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Training in intraoperative neuromonitoring of recurrent laryngeal nerves reduces the risk of their injury during thyroid surgery.

Arch Med Sci 2021 7;17(5):1294-1302. Epub 2019 Jun 7.

1 Department of General and Endocrinological Surgery, Medical University of Bialystok, Bialystok, Poland.

Introduction: Even though incidence of recurrent laryngeal nerve palsy (RLNP) is low, it affects importantly the quality of life of patients and remains one of main medicolegal litigation problems in surgery. Intraoperative neuromonitoring (IONM) has become widely accepted tool helping in recurrent laryngeal nerve identification, however no clear association of IONM with RLNP rate has been demonstrated. The aim of our study was to assess whether training in IONM influences rates of RNLP after thyroid surgery as an independent factor. Read More

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Thyroid function and risk of anemia: a multivariable-adjusted and Mendelian Randomization analysis in the UK Biobank.

J Clin Endocrinol Metab 2021 Sep 13. Epub 2021 Sep 13.

Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.

Context: Thyroid dysfunction is associated with higher anemia prevalence, though causality remains unclear.

Objective: To investigate the association between thyroid function and anemia.

Design: Cross-sectional and Mendelian Randomization study. Read More

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September 2021

Is There a Regular Pattern in the Recovery of Parathyroid Function After Thyroid Cancer Surgery?

Cancer Manag Res 2021 3;13:6891-6899. Epub 2021 Sep 3.

Department of Head and Neck Surgery, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, Fujian, 350011, People's Republic of China.

Purpose: To investigate whether there is a pattern of recovery of parathyroid function after thyroid cancer surgery.

Patients And Methods: The study included 183 patients with papillary thyroid cancer (PTC) who underwent "total thyroidectomy (TT)" plus "unilateral central lymph node dissection (UCLND)" or "bilateral central lymph node dissection (BCLND)". The intact parathyroid hormone (iPTH) and serum calcium (sCa) were analyzed several times within 1 month after surgery to explore the recovery pattern of parathyroid gland function. Read More

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September 2021

Core needle biopsy and ultrasonography are superior to fine needle aspiration in the management of follicular variant papillary thyroid carcinomas.

Endocrine 2021 Sep 9. Epub 2021 Sep 9.

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: Follicular variant papillary thyroid carcinoma (FVPTC) is a problematic entity. FVPTCs are often misdiagnosed by the standard fine needle aspiration (FNA); in addition, FVPTCs represent a mixed group of tumors with two biologically distinct subtypes: The indolent encapsulated FVPTC and the aggressive infiltrative FVPTC. Recent changes in guidelines suggests that FVPTC management may be improved if subtypes can be determined preoperatively. Read More

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September 2021

Dosimetric evaluation for temporomandibular joint cone beam computed tomography exams using different field of view.

Biomed Phys Eng Express 2021 Sep 17;7(6). Epub 2021 Sep 17.

Division of Oral Radiology, Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Campinas, São Paulo (SP), 13045-755, Brazil.

To optimize the absorbed organ dose in relation to the field of view for temporomandibular joint examinations in four cone beam computed tomography devices.An anthropomorphic adult head and neck phantom, and 192 LiF dosimeters (TLD-100) were used. The dosimeters were placed in the region corresponding to the lens, parotid glands, submandibular glands, and thyroid. Read More

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September 2021

Launching an Electronic Patient-Reported Outcomes Initiative in Real-Time Clinical Practice.

J Natl Cancer Inst Monogr 2021 Sep;2021(57):23-30

Departments of Health Services Research and General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Patient-reported outcomes play an essential role in improving care across the cancer continuum. This paper reports on the experience of a tertiary care center to standardize the use, collection, and reporting of patient-reported outcomes (PROs) in 10 disease-specific survivorship clinics. To minimize the burden of patients to complete surveys, an institutional committee with oversight on all patient surveys required an application be reviewed and approved before their distribution in a clinic. Read More

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September 2021

Thyroid Hormone Profile and Its Prognostic Impact on the Coronavirus Disease 2019 in Korean Patients.

