicated in bronchopulmonary dysplasia (BPD) have not yet been addressed. Hence, this study aimed to investigate a putative role of miR-214 in alveolarization among preterm neonates with BPD. Read More

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September 2021

[CacyBP promotes the proliferation and invasion of non-small cell lung cancer].

Zhonghua Zhong Liu Za Zhi 2021 Sep;43(9):924-931

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the effects and the mechanism of Calcyclin-binding protein (CacyBP) on the proliferation and invasion of non-small cell lung cancer (NSCLC) cells. Six lung cancer tissues and paired normal lung tissues were collected from NSCLC patients who underwent surgical treatment in Jinan Central Hospital during 2016. The expression of CacyBP in these tissues was examined by western blot. Read More

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September 2021

Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.

Int Immunopharmacol 2021 Sep 13;100:108106. Epub 2021 Sep 13.

Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Chinese Medicine, China. Electronic address:

Background: NOD-like receptor protein 3 (NLRP3) inflammasome activation has emerged as a crucial contributor to sepsis-induced lung injury. Geranylgeranyl diphosphate synthase 1 (GGPPS1) reportedly exerts the pro-inflammatory capability via activation of NLRP3 inflammasome. However, little is known about the role and mechanism of GGPPS1 in sepsis-induced lung injury. Read More

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September 2021

Hsa_circ_0001947/miR-661/DOK7 axis restrains non-small cell lung cancer development.

J Microbiol Biotechnol 2021 Sep 11;31(1). Epub 2021 Sep 11.

Pharmaceutical Preparation Section, Sanmen People's Hospital, 15 Taihe Road, Hairun Street, Sanmen County, Zhejiang Province, China.

Hsa_circ_0001947 is associated with multiple cancers, but its function in non-small cell lung cancer (NSCLC) is ambiguous and needs further research. The targeting relationship among circ_0001947, miR-661, and downstream of tyrosine kinase 7 (DOK7) was predicted by database and further verified by dual-luciferase reporter assay, while their expressions in cancer tissues and cells were detected by quantitative real-time polymerase chain reaction (qRT-PCR). After transfection, cell biological behaviors and expressions of miRNAs, miR-661 and DOK7 were determined by cell function experiments and qRT-PCR, respectively. Read More

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September 2021

Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells.

Elife 2021 09 16;10. Epub 2021 Sep 16.

John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, United States.

Multicellular organisms maintain structure and function of tissues/organs through emergent, self-organizing behavior. In this report, we demonstrate a critical role for lung mesenchymal stromal cell (L-MSC) aging in determining the capacity to form three-dimensional organoids or 'alveolospheres' with type 2 alveolar epithelial cells (AEC2s). In contrast to L-MSCs from aged mice, young L-MSCs support the efficient formation of alveolospheres when co-cultured with young or aged AEC2s. Read More

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September 2021

CARes-UNet: Content-Aware residual UNet for lesion segmentation of COVID-19 from chest CT images.

Med Phys 2021 Sep 15. Epub 2021 Sep 15.

Artificial Intelligence Medical Center, School of Intelligent Systems Engineering, Sun Yat-sen University, Shenzhen, 510275, China.

Purpose: Coronavirus Disease 2019 (COVID-19) has caused a serious global health crisis. It has been proven that the deep learning method has great potential to assist doctors in diagnosing COVID-19 by automatically segmenting the lesions in computed tomography (CT) slices. However, there are still several challenges restricting the application of these methods, including high variation in lesion characteristics and low-contrast between lesion areas and healthy tissues. Read More

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September 2021

The Oncogenic Role of APC/C Activator Protein Cdc20 by an Integrated Pan-Cancer Analysis in Human Tumors.

Front Oncol 2021 30;11:721797. Epub 2021 Aug 30.

Department of Urology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, China.

The landscape of gene expression and its biological impacts across different types of cancers remains largely unknown. Here, a pan-cancer analysis was performed to analyze the role of Cdc20 in various human cancers. Our results indicated that the expression levels of the gene were significantly elevated in bladder cancer, breast cancer, colon cancer, rectum cancer, stomach cancer, esophageal cancer, head and neck cancer, kidney cancer, liver cancer, lung cancer, prostate cancer, pancreatic cancer, and uterine cancer. Read More

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Validating Expression and Its Prognostic Significance in Lung Adenocarcinoma Based on Data Mining and Bioinformatics Methods.

Front Oncol 2021 30;11:720302. Epub 2021 Aug 30.

Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Hyaluronic acid-mediated motility receptor (), a tumor-related gene, plays a vital role in the occurrence and progression of various cancers. This research is aimed to reveal the effect of in lung adenocarcinoma (LUAD). We first obtained the gene expression profiles and clinical data of patients with LUAD from The Cancer Genome Atlas (TCGA) database. Read More

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An evolving role for endobronchial ultrasonography in the intensive care unit.

J Thorac Dis 2021 Aug;13(8):5183-5194

Section of Interventional Pulmonology, Pulmonary Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Endobronchial ultrasound (EBUS) bronchoscopy is an established minimally-invasive modality for visualization, characterization, and guidance of sampling of paratracheal and parabronchial structures and tissues. In the intensive care unit (ICU), rapidly obtaining an accurate diagnosis is paramount to the management of critically ill patients. In some instances, diagnosing and confirming terminal illness in a critically ill patient provides needed closure for patients and their loved ones. Read More

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Radical minimally invasive esophagectomy for esophageal cancer via transcervical and transhiatal approaches: a narrative review.

J Thorac Dis 2021 Aug;13(8):5104-5110

Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.

Objective: Minimally invasive esophagectomy (MIE) has been widely applied for the treatment of esophageal carcinoma. It is much less invasive, as it avoids employing a transthoracic procedure.

Background: MIE via transcervical and transhiatal approaches has been adopted in our center. Read More

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Screening and evaluation of the role of immune genes of brain metastasis in lung adenocarcinoma progression based on the TCGA and GEO databases.

J Thorac Dis 2021 Aug;13(8):5016-5034

Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Background: Brain metastasis was one of the factors leading to the poor long-term prognosis of patients with lung adenocarcinoma (LUAD).

Methods: The expression levels of immune genes in LUAD and LUAD brain metastases tissues were analyzed in GSE161116 dataset using the GEO2R, and the levels of differential immune genes in normal lung and LUAD tissues were verified. The biological functions and signaling mechanisms of the differential immune genes were explored via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis. Read More

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CHMP4C regulates lung squamous carcinogenesis and progression through cell cycle pathway.

J Thorac Dis 2021 Aug;13(8):4762-4774

The Qiqihar Medical College Department of Biochemistry, Qiqihar, China.

Background: Lung cancer is a common kind of human malignancies. Lung squamous cell carcinoma (LUSC) is a key subtype of lung cancer. Cell cycle plays an important role in the development and occurrence of LUSC, however, there is still a lack of cell cycle-related genes in LUSC diagnosis and prediction of prognosis. Read More

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Small cell carcinoma of the brain without apparent extracranial origin in the same intracranial region one year following resection of malignant glioma.

Int J Clin Exp Pathol 2021 15;14(8):875-880. Epub 2021 Aug 15.

National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences Beijing 100190, P. R. China.

Primary small cell carcinoma (SCC) of the brain is rare, and there have been no reports of small cell carcinoma located at the resection site of a glioma without extracranial tumours. Herein, we report a case of brain SCC in the same intracranial region from which a malignant glioma had been surgically resected a year prior. The patient, a 68-year-old male, had headaches as a symptom, and brain CT and MRI revealed a hyperdense region measuring 5. Read More

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Respiratory Microbiota Profiles Associated With the Progression From Airway Inflammation to Remodeling in Mice With OVA-Induced Asthma.

Front Microbiol 2021 30;12:723152. Epub 2021 Aug 30.

Department of Endocrine, Genetics and Metabolism, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: The dysbiosis of respiratory microbiota plays an important role in asthma development. However, there is limited information on the changes in the respiratory microbiota and how these affect the host during the progression from acute allergic inflammation to airway remodeling in asthma.

Objective: An ovalbumin (OVA)-induced mouse model of chronic asthma was established to explore the dynamic changes in the respiratory microbiota in the different stages of asthma and their association with chronic asthma progression. Read More

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Mapping of truncated O-glycans in cancers of epithelial and non-epithelial origin.

Br J Cancer 2021 Sep 15. Epub 2021 Sep 15.

Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen N, Denmark.

Background: Novel immunotherapies targeting cancer-associated truncated O-glycans Tn (GalNAcα-Ser/Thr) and STn (Neu5Acα2-6GalNacα-Ser/Thr) are promising strategies for cancer treatment. However, no comprehensive, antibody-based mapping of truncated O-glycans in tumours exist to guide drug development.

Methods: We used monoclonal antibodies to map the expression of truncated O-glycans in >700 tissue cores representing healthy and tumour tissues originating from breast, colon, lung, pancreas, skin, CNS and mesenchymal tissue. Read More

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September 2021