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Association of multiple preventive therapies postdischarge and long-term health outcomes after acute myocardial infarction.

J Chin Med Assoc 2021 Sep 20. Epub 2021 Sep 20.

Division of Cardiology, Department of Internal Medicine and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, Taiwan, ROC Taipei Heart institute, Taipei Medical University, Taipei, Taiwan, ROC Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC Department of Pharmacy, Taipei Medical University Hospital, Taipei, Taiwan, ROC School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC Office of Data Center, Taipei Medical University, Taipei, Taiwan, ROC School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan, ROC.

Background: Statins, beta-blockers, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers have been advocated by guidelines as secondary prevention medications to improve the long-term outcomes of post-acute myocardial infarction (AMI) patients. However, adequate drug adherence has always been challenging, and different treatment regimens may lead to divergent outcomes that remain unclear under current MI care standards. This study investigated the association between use of different preventive regimens post-AMI and patients' long-term outcomes. Read More

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September 2021

Global, regional, and national survey on the burden and quality of care of pancreatic cancer: a systematic analysis for the Global Burden of Disease study 1990-2017.

Pancreatology 2021 Sep 10. Epub 2021 Sep 10.

Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Pancreatic cancer (PC) is among the most lethal cancers worldwide, and the quality of care provided to PC patients is a vital public health concern. We aimed to investigate the quality of care of PC globally and to report its current burden.

Methods: The Quality of Care Index (QCI) was achieved by performing a Principal Component Analysis utilizing the results of the GBD study 2017. Read More

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September 2021

Chondrus crispus treated with ultrasound as a polysaccharides source with improved antitumoral potential.

Carbohydr Polym 2021 Dec 21;273:118588. Epub 2021 Aug 21.

Department of Chemical Engineering, Universidade de Vigo (Campus Ourense), Edificio Politécnico, As Lagoas, 32004 Ourense, Spain; CINBIO, Universidade de Vigo, 32004 Ourense, Spain.

Ultrasound-assisted extraction was used to recover gelling biopolymers and antioxidant compounds from Chondrus crispus with improved biological potential. The optimal processing conditions were evaluated using a Box-Behnken design, and the impact on the biological and thermo-rheological properties of the carrageenan fraction and on the bioactive features of the soluble extracts were studied. The optimum extraction parameters were defined by extraction time of ~34. Read More

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December 2021

Influenza vaccine uptake among at-risk adults (aged 16-64 years) in the UK: a retrospective database analysis.

BMC Public Health 2021 Sep 24;21(1):1734. Epub 2021 Sep 24.

Sanofi Pasteur, 410 Thames Valley Park Drive, Reading, RG6 1PT, UK.

Background: In the UK, annual influenza vaccination is currently recommended for adults aged 16-64 years who are in a clinical at-risk group. Despite recommendations, rates of vaccine uptake in the UK have historically been low and below national and international targets. This study aims to analyse vaccine uptake among adults in clinical at-risk groups from the 2015-2016 influenza season to the present. Read More

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September 2021

Awake craniotomy with transcortical motor evoked potential monitoring for resection of gliomas within or close to motor-related areas: validation of utility for predicting motor function.

J Neurosurg 2021 Sep 24:1-10. Epub 2021 Sep 24.

1Department of Neurosurgery.

Objective: The authors previously showed that combined evaluation of changes in intraoperative voluntary movement (IVM) during awake craniotomy and transcortical motor evoked potentials (MEPs) was useful for predicting postoperative motor function in 30 patients with precentral gyrus glioma. However, the validity of the previous report is limited to precentral gyrus gliomas. Therefore, the current study aimed to validate whether the combined findings of IVM during awake craniotomy and transcortical MEPs were useful for predicting postoperative motor function of patients with a glioma within or close to motor-related areas and not limited to the precentral gyrus. Read More

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September 2021

Assessment of Acute Mountain Sickness Using 1993 and 2018 Versions of the Lake Louise Score in a Large Chinese Cohort.

High Alt Med Biol 2021 Sep 23. Epub 2021 Sep 23.

Institute of Cardiovascular Diseases of PLA, The Second Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.