Endocrinol Metab (Seoul) 2021 08 27;36(4):769-777. Epub 2021 Aug 27.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.

Background: Data on the association between coronavirus disease 2019 (COVID-19) and thyroid have been reported, including overt thyrotoxicosis and suppression of thyroid function. We aimed to evaluate the thyroid hormone profile and its association with the prognosis of COVID-19 in Korean patients.

Methods: The clinical data of 119 patients with COVID-19, admitted in the Myongji Hospital, Goyang, South Korea, were retrospectively evaluated. Read More

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GA Genotype of the Arg280His Polymorphism on The Gene: Genetic Susceptibility Genotype in Differentiated Thyroid Carcinomas?

Balkan J Med Genet 2021 Jun 27;24(1):73-80. Epub 2021 Jul 27.

Department of Medical Biology, Başkent University Faculty of Medicine, Ankara, Turkey.

Differentiated thyroid carcinomas (DTC) are the most common form of endocrine malignancies. The role of genetic variations in the development of papillary thyroid carcinoma (PTC) is approximately 60.0-70. Read More

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Associations of serum phthalate metabolites with thyroid hormones in GraMo cohort, Southern Spain.

Environ Pollut 2021 Oct 18;287:117606. Epub 2021 Jun 18.

CIBER de Epidemiología y Salud Pública (CIBERESP), Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain; University of Granada, Center for Biomedical Research (CIBM), Granada, Spain. Electronic address:

The general population is continuously exposed to phthalates via various consumer products. Epidemiological research relating phthalate exposure to thyroid function during non-developmental periods is limited. This study aimed to investigate the associations between specific serum phthalate metabolites and indicators of thyroid function in adults. Read More

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October 2021

Comparison of Thyroid Risk Categorization Systems and Fine Needle Aspiration Recommendations in a Multi-institutional Thyroid Ultrasound Registry.

J Am Coll Radiol 2021 Aug 19. Epub 2021 Aug 19.

Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.

Objectives: The aim of this study was to compare how often fine needle aspiration (FNA) would be recommended for nodules in unselected, low-risk adult patients referred for sonographic evaluation of thyroid nodules by ACR Thyroid Imaging Reporting and Data System (TI-RADS), the American Thyroid Association guidelines (ATA), Korean Thyroid Imaging Reporting and Data System (K-TIRADS), European Thyroid Imaging Reporting and Data System (EU-TIRADS), and Artificial Intelligence Thyroid Imaging Reporting and Data System (AI-TIRADS).

Methods: Seven practices prospectively submitted thyroid ultrasound reports on adult patients to the ACR Thyroid Imaging Research Registry between October 2018 and March 2020. Data were collected about the sonographic features of each nodule using a structured reporting template with fields for the five ACR TI-RADS ultrasound categories plus maximum nodule size. Read More

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Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case-control study.

Exp Ther Med 2021 Sep 19;22(3):1033. Epub 2021 Jul 19.

Department of Diabetes, Nutrition and Metabolic Diseases, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Longitudinal studies have indicated an association between thyroid function and insulin resistance (IR) or a neutral relationship. Both the lowest tertile of free thyroxine (fT4) and the highest tertile of free triiodothyronine (fT3) were found to be associated with IR in cross-sectional studies. The aim of the present study was to analyze the association between IR and subclinical hypothyroidism in a female adult population from Bucharest, Romania. Read More

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September 2021

Diagnostic Accuracy of Five Different Classification Systems for Thyroid Nodules: A Prospective, Comparative Study.

J Ultrasound Med 2021 Aug 9. Epub 2021 Aug 9.

Department of Radiology, Goztepe City Hospital, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Objective: To compare the diagnostic performance of five different thyroid ultrasound classification systems, to determine which system is optimal for evaluating thyroid nodules and reducing the unnecessary biopsy rate.

