130,214 results match your criteria lung heart

Increased levels of VCAM-1 is associated with higher occurrence of coronary artery disease in adults with moderate to severe obstructive sleep apnea.

Sleep Med 2021 Jul 9;85:131-137. Epub 2021 Jul 9.

Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, 100029, China; Key Laboratory of Remodeling-related Cardiovascular Diseases, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China. Electronic address:

Background: Obstructive sleep apnea (OSA) leads to important vascular abnormalities, including the endothelial dysfunction and the production of endothelial cell adhesion molecules. The adhesion molecules play an important role in the process of endothelial dysfunction in the pathogenesis of atherosclerosis. We assess the relationship between the levels of adhesion molecules and the presence of coronary artery disease (CAD) in Chinese adults with moderate to severe OSA. Read More

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Outcomes of SARS-CoV-2 infection in patients with pulmonary sarcoidosis: A multicenter retrospective research network study.

Respir Med 2021 Jul 22;187:106538. Epub 2021 Jul 22.

Department of Internal Medicine, Department of Medicine, West Virginia University, Morgantown, WV, USA. Electronic address:

Background: Analyses of COVID-19 infection outcomes in patients with preexisting pulmonary sarcoidosis are lacking and are limited to case reports or small case series with the largest study reporting outcomes of 37 patients.

Research Question: Retrospective cohort study to assess clinical outcomes of 945 patients with pulmonary sarcoidosis, presenting with COVID 19, compared to a propensity matched cohort of patients without sarcoidosis.

Study Design And Methods: Analysis of a multi-center research network TriNETX was performed including patients more than 16 years of age diagnosed with COVID-19. Read More

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The serial connection of two extracorporeal membrane oxygenators for patient with refractory hypoxemia.

Heart Lung 2021 Jul 26;50(6):853-856. Epub 2021 Jul 26.

Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine and Gyeongsang National University Changwon Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon 51472, Republic of Korea. Electronic address:

A 34-year-old man developed severe hypoxemia and hypercapnia due to acute respiratory distress during ventilator care after surgery with acute intracranial hemorrhage. Severe hypoxemia had not been corrected even with maximum extracorporeal membrane oxygenation (ECMO) flow and full ventilator settings. We applied a novel technique for the serial connection of two veno-venous ECMO circuits for optimal oxygen delivery and CO2 removal and could wean VV ECMO. Read More

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Gender differences in psychosocial and clinical characteristics in the European Registry for Patients with Mechanical Circulatory Support.

Heart Lung 2021 Jul 26;50(6):845-852. Epub 2021 Jul 26.

Department of Nursing Science, Section Health Psychology, Trier University, Trier, Germany. Electronic address:

Background: Not much is known about psychosocial characteristics of men and women receiving continuous flow left ventricular assist devices (CF LVAD).

Objective: To investigate gender differences in clinical and psychosocial (demographic, behavioral, psychological) characteristics in CF LVAD recipients.

Methods: We analyzed European Registry for Patients with Mechanical Circulatory Support (EUROMACS) data (N=2395, 16. Read More

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Can optoelectronic plethysmography be used to evaluate the thoracoabdominal kinematics of people with morbidly obesity? A systematic review.

Heart Lung 2021 Jul 26;50(6):838-844. Epub 2021 Jul 26.

Núcleo de Ensino Pesquisa e Extensão em Fisioterapia no Pré e no Pós-Operatório de Cirurgias de Grande Porte da UDESC (PREPARA/UDESC), Brazil; Programa de Pós-Graduação em Fisioterapia da UDESC (PPGFT/UDESC), Brazil; Programa de Pós Graduação em Ciência do Movimento Humano da UDESC (PPGCMH/UDESC), Brazil; Universidade do Estado de Santa Catarina (UDESC) - Florianópolis (SC), Paschoal Simone, 358, Coqueiros, Florianópolis 88080-350, Brazil. Electronic address:

Background: Optoelectronic Plethysmography (OEP) is an effective method for evaluating thoracoabdominal kinematics. However, little is known about the viability and use the OEP in people with obesity.