Chen, Renzheng, Yong Wang, Chen Zhang, Xiaolin Luo, Jie Yang, Chuan Liu, and Lan Huang. Assessment of acute mountain sickness using 1993 and 2018 versions of the Lake Louise Score in a large Chinese cohort. 00:000-000, 2021. Read More

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September 2021

A pro-inflammatory diet is associated with increased odds of frailty after 12-year follow-up in a cohort of adults.

Am J Clin Nutr 2021 Sep 24. Epub 2021 Sep 24.

Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.

Background: Frailty occurs in 10-15% of community-living older adults and inflammation is a key determinant of frailty. Though diet is a modulator of inflammation, there are few prospective studies elucidating the role of diet-associated inflammation on frailty.

Objective: To determine whether a pro-inflammatory diet was associated with increased odds of frailty in adults from the Framingham Heart Study (FHS). Read More

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September 2021

Relationship between carbohydrate-to-fat intake ratio and the development of chronic kidney disease: A community-based prospective cohort study.

Clin Nutr 2021 Sep 9;40(10):5346-5354. Epub 2021 Sep 9.

Division of Nephrology, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea; Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea. Electronic address:

Background & Aims: It is well-known that high protein intake is associated with renal hyperfiltration and faster renal function decline, but the association of other macronutrients, carbohydrate and fat, with development of chronic kidney disease (CKD) is still inconclusive. Therefore, we aimed to examine the relationship between fat-to-carbohydrate intake ratio (F/C ratio) and incident CKD.

Methods: We included 9226 subjects from the Korean Genome and Epidemiology Study. Read More

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September 2021

Sulfation of O-glycans on mucin-type proteins from serous ovarian epithelial tumors.

Mol Cell Proteomics 2021 Sep 21:100150. Epub 2021 Sep 21.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. Electronic address:

Despite that sulfated O-linked glycans are abundant on ovarian cancer (OC) glycoproteins, their regulation during cancer development and involvement in cancer pathogenesis remain unexplored. We characterized O-glycans carrying sulfation on galactose residues and compared their expression to defined sulfotransferases regulated during OC development. Desialylated sulfated oligosaccharides were released from acidic glycoproteins in the cyst fluid from one patient with a benign serous cyst and one patient with serous OC. Read More

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September 2021

Socioeconomic Status, Physical Functioning and Mortality: Results From a Cohort Study of Older Adults in Hong Kong.

J Am Med Dir Assoc 2021 Sep 20. Epub 2021 Sep 20.

Jockey Club Institute of Ageing, Chinese University of Hong Kong, Hong Kong; Institute of Health Equity, Chinese University of Hong Kong, Hong Kong.

Objectives: It is inconsistent in the literature on whether inequalities of health in older age widen or narrow over time. We assessed the associations of socioeconomic status (SES), physical functioning, and mortality in an older age cohort in Hong Kong.

Design: Longitudinal cohort study. Read More

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September 2021

Mediterranean diet adherence among cosmetology students.

Rocz Panstw Zakl Hig 2021 ;72(3):301-307

Department of Dietetics, Faculty of Health Sciences, Wrocław Medical University, Wrocław, Poland.

Background: The Mediterranean diet (MD) is universally recognized as the healthiest model of nutrition whose beneficial effects help prevent many diet-related diseases.

Objective: The aim of the study was to assess cosmetology students' adherence to the Mediterranean Diet using the Mediterranean Diet Score (MDS).

Material And Methods: The study group consisted of 175 cosmetology students of the School of Physiotherapy whose dietary habits were assessed using a validated food frequency questionnaire (FFQ) consisting of 154 food and drink items representative of the diet during the last year. Read More

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January 2021

Obesity, smoking status and their relationships in selected population groups.

Rocz Panstw Zakl Hig 2021 ;72(3):291-299

Slovak University of Agriculture in Nitra, Faculty of Agrobiology and Food Resources, Department of Human Nutrition, Nitra, Slovakia.

Background: Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. Obesity is associated with many chronic diseases, including cardiovascular disease and diabetes, and recently the role of overweight and obesity in lung disease has received new interest. Chronic obstructive lung disease is the third-leading cause of death globally, and both obesity and diet appear to play roles in its pathophysiology. Read More

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January 2021

Unequal access and use of contraceptives among parenting adolescent girls in sub-Saharan Africa: a cross-sectional analysis of demographic and health surveys.

