25,471 results match your criteria lung doses

Minocycline attenuates oxidative and inflammatory injury in a intestinal perforation induced septic lung injury model via down-regulating lncRNA MALAT1 expression.

Int Immunopharmacol 2021 Sep 22;100:108115. Epub 2021 Sep 22.

Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province 430070, China. Electronic address:

Background: Oxidative stress and inflammatory responses play an important role in acute lung injury (ALI). Although minocycline (MINO) has anti-inflammatory effects and is a promising candidate in treating inflammatory diseases, the effect of MINO on ALI during sepsis is still unclear.

Methods: In the present study, a mouse model with intestinal perforation was established. Read More

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September 2021

Optimization of collimator angles in dual-arc volumetric modulated arc therapy planning for whole-brain radiotherapy with hippocampus and inner ear sparing.

Sci Rep 2021 Sep 24;11(1):19035. Epub 2021 Sep 24.

Department of Radiation Oncology and Therapy, The First Hospital of Jilin University, Changchun, 130021, China.

To optimize the collimator angles in dual-arc volumetric modulated arc therapy (VMAT) plans for whole-brain radiotherapy with hippocampus and inner ear sparing (HIS-WBRT). Two sets of dual-arc VMAT plans were generated for 13 small-cell lung cancer patients: (1) The collimator angles of arcs 1 and 2 (θ/θ) were 350°/10°, 350°/30°, 350°/45°, 350°/60°, and 350°/80°, i.e. Read More

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September 2021

Combination treatment with rituximab, low-dose cyclophosphamide and plasma exchange for severe antineutrophil cytoplasmic antibody-associated vasculitis.

Kidney Int 2021 Sep 21. Epub 2021 Sep 21.

Vasculitis Clinic, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London UK; Centre for Inflammatory Disease, Imperial College London, London UK. Electronic address:

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis can present with life-threatening lung-kidney syndromes. However, many controlled treatment trials excluded patients with diffuse alveolar hemorrhage or severely impaired glomerular filtration rates, and so the optimum treatment in these cases is unclear. In this retrospective cohort study, we report the outcomes of 64 patients with life-threatening disease treated with a combination regimen of rituximab, low-dose intravenous cyclophosphamide, oral glucocorticoids, and plasma exchange. Read More

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September 2021

Establishing scanning protocols for a CT lung cancer screening trial in the UK.

Br J Radiol 2021 Sep 24:20201343. Epub 2021 Sep 24.

Department of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.

Objectives: To develop a CT scanning protocol for lung cancer screening which achieved low radiation dose and a high level of objectively assessed image quality.

Methods: An anthropomorphic chest phantom and a commercially available lung screening image quality phantom were scanned on a series of scan protocols from a previous UK lung screening pilot and on an alternative protocol. The chest phantom scans were used to assess the CT dose metrics on community-based mobile CT scanners and comparisons were made with published recommended doses. Read More

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September 2021

Reconciling short-term clinical and Immunological outcomes of SARS-CoV-2 vaccination in Solid Organ Transplant recipients.

Am J Transplant 2021 Sep 23. Epub 2021 Sep 23.

Kidney transplant Unit. Nephrology department. Vall d, Hebron Hospital Universitari, Vall d'Hebron Institut de Recerca (VHIR), Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Vall d, Barcelona, Spain.

Relevant concerns are being raised regarding the weak serological response of solid organ transplant (SOT) recipients after receiving two doses of messenger RNA-based vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (1) and some severe cases of coronavirus disease (COVID-19) occurring after vaccination (2). Thus, additional preventive booster doses are proposed to enhance anti-viral immunity. Read More

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September 2021

Image-guided selection of [email protected] as sensitizers to improve radiotherapy of non-small cell lung cancer.

J Nanobiotechnology 2021 Sep 22;19(1):284. Epub 2021 Sep 22.

Department of Radiology, Biomedical Research Imaging Center, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 125 Mason Farm Road, Chapel Hill, NC, 27599, USA.

Background: Recently, gadolinium-intercalated carbon dots ([email protected]) have demonstrated potential advantages over traditional high-Z nanoparticles (HZNPs) as radiosensitizers due to their high stability, minimal metal leakage, and remarkable efficacy.