Methods: In this prospective study, 1,010 nodules referred for biopsy during a 2-year period were classified using five classification systems: the Kwak Thyroid Imaging Reporting and Data System (Kwak TI-RADS), the European TI-RADS (EU TI-RADS, the Korean TI-RADS (K TI-RADS), the American College of Radiology TI-RADS (ACR TI-RADS), and the American Thyroid Association (ATA) classification. After fine needle aspiration biopsy, all classifications were compared for all nodules and also particularly for nodules sized 1-3 cm. Read More

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A dosing algorithm for individualized radioiodine treatment of cats with hyperthyroidism.

J Vet Intern Med 2021 Aug 5. Epub 2021 Aug 5.

College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.

Background: Radioiodine ( I) is the treatment of choice for hyperthyroidism in cats, but current I-dosing protocols can induce iatrogenic hypothyroidism and expose azotemia.

Objectives: To develop a cat-specific algorithm to calculate the lowest I dose to resolve hyperthyroidism, while minimizing risk of iatrogenic hypothyroidism and subsequent azotemia.

Animals: One thousand and four hundred hyperthyroid cats treated with I. Read More

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Acrylamide induces a thyroid allostasis-adaptive response in prepubertal exposed rats.

Curr Res Toxicol 2020 Jun 31;1:124-132. Epub 2020 Oct 31.

Laboratory of Reproductive Toxicology, Department of Medicine, State University of Central-West, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil.

Some endocrine-disrupting chemicals (EDCs) can affect the endocrine system through covalent interactions with specific sites, leading to deregulation of physiological homeostasis. The acrylamide (AA) present in some fried or baked foods is an example of an electrophile molecule that is able to form adducts with nucleophilic regions of nervous system proteins leading to neurological defects. A positive correlation between increased urinary AA metabolite concentration and reduced levels of thyroid hormones (TH) was described in adolescents and young adults. Read More

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Diagnostic performance of US-based FNAB criteria of the 2020 Chinese guideline for malignant thyroid nodules: comparison with the 2017 American College of Radiology guideline, the 2015 American Thyroid Association guideline, and the 2016 Korean Thyroid Association guideline.

Quant Imaging Med Surg 2021 Aug;11(8):3604-3618

Department of Ultrasound, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Background: To investigate the diagnostic performance of the ultrasonography-based fine-needle aspiration biopsy criteria of the Chinese Thyroid Imaging Reporting and Data System (C-TIRADS) for malignant nodules compared to 3 other guidelines.

Methods: This study included 2,309 thyroid nodules in 1,697 patients with histopathological and cytopathological diagnoses of benign and malignant nodules from January 2018 to August 2020. The clinical and ultrasonographic features of the nodules were retrospectively reviewed and classified according to the Chinese guideline (C-TIRADS), the American College of Radiology guideline (ACR-TIRADS), the American Thyroid Association guideline (ATA guideline), and the Korean Thyroid Association guideline (K-TIRADS). Read More

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Cancer incidence and mortality in Zhejiang Province, Southeast China, 2016: a population-based study.

Chin Med J (Engl) 2021 07 29;134(16):1959-1966. Epub 2021 Jul 29.

Zhejiang Provincial Office for Cancer Prevention and Control, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.

Backgrounds: Cancer is one of the main causes of death worldwide, seriously threatening human health and life expectancy. We aimed to analyze the cancer incidence and mortality rates during 2016 in Zhejiang Province, Southeast China.

Methods: Data were collected from 14 population-based cancer registries across Zhejiang Province of China. Read More

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Chocolate consumption and all-cause and cause-specific mortality in a US population: a post hoc analysis of the PLCO cancer screening trial.

Aging (Albany NY) 2021 07 29;13(14):18564-18585. Epub 2021 Jul 29.

Department of Infectious Diseases, Institute for Viral Hepatitis, The Key Laboratory of Molecular Biology for Infectious Diseases, Chinese Ministry of Education, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Few studies with mixed results have examined the association between chocolate consumption and mortality. We aimed to examine this association in a US population. A population-based cohort of 91891 participants aged 55 to 74 years was identified. Read More

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Seasonal variations in the diagnosis of the top 10 cancers in Korea: A nationwide population-based study using a common data model.

J Gastroenterol Hepatol 2021 Jul 22. Epub 2021 Jul 22.

Department of Internal Medicine, Division of Gastroenterology, Kyung Hee University School of Medicine, Seoul, Korea.

