2,586 results match your criteria lung sod

Lecithinized superoxide dismutase in the past and in the present: Any role in the actual pandemia of COVID-19?

Biomed Pharmacother 2021 Jul 14;141:111922. Epub 2021 Jul 14.

Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and 6 Human Oncology, "Aldo Moro" University of Bari, Policlinico Hospital-Piazza Giulio Cesare n. 11, 70124 Bari, Italy.

The Coronavirus disease 19 (Covid-19) pandemic is devastating the public health: it is urgent to find a viable therapy to reduce the multiorgan damage of the disease. A validated therapeutic protocol is still missing. The most severe forms of the disease are related to an exaggerated inflammatory response. Read More

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Rheumatology (Oxford) 2021 Jul 28. Epub 2021 Jul 28.

Department of Experimental and Clinical Medicine, University of Florence, and Infectious and TropicalDiseases Unit, AOUC, Florence, Italy.

Objective: To identify the main computed tomography (CT) features that may help distinguishing a progression of interstitial lung disease (ILD) secondary to Systemic sclerosis (SSc) from COVID-19 pneumonia.

Methods: This multicentric study included 22 international readers divided in the radiologist group (RAD) and non-radiologist group (nRAD). A total of 99 patients, 52 with COVID-19 and 47 with SSc-ILD, were included in the study. Read More

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Drug Metab Dispos 2021 Jul 26. Epub 2021 Jul 26.

Center for Developmental Pharmacol & Toxicol, Shenyang Pharmaceutical University, China

Icotinib (ICT) is an anti-tumor drug approved by China National Medical Products Administration and is found to be effective to conquer non-small cell lung cancer. The present study aimed at the interaction of ICT with CYP3A. ICT exhibited time-, concentration- and NADPH-dependent inhibitory effect on recombinant human CYP3A4/5 (rhCYP3A4/5). Read More

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[2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside alleviates lipopolysaccharide-induced acute lung injury in rats].

J Chen H Liu

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1101-1106

Department of General Practice, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510030, China.

Objective: To observe the protective effect of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats and explore the underlying mechanism.

Methods: Thirty-six SD rats were randomized equally into 4 groups: the normal control group, ALI model group, and low- and high-dose TSG groups (treated with 50 and 100 mg/kg TSG via intragastric administration, respectively). In all but the normal control group, the rats were subjected to tail vein injection of LPS to induced ALI. Read More

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Isolation, purification, and characterization of antioxidant peptides from fresh mare's milk.

Food Sci Nutr 2021 Jul 11;9(7):4018-4027. Epub 2021 May 11.

Department of Pharmaceutics and Physical Chemistry College of Pharmacy, Xinjiang Medical University Urumqi China.

In this study, the whey protein of fresh mare's milk was used as raw material. The antioxidant peptide liquid XMNDT was extracted from fresh mare's milk solution and purified. The peptide had a molecular weight of 1594. Read More

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Polysaccharide from Potentilla anserina L ameliorate pulmonary edema induced by hypobaric hypoxia in rats.

Biomed Pharmacother 2021 Jul 7;139:111669. Epub 2021 May 7.

College of Life Science, Northwest Normal University, Lanzhou 730070, China; Institute of New Rural Development, Northwest Normal University, Lanzhou 730070, China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Lanzhou 730070, China. Electronic address:

High-altitude pulmonary edema (HAPE) is a life-threatening disease occurs in hypobaric hypoxia (HH) environment, which could be treated by Dexamethasone, but might cause side-effects. Potentilla anserina L polysaccharide (PAP) holds promising physiological and pharmacological properties which could be beneficial for HAPE treatment. In our study, the anti-hypoxia effect of PAP was firstly investigated through anti-normobaric hypoxia test and anti-acute hypoxia test. Read More

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Rapamycin inhibits LOC102553434-mediated pyroptosis to improve lung injury induced by limb ischemia-reperfusion.

3 Biotech 2021 Jul 16;11(7):335. Epub 2021 Jun 16.

Department of Anesthesiology, Jiangxi, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006 People's Republic of China.