Results: In this work, two [email protected] formulations were fabricated which bore carboxylic acid ([email protected]) or amino group ([email protected]), respectively, on the carbon shell. While it is critical to develop innovative nanomateirals for cancer therapy, determining their tumor accumulation and retention is equally important. Read More

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September 2021

sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension.

Hypertens Res 2021 Sep 22. Epub 2021 Sep 22.

Bayer AG, Wuppertal, Germany.

Therapy-resistant hypertension is a serious medical problem, causing end-organ damage, stroke, and heart failure if untreated. Since the standard of care fails in resistant hypertension patients, there is still a substantial unmet medical need for effective therapies. Active stimulation of soluble guanylyl cyclase via novel soluble guanylyl cyclase stimulators might provide an effective treatment option. Read More

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September 2021

Convalescent plasma therapy in B-cell-depleted and B-cell sufficient patients with life-threatening COVID-19 - A case series.

Transfus Apher Sci 2021 Sep 17:103278. Epub 2021 Sep 17.

Technical University of Munich, School of Medicine, University Hospital rechts der Isar, Department of Internal Medicine II, 81675 Munich, Germany. Electronic address:

Objective: To investigate the effect of convalescent plasma therapy (CPT) on clinical courses of B-cell-sufficient and B-cell-depleted patients with life-threatening COVID-19.

Patients And Methods: In this case series, we retrospectively analysed clinical, laboratory and cardiopulmonary parameters of six patients with life-threatening COVID-19 receiving convalescent plasma (CP) as rescue therapy between April 11, 2020 to October 10, 2020. Clinical and laboratory parameters before and after transfusion were compared in two B-cell-depleted patients and four B-cell sufficient patients (control group). Read More

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September 2021

Pharmacokinetic/pharmacodynamic profiles of baicalin against Mycoplasma gallisepticum in an in vivo infection model.

Poult Sci 2021 Aug 20;100(11):101437. Epub 2021 Aug 20.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, P. R. China.

Mycoplasma gallisepticum (M. gallisepticum), a devastating avian pathogen that commonly causes chronic respiratory disease in chicken, is responsible for tremendous economic losses to the poultry industry. Baicalin is the main constituent of Scutellaria baicalensis that shows potential therapeutic effects against M. Read More

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COVID vaccination and asthma exacerbation: might there be a link?

Int J Infect Dis 2021 Sep 18. Epub 2021 Sep 18.

Infectious Diseases I Unit, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia; Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia.

Introduction: There is an ongoing debate as to the role of acute SARS-CoV-2 infection on asthma exacerbation, and its long-term impact on the lung function of individuals with asthma. In contrast, the potential impact of COVID -19 vaccination on asthma is entirely unexplored.

Case Study: We are shedding light on this critical topic by examining a challenging case of severe asthma exacerbation that a 28-year-old female patient developed after receiving two doses of mRNA-based vaccine BNT162b2 (Pfizer-BioNTech) at our Hospital, IRCCS Policlinico San Matteo of Pavia, in Northern Italy. Read More

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September 2021

Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.

ACS Infect Dis 2021 Sep 21. Epub 2021 Sep 21.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.

The lengthy treatment time for tuberculosis (TB) is a primary cause for the emergence of multidrug resistant tuberculosis (MDR-TB). One approach to improve TB therapy is to develop an inhalational TB therapy that when administered in combination with oral TB drugs eases and shortens treatment. Spectinamides are new semisynthetic analogues of spectinomycin with excellent activity against (), including MDR and XDR strains. Read More

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September 2021

Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation.

Health Phys 2021 Oct;121(4):419-433

Department of Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226.

Abstract: The goal of this study was to develop rat models of partial body irradiation with bone-marrow sparing (leg-out PBI) to test medical countermeasures (MCM) of both acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE) under the FDA animal rule. The leg-out PBI models were developed in female and male WAG/RijCmcr rats at doses of 12.5-14. Read More

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October 2021

AEOL 10150 Alleviates Radiation-induced Innate Immune Responses in Non-human Primate Lung Tissue.

Health Phys 2021 Oct;121(4):331-344

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.

Abstract: To study the molecular and cellular mechanisms of radiation-induced lung injury (RILI) in a non-human primate model, Rhesus macaques were irradiated with lethal doses of radiation to the whole thorax. A subset of the irradiated animals was treated with AEOL 10150, a potent catalytic scavenger of reactive oxygen and nitrogen species. Lung tissues were collected at necropsy for molecular and immunohistochemical (IHC) studies. Read More

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October 2021

Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungs.