Background And Aim: A better understanding of seasonal variations in cancer diagnosis may be the first step toward optimal resource distribution in the National Cancer Screening Program (NCSP). This study aimed to identify seasonal variations in the diagnosis of the top 10 major cancers in Korea.

Methods: We conducted a retrospective, observational cohort study in participants aged ≥ 20 years between 2012 and 2016 from the Health Insurance Review and Assessment-National Patient Sample database, previously converted to a common data model. Read More

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Socioeconomic inequality in noncommunicable diseases: Results from a baseline Persian cohort study.

Med J Islam Repub Iran 2021 16;35:78. Epub 2021 Jun 16.

Hormozgan University of Medical Sciences, Hormozgan, Iran.

Contrary to health indices advancement during recent years, health inequalities are still a global challenge. This study aimed to determine socioeconomic factors for noncommunicable diseases using concentration indices (CI). This cross-sectional study was conducted on the baseline data from a cohort study in Fasa (southern Iran). Read More

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Usefulness of FT3 to FT4 Ratio to Predict Mortality in Euthyroid Patients With Prior Cardiovascular Events Undergoing PCI: Five-Year Findings From a Large Single-Center Cohort Study.

Front Endocrinol (Lausanne) 2021 5;12:700349. Epub 2021 Jul 5.

Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Background: In euthyroid patients undergoing percutaneous coronary intervention (PCI), it is still unclear whether free triiodothyronine to free thyroxine (FT3/FT4) ratio can predict the recurrence of cardiovascular events (CVEs). We aim to investigate its association with recurrent long-term adverse events in this population.

Methods: 3549 euthyroid patients with prior CVEs history undergoing PCI were consecutively enrolled in our study and subsequently divided into three FT3/FT4 ratio tertiles (T1<2. Read More

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Reproductive and thyroid endocrine axis cross-talk in rainbow trout (Oncorhynchus mykiss) alevins.

Gen Comp Endocrinol 2021 Oct 17;312:113855. Epub 2021 Jul 17.

Simon Fraser University, Department of Biological Sciences, 8888 University Dr, Burnaby, BC V5A 1S6, Canada.

The goal of this study was to characterize morphological and molecular effects in rainbow trout alevins after waterborne exposures to 17β-estradiol (E2; 0.0008 to 0.5 μg/L), triiodothyronine (T3; 0. Read More

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October 2021

Population exposure-response model of I in patients with benign thyroid disease.

Eur J Pharm Sci 2021 Oct 14;165:105942. Epub 2021 Jul 14.

Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade - Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Republic of Serbia.

Purpose: The study aimed to explore the relationship of different exposure measures with I therapy response in patients with benign thyroid disease, estimate the variability in the response, investigate possible covariates, and discuss dosing implications of the results.

Methods: A population exposure-response analysis was performed using nonlinear mixed-effects modelling. Data from 95 adult patients with benign thyroid disease were analysed. Read More

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October 2021

Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015.

PLoS One 2021 15;16(7):e0254630. Epub 2021 Jul 15.

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.

Objectives: Low-normal thyroid function is associated with numerous metabolic risk factors including insulin resistance (IR). Triglyceride-glucose (TyG) index is a new surrogate marker of IR calculated by fasting triglyceride and glucose levels. Here, we investigated the association between thyroid function and TyG index in non-diabetic euthyroid adults. Read More

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Evaluation of skin doses for cone-beam computed tomography in dentomaxillofacial imaging: A preclinical study.

PLoS One 2021 12;16(7):e0254510. Epub 2021 Jul 12.

Department of Oral and Craniomaxillofacial Surgery, Center for Dental Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Purpose: Evaluation of skin organ doses in six different cone-beam computed tomography scanners (CBCT) dedicated to dentomaxillofacial imaging. Our hypothesis is that the dose varies between different devices, protocols and skin areas.

Materials And Methods: An anthropomorphic adult head and neck phantom was used to which a dosimeter (Waterproof Farmer® Chamber, PTW, Freiburg, Germany) was attached to anatomic landmarks of both parotid glands, both ocular lenses, the thyroid gland and the neurocranium. Read More

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Associations of exposure to multiple trace elements with the risk of goiter: A case-control study.