Objective: Summarize information on the use and feasibility of OEP in the assessment of thoracoabdominal kinematics in people with obesity. Read More

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Patterns of pharmaceuticals use during the first wave of COVID-19 pandemic in Athens, Greece as revealed by wastewater-based epidemiology.

Sci Total Environ 2021 Jul 21;798:149014. Epub 2021 Jul 21.

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece. Electronic address:

Since 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), impaired public health with considerable morbidity and mortality due to the lack of vaccines and effective treatment. The severe disease mainly harmed adults with predisposing medical comorbidities (such as heart disease, hypertension, chronic lung disease), while it can occur in healthy individuals that may be asymptomatic. Wastewater-based Epidemiology (WBE), a non-invasive, objective, chemical tool was used to monitor and estimate the changes in drug's consumption and prescription patterns under normal conditions (2019) and under COVID-19 pandemic conditions (2020). Read More

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Reducing particulates in indoor air can improve the circulation and cardiorespiratory health of old people: A randomized, double-blind crossover trial of air filtration.

Sci Total Environ 2021 Jul 23;798:149248. Epub 2021 Jul 23.

Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing 400045, China; National Centre for International Research of Low-carbon and Green Buildings (Ministry of Science and Technology), Chongqing University, Chongqing, China. Electronic address:

Exposure to indoor air particulate pollution increases respiratory and cardiovascular morbidity and mortality, especially in the elderly. To assess a short-term, indoor air filtration's potential benefit on circulatory and cardiopulmonary health among healthy older people, a randomized, double-blind crossover trial was conducted with 24 healthy residents of an aged-care center in Chongqing, China in 2020. Each room received a high-efficiency particulate air filter air purifier and a placebo air purifier for two days. Read More

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Bacterial and fungal bloodstream infections in solid organ transplant recipients: result from a Danish cohort with nationwide follow-up.

Clin Microbiol Infect 2021 Jul 26. Epub 2021 Jul 26.

Viro-immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Surgical Gastroenterology and Transplantation, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Objectives: Bloodstream infections (BSI) are prevalent after solid organ transplantation (SOT). In this study, we aimed to investigate the incidence and risk factors for BSI in the first five years post-transplantation.

Methods: The study included 1322 SOT (kidney, liver, lung, and heart) recipients transplanted from 2010-2017 with a total of 5616 years of follow-up. Read More

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Development and internal validation of a clinical prediction model for 90-day mortality after lung resection: the RESECT-90 score.

Interact Cardiovasc Thorac Surg 2021 Jul 29. Epub 2021 Jul 29.

Division of Cardiovascular Sciences, University of Manchester, ERC, Manchester University Hospital NHS Foundation Trust, Manchester, UK.

Objectives: The ability to accurately estimate the risk of peri-operative mortality after lung resection is important. There are concerns about the performance and validity of existing models developed for this purpose, especially when predicting mortality within 90 days of surgery. The aim of this study was therefore to develop a clinical prediction model for mortality within 90 days of undergoing lung resection. Read More

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Extracorporeal Life Support Organization (ELSO) Guidelines for Follow-up After Neonatal and Pediatric Extracorporeal Membrane Oxygenation.

ASAIO J 2021 Jul 22. Epub 2021 Jul 22.

From the Department of Intensive Care and Pediatric Surgery, Erasmus MC-Sophia Children's Hospital University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Pediatric Surgery/IC Children and Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands Division of Neurosciences, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, Tennessee Division of Pediatric Critical Care, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, Tennessee Heart and Lung Directorate, Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, United Kingdom Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas National University Health System, Singapore Department of Surgery, University of Florida, Gainesville, Florida Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland Department of Critical Care Medicine, SickKids Research Institute, The Hospital for Sick Children, University of Toronto, Canada.

