178,627 results match your criteria lower subjects


A non-parametric propensity score for estimating the effect of interferon-beta or glatiramer acetate on long-term outcomes of multiple sclerosis.

Mult Scler Relat Disord 2021 May 30;53:103050. Epub 2021 May 30.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada; Department of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada.

Background: The few observational studies that investigated the long-term effects of interferon-beta and glatiramer acetate were usually focused on progression to irreversible disability and other outcomes such as number of relapses and transition to secondary-progressive multiple sclerosis (SPMS) have been rarely studied. The objective of this paper is to estimate the effect of interferon-beta/glatiramer acetate on progression to irreversible disability, transition from relapsing-remitting multiple sclerosis (RRMS) to SPMS and the rate of relapses over 10 years.

Methods: Analyses included 2498 patients with confirmed diagnosis of RRMS followed in Montréal from 1977 to 2016. Read More

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Feasibility of MR fingerprinting using a high-performance 0.55 T MRI system.

Magn Reson Imaging 2021 Jun 8. Epub 2021 Jun 8.

Department of Radiology, Case Western Reserve University, Cleveland, OH, United States of America. Electronic address:

Background: MR fingerprinting (MRF) is a versatile method for rapid multi-parametric quantification. The application of MRF for lower MRI field could enable multi-contrast imaging and improve exam efficiency on these systems. The purpose of this work is to demonstrate the feasibility of 3D whole-brain T1 and T2 mapping using MR fingerprinting on a contemporary 0. Read More

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The Incessant increase Curve during the Oral Glucose Tolerance Test and its association with gut hormone level in Chinese T2DM Adults: A preliminary study.

Peptides 2021 Jun 8:170595. Epub 2021 Jun 8.

Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.

Purpose: To investigate glucose curve shape during an oral glucose tolerance test (OGTT) and its association with β-cell function or gut hormone.

Materials And Methods: Glucose curves during 180 min OGTTs (n = 89) were classified as incessant increase and monophasic. Data on demographics, β-cell function, and insulin sensitivity were collected. Read More

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Lumbar Thecal Sac Dimensions and Axial Spinal Cord Areas on Magnetic Resosnace Imaging in 626 Healthy Subjects.

Spine (Phila Pa 1976) 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan Department of Orthopedics Surgery, Chubu Rosai Hospital, Minato-ku, Nagoya, Japan.

Study Design: A cross-sectional study.

Objective: The aim of this study was to investigate the lumbar thecal sac dimensions and spinal cord area on magnetic resonance (MR) imaging in healthy volunteers.

Summary Of Background Data: There are few reports regarding lumbar spine MRI in healthy subjects, and the difference in spinal canal dimensions by age remains unclear. Read More

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Towards planning of osteotomy around the knee with quantitative inclusion of the adduction moment: a biomechanical approach.

J Exp Orthop 2021 Jun 11;8(1):39. Epub 2021 Jun 11.

Lower Extremity Orthopaedics, Musculoskeletal Center, Schulthess Clinic, Zurich, Switzerland.

Purpose: Despite practised for decades, the planning of osteotomy around the knee, commonly using the Mikulicz-Line, is only empirically based, clinical outcome inconsistent and the target angle still controversial. A better target than the angle of frontal-plane static leg alignment might be the external frontal-plane lever arm (EFL) of the knee adduction moment. Hypothetically assessable from frontal-plane-radiograph skeleton dimensions, it might depend on the leg-alignment angle, the hip-centre-to-hip-centre distance, the femur- and tibia-length. Read More

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An evaluation of the nutritional status of elderly with the use of the MNA questionnaire and determination of factors contributing to malnutrition. A pilot study.

Rocz Panstw Zakl Hig 2021 ;72(2):175-183

University of Life Science, Faculty of Food Science and Biotechnology, Department of Chemistry, Akademicka street 15, 20-950, Lublin, Poland.

Background: In the elderly, nutrition significantly influences biological aging and physiological and pathological changes in the body. A balanced diet and physical activity are the key to good physical and mental health.

