J Nanobiotechnology 2021 Sep 22;19(1):284. Epub 2021 Sep 22.
Department of Radiology, Biomedical Research Imaging Center, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 125 Mason Farm Road, Chapel Hill, NC, 27599, USA.
Background: Recently, gadolinium-intercalated carbon dots ([email protected]) have demonstrated potential advantages over traditional high-Z nanoparticles (HZNPs) as radiosensitizers due to their high stability, minimal metal leakage, and remarkable efficacy.
Results: In this work, two [email protected] formulations were fabricated which bore carboxylic acid ([email protected]) or amino group ([email protected]), respectively, on the carbon shell. While it is critical to develop innovative nanomateirals for cancer therapy, determining their tumor accumulation and retention is equally important. Read More