Sci Rep 2021 Sep 20;11(1):18607. Epub 2021 Sep 20.

Department of Thoracic and Cardiovascular Surgery, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany.

Ex-vivo lung perfusion (EVLP) systems like XVIVO are more and more common in the setting of lung transplantation, since marginal donor-lungs can easily be subjected to a performance test or be treated with corticosteroids or antibiotics in high dose regimes. Donor lungs are frequently positive in bronchoalveolar lavage (BAL) bacterial cultures (46-89%) which leads to a donor-to-recipient transmission and after a higher risk of lung infection with reduced posttransplant outcome. We have previously shown that sphingosine very efficiently kills a variety of pathogens, including Pseudomonas aeruginosa, Staphylococcus aureus and epidermidis, Escherichia coli or Haemophilus influenzae. Read More

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September 2021

Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS-a randomized, placebo-controlled, double-blind trial.

Trials 2021 Sep 20;22(1):643. Epub 2021 Sep 20.

Department of Anesthesiology, University Hospital of Ludwig-Maximilians-University (LMU), Munich, Germany.

Background: Acute respiratory distress syndrome (ARDS) is a complex clinical diagnosis with various possible etiologies. One common feature, however, is pulmonary permeability edema, which leads to an increased alveolar diffusion pathway and, subsequently, impaired oxygenation and decarboxylation. A novel inhaled peptide agent (AP301, solnatide) was shown to markedly reduce pulmonary edema in animal models of ARDS and to be safe to administer to healthy humans in a Phase I clinical trial. Read More

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September 2021

Lung Ultrasound Assisted Comparison of Volume Effects of Fluid Replacement Regimens in Pediatric Patients Undergoing Penile Hypospadias Repair: A Randomized Controlled Trial.

Anesth Pain Med 2021 Jun 3;11(3):e115152. Epub 2021 Jul 3.

Lecturer of Anesthesia, Anesthesiology Department, Faculty of Medicine of Cairo University, Cairo, Egypt.

Background: Effective perioperative fluid therapy is a great consideration.

Objectives: Using lung ultrasound (LUS), this study evaluated the preference of the conventional and restrictive fluid replacement regimens for their volume impact in pediatric patients undergoing a relatively long procedure with limited volume loss (hypospadias repair).

Methods: Eighty pediatric patients scheduled for hypospadias repair surgery were enrolled for conventional (CG) or restrictive fluid management groups (RG). Read More

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Febuxostat, an inhibitor of xanthine oxidase, ameliorates ionizing radiation-induced lung injury by suppressing caspase-3, oxidative stress and NF-κB.

Drug Chem Toxicol 2021 Sep 19:1-8. Epub 2021 Sep 19.

Department of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Febuxostat (FBX), a selective inhibitor of xanthine oxidase, has several biological properties such as antioxidant, anti-inflammatory and anti-apoptosis activities. The purpose of this study was to evaluate the protective effect of FBX against ionizing radiation (IR)-induced lung injury through mitigation of oxidative stress, inflammation and apoptosis. Sixty-four mice were randomized into eight groups as control, FBX (5, 10, and 15 mg/kg), IR (6 Gy), and IR + FBX (IR + FBX in three doses). Read More

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September 2021

Fibroblast activation protein targeted therapy using [Lu]FAPI-46 compared with [Ac]FAPI-46 in a pancreatic cancer model.

Eur J Nucl Med Mol Imaging 2021 Sep 18. Epub 2021 Sep 18.

Institute for Radiation Sciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Purpose: Fibroblast activation protein (FAP), which has high expression in cancer-associated fibroblasts of epithelial cancers, can be used as a theranostic target. Our previous study used Cu and Ac-labelled FAP inhibitors (FAPI-04) for a FAP-expressing pancreatic cancer xenograft imaging and therapy. However, the optimal therapeutic radionuclide for FAPI needs to be investigated further. Read More

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September 2021

Airway hyperresponsiveness induced by intermittent hypoxia in rats.

Respir Physiol Neurobiol 2021 Sep 17;295:103787. Epub 2021 Sep 17.