Objective: The aim of this study was: (1) to perform nutritional screening tests in senior citizens residing in eastern Poland and (2) to evaluate the risk of malnutrition in elderly people who live with their families, seniors who live independently, and residents of nursing homes. Read More

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January 2021

Influence of Study Discontinuation during the Run-in Period on the Estimated Efficacy of Sacubitril/valsartan in the PARAGON-HF Trial.

Eur J Heart Fail 2021 Jun 11. Epub 2021 Jun 11.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Aims: The 4822 patients randomized in the PARAGON-HF trial were a subset of 5746 initially eligible patients who entered sequential run-in periods. We identified patient factors associated with study discontinuation during the run-in period and estimated the implications of these discontinuations for the overall study result.

Methods And Results: We utilized multivariable logistic regression models to identify patient factors associated with study discontinuation during the run-in. Read More

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Elderly traumatic central cord syndrome in the United States: a review of management and outcomes.

J Neurosurg Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurological Surgery, University of California, San Francisco, CA, USA -

Introduction: As the incidence of elderly spinal cord injury rises, improved understanding of risk profiles and outcomes is needed. This review summarizes clinical characteristics, management, and outcomes specific to the elderly (≥65-years) with acute traumatic central cord syndrome in the United States.

Evidence Aquisition: Literature review of the PubMed, Embase, and CINAHL databases (01/2007-03/2020) regarding elderly subjects with acute traumatic central cord syndrome. Read More

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Role of ABO blood system in COVID-19: Findings from a southern Italian study.

Transfus Med 2021 Jun 10. Epub 2021 Jun 10.

Clinical Pathology and Microbiology, Vito Fazzi Hospital, Lecce, Italy.

Background: COVID-19 is a worldwide infection caused by SARS-CoV-2 and infects humans by binding to the ACE2 receptor. Blood group ABO glycoproteins can influence the binding of the virus to ACE2. The role of ABO blood system in the susceptibility to infection as well as in the clinical outcome of infected patients is still controversial and needs to be clarified. Read More

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The diagnostic value of 2D-speckle tracking echocardiography for identifying subclinical ventricular dysfunction in subjects with early repolarization pattern.

Echocardiography 2021 Jun 10. Epub 2021 Jun 10.

Cardiology Department, KBU Educational and Research Hospital, Karabük, Turkey.

Introduction: Early repolarization pattern (ERP) can exist a silent substrate for arrhytmic events in accordance with the previous studies which have shown there has been evidence of morphological changes in left ventricle (LV) in ERP subjects. Despite structural changes in ERP subjects, it has not exactly known whether a change in LV functional parameters occur in ERP. The aim of our study was to investigate LV functional parameters in ERP athletes evaluated by 2D- speckle tracking echocardiography (2D-STE). Read More

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Single-Day Low-Residue Diet Prior to Colonoscopy Demonstrates Improved Bowel Preparation Quality and Patient Tolerance over Clear Liquid Diet: A Randomized, Single-Blinded, Dual-Center Trial.

Dig Dis Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Gastroenterology, Long Beach Veterans Affairs Healthcare System, Long Beach, CA, USA.

Background And Aims: Patients often refer to bowel preparation and associated dietary restrictions as the greatest deterrents to having a colonoscopy completed or performed. Large studies comparing a low-residue diet (LRD) and a clear liquid diet (CLD) are still limited. The aim of this study is to compare LRD and CLD with regard to bowel preparation quality, tolerance, and satisfaction among a diverse patient population. Read More

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Depletion of Omega-3 Fatty Acids in RBCs and Changes of Inflammation Markers in Patients With Morbid Obesity Undergoing Gastric Bypass.

J Nutr 2021 Jun 10. Epub 2021 Jun 10.

Hackensack University Medical Center, Hackensack, NJ, USA.

Background: Bariatric surgery is considered the most effective treatment for severe obesity. Despite this wide success, bariatric surgery is associated with increased risks of nutritional deficiencies.

Objectives: To examine whether Roux-en-Y-gastric bypass (RYGB) alters essential fatty acid (FA) status and inflammation markers. Read More

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Heart rate score, a measure related to chronotropic incompetence in pacemaker patients.