Neonates and children who have survived critical illness severe enough to require extracorporeal membrane oxygenation (ECMO) are at risk for neurologic insults, neurodevelopmental delays, worsening of underlying medical conditions, and development of new medical comorbidities. Structured neurodevelopmental follow-up is recommended for early identification and prompt interventions of any neurodevelopmental delays. Even children who initially survive this critical illness without new medical or neurologic deficits remain at risk of developing new morbidities/delays at least through adolescence, highlighting the importance of structured follow-up by personnel knowledgeable in the sequelae of critical illness and ECMO. Read More

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Who loses weight in a weight gain prevention program? A comparison of weight losers and weight maintainers at 3 years.

Health Psychol 2021 Jul 29. Epub 2021 Jul 29.

Weight Control and Diabetes Research Center.

Objective: Despite weight loss challenges in young adulthood, 17% of participants in the Study of Novel Approaches to Weight Gain Prevention (SNAP) weight gain prevention study lost ≥ 5% of their body weight at 3 years. These "weight losers" ( = 88) were compared to "weight maintainers" ( = 143), who successfully prevented weight gains by staying within ± 2.5% of their baseline weight at 3 years. Read More

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Socioeconomic status, diabetes, and gestation length in Native American and White women.

Health Psychol 2021 Jun;40(6):380-387

Department of Epidemiology and Biostatistics, University of California, San Francisco.

Objective: "Diminishing returns" of socioeconomic status (SES) suggests that higher SES may not confer equivalent health benefits for ethnic minority individuals as compared to White individuals. Little research has tested whether diminishing returns also affects Native Americans. The objective of this study was to determine whether higher SES is associated with lower diabetes risk and longer gestational length in both Native American and White women, and whether SES predicts gestational length indirectly via diabetes risk. Read More

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Identification of Arginine Finger as the Starter of the Biomimetic Motor in Driving Double-Stranded DNA.

ACS Nano 2021 Jul 29. Epub 2021 Jul 29.

Center for RNA Nanobiotechnology and Nanomedicine, College of Pharmacy and College of Medicine, The Ohio State University, Columbus, Ohio 43210, United States.

Nanomotors in nanotechnology may be as important as cars in daily life. Biomotors are nanoscale machines ubiquitous in living systems to carry out ATP-driven activities such as walking, breathing, blinking, mitosis, replication, transcription, and trafficking. The sequential action in an asymmetrical hexamer by a revolving mechanism has been confirmed in dsDNA packaging motors of phi29, herpesviruses, bacterial dsDNA translocase FtsK, and Streptomyces TraB for conjugative dsDNA transfer. Read More

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Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling.

J Am Heart Assoc 2021 Jul 29:e021768. Epub 2021 Jul 29.

Division of Cardiology Department of Medicine Heart, Lung Blood and Vascular Medicine InstituteSchool of MedicineUniversity of PittsburghUniversity of Pittsburgh Medical Center PA.

Background Sarcomere gene mutations lead to cardiomyocyte hypertrophy and pathological myocardial remodeling. However, there is considerable phenotypic heterogeneity at both the cellular and the organ level, suggesting modifiers regulate the effects of these mutations. We hypothesized that sarcomere dysfunction leads to cardiomyocyte genotoxic stress, and this modifies pathological ventricular remodeling. Read More

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Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection.

Am J Physiol Lung Cell Mol Physiol 2021 Jul 29. Epub 2021 Jul 29.

Department of Pediatrics, grid.16416.34University of Rochester, Rochester, NY, United States.