Environ Pollut 2021 Jul 6;288:117739. Epub 2021 Jul 6.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. Electronic address:

Goiter is one of common endocrine diseases, and its etiology has not been fully elucidated. The changes in trace elements' levels have an important impact on the thyroid. We designed a case-control study, which involved 383 goiter cases and 383 matched controls. Read More

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Elevated serum thyrotropin levels and endothelial dysfunction in a prospective hemodialysis cohort.

Hemodial Int 2021 Jul 6. Epub 2021 Jul 6.

Harold Simmons Center for Chronic Disease Research and Epidemiology, University of California Irvine School of Medicine, Orange, California, USA.

Introduction: Thyroid dysfunction is a highly prevalent yet under-recognized complication in hemodialysis patients. In the general population, hypothyroidism has been associated with endothelial dysfunction due to impaired vasodilator synthesis and activity. Little is known about the association of serum thyrotropin (TSH), the most sensitive and specific single biochemical metric of thyroid function, with endothelial function in hemodialysis patients. Read More

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Neonatal heel prick screening TSH concentration in the Netherlands as indicator of iodine status.

Nutr J 2021 07 4;20(1):63. Epub 2021 Jul 4.

National Institute for Public Health and the Environment (RIVM), PO box 1, 3720, Bilthoven, BA, The Netherlands.

Background: Neonatal Thyroid Stimulating Hormone (nTSH) is proposed as indicator of iodine deficiency in a population. Population's iodine sufficiency is indicated by a proportion of the newborns less than 3% having nTSH above 5 mIU/L. The aim of this study was to explore the Dutch neonatal heel prick screening TSH data to assess iodine status in the Netherlands and identify determinants and potential confounders of this assessment. Read More

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Thionamide-induced Agranulocytosis: A Retrospective Analysis of 36 Patients With Hyperthyroidism.

Endocr Pract 2021 Jun 30. Epub 2021 Jun 30.

Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, China; The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China. Electronic address:

Objective: Agranulocytosis is a rare but serious adverse drug reaction (ADR) of thionamide antithyroid drugs (ATDs). We explored the characteristics of ADRs in patients with hyperthyroidism.

Methods: This retrospective study included 3558 inpatients with Graves disease treated in a Class A Grade 3 hospital between 2015 and 2019. Read More

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Radiomics Score Combined with ACR TI-RADS in Discriminating Benign and Malignant Thyroid Nodules Based on Ultrasound Images: A Retrospective Study.

Diagnostics (Basel) 2021 Jun 1;11(6). Epub 2021 Jun 1.

Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

This study aimed to explore the ability of combination model of ultrasound radiomics score (Rad-score) and the thyroid imaging, reporting and data system by the American College of Radiology (ACR TI-RADS) in predicting benign and malignant thyroid nodules (TNs). Up to 286 radiomics features were extracted from ultrasound images of TNs. By using the lowest probability of classification error and average correlation coefficients (POE + ACC) and the least absolute shrinkage and selection operator (LASSO), we finally selected four features to establish Rad-score (Vertl-RLNonUni, Vertl-GLevNonU, WavEnLH-s4 and WavEnHL-s5). Read More

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Pro-Oxidative Effect of KIO and Protective Effect of Melatonin in the Thyroid-Comparison to Other Tissues.

Life (Basel) 2021 Jun 21;11(6). Epub 2021 Jun 21.

Department of Oncological Endocrinology, Medical University of Lodz, 7/9 Zeligowski St., 90-752 Lodz, Poland.

Not only iodine deficiency, but also its excess may contribute to thyroid cancer. Potassium iodate (KIO), which is broadly used in the salt iodization program, can increase oxidative damage to membrane lipids (lipid peroxidation, LPO) under experimental conditions, with the strongest damaging effect at KIO concentration of ~10 mM (corresponding to physiological iodine concentration in the thyroid). Melatonin is an effective antioxidant, which protects against KIO-induced LPO in the thyroid. Read More

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