Heart Rhythm O2 2021 Apr 20;2(2):124-131. Epub 2021 Feb 20.

Cleveland Clinic, Cleveland, Ohio.

Background: Heart rate score (HrSc) ≥70% in cardiac resynchronization therapy defibrillator and implantable cardioverter-defibrillator subjects predicts 5-year mortality risk. A high HrSc suggests few sensed cardiac cycles above the programmed lower rate.

Objective: To determine if HrSc is related to chronotropic incompetence (CI) in pacemaker (PM) subjects. Read More

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Racial difference in atrial size and extracellular matrix homeostatic response to hypertension: Is this a potential mechanism of reduced atrial fibrillation in African Americans?

Heart Rhythm O2 2021 Feb 12;2(1):37-45. Epub 2021 Jan 12.

Division of Cardiology, Medical University of South Carolina, Charleston, South Carolina.

Background: Atrial fibrillation (AF) is less common in African Americans (AA) than Caucasians (C) despite a higher prevalence of risk factors such as hypertension (HTN).

Objective: Test the hypothesis that differences in extracellular matrix (ECM) between AA and C in response to HTN might attenuate atrial enlargement and alter myocardial fibrosis.

Methods: ECM-related plasma biomarkers and echo data were collected from 326 C and 129 AA subjects with no history of AF, stratified by the presence of HTN, HTN with left ventricular hypertrophy (LVH), or HTN with LVH and heart failure with preserved ejection fraction (HFpEF). Read More

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February 2021

Maternal and Neonatal Factors Affecting Bone Mineral Content of Indonesian Term Newborns.

Front Pediatr 2021 25;9:680869. Epub 2021 May 25.

Department of Neonatology, Amsterdam University Medical Center Location VU University Medical Center, Emma Children's Hospital, VU University Amsterdam, Amsterdam, Netherlands.

Interactions between the genome and intrauterine environment can affect bone mineralization in newborns and even in adult life. Several studies show that intrauterine fetal bone mineralization or early postnatal bone condition influences the risk of osteoporosis in later life. To determine whole body bone mineral content (WB BMC) and factors that influence neonatal WB BMC in Indonesian term newborns. Read More

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Detection of cytokine storm in patients with achalasia using ELISA.

Biomed Rep 2021 Jul 31;15(1):62. Epub 2021 May 31.

Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8504, Japan.

Esophageal achalasia is characterized by abnormal peristaltic movements of the esophageal body and impaired relaxation of the lower esophageal sphincter (LES). However, its etiology remains unknown. In our previous study, it was shown that in the LES of patients with achalasia, hsv1-miR-H1 was overexpressed, ATG16L1 expression was downregulated and interleukin (IL)-1β levels were upregulated. Read More

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Nested Case-Control Study of Corin Combined with sFlt-1/PLGF in Predicting the Risk of Preeclampsia.

Int J Gen Med 2021 3;14:2313-2320. Epub 2021 Jun 3.

Postgraduate Department, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong.

Background: Preeclampsia (PE), a serious pregnancy disorder, is responsible for maternal and fetal mortality worldwide. At present, numerous candidate biomarkers have been studied to predict PE.

Objective: To explore the role of Corin in PE risk prediction and then evaluate the predictive ability of soluble vascular endothelial growth factor receptor-1 (sFlt-1), placenta growth factor (PLGF), and sFlt-1/PLGF after the addition of Corin. Read More

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The Association with COPD Readmission Rate and Access to Medical Institutions in Elderly Patients.

Int J Chron Obstruct Pulmon Dis 2021 3;16:1599-1606. Epub 2021 Jun 3.

Department of Health Policy & Management, Kangwon National University, Chuncheon, South Korea.

Purpose: Up to 20% of patients with chronic obstructive pulmonary disease (COPD) require re-admission within 30 days of discharge after hospitalization for acute exacerbations of the disease. These re-admissions can increase morbidity and the economic burden of COPD. Reducing re-admissions has become a policy target in many developed countries. Read More

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Remdesivir, Renal Function and Short-Term Clinical Outcomes in Elderly COVID-19 Pneumonia Patients: A Single-Centre Study.