It is well known that supplemental oxygen used to treat preterm infants in respiratory distress is associated with permanently disrupting lung development and the host response to influenza A virus (IAV). However, many infants who go home with normally functioning lungs are also at risk for hyperreactivity after a respiratory viral infection. We recently reported a new, low-dose hyperoxia mouse model (40% for 8 days; 40x8) that causes a transient change in lung function that resolves, rendering 40x8 adult animals functionally indistinguishable from room air controls. Read More

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[Constructing Brain Aβ-Targeting Nanoparticles Loaded with EGCG for Treating Alzheimer's Disease in Mice].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):605-611

Key Laboratory of Smart Drug Delivery of the Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, China.

Objective: To construct a nanodelivery system surface-modified with RD2 peptide (polypeptide sequence PTLHTHNRRRRR) for brain tissue penetration and β-amyloid (Aβ) binding. Epigallocatechin-3-gallate (EGCG) was selected for encapsulation in the targeted delivery system and its therapeutic potential for Alzheimer's disease (AD) was investigated.

Methods: EGCG-load nanoparticles (NP/EGCG), NP/EGCG with RD2 peptide surface modification (RD2-NP/EGCG), as well as RD2 peptide-modified blank nanoparticles (RD2-NP) were prepared and characterized. Read More

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Losing the dogmatic view of cerebral autoregulation.

Physiol Rep 2021 Aug;9(15):e14982

Center for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia - Okanagan, Kelowna, BC, Canada.

In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept suggested a relatively broad mean arterial pressure range (~60-150 mmHg) wherein cerebral blood flow remains constant. However, the assumption that this wide cerebral autoregulation plateau could be applied on a within-individual basis is incorrect and greatly variable between individuals. Read More

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ADP-ribosyltransferases, an update on function and nomenclature.

FEBS J 2021 Jul 29. Epub 2021 Jul 29.

Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway.

ADP-ribosylation, a modification of proteins, nucleic acids and metabolites, confers broad functions, including roles in stress responses elicited for example by DNA damage and viral infection and is involved in intra- and extracellular signaling, chromatin and transcriptional regulation, protein biosynthesis and cell death. ADP-ribosylation is catalyzed by ADP-ribosyltransferases, which transfer ADP-ribose from NAD onto substrates. The modification, which occurs as mono- or poly-ADP-ribosylation, is reversible due to the action of different ADP-ribosylhydrolases. Read More

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Pulmonary vascular involvement in COVID-19 pneumonitis: Is this the first and final insult?

Respirology 2021 Jul 28. Epub 2021 Jul 28.

National Lung and Heart Institute, Imperial College London, London, UK.

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Tiny golden angle ultrashort echo-time lung imaging in mice.

NMR Biomed 2021 Jul 28:e4591. Epub 2021 Jul 28.

Department of Internal Medicine II, Ulm University Medical Centre, Ulm, Germany.

Imaging the lung parenchyma with MRI is particularly difficult in small animals due to the high respiratory and heart rates, and ultrashort T2* at high magnetic field strength caused by the high susceptibilities induced by the air-tissue interfaces. In this study, a 2D ultrashort echo-time (UTE) technique was combined with tiny golden angle (tyGA) ordering. Data were acquired continuously at 11. Read More

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Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health.

Psoriasis (Auckl) 2021 21;11:99-108. Epub 2021 Jul 21.

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Psoriasis is a common chronic inflammatory condition associated with a higher risk of cardiovascular disease. Psoriasis confers a dose-dependent increase in risk for the metabolic syndrome and its components. The metabolic syndrome and its components have been associated with higher coronary atherosclerosis in psoriasis and cardiovascular events in the general population. Read More

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IL-8 correlates with reduced baseline femoral neck bone mineral density in adults with cystic fibrosis: a single center retrospective study.

Sci Rep 2021 Jul 28;11(1):15405. Epub 2021 Jul 28.

Division of Respiratory Medicine, St. Paul's Hospital, Vancouver, BC, Canada.