BMJ Open 2021 Sep 22;11(9):e051583. Epub 2021 Sep 22.

Population Dynamics and Sexual and Reproductive Health, African Population and Health Research Center, Nairobi, Kenya.

Objective: We examined the divergent patterns, prevalence and correlates of contraceptive use among parenting adolescents in sub-Saharan Africa using the Demographic and Health Survey datasets of 17 countries.

Design: We included a weighted sample of 9488 parenting adolescent girls in our analysis. Current contraceptive use was defined as the use of any methods to delay or avoid getting pregnant at the survey time. Read More

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September 2021

The global prevalence of dry eye disease: A Bayesian view.

Authors:
Eric B Papas

Ophthalmic Physiol Opt 2021 Sep 21. Epub 2021 Sep 21.

School of Optometry & Vision Science, University of New South Wales, Sydney, New South Wales, Australia.

Purpose: To provide estimates for the prevalence of dry eye disease globally and in sub-groups defined by: diagnostic criterion, sex, geographic location and age, using a Bayesian approach.

Methods: Modelling prevalence as a Beta distribution, estimates were inferred from Bayesian posterior distributions obtained by combing an uninformed prior with likelihood functions generated from all relevant studies reporting dry eye prevalence between 1997 and 2021.

Results: Global prevalence of dry eye disease was estimated at 11. Read More

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September 2021

Dietary fiber intake and risk of prediabetes in China: results from the TCLSIH Cohort Study.

Br J Nutr 2021 Sep 21:1-20. Epub 2021 Sep 21.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.

High dietary fiber intake has been associated with a lower risk of diabetes, but the association of dietary fiber with prediabetes is only speculative, especially in China, where the supportive data from prospective studies is lacking. This study aimed to examine the association between dietary fiber intake and risk of incident prediabetes among Chinese adults. We performed a prospective analysis in 18,085 participants of the TCLSIH cohort study who were free of diabetes, prediabetes, cancer, and cardiovascular disease at baseline. Read More

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September 2021

Metabolomics profile responses to changing environments in a common bean (Phaseolus vulgaris L.) germplasm collection.

Food Chem 2021 Aug 31;370:131003. Epub 2021 Aug 31.

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal; iBET, Instituto de Biologia Experimental e Tecnológica, Av. da República, Apartado 12, 2781-901 Oeiras, Portugal; Faculdade de Farmácia, Universidade de Lisboa, Av. das Forças Armadas, 1649-019 Lisboa, Portugal. Electronic address:

Metabolomics is one of the most powerful -omics to assist plant breeding. Despite the recognized genetic diversity in Portuguese common bean germplasm, details on its metabolomics profiles are still missing. Aiming to promote their use and to understand the environment's effect in bean metabolomics profiles, 107 Portuguese common bean accessions, cropped under contrasting environments, were analyzed using spectrophotometric, untargeted and targeted mass spectrometry approaches. Read More

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Prognostic value of haemoglobin drop in patients with acute coronary syndromes.

Eur J Clin Invest 2021 Sep 20:e13670. Epub 2021 Sep 20.

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.

Background: The prognostic value of in-hospital haemoglobin drop in patients with acute coronary syndrome (ACS) undergoing invasive therapy remains insufficiently investigated.

Materials And Methods: This observational study included 3838 patients with ACS with admission and in-hospital nadir haemoglobin values available. Haemoglobin drop was defined as a positive difference between admission and nadir haemoglobin values. Read More

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September 2021

Anterior Cruciate Ligament Reconstruction With Concomitant Meniscal Repair: Is Graft Choice Predictive of Meniscal Repair Success?

Orthop J Sports Med 2021 Sep 14;9(9):23259671211033584. Epub 2021 Sep 14.

CU Sports Medicine, Boulder, Colorado, USA.

Background: When meniscal repair is performed during anterior cruciate ligament (ACL) reconstruction (ACLR), the effect of ACL graft type on meniscal repair outcomes is unclear.