Department of Physiology, School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

This study investigated whether intermittent hypoxia (IH) induces airway hyperresponsiveness (AHR) and associated with lung inflammation. Male Brown Norway rats were exposed to 14-day IH or room air (RA) for 6 h/day. One day after the last exposure, total lung resistance to various doses of methacholine was measured as an index of bronchoconstrictive responses. Read More

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September 2021

Intensive care readmissions in the first year after lung transplantation: Incidence, early risk factors and outcome.

Anaesth Crit Care Pain Med 2021 Sep 15:100948. Epub 2021 Sep 15.

APHP, CHU Bichat-Claude Bernard, DMU PARABOL, 46, rue Henri Huchard, 75018 Paris, France; Université de Paris, UFR Paris Diderot, Paris, France; INSERM UMR 1152, ANR-10-LBX-17, Paris, France.

Background: Predictive factors of intensive care readmissions after lung transplantation (LT) have not been established. The main objective of this study was to assess early risk factors for ICU readmission during the first year after LT.

Methods: This retrospective, observational, single-centre study included all consecutive patients who underwent LT in our institution between January 2016 and November 2019. Read More

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September 2021

Baseline FDG PET/CT in free breathing versus deep inspiration breath-hold for pediatric patients with mediastinal lymphoma.

Acta Oncol 2021 Sep 17:1-8. Epub 2021 Sep 17.

Section of Radiotherapy, Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Introduction: The prospective TEDDI protocol investigates the feasibility of radiotherapy delivery in deep inspiration breath-hold (DIBH) for pediatric patients. To secure optimal radiotherapy planning, a diagnostic baseline FDG PET/CT in free breathing (FB) and DIBH was acquired. The anatomical changes in the mediastinum and the effect on PET metrics between the two breathing conditions were assessed for pediatric patients with mediastinal lymphoma. Read More

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September 2021

Prediction of Radiation Pneumonitis Using Genome-Scale Flux Analysis of RNA-Seq Derived From Peripheral Blood.

Front Med (Lausanne) 2021 31;8:715961. Epub 2021 Aug 31.

Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.

Radiation pneumonitis (RP) frequently occurs during a treatment course of chest radiotherapy, which significantly reduces the clinical outcome and efficacy of radiotherapy. The ability to easily predict RP before radiotherapy would allow this disease to be avoided. This study recruited 48 lung cancer patients requiring chest radiotherapy. Read More

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Epidural morphine in COVID ARDS patients with high respiratory drive: a structured summary of a study protocol for a randomised controlled trial.

Trials 2021 Sep 16;22(1):632. Epub 2021 Sep 16.

AIIMS Bhubaneswar: All India Institute of Medical Sciences - Bhubaneswar, Bhubaneswar, Odisha, India.

Objectives: We aim to study the effect of epidural morphine as a means to reduce high respiratory drive in COVID 19 patients on non-invasive ventilation (NIV)-primary end point-and to study its effect on respiratory parameters, subjective patient comfort, rates of endotracheal intubation, duration of mechanical ventilation and mortality.

Trial Design: Parallel group, randomised, double blind, single centre placebo control trial. Allocation ratio 1:1, superiority trial PARTICIPANTS: Trial site and population-COVID ICU patients in the All India Institute of Medical Sciences (AIIMS) Bhubaneswar, Odisha, India Inclusion and exclusion criteria Inclusion criteria Adult patients on NIV with COVID-19 Exclusion criteria Metabolic acidosis HCO-< 16 and pH < 7. Read More

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September 2021

The acute systemic toxicity of thallium in rats produces oxidative stress: attenuation by metallothionein and Prussian blue.

Biometals 2021 Sep 16. Epub 2021 Sep 16.

Laboratorio de Neuroprotección, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos Cuernavaca, Av. Universidad 1001 Col. Chamilpa, Cuernavaca, C.P. 62209, Morelos, Mexico.

Thallium (TI) is one of the most toxic heavy metals. Human exposure to Tl occurs through contaminated drinking water and from there to food, a threat to health. Recently, environmental contamination by Tl has been reported in several countries, urging the need for studies to determine the impact of endogenous and exogenous mechanisms preventing thallium toxicity. Read More

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September 2021

Carfilzomib, Lenalidomide, and Dexamethasone Followed by Lenalidomide Maintenance for Prevention of Symptomatic Multiple Myeloma in Patients With High-risk Smoldering Myeloma: A Phase 2 Nonrandomized Controlled Trial.