Clin Interv Aging 2021 3;16:1037-1046. Epub 2021 Jun 3.

Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy.

Background: Remdesivir, an antiviral agent able to reduce inflammatory cascade accompanying severe, life-threatening pneumonia, became the first drug approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus 2 related severe acute respiratory syndrome (SARS CoV2). As from its previously known clinical indications, the use of remdesivir in the presence of severe renal impairment is contraindicated; however, the impact of remdesivir on renal function in aging patients has not been elucidated.

Subjects And Methods: This retrospective observational study involved 109 individuals consecutively admitted in internal medicine section, Azienda Ospedaliero Universitaria Pisana hospital, in November-December 2020 due to a confirmed diagnosis of SARS CoV2 and receiving remdesivir according to international inclusion criteria. Read More

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Dietary phytochemical index and attention-deficit/hyperactivity disorder in Iranian children: a case control study.

Eur J Clin Nutr 2021 Jun 10. Epub 2021 Jun 10.

Department of Nutrition, School of Public Health, Shahid Sadughi University of Medical Sciences, Yazd, Iran.

Objective: Attention Deficit/Hyperactivity Disorder (ADHD) is a common behavioral disorder among children. Based on literature, it has been hypothesized that the higher intake of rich sources of phytochemicals may be inversely related to the risk of ADHD. We investigated the association of dietary phytochemical index (DPI) with odds of ADHD. Read More

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Associations of hypertension burden on subsequent dementia: a population-based cohort study.

Sci Rep 2021 Jun 10;11(1):12291. Epub 2021 Jun 10.

Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

In this nationwide cohort study, we assessed the effects of hypertension burden and blood pressure (BP) control on dementia in different age subgroups. From the Korean National Health Insurance Service-Health Screening cohort from January 1, 2005 to December 31, 2013, we enrolled 428,976 subjects aged 40-79 years without previous diagnosis of dementia or stroke. During a mean follow-up of 7. Read More

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Obesity and mortality in critically ill COVID-19 patients with respiratory failure.

Int J Obes (Lond) 2021 Jun 10. Epub 2021 Jun 10.

Specialized Obesity Center and Department of Endocrinology, Diabetology, Nutrition, CHRU-Nancy, Brabois Hospital, Université de Lorraine, Nancy, France.

Background: Patients with obesity are at increased risk of severe COVID-19, requiring mechanical ventilation due to acute respiratory failure. However, conflicting data are obtained for intensive care unit (ICU) mortality.

Objective: To analyze the relationship between obesity and in-hospital mortality of ICU patients with COVID-19. Read More

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SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy.

Sci Rep 2021 Jun 10;11(1):12312. Epub 2021 Jun 10.

IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

Lombardy is the Italian region most affected by COVID-19. We tested the presence of plasma anti-SARS-CoV-2 IgG antibodies in 3985 employees across 7 healthcare facilities in areas of Lombardy with different exposure to the SARS-CoV-2 epidemic. Subjects filled a questionnaire to self-report on COVID-19 symptoms, comorbidities, smoking, regular or remote working, and the exposure to COVID-infected individuals. Read More

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One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study.

Stem Cell Res Ther 2021 Jun 10;12(1):340. Epub 2021 Jun 10.

Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No 321, Zhongshan Road, Nanjing, 210008, Jiangsu, China.

Background: The preservation or restoration of β cell function in type 1 diabetes (T1D) remains as an attractive and challengeable therapeutic target. Mesenchymal stromal cells (MSCs) are multipotent cells with high capacity of immunoregulation, which emerged as a promising cell-based therapy for many immune disorders. The objective of this study was to examine the efficacy and safety of one repeated transplantation of allogeneic MSCs in individuals with T1D. Read More

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Complicated placenta accreta spectrum: identifying a high-risk cohort.

J Matern Fetal Neonatal Med 2021 Jun 10:1-9. Epub 2021 Jun 10.