Hypothesis: The authors hypothesized that meniscal repairs would fail at the lowest rate when concomitant ACLR was performed with bone--patellar tendon--bone (BTB) autograft.

Study Design: Cohort study; Level of evidence, 3. Read More

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September 2021

Recovery solutions for ecotourism centers during the Covid-19 pandemic: Utilizing Fuzzy DEMATEL and Fuzzy VIKOR methods.

Expert Syst Appl 2021 Dec 17;185:115594. Epub 2021 Jul 17.

Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Puebla, Mexico.

Obviously, the Covid-19 pandemic has huge impact on most businesses and has caused serious and countless problems for them. Therefore, providing solutions for affected businesses to recover and improve their activities during pandemic times is inevitable. In this regard, ecotourism centers are one of the businesses that went through this problem and have faced significant dilemmas in their activities. Read More

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December 2021

Treatment of Geriatric Acetabular Fractures-A Concise Review of the Literature.

Orthop Clin North Am 2021 Oct 29;52(4):323-333. Epub 2021 Jul 29.

Division of Orthopedic Surgery, St. Michael's Hospital, University of Toronto, 55 Queen Street East - Suite 800, Toronto, Ontario M5C 1R6, Canada. Electronic address:

Optimal management of acetabular fractures (AF) in the elderly has not been defined clearly. The incidence of such fractures is rising in the aging population. Advancements in implant technology have improved the longevity of combined or staggered total hip arthroplasty procedures for this patient population, thus allowing earlier weight bearing and continued functional independence. Read More

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October 2021

Exercise heart rate reserve and recovery as risk factors for sudden cardiac death.

Prog Cardiovasc Dis 2021 Sep 15. Epub 2021 Sep 15.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Graduate School of Urban Public Health, University of Seoul, Seoul, Republic of Korea.

Background: Little is known if heart rate responses during and after exercise test may be associated with the risk of sudden cardiac death (SCD). Our aim was to determine if exercise heart rate reserve and recovery, providing non-invasive indices, may predict SCD risk in general male population.

Methods: We evaluated the impact of delayed heart rate reserve and slow heart rate recovery and the risk of SCD in the Kuopio Ischemic Heart Disease prospective cohort study of randomly selected 1967 men aged 42-61 years at recruitment. Read More

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September 2021

Dairy protein intake is inversely related to development of non-alcoholic fatty liver disease.

Clin Nutr 2021 Aug 25;40(10):5252-5260. Epub 2021 Aug 25.

Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, 16995, Republic of Korea. Electronic address:

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is closely related to metabolic dysfunction, including insulin resistance, obesity, and metabolic syndrome. Dairy protein, rich in casein and whey protein, could help to reduce metabolic diseases. Therefore, we investigated the relationship between dairy protein intake and incident NAFLD. Read More

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Fruit and vegetable intake and risk of frailty: A systematic review and dose response meta-analysis.

Ageing Res Rev 2021 Sep 15;71:101460. Epub 2021 Sep 15.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Purpose: This systematic review and dose-response meta-analysis of observational studies was conducted to summarize available findings on the association between fruits and vegetables (FVs) consumption and risk of frailty.

Methods: Online databases including Medline, Scopus, and Embase were searched to detect related publications up to February 2021. Study selection and data extraction were performed by two investigators working in parallel. Read More

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September 2021

Combined association of cognitive impairment and poor oral health on mortality risk in older adults: results from the NHANES with 15 years of follow-up.

J Periodontol 2021 Sep 17. Epub 2021 Sep 17.

Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, China.

Background: Cognitive impairment and poor oral health are frequently seen among older adults. Both conditions have been identified as risk factors for mortality. However, the combined associations of cognitive impairment and poor oral health with mortality have not been well studied and are therefore the aim of this cohort study. Read More

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September 2021

Influence of changes in body fat on clinical outcomes in a general population: a 12-year follow-up report on the Ansan-Ansung cohort in the Korean Genome Environment Study.

Ann Med 2021 Dec;53(1):1646-1658

Division of Cardiology, Department of Internal Medicine, Hanyang University Medical Center, Seoul, South Korea.