JAMA Oncol 2021 Sep 16. Epub 2021 Sep 16.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Importance: High-risk smoldering myeloma has a 5-year risk of progression to symptomatic multiple myeloma of approximately 75%. Treatment with lenalidomide decreases the risk of progression; however, novel triplet regimens are superior, and earlier disease may be more treatment sensitive.

Objective: To evaluate the use of carfilzomib, lenalidomide, and dexamethasone (KRd) with lenalidomide maintenance therapy as early intervention in high-risk smoldering myeloma and to determine the rates of minimal residual disease (MRD)-negative complete response (CR). Read More

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September 2021

Radiation Induces Valvular Interstitial Cell Calcific Response in an Model of Calcific Aortic Valve Disease.

Front Cardiovasc Med 2021 30;8:687885. Epub 2021 Aug 30.

Department of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology (STEM), Eindhoven University of Technology, Eindhoven, Netherlands.

Mediastinal ionizing radiotherapy is associated with an increased risk of valvular disease, which demonstrates pathological hallmarks similar to calcific aortic valve disease (CAVD). Despite advances in radiotherapy techniques, the prevalence of comorbidities such as radiation-associated valvular disease is still increasing due to improved survival of patients receiving radiotherapy. However, the mechanisms of radiation-associated valvular disease are largely unknown. Read More

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Pembrolizumab-Induced Meningoencephalitis: A Brain Autopsy Case.

J Med Cases 2021 Sep 25;12(9):359-365. Epub 2021 Aug 25.

Department of Pathology, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka City, Osaka 543-0035, Japan.

Encephalitis is very rare, but often fatal immune-related adverse event (irAE) of immune checkpoint inhibitors (ICIs). A 65-year-old Japanese woman was admitted to our hospital because of general fatigue, chillness and high-grade fever for 4 days, 8 months after the initiation of the first-line pembrolizumab monotherapy for metastatic pulmonary adenocarcinoma. On the hospital day 3, she suddenly presented delirium and uncontrollable impaired consciousness. Read More

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September 2021

Lung Cancer as a Subsequent Malignant Neoplasm in Survivors of Childhood Cancer.

Cancer Epidemiol Biomarkers Prev 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatrics, University of Minnesota.

Background: Lung cancer, the most common cancer cause of death in adults, has not been well studied as a subsequent malignant neoplasm (SMN) in childhood cancer survivors. We assessed prevalence, risk factors, and outcomes for lung SMN in the Childhood Cancer Survivor Study (CCSS) cohort.

Methods: Among 25,654 five-year survivors, diagnosed with childhood cancer (<21 years), lung cancer was self-reported and confirmed by pathology record review. Read More

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September 2021

Observation of Unique Circulating miRNA Signatures in Non-Human Primates Exposed to Total-Body vs. Whole Thorax Lung Irradiation.

Radiat Res 2021 Sep 15. Epub 2021 Sep 15.

ChromoLogic LLC, Monrovia, California 91016.

A radiological/nuclear (RAD-NUC) incident, especially in an urban setting, results in diverse radiation-induced injuries due to heterogeneities in dose, the extent of partial-body shielding, human biodiversity and pre-existing health conditions. For example, acute radiation syndrome (ARS) can result in death within days to weeks of exposure to 0.7-10 Gy doses and is associated with destruction of the bone marrow, known as hematopoietic ARS (H-ARS). Read More

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September 2021

Long-term outcomes in severe aplastic anemia patients treated with immunosuppression and eltrombopag: a phase 2 study.

Blood 2021 Sep 15. Epub 2021 Sep 15.

NHLBI, NIH, Bethesda, Maryland, United States.

Patients with severe aplastic anemia (SAA) are either treated with bone marrow transplant (BMT) or immunosuppression (IST) depending on their age, comorbidities, and available donors. In 2017, our phase 2 trial reported improved hematologic responses with the addition of eltrombopag (EPAG) to standard IST for SAA when compared to a historical cohort treated with IST alone. However, the rates and characteristics of long-term complications, relapse, and clonal evolution, previously described in patients treated with IST alone are not yet known with this new regimen, IST and EPAG. Read More

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September 2021