Department of Obstetrics and Gynecology, University of California - Irvine, Irvine, CA, USA.

Objective: To assess differences in the perioperative complication rate between patients with placenta accreta spectrum (PAS) with and without complicating factors.

Methods: This retrospective cohort study included subjects who underwent cesarean hysterectomy with histology-proven PAS between 23 0/7 and 42 0/7 weeks gestational age (GA) from 1 July 2008 to 11 April 2017. Perioperative outcomes were compared between those with uncomplicated PAS and "complicated PAS," defined as PAS subjects who experienced ≥2 bleeding episodes, preterm premature rupture of membranes (PPROM), or premature contractions requiring tocolysis. Read More

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Strategies for maintaining dynamic balance in persons with neurological disorders during overground walking.

Proc Inst Mech Eng H 2021 Jun 11:9544119211023624. Epub 2021 Jun 11.

IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.

Maintaining a stable gait requires a dynamic balance control, that can be altered in persons with Multiple Sclerosis (MS), Stroke (ST), and Parkinson's disease (PD). The understanding of the strategy for Center of Mass (CoM) positioning adopted by patients during walking is important to be able to program treatments aimed at improving gait control and preventing falls. Forty-four persons with a mild-to-moderate neurological disorder (20 with MS, 14 with ST, 10 with PD) underwent clinical examination and gait analysis. Read More

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Differences in fatigability of vastus medialis muscle between patients with limb symmetry index of <90% and ≥90% after chronic anterior cruciate ligament reconstruction.

Knee 2021 Jun 7;31:39-45. Epub 2021 Jun 7.

Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-8509, Japan. Electronic address:

Background: A limb symmetry index (LSI) of ≥90% for the quadriceps is recommended for return to sports activity after anterior cruciate ligament reconstruction (ACLR). However, there is no information on differences in muscle fatigability between patients with LSI of <90% and ≥90%. The aim of this study was to assess the difference in quadriceps muscle fatigability on the involved side between post-ACLR patients with LSI of <90% and ≥90%. Read More

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Relating Retinal Vascular Oxygen Saturation and Microvasculature Morphology at Progressive Stages of Diabetic Retinopathy.

Transl Vis Sci Technol 2021 May;10(6)

Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA.

Purpose: Diabetic retinopathy (DR) is a common cause of vision loss in working age adults and presents changes in retinal vessel oxygenation and morphology. The purpose of this study was to test the hypothesis that there is an association of retinal vessel oxygen saturation with vessel density (VD) and tortuosity in DR.

Methods: Ninety-five subjects were classified in the following groups: nondiabetic control (N = 25), no DR (N = 28), mild nonproliferative DR (NPDR; N = 21), moderate to severe NPDR (N = 14), or treated proliferative DR (PDR; N = 7). Read More

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Life-time tobacco consumption and oral cancer among citizens of a high incidence metropolis.

J Pak Med Assoc 2021 Jun;71(6):1588-1591

Department of Pathology, Ziauddin University, Clifton Campus, Karachi, Pakistan.

Objective: To analyse dose-response relationship between the common risk factor of tobacco consumption and oral lesions like squamous cell carcinoma and pre-cancerous lesions.

Methods: The cross-sectional case-control study was conducted at Ziauddin University, Karachi from 2011 to 2016, and comprised histologically-confirmed cases of oral squamous cell carcinoma in group A, clinically-diagnosed oral pre-cancerous lesions in group B, and habit-matched controls in group C. The subjects were enrolled from 2011 to 2016. Read More

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Astaxanthin supplementation enhances metabolic adaptation with aerobic training in the elderly.

Physiol Rep 2021 Jun;9(11):e14887

Department of Radiology, University of Washington, Seattle, WA, USA.

Endurance training (ET) is recommended for the elderly to improve metabolic health and aerobic capacity. However, ET-induced adaptations may be suboptimal due to oxidative stress and exaggerated inflammatory response to ET. The natural antioxidant and anti-inflammatory dietary supplement astaxanthin (AX) has been found to increase endurance performance among young athletes, but limited investigations have focused on the elderly. Read More

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