Limb ischemia reperfusion (I/R) triggers local or systemic injury, and whether the process is mediated by pyroptosis remains unclear, we aimed to explore whether pyroptosis was involved in the process of rapamycin alleviating lung injury induced by I/R and investigate the molecular mechanisms. The histopathology of lung injury induced by I/R was confirmed by hematoxylin-eosin (HE) staining, and malondialdehyde (MDA), superoxide dismutase (SOD), and the expression of pyroptosis related molecules were detected. RNA sequencing was used to mine key long non-coding RNAs (lncRNAs). Read More

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Mitochondrial-Targeting Antioxidant SS-31 Suppresses Airway Inflammation and Oxidative Stress Induced by Cigarette Smoke.

Oxid Med Cell Longev 2021 15;2021:6644238. Epub 2021 Jun 15.

Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.

This study investigated whether the mitochondrial-targeted peptide SS-31 can protect against cigarette smoke- (CS-) induced airway inflammation and oxidative stress and . Mice were exposed to CS for 4 weeks to establish a CS-induced airway inflammation model, and those in the experimental group were pretreated with SS-31 1 h before CS exposure. Pathologic changes and oxidative stress in lung tissue, inflammatory cell counts, and proinflammatory cytokine levels in bronchoalveolar lavage fluid (BALF) were examined. Read More

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Diallyl disulfide prevents cigarette smoke-induced emphysema in mice.

Pulm Pharmacol Ther 2021 Jul 5;69:102053. Epub 2021 Jul 5.

Instituto de Ciências Biomédicas, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil.

Introduction: Cigarette smoke (CS) is the main risk factor for the development of chronic obstructive pulmonary disease (COPD) and pulmonary emphysema. The use of antioxidants has emerged as a potential therapeutic strategy to treat airway inflammation and lung diseases. In the current study, we investigated the potential therapeutic impact of diallyl disulfide (Dads) treatment in a murine model of CS-induced emphysema. Read More

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Baicalin Magnesium Salt Attenuates Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting of TLR4/NF-B Signaling Pathway.

J Immunol Res 2021 8;2021:6629531. Epub 2021 Jun 8.

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.

Baicalin (BA) magnesium salt (BA-Mg) is a good water-soluble ingredient extracted from , a commonly used traditional Chinese medicine. This study is aimed at investigating whether BA-Mg could exert a better protective effect on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice and illuminate the underlying mechanisms in vivo and in vitro. Mice were intraperitoneally administrated with equimolar BA-Mg, BA, and MgSO before LPS inducing ALI. Read More

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β-caryophyllene ameliorated obesity-associated airway hyperresponsiveness through some non-conventional targets.

Phytomedicine 2021 May 25;89:153610. Epub 2021 May 25.

Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur, 784001, India. Electronic address:

Background: Obesity worsens airway hyperresponsiveness (AHR) in asthmatic subjects by up-regulating macrophage polarization that leads to excessive secretion of pro-inflammatory adipokines from white adipose tissue followed by generation of oxidative stress in the respiratory system. Treatment through conventional signaling pathways proved to be inadequate in obese asthmatics, so a therapeutical approach through a non-conventional pathway may prove to be effective.

Purpose: This study aimed to investigate the efficacy of a FDA-approved food additive, β-caryophyllene (BCP) in obesity-associated AHR. Read More

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Catalase, a therapeutic target in the reversal of estrogen-mediated aging.

Mol Ther 2021 Jun 23. Epub 2021 Jun 23.

DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, 33136; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep, University of Arizona College of Medicine, Phoenix, AZ, 85004. Electronic address:

Despite increasing interest in the reversal of age-related processes, there is a paucity of data regarding the effects of post-menopausal associated estrogen loss on cellular function. We studied human adipose derived-mesenchymal stem cell (hASCs) isolated from women under 45 years old (pre-menopause, pre-hASC) or older than 55 years old (post-menopause, post-hASC). In this study, we provide proof of concept that the age-related ineffective functionality of ASCs can be reversed to improve their ability in promoting tissue repair. Read More

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Mesna ameliorates acute lung injury induced by intestinal ischemia-reperfusion in rats.

Sci Rep 2021 Jun 25;11(1):13356. Epub 2021 Jun 25.