Cystic fibrosis (CF) is a multi-system disease that is characterized by lung disease due to recurrent airway infection and inflammation. Endocrine complications, such as CF bone disease (CFBD), are increasingly identified as patients are living longer. The cause of CFBD is multifactorial with chronic systemic inflammation theorized to be a contributing factor. Read More

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A TLR4 agonist improves immune checkpoint blockade treatment by increasing the ratio of effector to regulatory cells within the tumor microenvironment.

Sci Rep 2021 Jul 28;11(1):15406. Epub 2021 Jul 28.

Fundación Instituto Leloir, IIBBA, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Brucella lumazine synthase (BLS) is a homodecameric protein that activates dendritic cells via toll like receptor 4, inducing the secretion of pro-inflammatory cytokines and chemokines. We have previously shown that BLS has a therapeutic effect in B16 melanoma-bearing mice only when administered at early stages of tumor growth. In this work, we study the mechanisms underlying the therapeutic effect of BLS, by analyzing the tumor microenvironment. Read More

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Genomic characterization of sporadic isolates of the dominant clone of Mycobacterium abscessus subspecies massiliense.

Sci Rep 2021 Jul 28;11(1):15336. Epub 2021 Jul 28.

Department of Microbiology, University of Texas Health Science Center at Tyler, Tyler, TX, USA.

Recent studies have characterized a dominant clone (Clone 1) of Mycobacterium abscessus subspecies massiliense (M. massiliense) associated with high prevalence in cystic fibrosis (CF) patients, pulmonary outbreaks in the United States (US) and United Kingdom (UK), and a Brazilian epidemic of skin infections. The prevalence of Clone 1 in non-CF patients in the US and the relationship of sporadic US isolates to outbreak clones are not known. Read More

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IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.

Nat Commun 2021 07 28;12(1):4584. Epub 2021 Jul 28.

Department of Internal Medicine I, Ulm University Medical Center, Ulm, Germany.

Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. However, endogenous IFITM expression supports efficient infection of SARS-CoV-2 in human lung cells. Read More

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Behavioural interventions for CVD risk reduction for blue-collar workers: a systematic review.

J Epidemiol Community Health 2021 Jul 28. Epub 2021 Jul 28.

Department of Preventive Medicine, Rush University Medical Center, Chicago, Illinois, USA.

Objectives: Individuals working in blue-collar occupations experience high rates of cardiovascular disease (CVD). The purpose of this systematic review is to describe the characteristics and efficacy of behavioural interventions that have targeted CVD risk factors in this high-risk group.

Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched seven databases to find interventions focused on changing the following: blood pressure, cholesterol, diet, physical activity, smoking or weight. Read More

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Cardiopulmonary alterations by ultrasound in a patient with uncomplicated mixed malaria infection: a case report from the Amazon Basin.

Malar J 2021 Jul 28;20(1):330. Epub 2021 Jul 28.

Multidisciplinary Centre, Federal University of Acre, Câmpus Floresta, Cruzeiro do Sul, Acre, Brazil.

Background: Information on cardiopulmonary complications in clinical malaria is sparse and diagnosis may be difficult in resource-limited areas due to lack of proper diagnostic tools and access to medical care. A case of pericardial effusion and pulmonary alterations assessed by ultrasound in a patient with uncomplicated mixed malaria infection is described.

Case Presentation: A previously healthy 23-year-old male from the Amazon Basin was diagnosed with mixed infection of Plasmodium vivax and Plasmodium falciparum by peripheral blood smear. Read More

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Temporal trends in cause-specific mortality among individuals with newly diagnosed atrial fibrillation in the Framingham Heart Study.

BMC Med 2021 Jul 29;19(1):170. Epub 2021 Jul 29.

Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.

Background: All-cause mortality following atrial fibrillation (AF) has decreased over time. Data regarding temporal trends in causes of death among individuals with AF are scarce. The aim of our study was to analyze temporal trends in cause-specific mortality and predictors for cardiovascular (CVD) and non-CVD deaths among participants with incident AF in the Framingham Heart Study. Read More

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