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Factors associated with complicated pneumonia in children.

Pediatr Pulmonol 2021 May 15. Epub 2021 May 15.

Pediatric Pulmonary Institute and CF Center, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.

Introduction: CAP (community acquired pneumonia) is a leading cause of morbidity in children, despite advances in healthcare and anti-pneumococcal vaccine. Complicated pneumonia accounts for a significant burden with prolonged hospitalization. Finding risk factors for complicated pneumonia may help in tailoring management. Read More

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Analysis of the effects of a delay of surgery in patients with hip fractures: outcome and causes.

Osteoporos Int 2021 May 14. Epub 2021 May 14.

Department of Orthopedics and Traumatology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090, Brussels, Belgium.

This study analyzed characteristics of hip fracture patients who did not undergo surgery within 24 hours after hospitalization, as recommended by the Belgian quality standards. Reasons for delay were analyzed. Delay in surgery for hip fracture was related to the medical condition of the patients. Read More

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Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy.

J Immunother Cancer 2021 May;9(5)

Ella Lemelbaum Institute for Immuno-Oncology, Sheba Medical Center at Tel Hashomer, Tel Hashomer, Israel

Background: Adoptive cell therapy with T cells genetically engineered to express a chimeric antigen receptor (CAR-T) or tumor-infiltrating T lymphocytes (TIL) demonstrates impressive clinical results in patients with cancer. Lymphodepleting preconditioning prior to cell infusion is an integral part of all adoptive T cell therapies. However, to date, there is no standardization and no data comparing different non-myeloablative (NMA) regimens. Read More

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Single direct oral anticoagulant therapy in stable patients with atrial fibrillation beyond 1 year after coronary stent implantation.

Heart 2021 May 14. Epub 2021 May 14.

Division of Cardiology, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Objective: Optimal antithrombotic therapy in patients with atrial fibrillation (AF) beyond 1 year after coronary stent implantation has not been well established in the era of direct oral anticoagulant (DOAC).

Methods: Using Korean National Health Insurance Service data, we analysed 4294 patients with AF who were prescribed DOAC beyond 1 year after coronary stent implantation. Subjects were classified into the monotherapy group (DOAC single therapy, n=1221) or the combination therapy group (DOAC with an antiplatelet agent, n=3073). Read More

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Sleep assessment in cystic fibrosis patients using a minimal-impact biomotion system.

Sleep Med 2021 Apr 22;83:21-25. Epub 2021 Apr 22.

Department of Pneumology, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Tüschener Weg 40, 45239, Essen, Germany. Electronic address:

Purpose: In our study we aimed to analyze sleep variability and activity in patients with cystic fibrosis (CF) during their hospital stay.

Methods: Forty-three CF patients were recruited and have been divided into two subgroups: exacerbated (n = 18) and non-exacerbated (n = 25). During the course of their hospital stay we used VitaLog, a minimal-impact biomotion device, in order to determine total sleep time (TST), time in bed (TIB), sleep efficiency (SE) and intra patient standard deviation (IPSD) of TST. Read More

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Comparison of percutaneous endoscopic lumbar discectomy and open lumbar discectomy in the treatment of adolescent lumbar disc herniation: A retrospective analysis.

World Neurosurg 2021 May 11. Epub 2021 May 11.

Department of Orthopedics, Peking University Third Hospital, Beijing, China. Electronic address:

Objective: To compare and analyze the efficacy and safety of percutaneous endoscopic lumbar discectomy (PELD) and open lumbar discectomy (OLD) for adolescent lumbar disc herniation (ALDH).

Methods: The clinical data of 257 patients with single-segment ALDH who underwent surgical treatment at our hospital from January 2015 to December 2019 were retrospectively collected. According to different surgical methods, these patients were divided into PELD group and OLD group. Read More

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Dying with dementia in Medicare Advantage, Accountable Care Organizations, or traditional Medicare.

J Am Geriatr Soc 2021 May 14. Epub 2021 May 14.

Department of Health Services, Policy and Practice, Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Background/objective: Medicare Advantage (MA) and Accountable Care Organizations (ACOs) operate under incentives to reduce burdensome and costly care at the end of life. We compared end-of-life care for persons with dementia who are in MA, ACOs, or traditional Medicare (TM).

Design, Setting, And Participants: Retrospective study of decedents with dementia enrolled in MA, attributed to an ACO, or in TM. Read More

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Circulating neprilysin hypothesis: A new opportunity for sacubitril/valsartan in patients with heart failure and preserved ejection fraction?

PLoS One 2021 14;16(5):e0249674. Epub 2021 May 14.

Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.

Background: Circulating Neprilysin (sNEP) has emerged as a potential prognostic biomarker in heart failure (HF). In PARAGON-HF benefit of sacubitril/valsartan was only observed in patients with left ventricular ejection fraction (LVEF) ≤57%. We aimed to assess the prognostic value of sNEP in outpatients with HF and LVEF >57%, in comparison with patients with LVEF ≤57%. Read More

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Treatment Effect With Paliperidone Palmitate Compared With Oral Antipsychotics in Black/African American Patients With Schizophrenia and a History of Criminal Justice System Involvement: A Post Hoc Analysis of the PRIDE Study.

J Clin Psychiatry 2021 Feb 23;82(2). Epub 2021 Feb 23.

Janssen Scientific Affairs, LLC, Titusville, New Jersey.

Objective: To examine the efficacy and safety of paliperidone palmitate once-monthly (PP1M) versus oral antipsychotics (OAPs) in Black/African American patients with schizophrenia and a history of criminal justice system involvement.

Methods: This was a post hoc analysis of a 15-month prospective, randomized, open-label, parallel-group, multicenter US study conducted from May 2010 to December 2013 that examined a subpopulation of Black/African American patients with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria). The primary objective was to compare time to first treatment failure in patients treated with PP1M versus OAPs. Read More

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February 2021

Chronic Oral Anticoagulation and Clinical Outcome in Hospitalized COVID-19 Patients.

Cardiovasc Drugs Ther 2021 May 14. Epub 2021 May 14.

Division of Cardiology, "Bolognini" Hospital, ASST Bergamo Est, Seriate, BG, Italy.

Purpose: The clinical course of COVID-19 may be complicated by acute respiratory distress syndrome (ARDS) and thromboembolic events, which are associated with high risk of mortality. Although previous studies reported a lower rate of death in patients treated with heparin, the potential benefit of chronic oral anticoagulation therapy (OAT) remains unknown. We aimed to investigate the association between OAT with the risk of ARDS and mortality in hospitalized patients with COVID-19. Read More

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Association of Statins With Functional Outcome and 30-Day Mortality in Patients With Intracerebral Hemorrhage.

Cureus 2021 Apr 11;13(4):e14421. Epub 2021 Apr 11.

Stroke Unit, Centro Hospitalar Tondela-Viseu, Viseu, PRT.

Aim The effect of statins is well established in cardiac and cerebrovascular diseases. However, its impact on intracerebral hemorrhage (ICH) is unclear. We aim to identify an association of pre-ICH statin treatment and statin use during admission for ICH with functional outcome at discharge and 30-day mortality. Read More

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