Department of Medical Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, 44519, Asharquia, Egypt.

The lung is severely affected by intestinal ischemia-reperfusion (I-R) injury. Mesna, a thiol compound, possess anti-inflammatory and antioxidant properties. We aimed in the present work to explore the potential beneficial effects of Mesna on the acute lung damage mediated by intestinal I-R in a rat model. Read More

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Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties.

J Pharm Pharmacol 2021 Jun 23. Epub 2021 Jun 23.

Faculty of Pharmacy, Department of Biochemistry, Ataturk University, Erzurum, Turkey.

Objectives: We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly and histopathologically.

Methods: A total of 40 rats were divided into 5 groups with 8 animals in each group. Group 1 (SHAM), control group; Group 2 (CLP), cecal ligation and puncture; Group 3 (CLP + APRE10), rats were administered CLP + 10 mg/kg aprepitant; Group 4 (CLP + APRE20), rats were administered CLP + 20 mg/kg aprepitant; and Group 5 (CLP + APRE40), rats were administered CLP + 40 mg/kg aprepitant. Read More

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Edaravone attenuates smoke inhalation injury in rats by the Notch pathway.

Am J Transl Res 2021 15;13(5):4712-4718. Epub 2021 May 15.

Department of Burn and Plastic Surgery, Affiliated Hospital of Chengde Medical University Chengde 067000, Hebei Province, China.

Objective: To explore the protective effect of inhaled edaravone (EDA) on inflammation, oxidative stress (OS), and pulmonary function (PF) in rats after smoke inhalation injury (SII), as well as its mechanisms.

Methods: Twenty-four rats were designated as group A (model group), group B (EBA prevention group), group C (low-dose group) and group D (high-dose group) (n=6 for each group). SII models were induced in all groups. Read More

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Non-clinical safety profile and pharmacodynamics of two formulations of the anti-sepsis drug candidate Rejuveinix (RJX).

Biomed Pharmacother 2021 Jun 17;141:111823. Epub 2021 Jun 17.

Department of Animal Nutrition, Faculty of Veterinary, Firat University, Elazig 23119, Turkey. Electronic address:

Here, we demonstrate that the two distinct formulations of our anti-sepsis drug candidate Rejuveinix (RJX), have a very favorable safety profile in Wistar Albino rats at dose levels comparable to the projected clinical dose levels. 14-day treatment with RJX-P (RJX PPP.18. Read More

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PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice.

Ecotoxicol Environ Saf 2021 Sep 17;221:112433. Epub 2021 Jun 17.

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address:

Fine particulate matter (PM2.5) is one of the most important components of environmental pollutants and is associated with lung injury. Pyroptosis, a form of programmed cell death mainly mediated by the NLRP3 inflammasome, has been reported to be involved in sepsis-induced or ischemia/reperfusion-induced lung injury. Read More

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September 2021

circSNX6 (hsa_circ_0031608) enhances drug resistance of non-small cell lung cancer (NSCLC) via miR-137.

Biochem Biophys Res Commun 2021 Aug 16;567:79-85. Epub 2021 Jun 16.

Department of Cardiothoracic Surgery, The Affiliated Hospital of Jiangnan University, Wuxi, China. Electronic address:

circRNAs have been suggested to modulate NSCLC tumorigenesis and drug resistance. Whether circSNX6 affects NSCLC remains unclear. In this study, we aim to investigate the role of circSNX6 in drug resistance of NSCLC exposed to cisplatin. Read More

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Mesenchymal Stromal Cells From Emphysematous Donors and Their Extracellular Vesicles Are Unable to Reverse Cardiorespiratory Dysfunction in Experimental Severe Emphysema.

Front Cell Dev Biol 2021 31;9:661385. Epub 2021 May 31.

Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Although bone marrow-derived mesenchymal stromal cells (BM-MSCs) from patients with chronic obstructive pulmonary disease (COPD) appear to be phenotypically and functionally similar to BM-MSCs from healthy sources , the impact of COPD on MSC metabolism and mitochondrial function has not been evaluated. In this study, we aimed to comparatively characterize MSCs from healthy and emphysematous donors (H-MSCs and E-MSCs) and to assess the therapeutic potential of these MSCs and their extracellular vesicles (H-EVs and E-EVs) in an model of severe emphysema. For this purpose, C57BL/6 mice received intratracheal porcine pancreatic elastase once weekly for 4 weeks to induce emphysema; control animals received saline under the same protocol. Read More

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Mechanism of Yifei Decoction Combined with MitoQ on Inhibition of TGF1/NOX4 and PDGF/ROCK Signal Pathway in Idiopathic Pulmonary Fibrosis.

Evid Based Complement Alternat Med 2021 28;2021:6615615. Epub 2021 May 28.

Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunmin, Yunnan 650000, China.

Background: Rho-related coiled helix forming protein kinase (Rho-ROCK) and another important fibrogenic factor-PDGF play a critical role in collagen deposition in rat lung tissue. Yifei decoction (YFT), a Chinese herbal decoction, has been used to treat idiopathic pulmonary fibrosis (IPF) in clinical practice and has produced positive outcomes; however, convincing evidence is currently lacking. The present study aimed to investigate the effects of YFT combined with MitoQ in rats with IPF and to explore the underlying mechanism. Read More

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Endogenous Hydrogen Sulfide Is an Important Factor in Maintaining Arterial Oxygen Saturation.

Front Pharmacol 2021 31;12:677110. Epub 2021 May 31.

National Clinical Research Center for Geriatric Disorders and Research Center for Molecular Metabolomics, Xiangya Hospital, Central South University, Changsha, China.

The gasotransmitter HS is involved in various physiological and pathophysiological processes. The aim of this study was to investigate the physiological functions of HS in the lungs. In the model of mouse with genetic deficiency in a HS natural synthesis enzyme cystathionine--lyase (CSE), we found that arterial oxygen saturation (SaO) was decreased compared with wild type mice. Read More

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[Luteolin has a significant protective effect against cadmium-induced injury in lung epithelial Beas-2B cells].

Nan Fang Yi Ke Da Xue Xue Bao 2021 May;41(5):729-735

School of Public Health, Bengbu Medical College, Bengbu 233000, China.

Objective: To investigate the protective effect of luteolin against cadmium (Cd)-induced injury in human lung epithelial Beas-2B cells.

Objective: Beas-2B cells were treated with different concentrations of luteolin (0-160 μmol/L) or Cd (0-40 μmol/L) for 24 h, and the cell viability was examined using MTT assay. After treatment with luteolin (0. Read More

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[Betelnut polyphenols provide protection against high-altitude hypoxia in rats].

Nan Fang Yi Ke Da Xue Xue Bao 2021 May;41(5):671-678

School of Pharmacy, Lanzhou University, Lanzhou 730000, China.

Objective: To investigate the protective effects of betelnut polyphenols on the vital organs against high-altitude hypoxia in rats.

Objective: We compared low-, medium-, and high- dose betelnut polyphenols (400, 800, and 1600 mg/kg, respectively) and rhodiola the effects of against high-altitude hypoxia in Wistar rats. The rats were kept in normal condition and given the drugs daily for 3 days before transfer to a facility at the altitude of 4010 m, where the rats were kept for 5 consecutive days for hypoxic exposure. Read More

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[Effect of electroacupuncture at Neiguan (PC 6) on pulmonary function during one-lung ventilation in patients with lobectomy].

Zhongguo Zhen Jiu 2021 Jun;41(6):598-602

Department of Anesthesiology, First Affiliated Hospital of Guangxi University of CM, Nanning 530023, China.

Objective: To observe the protective effect of electroacupuncture (EA) at Neiguan (PC 6) on pulmonary function during one-lung ventilation (OLV) in patients with lobectomy, and explore its action mechanism.

Methods: Sixty patients with lobectomy were randomly divided into an observation group and a control group, 30 cases in each one. The patients in the control group were treated with general anesthesia, and OLV was given when surgery began; when the surgery finished, air was removed from the thoracic cavity and two-lung ventilation was performed. Read More

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Protective Effects of Thymoquinone, an Active Compound of , on Rats with -Induced Lung Injury through Regulation of Oxidative Stress and Inflammation.

Molecules 2021 May 27;26(11). Epub 2021 May 27.

Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.

Benzopyrene [B(a)P] is a well-recognized environmental carcinogen, which promotes oxidative stress, inflammation, and other metabolic complications. In the current study, the therapeutic effects of thymoquinone (TQ) against B(a)P-induced lung injury in experimental rats were examined. B(a)P used at 50 mg/kg b. Read More

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Protective effects of sulfated polysaccharides from Lentinula edodes on the lung and liver of MODS mice.

Food Funct 2021 Jul 31;12(14):6389-6402. Epub 2021 May 31.

College of Life Science, Shandong Agricultural University, Taian 271018, PR China. :

In this work, the effects of sulfated polysaccharides from Lentinula edodes (SPLE) on zymosan (ZYM)-induced multiple organ dysfunction syndrome (MODS) mice were investigated. Using the MODS mice model, biochemical works have already shown that in mice treated with SPLE, the lung parameters of GGT, C3 and hs-CRP were down-regulated and the hepatic parameters of TC, TG, ALT and AST, HDLC, LDL-C and VLDL-C were improved, the serum levels of CK, Cr and Amy were decreased, and the levels of inflammatory factors such as TNF-α, IL-1β, IL-6 and IL-10 were also reduced, the activity of antioxidant enzymes SOD and CAT enhanced, and the content of MDA was reduced. In addition, histopathology of the lung and liver confirmed the beneficial effects of SPLE on MODS mice, indicating that SPLE played a role in protecting the organ function of MODS mice. Read More

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Etomidate attenuates hyperoxia-induced acute lung injury in mice by modulating the Nrf2/HO-1 signaling pathway.

Exp Ther Med 2021 Jul 19;22(1):785. Epub 2021 May 19.

Department of Anesthesiology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, P.R. China.

The present study aimed to investigate the protective effects of etomidate on hyperoxia-induced acute lung injury in mice, particularly on the nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. Fifty specific pathogen-free mice were randomly divided into the blank control, model, high oxygen exposure + low etomidate dose (0.3 mg·kg), a high oxygen exposure + moderate etomidate dose (3 mg·kg), and a high oxygen exposure + high etomidate dose (10 mg·kg) groups, with ten mice allotted per group. Read More

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Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice.

Life Sci 2021 Aug 28;279:119659. Epub 2021 May 28.

College of Basic Medical Sciences and Institute of Atherosclerosis, Shandong First Medical University & Shandong Academy of Medical Science, Taian 271000, China. Electronic address:

Aims: Limb ischaemia/reperfusion (LIR) occurs in various clinical conditions including critical limb ischaemia, abdominal aortic aneurysm, and traumatic arterial injury. Reperfusion of the acutely ischemic limb can lead to a systemic inflammation response and multiple organ dysfunction syndrome, further resulting in significant morbidity and mortality. Molecular hydrogen exhibits therapeutic activity for the treatment and prevention of many diseases. Read More

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Aerobic Exercise Alleviates Inflammation, Oxidative Stress, and Apoptosis in Mice with Chronic Obstructive Pulmonary Disease.

Int J Chron Obstruct Pulmon Dis 2021;16:1369-1379. Epub 2021 May 17.

Department of College of P.E and Sport, Beijing Normal University, Beijing, People's Republic of China.

Background: Chronic inflammation, oxidative stress, and apoptosis play critical roles in chronic obstructive pulmonary disease (COPD) pathogenesis. Here, we attempted to determine whether aerobic exercise (AE) could improve COPD by counteracting the COPD-associated inflammatory response, oxidative stress, and apoptosis in mice.

Methods: Thirty male ICR mice were assigned into one of three groups: control (Con), COPD, and COPD + AE. Read More

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Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats.

Toxicol Mech Methods 2021 Jun 21:1-8. Epub 2021 Jun 21.

Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Radiation-induced pulmonary fibrosis (RIPF) is a known complication in cancer patients after getting thoracic radiotherapy. Aromatase inhibitors (AIs) as anastrozole have been used instead of tamoxifen for adjuvant endocrine treatment of postmenopausal women with hormone sensitive breast cancer. This study is to evaluate the concurrent treatment of anastrozole and RIPF in rats. Read More

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