Background: The impact of the changes in the obesity status on mortality has not been established; thus, we investigated the long-term influence of body fat (BF) changes on all-cause deaths and cardiovascular outcomes in a general population.

Methods: A total of 8374 participants were observed for 12 years. BF was measured at least two times using a bioimpedance method. Read More

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December 2021

Increased Blood Pressure Variability and the Risk of Probable Dementia or Mild Cognitive Impairment: A Post Hoc Analysis of the SPRINT MIND Trial.

J Am Heart Assoc 2021 Sep 17;10(18):e022206. Epub 2021 Sep 17.

Department of Neurology Harvard University Boston MA.

Background Increased systolic blood pressure variability (BPV) is associated with stroke, cardiovascular disease, and dementia and mild cognitive impairment. However, prior studies assessing the relationship between BPV and dementia or mild cognitive impairment had infrequent measurement of blood pressure or suboptimal blood pressure control. Methods and Results We performed a post hoc analysis of the SPRINT (Systolic Blood Pressure Intervention Trial) MIND (Memory and Cognition in Decreased Hypertension) trial. Read More

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September 2021

Beta-cell failure rather than insulin resistance is the major cause of abnormal glucose tolerance in Africans: insight from the Africans in America study.

BMJ Open Diabetes Res Care 2021 Sep;9(1)

NIDDK, National Institutes of Health, Bethesda, Maryland, USA

Introduction: Uncertainties exist on whether the main determinant of abnormal glucose tolerance (Abnl-GT) in Africans is β-cell failure or insulin resistance (IR). Therefore, we determined the prevalence, phenotype and characteristics of Abnl-GT due to β-cell failure versus IR in 486 African-born blacks (male: 64%, age: 38±10 years (mean±SD)) living in America.

Research Design And Methods: Oral glucose tolerance test were performed. Read More

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September 2021

Selecting proper distal fusion level in severe thoracolumbar kyphosis secondary to late osteoporotic vertebral compression fracture to limit distal complications.

J Orthop Sci 2021 Sep 13. Epub 2021 Sep 13.

Department of Orthopaedic Surgery, Capital Medical University Xuanwu Hospital, Beijing, China; National Clinical Research Center for Geriatric Diseases, Beijing, China. Electronic address:

Background: Surgical treatment of severe thoracolumbar kyphosis (TLK) secondary to late osteoporotic vertebral compression fracture (OVCF) presents several challenges to spine surgeons. Proper selection of distal fusion level is an important issue in surgical planning to decrease the likelihood of distal mechanical complications. This study was designed to compare the clinical and radiographic outcomes in elderly patients suffering from severe TLK related with late OVCF between different distal fusion strategies and to recommend a superior distal fusion level for these patients. Read More

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September 2021

Genotype by climate zone interactions for fertility, somatic cell score, and production in Iranian Holsteins.

J Dairy Sci 2021 Sep 13. Epub 2021 Sep 13.

Center for Quantitative Genetic and Genomics, Aarhus University, 8830 Tjele, Denmark. Electronic address:

The objective of this study was to investigate genetic variation and genotype by environment (G × E) interactions for fertility (including age at first calving and calving interval), somatic cell score (SCS), and milk production traits for Iranian Holsteins. Different environments were defined based on the climatic zones (cold, semi-cold, and moderate) and considering the herd location. Data were collected between 2003 and 2018 by the National Animal Breeding Center of Iran (Karaj). Read More

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September 2021

Association between low-density cholesterol change and outcomes in acute ischemic stroke patients who underwent reperfusion therapy.

BMC Neurol 2021 Sep 16;21(1):360. Epub 2021 Sep 16.

Center of Cerebrovascular Diseases, Department of Neurology, West China Hospital, Sichuan University, No.37 Guo Xue Xiang, Sichuan, 610041, Chengdu, China.

Background: Low-density lipoprotein cholesterol (LDL-C) can increase cardiovascular risk. However, the association between LDL-C change and functional outcomes in acute ischemic stroke (AIS) patients who underwent reperfusion therapy remains unclear.

Methods: Patients who received reperfusion therapy were consecutively enrolled. Read More

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September 2021